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公开(公告)号：US20170145005A1
公开(公告)日：2017-05-25
申请号：US15116955
申请日：2015-02-13
Inventor： Tetsuo NAGANO , Hirofumi NAKANO , Tsukasa HASEGAWA , Nae SAITO , Hirotatsu KOJIMA , Takayoshi OKABE , Naofumi MUKAIDA
IPC: C07D471/04 , C07D519/00
CPC classification number: C07D471/04 , A61K9/0019 , C07B2200/07 , C07D519/00
Abstract: [Problem]To provide a novel PIM-3 inhibitor and a novel cancer therapeutic drug, in particular, a therapeutic drug for pancreatic cancer.[Solution]A PIM-3 kinase inhibitor comprising a compound represented by general formula (I) or a pharmacologically acceptable salt, hydrate or solvate thereof.
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公开(公告)号：US09581505B2
公开(公告)日：2017-02-28
申请号：US14899496
申请日：2014-05-14
Inventor： Toshio Inoue , Toshihiko Komatsuzaki
CPC classification number: G01L1/2287 , G01L1/12 , G01L1/125 , G01L1/20 , G01L1/225
Abstract: The detection range and the detection precision of a sensor device that makes use of the deformation of a viscoelastic elastomer are made variable. The sensor device comprises a magnetic viscoelastic elastomer containing electroconductive magnetic particles dispersed therein so as to demonstrate an elastic modulus that varies depending on a magnetic field applied thereto and an electric resistance in a prescribed direction that varies depending on a deformation thereof, electromagnets for applying a magnetic field that can be varied to the magnetic viscoelastic elastomer, a resistance detection circuit for detecting the electric resistance of the magnetic viscoelastic elastomer, and a control unit for computing at least one of a deformation state of the magnetic viscoelastic elastomer and a load applied to the magnetic viscoelastic elastomer according to a detection value of the resistance detection circuit and a magnitude of the magnetic field applied by the electromagnets.
Abstract translation: 利用粘弹性弹性体变形的传感器装置的检测范围和检测精度是可变的。 传感器装置包括含有分散在其中的导电磁性颗粒的磁性粘弹性弹性体，以显示根据施加到其上的磁场而变化的弹性模量和根据其变形而变化的规定方向的电阻， 对磁性粘弹性弹性体可以变化的磁场，用于检测磁性粘弹性弹性体的电阻的电阻检测电路，以及用于计算磁性粘弹性弹性体的变形状态和施加到 根据电阻检测电路的检测值的磁性粘弹性弹性体和由电磁体施加的磁场的大小。
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23.发明授权Optically active poly(diphenylacetylene) compound, preparation method therefor, and use thereof as optical isomer separating agent 有权光学活性聚（二苯基乙炔）化合物及其制备方法及其用作旋光异构体分离剂公开(公告)号：US09562121B2
公开(公告)日：2017-02-07
申请号：US14766853
申请日：2014-02-10
Inventor： Katsuhiro Maeda , Shigeyoshi Kanoh , Tomoyuki Ikai , Kouhei Shimomura , Miyuki Maruta
IPC: C08F38/00 , C08F138/00 , C08F238/00 , C08F8/00 , C08F8/14 , G01N30/88 , B01J20/29 , B01J20/32
CPC classification number: C08F138/00 , B01J20/29 , B01J20/3204 , B01J20/3208 , B01J20/327 , B01J20/328 , C08F8/00 , C08F8/14 , C08F38/00 , C08F238/00 , G01N30/88 , G01N2030/8877
Abstract: The present invention provides an optically active poly(diphenylacetylene) compound represented by the following formula (I): [wherein each symbol is as described in the DESCRIPTION], and a production method thereof, an optical isomer separating agent containing the poly(diphenylacetylene) compound, and a packing material for a chiral column, containing the optical isomer separating agent coated on a carrier. According to the present invention, a practical optical isomer separation agent having a high optical resolution ability for a wide variety of racemic compounds and an optical isomer separation method can be provided.
Abstract translation: 本发明提供由下式（I）表示的光学活性聚（二苯基乙炔）化合物：[其中各符号如说明书所述]及其制备方法，含有聚（二苯基乙炔） 化合物和用于手性柱的包装材料，其包含涂覆在载体上的旋光异构体分离剂。 根据本发明，可以提供对各种外消旋化合物具有高的光学拆分能力和旋光异构体分离方法的实用的光学异构体分离剂。
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公开(公告)号：US09512490B2
公开(公告)日：2016-12-06
申请号：US14551666
申请日：2014-11-24
Inventor： Shuichi Kaneko , Masao Honda , Yoshio Sakai , Taro Yamashita
CPC classification number: C12Q1/6886 , C12Q2600/158 , C12Q2600/16
Abstract: The present invention provides a method and a reagent for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient by analyzing genes with expression levels (in peripheral blood) that vary in association with digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer cases, compared with normal healthy subjects. Specifically, the method for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient based on expression profiles comprises obtaining the expression profile of at least one gene selected from the group consisting of probes corresponding to genes with expression levels (in peripheral blood) that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, and biliary tract cancer cases, compared with normal healthy subjects. The reagent for detecting digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer contains nucleotides or partial sequences thereof consisting of the nucleotide sequence of at least one gene selected from the group consisting of probes with expression levels that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer, or nucleotides containing sequences complementary thereto.
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25.发明授权公开(公告)号：US09441276B2
公开(公告)日：2016-09-13
申请号：US14551651
申请日：2014-11-24
Inventor： Shuichi Kaneko , Masao Honda , Yoshio Sakai , Taro Yamashita
CPC classification number: C12Q1/6886 , C12Q2600/158 , C12Q2600/16
Abstract: The present invention provides a method and a reagent for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient based on expression profiles. The method comprises obtaining the expression profile of at least one gene selected from the group consisting of probes corresponding to genes with expression levels (in peripheral blood) that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, and biliary tract cancer cases, compared with normal healthy subjects. The reagent for detecting digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer contains nucleotides or partial sequences thereof consisting of the nucleotide sequence of at least one gene selected from the group consisting of probes with expression levels that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer, or nucleotides containing sequences complementary thereto.
Abstract translation: 本发明提供了一种用于基于表达谱来检测消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌患者的方法和试剂。 该方法包括获得选自对应于在消化器官癌，胃癌，结肠直肠癌，胰腺癌和胆道癌中变化的表达水平（在外周血中）的基因的探针中的至少一种基因的表达谱。 病例与正常健康受试者相比。 用于检测消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌的试剂含有由至少一种基因的核苷酸序列组成的核苷酸或其部分序列，所述核苷酸序列选自下组的探针：表达水平在 消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌，或含有与其互补的序列的核苷酸。
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Patent Agency Ranking
公开(公告)号：US20160153846A1
公开(公告)日：2016-06-02
申请号：US14899496
申请日：2014-05-14
Inventor： Toshio INOUE , Toshihiko KOMATSUZAKI
IPC: G01L1/22
CPC classification number: G01L1/2287 , G01L1/12 , G01L1/125 , G01L1/20 , G01L1/225
Abstract: The detection range and the detection precision of a sensor device that makes use of the deformation of a viscoelastic elastomer are made variable. The sensor device comprises a magnetic viscoelastic elastomer containing electroconductive magnetic particles dispersed therein so as to demonstrate an elastic modulus that varies depending on a magnetic field applied thereto and an electric resistance in a prescribed direction that varies depending on a deformation thereof, electromagnets for applying a magnetic field that can be varied to the magnetic viscoelastic elastomer, a resistance detection circuit for detecting the electric resistance of the magnetic viscoelastic elastomer, and a control unit for computing at least one of a deformation state of the magnetic viscoelastic elastomer and a load applied to the magnetic viscoelastic elastomer according to a detection value of the resistance detection circuit and a magnitude of the magnetic field applied by the electromagnets.
Abstract translation: 利用粘弹性弹性体变形的传感器装置的检测范围和检测精度是可变的。 传感器装置包括含有分散在其中的导电磁性颗粒的磁性粘弹性弹性体，以显示根据施加到其上的磁场而变化的弹性模量和根据其变形而变化的规定方向的电阻， 对磁性粘弹性弹性体可以变化的磁场，用于检测磁性粘弹性弹性体的电阻的电阻检测电路，以及用于计算磁性粘弹性弹性体的变形状态和施加到 根据电阻检测电路的检测值的磁性粘弹性弹性体和由电磁体施加的磁场的大小。
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公开(公告)号：US20160083826A1
公开(公告)日：2016-03-24
申请号：US14955318
申请日：2015-12-01
Inventor： Ryoichi MONZEN , Naokuni MURAMATSU
Abstract: A method for manufacturing a copper alloy of the present invention is a method for manufacturing a Cu—Ni—Sn-based copper alloy and includes: a first aging treatment step of performing an aging treatment in a temperature range of 300° C. to 500° C. using a solution treated material; an inter-aging processing step of performing cold working after the first aging treatment step; and a second aging treatment step of performing an aging treatment in a temperature range of 300° C. to 500° C. after the inter-aging processing step. In the first aging treatment step, a peak aging treatment is preferably performed. In addition, in the second aging treatment step, the aging treatment is preferably performed for a short period as compared to that of the aging treatment in the first aging treatment step. In the inter-aging processing step, cold working is preferably performed at a processing rate of more than 60% to 99%.
Abstract translation: 本发明的铜合金的制造方法是一种Cu-Ni-Sn系铜合金的制造方法，其特征在于，包括：在300℃〜500℃的温度范围内进行时效处理的第一时效处理工序 ℃使用溶液处理的材料; 在第一时效处理步骤之后执行冷加工的时效处理步骤; 以及在中间时间处理步骤之后在300℃至500℃的温度范围内进行时效处理的第二时效处理步骤。 在第一时效处理步骤中，优选进行峰值时效处理。 另外，在第二时效处理工序中，与第一时效处理工序中的时效处理相比，优选进行短时间的时效处理。 在时效处理工序中，优选以超过60％〜99％的加工速度进行冷加工。
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公开(公告)号：US20160047841A1
公开(公告)日：2016-02-18
申请号：US14779622
申请日：2014-03-04
Inventor： Takeshi FUKUMA , Kazuki MIYATA
IPC: G01Q20/00
Abstract: A signal detection circuit includes: a VCO that generates a reference signal; a complex signal generation circuit that generates a complex signal from an input signal and the reference signal; a vector operation circuit that calculates an argument of the complex signal by performing a vector operation; and a subtracting phase comparator that compares the argument with a phase of the reference signal by calculating a difference between the argument and the phase of the reference signal, wherein the complex signal generation circuit includes: a multiplication circuit that multiplies the input signal by the reference signal; and an HPF that removes a DC component from a signal output from the multiplication circuit.
Abstract translation: 信号检测电路包括：产生参考信号的VCO; 复信号发生电路，从输入信号和参考信号产生复信号; 矢量运算电路，通过执行矢量运算来计算复信号的自变量; 以及减法相位比较器，通过计算参考信号的参数和相位之间的差，将参数与参考信号的相位进行比较，其中复数信号产生电路包括：乘法电路，将输入信号乘以参考 信号; 以及从乘法电路输出的信号中去除直流分量的HPF。
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29.发明申请DETECTION OF DIGESTIVE ORGAN CANCER, GASTRIC CANCER, COLORECTAL CANCER, PANCREATIC CANCER, AND BILIARY TRACT CANCER BY GENE EXPRESSION PROFILING 有权根据基因表达分析检测消化性癌，胃癌，色素性癌，胰腺癌和胆汁性肝癌公开(公告)号：US20150133335A1
公开(公告)日：2015-05-14
申请号：US14551674
申请日：2014-11-24
Inventor： Shuichi KANEKO , Masao HONDA , Yoshio SAKAI , Taro YAMASHITA
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/158 , C12Q2600/16
Abstract: The present invention provides a method and a reagent for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient by analyzing genes with expression levels (in peripheral blood) that vary in association with digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer cases, compared with normal healthy subjects. Specifically, the method for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient based on expression profiles comprises obtaining the expression profile of at least one gene selected from the group consisting of probes corresponding to genes with expression levels (in peripheral blood) that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, and biliary tract cancer cases, compared with normal healthy subjects. The reagent for detecting digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer contains nucleotides or partial sequences thereof consisting of the nucleotide sequence of at least one gene selected from the group consisting of probes with expression levels that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer, or nucleotides containing sequences complementary thereto.
Abstract translation: 本发明提供了通过分析与消化器官癌相关的变化的表达水平（外周血）的基因来检测消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌患者的方法和试剂， 胃癌，结肠直肠癌，胰腺癌或胆道癌，与正常健康人相比。 具体地，基于表达谱，检测消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌患者的方法包括获得至少一种基因的表达谱，所述基因选自对应于具有 与正常健康受试者相比，消化器官癌，胃癌，结肠直肠癌，胰腺癌和胆道癌患者的表达水平（外周血）差异不大。 用于检测消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌的试剂含有由至少一种基因的核苷酸序列组成的核苷酸或其部分序列，所述核苷酸序列选自下组的探针：表达水平在 消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌，或含有与其互补的序列的核苷酸。
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公开(公告)号：US20140289910A1
公开(公告)日：2014-09-25
申请号：US14357011
申请日：2012-11-15
Inventor： Takeshi Fukuma , Hitoshi Asakawa , Yukitoshi Katagiri
IPC: G01Q10/00
CPC classification number: G01Q30/14 , B82Y35/00 , G01Q10/00 , G01Q20/02 , G01Q30/08 , G01Q30/12 , G01Q30/18 , G01Q60/24 , G01Q60/32 , G01Q70/02
Abstract: Provided is a sealed AFM cell in which measurement accuracy does not decrease and the types of observation liquids are not limited. A sealed AFM cell according to the present invention includes: a cantilever including a probe; a sample holder for fixing the sample; a scanner for moving the sample holder; a lid part which holds the cantilever so as to position the probe near a measurement surface of the sample; and a main body part which is a component for holding the scanner and positioned opposite the lid part with the sample in between, in which the lid part and the main body part are joined via a sealing liquid to seal the observation liquid inside a space formed by the lid part, the main body part, and the sealing liquid, the sealing liquid being different from the observation liquid and not in contact with the observation liquid.
Abstract translation: 提供了一种密封的AFM电池，其中测量精度不降低，并且观察液体的类型不受限制。 根据本发明的密封AFM电池包括：包括探针的悬臂; 用于固定样品的样品架; 用于移动样品架的扫描器; 盖部，其保持悬臂，以将探针定位在样品的测量表面附近; 以及主体部，其是用于保持扫描仪并且与盖部分相对设置在其间的样品的部件，其中盖部分和主体部分经由密封液接合，以将观察液体密封在形成的空间内 通过盖部，主体部和密封液，密封液与观察液不同，不与观察液接触。
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