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公开(公告)号：US5747449A
公开(公告)日：1998-05-05
申请号：US086630
申请日：1993-07-01
Applicant: Ignace Lasters , Marc De Maeyer , William Charles Ripka
Inventor： Ignace Lasters , Marc De Maeyer , William Charles Ripka
IPC: C12N15/09 , A61K38/00 , A61K38/55 , A61P7/02 , C07K14/47 , C07K14/81 , C12N1/19 , C12N1/21 , C12N9/99 , C12N15/15 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/84 , A61K38/57
CPC classification number: C07K14/8117 , A61K38/00
Abstract: A compound derived from BPTI which inhibits Factor Xa with an inhibition constant less than 50 nM.
Abstract translation: 衍生自BPTI的抑制因子Xa的抑制常数小于50nM的化合物。
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22.发明授权Modified prokaryotic glucose isomerase enzymes with altered pH activity profiles 失效改变的原始葡萄糖异构酶与pH活性变化曲线
公开(公告)号：US5340738A
公开(公告)日：1994-08-23
申请号：US637399
申请日：1991-01-04
Applicant: Anne-Marie Lambeir , Ignace Lasters , Nadir Mrabet , Wilhelmus J. Quax , Jan M. Van der Laan , Onno Misset
Inventor： Anne-Marie Lambeir , Ignace Lasters , Nadir Mrabet , Wilhelmus J. Quax , Jan M. Van der Laan , Onno Misset
IPC: C12N9/00 , C12N9/90 , C12N9/92 , C12N15/09 , C12N15/54 , C12N15/61 , C12P19/02 , C12R1/045 , C12R1/19 , C12M15/61 , C12M9/92 , C12M15/70 , C12M15/74
CPC classification number: C12N9/92
Abstract: A method for selecting amino acid residues is disclosed which upon replacement will give rise to an enzyme with an altered pH optimum. The method is specific for metalloenzymes which are inactivated at low pH due to the dissociation of the metal ions. The method is based on altering the pK.sub.a of the metal coordinating ligands or altering the K.sub.ass for the metal binding. New glucose isomerases with an altered pH optimum are provided according to this method. These altered properties enable starch degradation to be performed at lower pH values.
Abstract translation: 公开了一种选择氨基酸残基的方法，其在置换时将产生具有改变的pH最佳值的酶。 该方法对于在低pH下由于金属离子的解离而失活的金属酶特异性。 该方法基于改变金属配位配体的pKa或改变Kass的金属结合。 根据该方法提供具有改变的pH最佳值的新葡萄糖异构酶。 这些改变的性质使淀粉降解能够在较低的pH值下进行。
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公开(公告)号：US08538706B2
公开(公告)日：2013-09-17
申请号：US13270931
申请日：2011-10-11
Applicant: Johan Desmet , Geert Meersseman , Nathalie Boutonnet , Jurgen Pletinckx , Krista De Clercq , Ignace Lasters
Inventor： Johan Desmet , Geert Meersseman , Nathalie Boutonnet , Jurgen Pletinckx , Krista De Clercq , Ignace Lasters
Abstract: The present invention is related to a quantitative structure-based affinity scoring method for peptide/protein complexes. More specifically, the present invention comprises a method that operates on the basis of a highly specific force field function (e.g. CHARMM) that is applied to all-atom structural representations of peptide/receptor complexes. Peptide side-chain contributions to total affinity are scored after detailed rotameric sampling followed by controlled energy refinement. The method of the invention further comprises a de novo approach to estimate dehydration energies from the simulation of individual amino acids in a solvent box filled with explicit water molecules and applying the same force field function as used to evaluate peptide/receptor complex interactions.
Abstract translation: 本发明涉及肽/蛋白复合物的基于定量结构的亲和评分方法。 更具体地说，本发明包括一种基于应用于肽/受体复合物的全原子结构表示的高度特异性的力场函数（例如CHARMM）来操作的方法。 在详细的旋转异构体取样之后进行受控能量细化，对总亲和力的肽侧链贡献进行评分。 本发明的方法还包括从填充有显性水分子的溶剂盒中的各个氨基酸的模拟估算脱水能量并应用用于评估肽/受体复合物相互作用的相同的力场函数的从头方法。
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公开(公告)号：US20130211808A2
公开(公告)日：2013-08-15
申请号：US13472080
申请日：2012-05-15
Applicant: Johan DESMET , Ignace LASTERS , Dominique VLIEGHE , Carlo BOUTTON , Philippe STAS
Inventor： Johan DESMET , Ignace LASTERS , Dominique VLIEGHE , Carlo BOUTTON , Philippe STAS
CPC classification number: G06F19/16
Abstract: The present invention provides methods and apparatus for analyzing a protein structure.
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25.发明申请APPARATUS AND METHOD FOR STRUCTURE-BASED PREDICTION OF AMINO ACID SEQUENCES 审中-公开用于氨基酸序列的结构预测的装置和方法公开(公告)号：US20110245463A1
公开(公告)日：2011-10-06
申请号：US13020452
申请日：2011-02-03
Applicant: JOHAN DESMET , IGNACE LASTERS , DOMINIQUE VLIEGHE , CARLO BOUTTON , PHILIPPE STAS
Inventor： JOHAN DESMET , IGNACE LASTERS , DOMINIQUE VLIEGHE , CARLO BOUTTON , PHILIPPE STAS
IPC: C07K14/00
CPC classification number: G16B15/00
Abstract: The present invention provides methods and apparatus for analyzing a protein structure.
Abstract translation: 本发明提供了分析蛋白质结构的方法和装置。
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Patent Agency Ranking
26.发明申请Method, computing routine, device for predicting properties of MHC/peptide complexes, and data and peptides produced therefrom. 审中-公开方法，计算程序，用于预测MHC /肽复合物的性质的装置，以及由其制备的数据和肽。公开(公告)号：US20100168398A1
公开(公告)日：2010-07-01
申请号：US12660774
申请日：2010-03-04
Applicant: Ignace Lasters , Johan Desmet
Inventor： Ignace Lasters , Johan Desmet
Abstract: The present invention relates to a method for structure-based prediction of properties of peptides and peptide analogs in complex with major histocompatibility (MHC) class I and class II molecules. The said properties mainly relate to the three-dimensional structure of an MHC/peptide complex and the binding affinity of a peptide for an MHC receptor. The invention further relates to a computer program and a device therefor. The invention further relates to data produced by a method of the invention. The invention further relates to peptides and peptide analogs predicted to bind to target-MHC molecules. The present invention thus relates to the field of immunology, with possible applications in manufacture of vaccinates, de-immunization of proteins, and manufacture of therapeutic agents, especially immunotherapeutic agents.
Abstract translation: 本发明涉及与主要组织相容性（MHC）I类和II类分子复合的肽和肽类似物的基于结构的预测性质的方法。 所述性质主要涉及MHC /肽复合物的三维结构和肽对MHC受体的结合亲和力。 本发明还涉及一种计算机程序及其装置。 本发明还涉及通过本发明的方法产生的数据。 本发明还涉及预期与靶MHC分子结合的肽和肽类似物。 因此，本发明涉及免疫学领域，可能应用于疫苗接种的制造，蛋白质的去免疫，以及治疗剂，特别是免疫治疗剂的制造。
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27.发明申请Method, computing routine, device for predicting properties of mhc/peptide complexes, and data and peptides produced therefrom 有权方法，计算程序，用于预测mhc /肽复合物的性质的装置，以及由其制备的数据和肽公开(公告)号：US20060111554A1
公开(公告)日：2006-05-25
申请号：US10516628
申请日：2003-06-10
Applicant: Ignace Lasters , Johan Desmet
Inventor： Ignace Lasters , Johan Desmet
Abstract: The present invention relates to a method for structure-based prediction of properties of peptides and peptide analogs in complex with major histocompatibility (MHC) class I and class II molecules. The said properties mainly relate to the three-dimensional structure of an MHC/peptide complex and the binding affinity of a peptide for an MHC receptor. The invention further relates to a computer program and a device therefor. The invention further relates to data produced by a method of the invention. The invention further relates to peptides and peptide analogs predicted to bind to target-MHC molecules. The present invention thus relates to the field of immunology, with possible applications in manufacture of vaccinates, de-immunization of proteins, and manufacture of therapeutic agents, especially immunotherapeutic agents.
Abstract translation: 本发明涉及与主要组织相容性（MHC）I类和II类分子复合的肽和肽类似物的基于结构的预测性质的方法。 所述性质主要涉及MHC /肽复合物的三维结构和肽对MHC受体的结合亲和力。 本发明还涉及一种计算机程序及其装置。 本发明还涉及通过本发明的方法产生的数据。 本发明还涉及预期与靶MHC分子结合的肽和肽类似物。 因此，本发明涉及免疫学领域，可能应用于疫苗接种的制造，蛋白质的去免疫，以及治疗剂，特别是免疫治疗剂的制造。
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28.发明申请公开(公告)号：US20060093617A1
公开(公告)日：2006-05-04
申请号：US11140487
申请日：2005-05-31
Applicant: Marie-Ange Buyse , Geert Maertens , Erik Depla , Ignace Lasters , Johan Desmet , Denise Baker , Robert Chesnut , Mark Newman , Alessandro Sette , John Sidney , Scott Southwood
Inventor： Marie-Ange Buyse , Geert Maertens , Erik Depla , Ignace Lasters , Johan Desmet , Denise Baker , Robert Chesnut , Mark Newman , Alessandro Sette , John Sidney , Scott Southwood
CPC classification number: C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/55566 , A61K2039/57 , C12N2770/24222 , C12N2770/24234
Abstract: The present invention is directed to peptides, and nucleic acids encoding them, derived from the Hepatitis C Virus (HCV). The peptides are those which elicit a CTL and/or HTL response in a host. The invention is also directed to compositions and vaccines for prevention and treatment of HCV infection and diagnostic methods for detection of HCV exposure in patients.
Abstract translation: 本发明涉及衍生自丙型肝炎病毒（HCV）的肽和编码它们的核酸。 肽是在宿主中引起CTL和/或HTL应答的肽。 本发明还涉及用于预防和治疗HCV感染的组合物和疫苗以及用于检测患者中HCV暴露的诊断方法。
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公开(公告)号：US5384257A
公开(公告)日：1995-01-24
申请号：US112703
申请日：1993-08-26
Applicant: Anne-Marie Lambeir , Ignace Lasters , Nadir Mrabet , Wilhelmus J. Quax , Jan M. Van der Laan , Onno Misset
Inventor： Anne-Marie Lambeir , Ignace Lasters , Nadir Mrabet , Wilhelmus J. Quax , Jan M. Van der Laan , Onno Misset
IPC: C12N9/00 , C12N9/90 , C12N9/92 , C12N15/09 , C12N15/54 , C12N15/61 , C12P19/02 , C12R1/045 , C12R1/19 , C12N13/61 , C12N15/70 , C12N15/74
CPC classification number: C12N9/92
Abstract: A method for selecting amino acid residues is disclosed which upon replacement will give rise to an enzyme with an altered pH optimum. The method is specific for metalloenzymes which are inactivated at low pH due to the dissociation of the metal ions. The method is based on altering the pK.sub.a of the metal coordinating ligands or altering the K.sub.ass for the metal binding. New glucose isomerases with an altered pH optimum are provided according to this method. These altered properties enable starch degradation to be performed at lower pH values.
Abstract translation: 公开了一种选择氨基酸残基的方法，其在置换时将产生具有改变的pH最佳值的酶。 该方法对于在低pH下由于金属离子的解离而失活的金属酶特异性。 该方法基于改变金属配位配体的pKa或改变金属结合的Kass。 根据该方法提供具有改变的pH最佳值的新葡萄糖异构酶。 这些改变的性质使淀粉降解能够在较低的pH值下进行。
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公开(公告)号：US5290690A
公开(公告)日：1994-03-01
申请号：US398706
申请日：1989-08-25
Applicant: Nadir Mrabet , Ignace Lasters , Patrick Stanssens , Gaston Matthyssens , Shoshana Wodak , Wilhelmus J. Quax
Inventor： Nadir Mrabet , Ignace Lasters , Patrick Stanssens , Gaston Matthyssens , Shoshana Wodak , Wilhelmus J. Quax
CPC classification number: C12Y102/01012 , C12N9/0008 , C12N9/0089 , C12N9/10 , C12N9/92 , C12P21/02
Abstract: The invention pertains to a method for the production of a biologically active modified protein derived from a starting protein having essentially the same kind of biological activity with an attendant modulation effect on, particularly increase of, the stability as compared with that of the starting protein. The method comprises substituting an arginine residue for a lysine residue of the starting protein at a site that can sterically accommodate the substitution, without substantially altering the biological activity of the starting protein, said site being preferably of low solvent accessibility, at interfaces between domains or sub-units of the starting protein.
Abstract translation: 本发明涉及一种生产生物活性的修饰蛋白质的方法，该蛋白质具有与起始蛋白质相比具有基本上相同种类的生物活性的起始蛋白质，具有伴随的调节作用，特别是增加的稳定性。 该方法包括在可以空间适应取代的位置处将起始蛋白质的赖氨酸残基取代，而基本上不改变起始蛋白质的生物活性，所述位点优选在溶剂可接近性低的区域之间， 起始蛋白质的亚单位。
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