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公开(公告)号：US20130018324A1
公开(公告)日：2013-01-17
申请号：US13261424
申请日：2011-02-28
IPC分类号： A61M5/32
CPC分类号： A61M5/3202 , A61M5/2466 , A61M5/326 , A61M5/3272 , A61M5/3287 , A61M5/3293 , A61M2005/2414 , A61M2005/247 , A61M2005/3267 , A61M2005/3289
摘要： An injection device (10) comprising a housing (12), a needle hub (38) slidable within the housing (12), a needle (40) having a distal end piercing tip (42) and a proximal end piercing tip (44), the needle hub being moveable from a first position wherein the distal end piercing tip (42) is within the housing to a second position wherein the distal end piercing tip (42) extends outwardly of the housing (12), a spring (23) biasing the needle hub (38) towards the first position, and a cartridge receiving member (48) mounted within the housing (12), and a plunger rod assembly (66) for exerting pressure on the cartridge receiving member (48) to move the cartridge (26) and the needle hub (38) from the first position to the second position, the plunger rod assembly (66) and the cartridge receiving member (48) being arranged such that when the cartridge rod assembly is pushed, a rotational movement is imparted to the cartridge receiving member (48) to thereby prevent access to the cartridge after injection.
摘要翻译： 一种注射装置（10），包括壳体（12），可在所述壳体（12）内滑动的针座（38），具有远端刺穿尖端（42）和近端刺穿尖端（44）的针（40） 所述针毂可从第一位置移动，其中所述远端刺穿末端（42）处于所述壳体内至第二位置，其中所述远端刺穿末端（42）从所述壳体（12）向外延伸，弹簧（23） 将针座（38）偏置到第一位置，以及安装在壳体（12）内的盒容纳构件（48），以及用于在盒容纳构件（48）上施加压力以移动 盒（26）和针座（38）从第一位置到第二位置，柱塞杆组件（66）和盒接收构件（48）被布置成使得当推动盒式杆组件时，旋转运动 被施加到盒接收构件（48），从而防止盒后部进入 呃注射。
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公开(公告)号：US20120330280A1
公开(公告)日：2012-12-27
申请号：US13507273
申请日：2012-06-18
IPC分类号： A61M5/31
CPC分类号： A61M5/385 , A61J1/201 , A61J1/2055 , A61J1/2096
摘要： A method for transferring and mixing a pharmaceutical mixture utilizing a by-pass cartridge and a syringe. After mixing the dry component and the diluent in the by-pass cartridge, the mixture can be passed to a syringe which includes a syringe plunger having a fluid passageway therein with a hydrophobic membrane covering the passageway. The mixture can be transferred back and forth between the by-pass cartridge and the syringe through a small bore to achieve mixing, particularly in the case of microspheres held in suspension.
摘要翻译： 一种利用旁路药筒和注射器转运和混合药物混合物的方法。 在旁路盒中混合干燥组分和稀释剂之后，可以将混合物送入注射器，该注射器包括其中具有流体通道的注射器柱塞，其中覆盖通道的疏水膜。 混合物可以通过小孔在旁路筒和注射器之间来回传递以实现混合，特别是在保持悬浮的微球的情况下。
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公开(公告)号：US08123084B2
公开(公告)日：2012-02-28
申请号：US12737013
申请日：2009-06-10
IPC分类号： B67D7/60
CPC分类号： B01F15/0201 , A61M5/2448 , A61M2005/3152 , B01F13/002 , B01F13/0023 , B01F15/0087 , B01F15/0237
摘要： A device for mixing a substance comprised of two constituents contained in a cartridge (12) and having a cartridge holder (32) thereabout, the device comprising a plunger rod (46) for pushing a closure member (20) to permit the transfer of a diluent in a second chamber (28) through a by-pass channel (24) to mix with a constituent in a first chamber (26), the plunger rod (48) being driven by means of a rack (48) and a pinion gear (50) arrangement to prevent overly rapid movement of the plunger rod (46).
摘要翻译： 一种用于混合包含在盒（12）中的两个组分并且在其周围具有盒保持器（32）的物质的装置，该装置包括用于推动封闭构件（20）以允许传送一个 稀释剂通过旁通通道（24）在第二腔室（28）中与第一腔室（26）中的组分混合，柱塞杆（48）通过齿条（48）和小齿轮 （50）布置以防止柱塞杆（46）的过度快速移动。
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公开(公告)号：US08088118B2
公开(公告)日：2012-01-03
申请号：US12157867
申请日：2008-06-13
CPC分类号： A61J1/2089 , A61J1/062 , A61J1/201 , A61J1/2013 , A61J1/2051
摘要： A system and method for transferring a fluid from a first container to a second container, the system comprising a first container (112) having a fluid (126) therein, the first container being sealed by a septum (124) and a piston (122), the second container being sealed at its mouth by a pierceable septum (132) and having a plunger (130) at the opposite end, a moveable needle shuttle (116) having first (144) and second (146) piercing ends, the arrangement being such that upon advancement of the first container with respect to the second container, a second one of the piercing ends (144) is adapted to pierce plunger (130) of the second container and a first piercing end (146) being designed to pierce the septum (124) of the first container.
摘要翻译： 一种用于将流体从第一容器传送到第二容器的系统和方法，所述系统包括其中具有流体（126）的第一容器（112），所述第一容器由隔膜（124）和活塞（122）密封 ），第二容器在其口部由可刺破的隔膜（132）密封并且在相对端具有柱塞（130），具有第一（144）和第二（146）穿刺端部的可移动的针梭（116） 布置使得在相对于第二容器推进第一容器时，穿刺端（144）中的第二个适于刺穿第二容器的柱塞（130），并且第一刺穿端（146）设计成 刺穿第一个容器的隔膜（124）。
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公开(公告)号：US20110106045A1
公开(公告)日：2011-05-05
申请号：US12925924
申请日：2010-11-01
IPC分类号： A61J1/20
CPC分类号： A61J1/2089 , A61J1/1406 , A61J1/2013 , A61J1/2055 , A61J1/2096 , B65B3/003
摘要： A transfer system suitable for medicaments comprising a vial socket, a housing having first and second open ends with the first open end being releasably connected to the vial socket, a needle hub mounted within the housing, a needle having first and second piercing ends mounted in the needle hub, a vial having a neck and a body, the vial being inserted in the vial socket and being non removably retained therein, a cartridge having a plunger sealing an open end thereof and a septum located at an opposite end of the cartridge, and an activation cap for causing the needle to penetrate a septum of the vial and the septum of the cartridge to permit transfer of components therebetween.
摘要翻译： 一种适用于药物的转运系统，包括小瓶插座，具有第一开口端和第二开口端的壳体，第一开口端可拆卸地连接到小瓶插座;安装在壳体内的针座;具有安装在第一和第二穿刺端 针座，具有颈部和主体的小瓶，小瓶插入小瓶插座中并且不可移除地保持在其中;具有密封其开口端的柱塞的盒和位于盒的相对端的隔膜， 以及激活帽，用于使针穿透小瓶的隔膜和药筒的隔膜，以允许其间的部件传递。
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公开(公告)号：US20080188828A1
公开(公告)日：2008-08-07
申请号：US12009783
申请日：2008-01-22
CPC分类号： A61M5/385 , A61J1/201 , A61J1/2055 , A61J1/2096
摘要： A transfer and mixing device which utilizes a by-pass cartridge and a syringe. After mixing the dry component and the diluent in the by-pass cartridge, the mixture can be passed to a syringe which includes a syringe plunger having a fluid passageway therein with a hydrophobic membrane covering the passageway. The mixture can be transferred back and forth between the by-pass cartridge and the syringe through a small bore to achieve mixing, particularly in the case of microspheres held in suspension.
摘要翻译： 一种利用旁路药筒和注射器的转运和混合装置。 在旁路盒中混合干燥组分和稀释剂之后，可以将混合物送入注射器，该注射器包括其中具有流体通道的注射器柱塞，其中覆盖通道的疏水膜。 混合物可以通过小孔在旁路筒和注射器之间来回传递以实现混合，特别是在保持悬浮的微球的情况下。
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公开(公告)号：US5364369A
公开(公告)日：1994-11-15
申请号：US791399
申请日：1991-11-14
申请人： David L. Reynolds
发明人： David L. Reynolds
CPC分类号： A61J1/2096 , A61J1/2089 , A61M5/28 , A61M5/284 , A61J1/10 , A61J1/1475 , A61J1/201 , A61J1/2013 , A61J1/2044 , A61J1/2075 , A61M2005/3139 , A61M5/1452
摘要： A prefilled syringe for one or two component medicaments is based upon the use of a vial containing a medicament or one component of a medicament, the vial having an open bottom closed by a piston. When a flexible extension of the piston is coupled with a tubular plunger, and an adaptor cap having an internal needle and an external connection for a needle is placed over a cap of the vial, the latter is converted into a prefilled syringe. The piston may have an axial passage closed by a resealable septum, so that a separate diluent stored in a flexible capsule may be introduced into the vial through the piston by a double ended needle mounted on a further cap applied to the capsule, the further cap being coupled within the tubular interior of the plunger so that the double ended needle penetrates the septum in the piston. The capsule is pushed forward onto the double ended needle when its contents are to be expelled into the vial. The capsule and its cap are then removed and discarded. In an alternative arrangement, the cap of the capsule is coupled to the adaptor cap and the diluent introduced into the vial through a closure secured by the cap of the vial, after which the capsule is removed from the plunger and the latter is coupled to the piston. In further embodiments, the capsule is replaced by a shell vial. The open bottom of the vial is formed with a strengthening bead designed not to interfere with handling of the vials by conventional vial sterilizing, filling and capping machinery.
摘要翻译： 用于一种或两种组分药物的预充式注射器基于使用含有药物或药物的一种成分的小瓶，该小瓶具有由活塞封闭的开口底部。 当活塞的柔性延伸部与管状柱塞联接时，具有内针和用于针头的外部连接件的适配器盖被放置在小瓶的帽上，后者被转换成预充式注射器。 活塞可以具有由可重新密封的隔膜封闭的轴向通道，使得存储在柔性胶囊中的单独的稀释剂可以通过安装在施加到胶囊的另一盖上的双端针通过活塞引入小瓶中，另外的帽 联接在柱塞的管状内部中，使得双端针穿透活塞中的隔膜。 当其内容物被排出到小瓶中时，胶囊被推向双端针。 然后将胶囊和其盖子取出并丢弃。 在另一种布置中，胶囊的盖连接到适配器盖，并且通过由小瓶的帽固定的封闭物引入到小瓶中的稀释剂，之后将胶囊从柱塞移除，并且后者耦合到 活塞。 在另外的实施例中，胶囊被壳小瓶代替。 小瓶的开口底部形成有加强珠，其设计成不会通过常规的小瓶灭菌，填充和封盖机械干扰处理小瓶。
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公开(公告)号：US5137511A
公开(公告)日：1992-08-11
申请号：US437203
申请日：1989-11-16
申请人： David L. Reynolds
发明人： David L. Reynolds
CPC分类号： A61M5/284 , A61M2005/3139 , A61M5/1411 , A61M5/1452 , A61M5/1456
摘要： A prefilled syringe for one or two component medicaments is based upon the use of a vial containing a medicament or one component of a medicament, the vial having an open bottom closed by a piston. When a flexible extension of the piston is coupled with a tubular plunger, and an adaptor cap having an internal needle and an external connection for a needle is placed over a cap of the vial, the latter is converted into a prefilled syringe. The piston may have an axial passage closed by a resealable septum, so that a separate diluent stored in a flexible capsule may be introduced into the vial through the piston by a double ended needle mounted on a further cap applied to the capsule, the further cap being coupled within the tubular interior of the plunger so that the double ended needle penetrates the septum in the piston. The capsule is pushed forward onto the double ended needle when its contents are to be expelled into the vial. The capsule and its cap are then removed and discarded. In an alternative arrangement, the cap of the capsule is coupled to the adaptor cap and the diluent introduced into the vial through a closure secured by the cap of the vial, after which the capsule is removed from the plunger and the latter is coupled to the piston.
摘要翻译： 用于一种或两种组分药物的预充式注射器基于使用含有药物或药物的一种成分的小瓶，该小瓶具有由活塞封闭的开口底部。 当活塞的柔性延伸部与管状柱塞联接时，具有内针和用于针头的外部连接件的适配器盖被放置在小瓶的帽上，后者被转换成预充式注射器。 活塞可以具有由可重新密封的隔膜封闭的轴向通道，使得存储在柔性胶囊中的单独的稀释剂可以通过安装在施加到胶囊的另一盖上的双端针通过活塞引入小瓶中，另外的帽 联接在柱塞的管状内部中，使得双端针穿透活塞中的隔膜。 当其内容物被排出到小瓶中时，胶囊被推向双端针。 然后将胶囊和其盖子取出并丢弃。 在另一种布置中，胶囊的盖连接到适配器盖，并且通过由小瓶的帽固定的封闭物引入到小瓶中的稀释剂，之后将胶囊从柱塞移除，并且后者耦合到 活塞。
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公开(公告)号：US4861335A
公开(公告)日：1989-08-29
申请号：US18934
申请日：1987-02-25
申请人： David L. Reynolds
发明人： David L. Reynolds
CPC分类号： B01F1/0022 , A61M5/2448 , A61M5/31596 , B01F13/0023 , B01F15/0212 , B01F15/0225 , A61M2005/31598 , A61M5/2425
摘要： A syringe provides for the isolated storage of two components of a medicament until immediately prior to use of the syringe. One liquid component is stored in a collapsible chamber of a sealed capsule within a hollow plunger stem of the syringe, and the other component beneath the head of the plunger. A double headed needle arrangement between the head and stem of the plunger is caused to penetrate the plunger head and the capsule when the syringe is to be used so that the plunger may be drawn back to exhaust the contents of the capsule chamber into admixture with the component stored beneath the head of the plunger. Communication through the double headed needle arrangement is then interrupted before the plunger is used to eject the syringe contents through an external needle fitted to the syringe.
摘要翻译： 注射器提供药物的两个组分的隔离储存，直到使用注射器之前。 一个液体组分存储在注射器的中空柱塞杆内的密封胶囊的可折叠室中，而在柱塞头部下方存储另一个部件。 当使用注射器时，在柱塞的头部和杆部之间的双头针布置被穿过柱塞头和胶囊，使得柱塞可以被拉回以将胶囊室的内容物排出与 存储在柱塞头部下方的部件。 然后在使用柱塞通过装配到注射器的外部针头喷射注射器内容物之前通过双头针布置的通信被中断。
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公开(公告)号：US09662457B2
公开(公告)日：2017-05-30
申请号：US13261780
申请日：2012-06-01
CPC分类号： A61M5/3294 , A61M5/1782 , A61M5/19 , A61M5/2448 , A61M5/2466 , A61M5/31511 , A61M5/3202 , A61M5/326 , A61M5/3272 , A61M5/3287 , A61M5/3293 , A61M5/3298 , A61M2005/2407 , A61M2005/2414 , A61M2005/247 , A61M2005/3267 , A61M2005/3289
摘要： An injection device which includes a housing (12), a needle hub (38) slidable within the housing (12), a needle (40) having a distal end piercing tip (42) and a proximal end piercing tip (44), the needle hub (40) being moveable from a first position wherein the distal piercing tip (42) is within the housing to a second position wherein the distal end piercing tip (42) extends outwardly of housing (12), a first spring (23) biasing the needle hub (38) towards the first position, and a cartridge receiving member (48) mounted within the housing, and a plunger rod assembly (166), the plunger rod assembly (166) having a distal interior chamber (102) and a proximal interior chamber (103), the distal interior chamber (102) being designed to receive a cartridge (85) containing a liquid (89), the cartridge having a septum (87) and a plunger (88) to prevent exit of the liquid, and a second needle hub (91) located in the proximal chamber, a second hollow needle (92) mounted in the second needle hub, the second hollow needle having a distal piercing tip (94) and a proximal piercing tip (93), the second hollow needle being moveable from a first non piercing position to a second position whereby said distal piercing tip (94) will pierce the septum (87).
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