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    Methods and compositions for identifying subjects at risk of developing stent thrombosis
    22.
    发明授权
    Methods and compositions for identifying subjects at risk of developing stent thrombosis 有权
    用于识别发生支架血栓形成危险的受试者的方法和组合物

    公开(公告)号：US08864821B2

    公开(公告)日：2014-10-21

    申请号：US12625264

    申请日：2009-11-24

    Applicant: Farouc Jaffer ,  Milind Rajopadhye

    Inventor： Farouc Jaffer ,  Milind Rajopadhye

    IPC: A61F2/82 ,  A61B5/00 ,  A61B5/02 ,  A61K49/00

    CPC classification number: A61B5/0071 ,  A61B1/043 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0073 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/02007 ,  A61B5/061 ,  A61B5/066 ,  A61B5/4851 ,  A61B5/7275 ,  A61B90/20 ,  A61B2576/02 ,  A61F2/82 ,  A61K49/0034 ,  A61K49/0097

    Abstract: The invention provides methods and compositions for determining whether a subject containing a stent immobilized in a blood vessel has asymptomatic stent thrombosis or is at risk of developing clinically symptomatic stent thrombosis. In one approach, the method involves imaging a region of the blood vessel that contains the stent using a probe that contains a fluorochrome, for example, a near-infrared fluorochrome, and a targeting moiety that binds a molecular marker indicative of the presence of asymptomatic stent thrombosis or the development of symptomatic stent thrombosis. To the extent that the subject displays one or more such markers, the probe binds to the markers and increases the local concentration of the probe in the vicinity of the stent. The imaging method identifies those patients that display a higher density of such markers in the vicinity of the stent. As a result, those patients can be monitored for, and/or treated to prevent, symptomatic stent thrombosis.

    Abstract translation: 本发明提供了用于确定含有固定在血管中的支架的受试者是否具有无症状的支架内血栓形成或具有发展为临床症状性支架内血栓形成的风险的方法和组合物。 在一种方法中，该方法涉及使用包含荧光染料（例如近红外荧光染料）的探针对含有支架的血管的区域成像，以及结合指示存在无症状的分子标记的靶向部分 支架血栓形成或症状性支架血栓形成的发展。 在受试者显示一种或多种这样的标记物的程度上，探针结合标记并增加探针在支架附近的局部浓度。 成像方法识别那些在支架附近显示较高密度的标记物的患者。 因此，可以监测和/或治疗这些患者以防止症状性支架内血栓形成。

    Methods and Compositions for Identifying Subjects at Risk of Developing Stent Thrombosis
    25.
    发明申请
    Methods and Compositions for Identifying Subjects at Risk of Developing Stent Thrombosis 有权
    识别发生支架血栓风险的受试者的方法和组成

    公开(公告)号：US20100268070A1

    公开(公告)日：2010-10-21

    申请号：US12625264

    申请日：2009-11-24

    Applicant: Farouc Jaffer ,  Milind Rajopadhye

    Inventor： Farouc Jaffer ,  Milind Rajopadhye

    IPC: A61B5/05 ,  A61F2/82

    CPC classification number: A61B5/0071 ,  A61B1/043 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0073 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/02007 ,  A61B5/061 ,  A61B5/066 ,  A61B5/4851 ,  A61B5/7275 ,  A61B90/20 ,  A61B2576/02 ,  A61F2/82 ,  A61K49/0034 ,  A61K49/0097

    Abstract: The invention provides methods and compositions for determining whether a subject containing a stent immobilized in a blood vessel has asymptomatic stent thrombosis or is at risk of developing clinically symptomatic stent thrombosis. In one approach, the method involves imaging a region of the blood vessel that contains the stent using a probe that contains a fluorochrome, for example, a near-infrared fluorochrome, and a targeting moiety that binds a molecular marker indicative of the presence of asymptomatic stent thrombosis or the development of symptomatic stent thrombosis. To the extent that the subject displays one or more such markers, the probe binds to the markers and increases the local concentration of the probe in the vicinity of the stent. The imaging method identifies those patients that display a higher density of such markers in the vicinity of the stent. As a result, those patients can be monitored for, and/or treated to prevent, symptomatic stent thrombosis.

    Abstract translation: 本发明提供了用于确定含有固定在血管中的支架的受试者是否具有无症状的支架内血栓形成或具有发展为临床症状性支架内血栓形成的风险的方法和组合物。 在一种方法中，该方法涉及使用包含荧光染料（例如近红外荧光染料）的探针对含有支架的血管的区域成像，以及结合指示存在无症状的分子标记的靶向部分 支架血栓形成或症状性支架血栓形成的发展。 在受试者显示一种或多种这样的标记物的程度上，探针结合标记并增加探针在支架附近的局部浓度。 成像方法识别那些在支架附近显示较高密度的标记物的患者。 因此，可以监测和/或治疗这些患者以防止症状性支架内血栓形成。

    Vitronectin receptor antagonist pharmaceuticals
    29.
    发明授权
    Vitronectin receptor antagonist pharmaceuticals 失效

    公开(公告)号：US06683163B2

    公开(公告)日：2004-01-27

    申请号：US09948807

    申请日：2001-09-07

    Applicant: Thomas D. Harris ,  Milind Rajopadhye

    Inventor： Thomas D. Harris ,  Milind Rajopadhye

    IPC: C07F500

    CPC classification number: C07D401/14 ,  A61K49/0002 ,  A61K49/04 ,  A61K49/085 ,  A61K49/10 ,  A61K49/223 ,  A61K51/0497 ,  C07D401/12

    Abstract: The present invention describes novel compounds of the formula: (Q)d-Ln-Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. The present invention also provides novel compounds useful for monitoring therapeutic angiogenesis treatment and destruction of new angiogenic vasculature. The present invention further provides novel compounds useful for imaging atherosclerosis, restenosis, cardiac ischemia, and myocardial reperfusion injury. The present invention still further provides novel compounds useful for the treatment of rheumatoid arthritis. The pharmaceuticals are comprised of a targeting moiety that binds to a receptor that is upregulated during angiogenesis, an optional linking group, and a therapeutically effective radioisotope or diagnostically effective imageable moiety. The imageable moiety is a gamma ray or positron emitting radioisotope, a magnetic resonance imaging contrast agent, an X-ray contrast agent, or an ultrasound contrast agent.

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