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1.发明申请公开(公告)号：US20060093617A1
公开(公告)日：2006-05-04
申请号：US11140487
申请日：2005-05-31
申请人： Marie-Ange Buyse , Geert Maertens , Erik Depla , Ignace Lasters , Johan Desmet , Denise Baker , Robert Chesnut , Mark Newman , Alessandro Sette , John Sidney , Scott Southwood
发明人： Marie-Ange Buyse , Geert Maertens , Erik Depla , Ignace Lasters , Johan Desmet , Denise Baker , Robert Chesnut , Mark Newman , Alessandro Sette , John Sidney , Scott Southwood
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/55566 , A61K2039/57 , C12N2770/24222 , C12N2770/24234
摘要： The present invention is directed to peptides, and nucleic acids encoding them, derived from the Hepatitis C Virus (HCV). The peptides are those which elicit a CTL and/or HTL response in a host. The invention is also directed to compositions and vaccines for prevention and treatment of HCV infection and diagnostic methods for detection of HCV exposure in patients.
摘要翻译： 本发明涉及衍生自丙型肝炎病毒（HCV）的肽和编码它们的核酸。 肽是在宿主中引起CTL和/或HTL应答的肽。 本发明还涉及用于预防和治疗HCV感染的组合物和疫苗以及用于检测患者中HCV暴露的诊断方法。
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2.发明申请PEPTIDES FOR INDUCING A CTL AND/OR HTL RESPONSE TO HEPATITIS C VIRUS 审中-公开用于诱导针对HEPATITIS C病毒的CTL和/或HTL反应的肽公开(公告)号：US20100099613A1
公开(公告)日：2010-04-22
申请号：US12574214
申请日：2009-10-06
申请人： Marie-Ange Buyse , Geert Maertens , Erik Depla , Ignace Lasters , Johan Desmet , Denise Baker , Robert W. Chesnut , Mark Newman , Alessandra Sette , John Sidney , Scott Southwood
发明人： Marie-Ange Buyse , Geert Maertens , Erik Depla , Ignace Lasters , Johan Desmet , Denise Baker , Robert W. Chesnut , Mark Newman , Alessandra Sette , John Sidney , Scott Southwood
IPC分类号： A61K38/16 , A61K31/7052 , A61P37/00 , A61K38/10 , A61K38/08
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/55566 , A61K2039/57 , C12N2770/24222 , C12N2770/24234
摘要： The present invention is directed to peptides, and nucleic acids encoding them, derived from the Hepatitis C Virus (HCV). The peptides are those which elicit a CTL and/or HTL response in a host. The invention is also directed to compositions and vaccines for prevention and treatment of HCV infection and diagnostic methods for detection of HCV exposure in patients.
摘要翻译： 本发明涉及衍生自丙型肝炎病毒（HCV）的肽和编码它们的核酸。 肽是在宿主中引起CTL和/或HTL应答的肽。 本发明还涉及用于预防和治疗HCV感染的组合物和疫苗以及用于检测患者中HCV暴露的诊断方法。
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3.发明申请Inducing cellular immune responses to human immunodeficiency virus-1 using peptide and nucleic acid compositions 审中-公开使用肽和核酸组合物诱导人免疫缺陷病毒-1的细胞免疫应答公开(公告)号：US20050271676A1
公开(公告)日：2005-12-08
申请号：US11045024
申请日：2005-01-28
申请人： Alessandro Sette , John Sidney , Scott Southwood , Brian Livingston , Robert Chesnut , Denise Baker , Esteban Celis , Ralph Kubo , Howard Grey
发明人： Alessandro Sette , John Sidney , Scott Southwood , Brian Livingston , Robert Chesnut , Denise Baker , Esteban Celis , Ralph Kubo , Howard Grey
CPC分类号： C07K14/005 , A61K2039/5154 , A61K2039/53 , A61K2039/545 , A61K2039/55555 , A61K2039/6018 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare human immunodeficiency virus (HIV) epitopes, and to develop epitope-based vaccines directed towards HIV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HIV infection.
摘要翻译： 本发明使用我们对抗原被T细胞识别并制备人免疫缺陷病毒（HIV）表位的机制的知识，并开发针对HIV的基于表位的疫苗。 更具体地说，本申请将我们发现的药物组合物和使用方法用于预防和治疗HIV感染。
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4.发明申请HLA CLASS I A2 TUMOR ASSOCIATED ANTIGEN PEPTIDES AND VACCINE COMPOSITIONS 审中-公开HLA I类A2肿瘤相关抗原肽和疫苗组合物公开(公告)号：US20140147490A1
公开(公告)日：2014-05-29
申请号：US13662906
申请日：2012-10-29
申请人： John D. Fikes , Alessandro Sette , John Sidney , Scott Southwood , Esteban Celis , Elissa A. Keogh , Robert Chesnut
发明人： John D. Fikes , Alessandro Sette , John Sidney , Scott Southwood , Esteban Celis , Elissa A. Keogh , Robert Chesnut
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A61K2039/55516
摘要： A composition or vaccine composition comprising at least one peptide that has less than 600 contiguous amino acids having 100% identity to a native sequence of CEA, HER2/neu, MAGE2, MAGE3, or p53, the peptide further comprising at least one epitope selected from Table 6.
摘要翻译： 一种组合物或疫苗组合物，其包含至少一种具有小于600个连续氨基酸的肽，其具有与CEA，HER2 / neu，MAGE2，MAGE3或p53的天然序列具有100％同一性，所述肽还包含至少一个选自 表6。
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5.发明授权Inducing cellular immune responses to hepatitis B virus using peptide compositions 有权使用肽组合物诱导对乙型肝炎病毒的细胞免疫应答公开(公告)号：US07611713B2
公开(公告)日：2009-11-03
申请号：US10654601
申请日：2003-09-04
申请人： Alessandro Sette , John Sidney , Scott Southwood , Maria Vitiello , Brian Livingston , Esteban Celis , Ralph Kubo , Howard Grey , Robert Chesnut
发明人： Alessandro Sette , John Sidney , Scott Southwood , Maria Vitiello , Brian Livingston , Esteban Celis , Ralph Kubo , Howard Grey , Robert Chesnut
CPC分类号： C07K14/005 , A61K38/00 , C07K14/70539 , C12N2730/10122
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.
摘要翻译： 本发明使用我们对T细胞识别抗原的机制的知识来开发针对HBV的基于表位的疫苗。 更具体地说，本申请介绍了我们在预防和治疗HBV感染中的药物组合物和使用方法的发现。
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6.发明申请HLA class I A2 tumor associated antigen peptides and vaccine compositions 审中-公开HLA I类A2肿瘤相关抗原肽和疫苗组合物公开(公告)号：US20080279924A1
公开(公告)日：2008-11-13
申请号：US11976908
申请日：2007-10-29
申请人： John D. Fikes , Alessandro Sette , John Sidney , Scott Southwood , Esteban Celis , Elissa A. Keogh , Robert Chesnut
发明人： John D. Fikes , Alessandro Sette , John Sidney , Scott Southwood , Esteban Celis , Elissa A. Keogh , Robert Chesnut
CPC分类号： A61K9/0019 , A61K9/127 , A61K38/08
摘要： A composition or vaccine composition comprising at least one peptide that has less than 600 contiguous amino acids having 100% identity to a native sequence of CEA, HER2/neu, MAGE2, MAGE3, or p53, the peptide further comprising at least one epitope selected from Table 6.
摘要翻译： 一种组合物或疫苗组合物，其包含至少一种具有小于600个连续氨基酸的肽，其具有与CEA，HER2 / neu，MAGE2，MAGE3或p53的天然序列具有100％同一性，所述肽还包含至少一个选自 表6。
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7.发明申请Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions 有权使用肽和核酸组合物诱导对乙型肝炎病毒的细胞免疫应答公开(公告)号：US20050063983A1
公开(公告)日：2005-03-24
申请号：US10654601
申请日：2003-09-04
申请人： Alessandro Sette , John Sidney , Scott Southwood , Maria Vitiello , Brian Livingston , Esteban Celis , Ralph Kubo , Howard Grey , Robert Chesnut
发明人： Alessandro Sette , John Sidney , Scott Southwood , Maria Vitiello , Brian Livingston , Esteban Celis , Ralph Kubo , Howard Grey , Robert Chesnut
CPC分类号： C07K14/005 , A61K38/00 , C07K14/70539 , C12N2730/10122
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.
摘要翻译： 本发明使用我们对T细胞识别抗原的机制的知识来开发针对HBV的基于表位的疫苗。 更具体地说，本申请介绍了我们在预防和治疗HBV感染中的药物组合物和使用方法的发现。
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公开(公告)号：US09340577B2
公开(公告)日：2016-05-17
申请号：US10817970
申请日：2004-04-06
申请人： Howard M. Grey , Alessandro Sette , John Sidney , Scott Southwood , Ralph T. Kubo , Esteban Celis , Robert Chesnut , W. Martin Kast
发明人： Howard M. Grey , Alessandro Sette , John Sidney , Scott Southwood , Ralph T. Kubo , Esteban Celis , Robert Chesnut , W. Martin Kast
IPC分类号： A61K38/10 , A61K39/145 , C07K7/08 , C07K7/06 , A61K39/02 , A61K39/12 , C07K14/74 , A61K38/00 , A61K39/00
CPC分类号： A61K38/00 , A61K38/10 , A61K39/00 , A61K39/0011 , A61K39/02 , A61K39/12 , A61K39/145 , A61K2039/5158 , A61K2039/55516 , A61K2039/55566 , A61K2039/572 , C07K7/06 , C07K14/70539 , C07K2319/01 , C07K2319/33 , C07K2319/40 , C12N2710/00088 , C12N2710/20034 , C12N2730/10134 , C12N2740/16034 , C12N2770/24234
摘要： The present invention provides the means and methods for selecting immunogenic peptides and the immunogenic peptide compositions capable of specifically binding glycoproteins encoded by HLA alleles and inducing T cell activation in T cells restricted by the allele. One such peptide, NMLSTVLGV (SEQ ID NO: 183) is useful to elicit an immune response against influenza. The present invention also provides a heteropolymer of an isolated immunogenic peptide less than 15 amino acids in length comprising the oligopeptide NMLSTVLGV (SEQ ID NO: 183) and at least one different peptide.
摘要翻译： 本发明提供了选择免疫原性肽的方法和方法以及能够特异性结合由HLA等位基因编码的糖蛋白并诱导由等位基因限制的T细胞中的T细胞活化的免疫原性肽组合物。 一种这样的肽NMLSTVLGV（SEQ ID NO：183）可用于引发针对流感的免疫应答。 本发明还提供了长度小于15个氨基酸的分离的免疫原性肽的杂聚物，其包含寡肽NMLSTVLGV（SEQ ID NO：183）和至少一种不同的肽。
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9.发明申请HLA CLASS I A2 TUMOR ASSOCIATED ANTIGEN PEPTIDES AND VACCINE COMPOSITIONS 审中-公开HLA I类A2肿瘤相关抗原肽和疫苗组合物公开(公告)号：US20110318408A1
公开(公告)日：2011-12-29
申请号：US13155307
申请日：2011-06-07
申请人： John D. Fikes , Alessandro Sette , John Sidney , Scott Southwood , Esteban Celis , Elissa A. Keogh , Robert Chesnut
发明人： John D. Fikes , Alessandro Sette , John Sidney , Scott Southwood , Esteban Celis , Elissa A. Keogh , Robert Chesnut
IPC分类号： A61K9/127 , C07K7/08 , C07K14/00 , A61K39/00 , C12N5/0784
CPC分类号： A61K9/0019 , A61K9/127 , A61K38/08
摘要： A composition or vaccine composition comprising at least one peptide that has less than 600 contiguous amino acids having 100% identity to a native sequence of CEA, HER2/neu, MAGE2, MAGE3, or p53, the peptide further comprising at least one epitope selected from Table 6.
摘要翻译： 一种组合物或疫苗组合物，其包含至少一种具有小于600个连续氨基酸的肽，其具有与CEA，HER2 / neu，MAGE2，MAGE3或p53的天然序列具有100％同一性，所述肽还包含至少一个选自 表6。
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10.发明申请公开(公告)号：US20090214632A1
公开(公告)日：2009-08-27
申请号：US12292281
申请日：2008-11-14
申请人： Alessandro Sette , John Sidney , Scott Southwood , Robert Chesnut , Esteban Celis , Howard M. Grey
发明人： Alessandro Sette , John Sidney , Scott Southwood , Robert Chesnut , Esteban Celis , Howard M. Grey
IPC分类号： A61K39/12 , C07K14/005 , A61K9/127 , C12N5/08 , C07H21/00
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5158 , A61K2039/53 , A61K2039/55516 , A61K2039/55555 , A61K2039/57 , C12N2710/20022 , C12N2710/20034
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare human papillomavirus (HPV) epitopes, and to develop epitope-based vaccines directed towards HPV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HPV infection.
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