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公开(公告)号：US20110013474A1
公开(公告)日：2011-01-20
申请号：US12921407
申请日：2009-03-18
申请人： Jens Ludwig , Oscar-Werner Reif , Gerhard Greller , Wolfgang Kahlert , Guenther Pradel , Michael Bates , Magail Barbaroux , Stephane Baud , Isabelle Gay , Sebastian Chaussin
发明人： Jens Ludwig , Oscar-Werner Reif , Gerhard Greller , Wolfgang Kahlert , Guenther Pradel , Michael Bates , Magail Barbaroux , Stephane Baud , Isabelle Gay , Sebastian Chaussin
CPC分类号： B01F3/04269 , B01F7/00633 , B01F7/00691 , B01F7/1695 , B01F7/22 , B01F13/0827 , B01F13/0872 , B01F15/00071 , B01F15/00123 , B01F15/00396 , B01F15/00707 , B01F15/00831 , B01F15/0085 , B01F15/065 , B01F2003/04326 , B01F2003/04361 , B01F2003/04879 , B01F2003/04893 , B01F2015/062 , B01F2215/0073 , C12M23/26 , C12M27/02 , C12M29/06
摘要： A disposable mixing vessel comprising a flexible container, a centrally disposed shaft having first and second ends with one or more impellers thereon and a magnetic element associated with a first shaft end, a first flange adapted to rotatably engage the first shaft end and a second flange adapted to rotatably engage the second shaft end.
摘要翻译： 一种一次性混合容器，包括柔性容器，居中设置的轴，其具有在其上的一个或多个叶轮的第一和第二端和与第一轴端相关联的磁性元件，适于可旋转地接合第一轴端的第一凸缘和第二凸缘 适于可旋转地接合第二轴端。
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公开(公告)号：US20090314666A1
公开(公告)日：2009-12-24
申请号：US12226082
申请日：2007-04-12
IPC分类号： B65D25/00
CPC分类号： B01F15/0085 , B01F7/16 , B01F11/04 , B01F13/08 , B01F15/00896 , B01F2215/0032
摘要： Container system with one container (1) with a flexible partition, in particular a disposable container, that can be inserted into a carrying container that supports its lateral container partition (10) and in which liquid medium (8) that has been poured in can be mixed, with the carrying container (4) featuring at least one baffle (15, 15′, 15″, 15′″) on the internal support partition (11) that forms the lateral container partition.
摘要翻译： 具有一个容器（1）的容器系统，其具有柔性分隔物，特别是一次性容器，其可以插入到支撑其侧向容器隔板（10）的运载容器中，并且其中已经注入罐的液体介质（8） 与在内部支撑隔板（11）上具有至少一个挡板（15,15'，15“，15”）的承载容器（4）混合，形成侧向容器隔板。
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23.发明授权Container having flexible walls with connecting piece for mixer shaft and coupling piece for drive device fixed magnetically to opposite inner and outer surfaces of container wall 有权容器具有柔性壁，其具有用于混合器轴的连接件和用于驱动装置的联接件，磁力固定到容器壁的相对的内表面和外表面公开(公告)号：US09095828B2
公开(公告)日：2015-08-04
申请号：US11717357
申请日：2007-03-13
CPC分类号： B01F13/0827 , B01F11/0082 , B01F11/0091 , B01F13/0863 , B01F15/0085 , B01F2215/0032
摘要： A container has flexible walls defining an interior. A mixer is arranged in the interior of the container and includes a mixer shaft with opposite first and second ends. A mixing element is mounted to the first end of the mixer shaft. The second end of the mixer shaft is fixed magnetically to a coupling piece disposed on the exterior of the flexible wall of the container. The coupling piece is connected operatively to a force introducing device that generates movement of the mixer.
摘要翻译： 容器具有限定内部的柔性壁。 混合器布置在容器的内部，并包括具有相对的第一和第二端的混合器轴。 混合元件安装到混合器轴的第一端。 混合器轴的第二端固定地固定在设置在容器的柔性壁的外部上的联接件上。 联接件可操作地连接到产生混合器运动的力导入装置。
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公开(公告)号：US09044718B2
公开(公告)日：2015-06-02
申请号：US12918351
申请日：2009-03-18
申请人： Jens Ludwig , Oscar-Werner Reif , Gerhard Greller , Wolfgang Kahlert , Günter Pradel , Michael Bates , Magali Barbaroux , Stephanie Baud , Isabelle Gay , Sebastien Chaussin
发明人： Jens Ludwig , Oscar-Werner Reif , Gerhard Greller , Wolfgang Kahlert , Günter Pradel , Michael Bates , Magali Barbaroux , Stephanie Baud , Isabelle Gay , Sebastien Chaussin
IPC分类号： B01F3/04 , B01F7/00 , B01F7/16 , B01F7/22 , B01F13/08 , B01F15/00 , B01F15/06 , C12M1/00 , C12M1/06
CPC分类号： B01F3/04269 , B01F7/00633 , B01F7/00691 , B01F7/1695 , B01F7/22 , B01F13/0827 , B01F13/0872 , B01F15/00071 , B01F15/00123 , B01F15/00396 , B01F15/00707 , B01F15/00831 , B01F15/0085 , B01F15/065 , B01F2003/04326 , B01F2003/04361 , B01F2003/04879 , B01F2003/04893 , B01F2015/062 , B01F2215/0073 , C12M23/26 , C12M27/02 , C12M29/06
摘要： A mixing vessel includes a flexible container, elements for mixing its contents, aeration elements, a drain/lower bearing port having a rigid flange provided with a drain passage, attached in a tight manner to the lower portion of the container wall, supporting a lower bearing that is adjacent to the drain passage. The vessel includes an extended element for dispensing aeration gas and is spaced essentially radially from the drain/bearing port; at least one tubular element for dispensing aeration gas extends from the extended dispensing element, in the inside space, along the inside surface of the lower portion and the side portion of the wall of the container and extends on the outside of the container from the upper portion; at least one mixing element is spaced essentially from the lower portion of the container wall, from the lower bearing, and from at least one extended element for dispensing aeration gas.
摘要翻译： 混合容器包括柔性容器，用于混合其内容物的元件，曝气元件，具有设置有排水通道的刚性凸缘的排水/下轴承端口，紧密地附接到容器壁的下部， 与排水通道相邻的轴承。 容器包括用于分配曝气气体的延伸元件，并且与排放/承载端口基本上径向间隔开; 用于分配曝气气体的至少一个管状元件沿着内部空间中的延伸的分配元件沿容器的下部和内侧面的内表面延伸，并从容器的上部在容器的外侧延伸 一部分; 至少一个混合元件基本上与容器壁的下部，下部轴承以及用于分配曝气的至少一个延伸元件间隔开。
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25.发明授权Sensor device, comprising an optical sensor, a container and a compartmentalization means 有权传感器装置，包括光学传感器，容器和分隔装置公开(公告)号：US08859949B2
公开(公告)日：2014-10-14
申请号：US13377845
申请日：2010-05-22
申请人： Reinhard Baumfalk , Stefan Weisshaar , Gerhard Greller , Daniel Riechers , Julia Lueders , Peter Polossek
发明人： Reinhard Baumfalk , Stefan Weisshaar , Gerhard Greller , Daniel Riechers , Julia Lueders , Peter Polossek
CPC分类号： A61L2/28 , A61L2/081 , G01N21/80 , G01N21/90 , G01N2021/7786
摘要： A sensor device has an optical sensor (1), a container (2) and a compartmentalizer (3) that temporarily divides the container into a main space (4) and an adjacent space (5), in which the optical sensor (1) is located. The gas volume in the direct vicinity of the optical sensor (1) is reduced, as are also, consequently, the reactive products generated by radiation sterilization. The adjacent space (5) can be united with the main space (4) after the sterilization as a result of the temporary compartmentalization. The optical sensor is suitable for implementation in containers and laboratory products, such as, for example, disposable bioreactors, that are sterilized by gamma radiation.
摘要翻译： 传感器装置具有光学传感器（1），容器（2）和分隔器（3），其将容器暂时分为主空间（4）和相邻的空间（5），其中光传感器（1） 位于。 直接靠近光学传感器（1）的气体体积减少，因此减少由辐射灭菌产生的反应性产物。 由于临时分隔，相邻的空间（5）可以在灭菌之后与主空间（4）结合。 光学传感器适用于容器和实验室产品，例如通过γ辐射灭菌的一次性生物反应器。
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公开(公告)号：US08690418B2
公开(公告)日：2014-04-08
申请号：US12921412
申请日：2009-03-18
申请人： Jens Ludwig , Oscar-Werner Reif , Gerhard Greller , Wolfgang Kahlert , Guenther Pradel , Michael Bates , Magail Barbaroux , Stephane Baud , Isabelle Gay , Sebastian Chaussin
发明人： Jens Ludwig , Oscar-Werner Reif , Gerhard Greller , Wolfgang Kahlert , Guenther Pradel , Michael Bates , Magail Barbaroux , Stephane Baud , Isabelle Gay , Sebastian Chaussin
CPC分类号： B01F3/04269 , B01F7/00633 , B01F7/00691 , B01F7/1695 , B01F7/22 , B01F13/0827 , B01F13/0872 , B01F15/00071 , B01F15/00123 , B01F15/00396 , B01F15/00707 , B01F15/00831 , B01F15/0085 , B01F15/065 , B01F2003/04326 , B01F2003/04361 , B01F2003/04879 , B01F2003/04893 , B01F2015/062 , B01F2215/0073 , C12M23/26 , C12M27/02 , C12M29/06
摘要： A method of mixing including providing a flexible container which comprises at least two components, assembling the components from outside the flexible container to form a centrally disposed magnetic driven shaft with at least one impeller, whereby the integrity of the flexible container is maintained, filling the flexible container having the centrally disposed magnetic driven shaft with one or more ingredients of the contents to be mixed; engaging a magnetic element of the centrally disposed magnetic driven shaft with an external magnetic drive element; analyzing the contents of the flexible container using at least one sensor or a sampling line on the flexible container; and draining the contents of the flexible container through a drain port at the bottom of the flexible container.
摘要翻译： 一种混合方法，包括提供柔性容器，其包括至少两个部件，从柔性容器外部组装部件以形成具有至少一个叶轮的居中设置的磁力驱动轴，由此维持柔性容器的完整性，填充 柔性容器具有中心设置的磁力驱动轴，其中一个或多个要混合的内容物成分; 将中心设置的磁驱动轴的磁性元件与外部磁性驱动元件接合; 使用柔性容器上的至少一个传感器或取样管线分析柔性容器的内容物; 并通过柔性容器底部的排水口排出柔性容器的内容物。
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公开(公告)号：US20120313267A1
公开(公告)日：2012-12-13
申请号：US13508074
申请日：2010-10-28
CPC分类号： B01F3/04531 , B01F3/04099 , B01F3/04106 , B01F3/04262 , B01F2003/04673 , C12M29/06
摘要： Aeration device for bioreactors with a first aeration element with gas outlet openings of a first size and with at least one second aeration element with gas outlet openings of a second size, the aeration elements being formed by a common housing with separate aeration channels.
摘要翻译： 具有第一曝气元件的生物反应器的曝气装置，其具有第一尺寸的气体出口开口和具有第二尺寸的气体出口开口的至少一个第二曝气元件，曝气元件由具有单独曝气通道的公共壳体形成。
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公开(公告)号：US20110026360A1
公开(公告)日：2011-02-03
申请号：US12933453
申请日：2009-03-27
申请人： Gerhard Greller , Guenter Pradel
发明人： Gerhard Greller , Guenter Pradel
CPC分类号： B01F7/00633 , B01F7/00691 , B01F7/007 , B01F7/00716 , B01F7/22 , B01F15/00831 , B01F15/0085 , C12M23/14 , C12M27/02 , F16C3/03
摘要： A flexible pouch has a mixing apparatus, the mixer shaft of which is adjustable in length for use as a bioreactor for culturing microorganisms and cells.
摘要翻译： 柔性袋具有混合装置，其混合器轴的长度可调节用作用于培养微生物和细胞的生物反应器。
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公开(公告)号：US20110013473A1
公开(公告)日：2011-01-20
申请号：US12921412
申请日：2009-03-18
申请人： Jens Ludwig , Oscar-Werner Reif , Gerhard Greller , Wolfgang Kahlert , Guenther Pradel , Michael Bates , Magail Barbaroux , Stephane Baud , Isabelle Gay , Sebastian Chaussin
发明人： Jens Ludwig , Oscar-Werner Reif , Gerhard Greller , Wolfgang Kahlert , Guenther Pradel , Michael Bates , Magail Barbaroux , Stephane Baud , Isabelle Gay , Sebastian Chaussin
CPC分类号： B01F3/04269 , B01F7/00633 , B01F7/00691 , B01F7/1695 , B01F7/22 , B01F13/0827 , B01F13/0872 , B01F15/00071 , B01F15/00123 , B01F15/00396 , B01F15/00707 , B01F15/00831 , B01F15/0085 , B01F15/065 , B01F2003/04326 , B01F2003/04361 , B01F2003/04879 , B01F2003/04893 , B01F2015/062 , B01F2215/0073 , C12M23/26 , C12M27/02 , C12M29/06
摘要： A method of mixing including providing a flexible container which comprises at least two components, assembling the components from outside the flexible container to form a centrally disposed magnetic driven shaft with at least one impeller, whereby the integrity of the flexible container is maintained, filling the flexible container having the centrally disposed magnetic driven shaft with one or more ingredients of the contents to be mixed; engaging a magnetic element of the centrally disposed magnetic driven shaft with an external magnetic drive element; analyzing the contents of the flexible container using at least one sensor or a sampling line on the flexible container; and draining the contents of the flexible container through a drain port at the bottom of the flexible container.
摘要翻译： 一种混合方法，包括提供包括至少两个部件的柔性容器，从柔性容器外部组装部件以形成具有至少一个叶轮的居中设置的磁力驱动轴，从而保持柔性容器的完整性，填充 具有中心设置的磁力驱动轴的柔性容器，所述磁力驱动轴具有要混合的内容物的一种或多种成分; 将中心设置的磁驱动轴的磁性元件与外部磁性驱动元件接合; 使用柔性容器上的至少一个传感器或取样管线分析柔性容器的内容物; 并通过柔性容器底部的排水口排出柔性容器的内容物。
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公开(公告)号：US20090275121A1
公开(公告)日：2009-11-05
申请号：US12226297
申请日：2007-04-24
申请人： Gerhard Greller , Oscar-Werner Reif
发明人： Gerhard Greller , Oscar-Werner Reif
IPC分类号： C12M1/08
CPC分类号： B01F11/0082 , B01F3/04262 , B01F11/0091 , B01F15/00071 , B01F15/0085 , B01F2215/0073 , C12M23/28 , C12M27/16 , C12M27/22
摘要： A vibrational mixer (1), in particular a single-path mixer for use in single-path bioreactors (4) with flexible walls, consisting of a mixer shaft (2) that can be set into longitudinal motions by a drive (8), with at least one mixing element (3), wherein at least one channel (13) is arranged in the mixer shaft with an opening to an interior reactor space (6).
摘要翻译： 振动混合器（1），特别是用于具有柔性壁的单路生物反应器（4）的单路混合器，由混合器轴（2）组成，该混合器轴可由驱动器（8）设置成纵向运动， 至少一个混合元件（3），其中至少一个通道（13）布置在混合器轴中，开口通向内部反应器空间（6）。
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