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公开(公告)号：US10695162B2
公开(公告)日：2020-06-30
申请号：US15843482
申请日：2017-12-15
Applicant: NEOGRAFT TECHNOLOGIES, INC.
Inventor： Lorenzo Soletti , Mohammed S. El-Kurdi , Jon McGrath , J. Christopher Flaherty , Liem Vu , Jerry Brightbill , Stephen Evans , Joseph Ting , David Rezac , Timothy Robinson
Abstract: A system for applying a fiber matrix on a tubular member is provided. A mandrel, configured for atraumatic placement within the tubular member, is included. Methods for atraumatic placement of a mandrel into a tubular member are also provided.
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公开(公告)号：US20190239879A1
公开(公告)日：2019-08-08
申请号：US16047909
申请日：2018-07-27
Applicant: NEOGRAFT TECHNOLOGIES, INC.
Inventor： Peter P. ZILLA , Nasser RAFIEE , Deon BEZUIDENHOUT , Thomas FRANZ , Mark YEOMAN , Hellmut C. BOWLES , Nareak DOUK , Michael F. WOLF , Paul HUMAN
CPC classification number: A61B17/11 , A61B5/1076 , A61B2017/1107 , A61B2017/1132 , A61B2017/1135 , A61B2017/1139 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/95 , A61F2240/002
Abstract: Stents and methods of using stents are provided. Stents of the invention provide external support structure for a blood vessel segment disposed within, wherein the stents are capable of resilient radial expansion in a manner mimicking the compliance properties of an artery. The stent may be formed of a knitted or braided mesh formed so as to provide the needed compliance properties. A venous graft with the stent and a vein segment disposed within is provided, wherein graft is capable of mimicking the compliance properties of an artery. Methods of selecting stents for downsizing and methods of using the stents of the invention in downsizing and smoothening are provided. Methods of replacing a section of an artery with a venous graft including a stent of the invention are provided. Methods of reducing intimal hyperplasia in implanted vein segment in a venous graft using stents of the invention are provided.
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公开(公告)号：US10149750B2
公开(公告)日：2018-12-11
申请号：US15044369
申请日：2016-02-16
Applicant: Neograft Technologies, Inc.
Inventor： David Wagner , Lorenzo Soletti , Mohammed S. El-Kurdi , Jon McGrath , John T. Garibotto , J. Christopher Flaherty
IPC: A61F2/06 , A61L27/18 , A61L27/56 , A61L27/58 , A61L27/54 , A61L27/04 , A61L27/16 , A61L27/34 , A61L27/14 , A61L27/36 , A61F2/04
Abstract: A graft device is provided comprising a flow conduit and a surrounding covering. The graft device can connect a first body space and a second body space. In one embodiment, the flow conduit is a vein, such as a harvested saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided are methods of preparing a graft device and connecting the graft device between a first body space and a second body space, such as the aorta and a location on an occluded coronary artery, distal to the occlusion.
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公开(公告)号：US20180289466A1
公开(公告)日：2018-10-11
申请号：US15843482
申请日：2017-12-15
Applicant: NEOGRAFT TECHNOLOGIES, INC.
Inventor： Lorenzo SOLETTI , Mohammed S. EL-Kurdi , Jon Mcgrath , J. Christopher Flaherty , Liem Vu , Jerry Brightbill , Stephen Evans , Joseph Ting , David Rezac , Timothy Robinson
CPC classification number: A61F2/062 , A61B2017/00526 , A61B2017/00969 , A61F2210/0076 , B05B13/0436 , B05B13/0627
Abstract: A system for applying a fiber matrix on a tubular member is provided. A mandrel, configured for atraumatic placement within the tubular member, is included. Methods for atraumatic placement of a mandrel into a tubular member are also provided.
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公开(公告)号：US10092293B2
公开(公告)日：2018-10-09
申请号：US15344998
申请日：2016-11-07
Applicant: NEOGRAFT TECHNOLOGIES, INC.
Inventor： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut C. Bowles , Nareak Douk , Michael F. Wolf , Paul Human
Abstract: Stents and methods of using stents are provided. Stents of the invention provide external support structure for a blood vessel segment disposed within, wherein the stents are capable of resilient radial expansion in a manner mimicking the compliance properties of an artery. The stent may be formed of a knitted or braided mesh formed so as to provide the needed compliance properties. A venous graft with the stent and a vein segment disposed within is provided, wherein graft is capable of mimicking the compliance properties of an artery. Methods of selecting stents for downsizing and methods of using the stents of the invention in downsizing and smoothening are provided. Methods of replacing a section of an artery with a venous graft including a stent of the invention are provided. Methods of reducing intimal hyperplasia in implanted vein segment in a venous graft using stents of the invention are provided.
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Patent Agency Ranking
公开(公告)号：US10065352B2
公开(公告)日：2018-09-04
申请号：US15499242
申请日：2017-04-27
Applicant: Neograft Technologies, Inc.
Inventor： Jon McGrath , Lorenzo Soletti , Mohammed S. El-Kurdi , William R. Wagner , J. Christopher Flaherty
Abstract: A system for electrospinning a fiber matrix on a tubular member includes at least one nozzle, a tubular member in a spaced relationship to the at least one nozzle, and a fluid source for pressurizing a lumen of the tubular member. An electrical potential is applied between the at least one nozzle and either the tubular member or fluid from the fluid source. The electrical potential draws at least one fiber from the at least one nozzle to the tubular member.
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公开(公告)号：US20170258609A1
公开(公告)日：2017-09-14
申请号：US15414216
申请日：2017-01-24
Applicant: Neograft Technologies, Inc.
Inventor： Jon MCGRATH , Mohammed S. EL-KURDI , Lorenzo SOLETTI , J. Christopher FLAHERTY
CPC classification number: A61F2/82 , A61B17/00008 , A61B17/11 , A61B17/135 , A61B2017/00778 , A61B2017/00969 , A61B2017/1107 , A61B2017/1132 , A61B2017/22097 , A61L27/3625 , A61L27/3687 , A61L27/3691 , A61L27/507
Abstract: Methods and devices for treating a vessel for use in a medical procedure are disclosed. A vein or other vessel can be modified in situ, prior to harvesting. Subsequently, at least a portion of the vessel is removed, and subsequently implanted to treat a patient, typically in a bypass procedure in which the vessel portion fluidly connects a source of oxygenated blood to an occluded artery.
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公开(公告)号：US20170043360A1
公开(公告)日：2017-02-16
申请号：US15228339
申请日：2016-08-04
Applicant: Neograft Technologies, Inc.
Inventor： Lorenzo SOLETTI , Mohammed S. EL-KURDI , Jon MCGRATH , Andrew ZIEGLER , J. Christopher FLAHERTY , William R. WAGNER , David VORP
CPC classification number: B05B5/12 , A61B90/00 , A61F2/022 , A61F2/04 , A61F2/06 , A61F2/07 , A61F2002/043 , A61F2002/046 , A61F2002/047 , A61F2002/048 , A61F2240/001 , A61L27/3625 , B05B5/0255 , D01D5/0084 , D01D13/02
Abstract: A cartridge device is provided for applying a fiber matrix to a tubular member such as a saphenous vein graft. The cartridge includes a housing, a tubular member holder, a rotational drive, and a polymer delivery assembly. The housing defines a chamber which surrounds the tubular member holder. The rotational drive rotates the tubular member during the fiber application process.
Abstract translation: 提供了用于将纤维基质施加到诸如隐静脉移植物的管状构件上的药筒装置。 盒包括壳体，管状构件保持器，旋转驱动器和聚合物输送组件。 壳体限定围绕管状构件保持器的腔室。 旋转驱动器在纤维施加过程中旋转管状构件。
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公开(公告)号：US09517069B2
公开(公告)日：2016-12-13
申请号：US14448694
申请日：2014-07-31
Applicant: Neograft Technologies, Inc.
Inventor： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut C. Bowles , Nareak Douk , Michael F. Wolf , Paul Human
CPC classification number: A61B17/11 , A61B5/1076 , A61B2017/1107 , A61B2017/1132 , A61B2017/1135 , A61B2017/1139 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/95 , A61F2240/002
Abstract: Stents and methods of using stents are provided. Stents of the invention provide external support structure for a blood vessel segment disposed within, wherein the stents are capable of resilient radial expansion in a manner mimicking the compliance properties of an artery. The stent may be formed of a knitted or braided mesh formed so as to provide the needed compliance properties. A venous graft with the stent and a vein segment disposed within is provided, wherein graft is capable of mimicking the compliance properties of an artery. Methods of selecting stents for downsizing and methods of using the stents of the invention in downsizing and smoothening are provided. Methods of replacing a section of an artery with a venous graft including a stent of the invention are provided. Methods of reducing intimal hyperplasia in implanted vein segment in a venous graft using stents of the invention are provided.
Abstract translation: 提供支架和使用支架的方法。 本发明的支架为设置在其内的血管段提供外部支撑结构，其中支架能够以模仿动脉的顺应性的方式弹性径向扩张。 支架可以由形成的针织或编织网形成，以便提供所需的顺应性。 提供具有支架和设置在其内的静脉段的静脉移植物，其中移植物能够模拟动脉的顺应性。 提供了选择小型化支架的方法和使用本发明的支架在缩小和平滑方面的方法。 提供了用包括本发明的支架的静脉移植物代替动脉的一部分的方法。 提供了使用本发明的支架在静脉移植物中减少植入静脉段内膜增生的方法。
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公开(公告)号：US20160067032A1
公开(公告)日：2016-03-10
申请号：US14851946
申请日：2015-09-11
Applicant: NEOGRAFT TECHNOLOGIES, INC.
Inventor： Lorenzo SOLETTI , Mohammed S. EL-KURDI , Jon MCGRATH , J. Christopher FLAHERTY
CPC classification number: A61F2/062 , A61F2/06 , B05D1/007 , B05D1/42 , B29C47/0023 , B29C47/908 , B29C65/48 , B29C66/5221 , B32B1/08 , D01D5/0084 , D04H1/728 , D04H1/76 , D04H3/073
Abstract: In some aspects, a system for applying a fiber matrix on a tubular conduit is provided. The system can include a tubular conduit, a mandrel and a fiber matrix delivery assembly. The mandrel can comprise an elongate shaft and a rolling membrane configured to atraumatically engage the tubular conduit.
Abstract translation: 在一些方面，提供了一种在管状导管上施加纤维基质的系统。 该系统可以包括管状导管，心轴和纤维矩阵输送组件。 心轴可以包括细长轴和构造成与管状导管无接触地接合的滚动膜。
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