中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

44 records (took 0.041 seconds)

    METHODS OF SYNTHESIS OF BENZAZEPINE DERIVATIVES
    23.
    发明申请
    METHODS OF SYNTHESIS OF BENZAZEPINE DERIVATIVES 有权
    苯并噻吩衍生物的合成方法

    公开(公告)号：US20100216989A1

    公开(公告)日：2010-08-26

    申请号：US12614048

    申请日：2009-11-06

    Applicant: J. Jeffry Howbert ,  Venkat R. Kusukuntla ,  Alexander Tretyakov ,  Nathan Nielsen ,  Pavel Krasik ,  Ji-Long Jiang ,  Hong Woon Yang

    Inventor： J. Jeffry Howbert ,  Venkat R. Kusukuntla ,  Alexander Tretyakov ,  Nathan Nielsen ,  Pavel Krasik ,  Ji-Long Jiang ,  Hong Woon Yang

    IPC: C07D403/10

    CPC classification number: C07D403/10 ,  C07D223/16

    Abstract: The disclosure describes method of synthesis of substituted benzazepine derivatives. Preferred methods according to the disclosure allow for large-scale preparation of benzazepine compounds having low levels of metal impurities. In some embodiments, preferred methods according to the disclosure also allow for the preparation of benzazepine derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. The methods disclosed herein find utility in synthetic organic chemistry as well as medicinal chemistry.

    Abstract translation: 本公开描述了取代的苯并氮杂衍生物的合成方法。 根据本公开的优选方法允许大规模制备具有低水平金属杂质的苯并氮杂化合物。 在一些实施方案中，根据本公开的优选方法还允许制备苯并氮杂衍生物，而不使用色谱纯化方法，并且比以前使用的制备此类化合物的方法更好的产率。 本文公开的方法可用于合成有机化学以及药物化学。

    Methods and compositions for determining the sequence of nucleic acid molecules
    27.
    发明授权
    Methods and compositions for determining the sequence of nucleic acid molecules 失效
    用于确定核酸分子序列的方法和组合物

    公开(公告)号：US06312893B1

    公开(公告)日：2001-11-06

    申请号：US08898180

    申请日：1997-07-22

    Applicant: Jeffrey Van Ness ,  John C. Tabone ,  J. Jeffry Howbert ,  John T. Mulligan

    Inventor： Jeffrey Van Ness ,  John C. Tabone ,  J. Jeffry Howbert ,  John T. Mulligan

    IPC: C12Q168

    CPC classification number: C07H21/00 ,  C07B2200/11 ,  C07D211/78 ,  C07H21/04 ,  C12Q1/6872 ,  C12Q1/6874 ,  C40B40/00 ,  Y10T436/24 ,  C12Q2565/629 ,  C12Q2563/167

    Abstract: Methods and compounds, including compositions therefrom, are provided for determining the sequence of nucleic acid molecules. The methods permit the determination of multiple nucleic acid sequences simultaneously. The compounds are used as tags to generate tagged nucleic acid fragments which are complementary to a selected target nucleic acid molecule. Each tag is correlative with a particular nucleotide and, in a preferred embodiment, is detectable by mass spectrometry. Following separation of the tagged fragments by sequential length, the tags are cleaved from the tagged fragments. In a preferred embodiment, the tags are detected by mass spectrometry and the sequence of the nucleic acid molecule is determined therefrom. The individual steps of the methods can be used in automated format, e.g., by the incorporation into systems.

    Abstract translation: 提供方法和化合物，包括其组合物，用于确定核酸分子的序列。 该方法允许同时测定多个核酸序列。 该化合物用作标签以产生与选定的靶核酸分子互补的标记的核酸片段。 每个标签与特定核苷酸相关，并且在优选实施方案中可通过质谱法检测。 在通过连续长度分离标记的片段之后，从标记的片段切割标签。 在优选的实施方案中，通过质谱检测标签，并由此确定核酸分子的序列。 方法的各个步骤可以以自动格式使用，例如通过并入系统。

Patent Agency Ranking