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公开(公告)号：US20170312100A1
公开(公告)日：2017-11-02
申请号：US15431311
申请日：2017-02-13
Applicant: Neograft Technologies, Inc.
Inventor： Lorenzo SOLETTI , Mohammed S. EL-KURDI , Jon MCGRATH , J. Christopher FLAHERTY
CPC classification number: A61F2/82 , A61B17/11 , A61B17/122 , A61B2017/00252 , A61B2017/00969 , A61B2017/1107 , A61B2017/1135 , A61F2/06 , A61F2/064 , A61F2210/0076 , A61L27/44 , A61L27/507 , A61L27/56
Abstract: In some aspects, graft devices for a mammalian patient can include a tubular member comprising a first end; and a fiber matrix surrounding the tubular member, wherein the fiber matrix is designed and constructed to be substantially continuously tapered at the first end to define a diameter that increases as it approaches the first end.
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公开(公告)号：US20160287374A1
公开(公告)日：2016-10-06
申请号：US15036304
申请日：2014-11-14
Applicant: NEOGRAFT TECHNOLOGIES, INC.
Inventor： Lorenzo SOLETTI , Cory LEESON , Jon MCGRATH , Matthew MANNARINO , John SPIRIDIGLIOZZI
CPC classification number: A61F2/07 , A61F2/04 , A61F2/06 , A61F2/88 , A61F2002/825 , A61F2210/0014 , A61F2210/0076 , A61F2240/002 , A61L27/34 , A61L27/507 , A61L2420/02 , A61L2420/06
Abstract: A graft device for a mammalian patient comprises a tubular conduit and a fiber matrix surrounding the tubular conduit. The fiber matrix can comprise one or more polymers delivered by an electrospinning device. Systems and methods of creating a graft device are also provided.
Abstract translation: 用于哺乳动物患者的移植装置包括管状导管和围绕管状导管的纤维基质。 纤维基质可以包含一种或多种由静电纺丝装置递送的聚合物。 还提供了创建移植装置的系统和方法。
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公开(公告)号：US20190263068A1
公开(公告)日：2019-08-29
申请号：US16308216
申请日：2017-06-09
Applicant: NEOGRAFT TECHNOLOGIES, INC.
Inventor： Matthew MANNARINO , Jon MCGRATH , Cory LEESON , Mohammed EL-KURDI , Danielle CZARNOWSKI , Kermit SANTIAGO , J. Christopher FLAHERTY
Abstract: A system for producing a graft device for a patient may comprise: an imaging device configured to produce image data of a tubular conduit; and a processing unit configured to receive the image data from the imaging device. The processing unit may comprise an algorithm configured to process the image data, and produce a construction signal based on the image data. A material delivery device may be configured to receive the construction signal from the processor, and deliver material to produce a 3D covering based on the construction signal. The graft device may comprise the 3D covering positioned about the tubular conduit. Graft devices and methods of producing graft devices may also be provided.
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公开(公告)号：US20160157989A1
公开(公告)日：2016-06-09
申请号：US15044369
申请日：2016-02-16
Applicant: Neograft Technologies, Inc.
Inventor： David WAGNER , Lorenzo SOLETTI , Mohammed S. EL-KURDI , Jon MCGRATH , John T. GARIBOTTO , J. Christopher FLAHERTY
CPC classification number: A61F2/06 , A61F2/04 , A61F2/064 , A61F2210/0076 , A61F2250/0039 , A61L27/047 , A61L27/14 , A61L27/16 , A61L27/18 , A61L27/34 , A61L27/36 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/412 , A61L2430/36
Abstract: A graft device is provided comprising a flow conduit and a surrounding covering. The graft device can connect a first body space and a second body space. In one embodiment, the flow conduit is a vein, such as a harvested saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided are methods of preparing a graft device and connecting the graft device between a first body space and a second body space, such as the aorta and a location on an occluded coronary artery, distal to the occlusion.
Abstract translation: 提供了移植装置，其包括流动管道和周围的覆盖物。 移植装置可以连接第一身体空间和第二身体空间。 在一个实施例中，流动导管是静脉，例如收获的隐静脉，可用作动脉移植物，例如但不限于冠状动脉旁路手术。 还提供了制备移植装置并将移植装置连接到第一身体空间和第二身体空间（例如主动脉）和封堵冠状动脉远端的位置的方法。
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公开(公告)号：US20180368968A1
公开(公告)日：2018-12-27
申请号：US16063503
申请日：2016-12-20
Applicant: NEOGRAFT TECHNOLOGIES, INC.
Inventor： Cory LEESON , Matthew MANNARINO , Mohammed EL-KURDI , Jon MCGRATH
Abstract: Provided are systems for applying a polymer fiber matrix to a tubular conduit to create a graft device. The system comprises a polymer solution comprising at least one polymer and at least one solvent; a polymer delivery assembly constructed and arranged to receive the polymer solution and to deliver the polymer fiber matrix to the tubular conduit; a rotating assembly constructed and arranged to rotate at least one of the tubular conduit or the polymer delivery assembly; and a controller constructed and arranged to control the polymer delivery assembly and the rotating assembly. The system is constructed and arranged to reduce the amount of the solvent in the graft device. Methods of applying a polymer fiber matrix with reduced solvent are also provided.
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Patent Agency Ranking
公开(公告)号：US20170326772A1
公开(公告)日：2017-11-16
申请号：US15499242
申请日：2017-04-27
Applicant: Neograft Technologies, Inc.
Inventor： Jon MCGRATH , Lorenzo SOLETTI , Mohammed S. EL-KURDI , William R. WAGNER , J. Christopher FLAHERTY
CPC classification number: B29C47/0076 , A61F2/06 , A61F2/062 , A61F2240/001 , A61L27/14 , A61L27/38 , A61L27/50 , D01D5/0076 , D04H1/728
Abstract: A system for electrospinning a fiber matrix on a tubular member includes at least one nozzle, a tubular member in a spaced relationship to the at least one nozzle, and a fluid source for pressurizing a lumen of the tubular member. An electrical potential is applied between the at least one nozzle and either the tubular member or fluid from the fluid source. The electrical potential draws at least one fiber from the at least one nozzle to the tubular member.
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公开(公告)号：US20160325480A1
公开(公告)日：2016-11-10
申请号：US15108970
申请日：2014-12-30
Applicant: NEOGRAFT TECHNOLOGIES, INC.
Inventor： Lorenzo SOLETTI , Jon MCGRATH , J. Christopher FLAHERTY
CPC classification number: B29C48/92 , A61F2/06 , A61F2240/001 , A61F2250/003 , B29D23/00 , D01D5/0061 , D01D5/0084 , G01N21/952
Abstract: In some aspects, a system for producing a graft device can include a rotating assembly, a polymer delivery assembly, a controller and a diagnostic assembly. The rotating assembly can be constructed and arranged to rotate a tubular conduit. The polymer delivery assembly can be constructed and arranged to receive a polymer and deliver a fiber matrix comprising the polymer about the tubular conduit. The controller can be constructed and arranged to control the polymer delivery assembly and the rotating assembly. The diagnostic assembly can be constructed and arranged to detect an undesired state of at least one of the system or the graft device. Methods for producing a graft device are also provided.
Abstract translation: 在一些方面，用于生产移植装置的系统可以包括旋转组件，聚合物输送组件，控制器和诊断组件。 旋转组件可以被构造和布置成旋转管状导管。 聚合物递送组件可以被构造和布置成接收聚合物并且将围绕管状导管的包含聚合物的纤维基质递送。 控制器可以被构造和布置成控制聚合物输送组件和旋转组件。 可以构造和布置诊断组件以检测系统或移植装置中的至少一个的不期望的状态。 还提供了用于生产移植装置的方法。
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公开(公告)号：US20160262868A1
公开(公告)日：2016-09-15
申请号：US15023265
申请日：2014-09-18
Applicant: NEOGRAFT TECHNOLOGIES, INC.
Inventor： Lorenzo SOLETTI , John SPIRIDIGLIOZZI , Mohammed S. El-KURDI , Jon MCGRATH , J. Christopher FLAHERTY
IPC: A61F2/07
CPC classification number: A61F2/07 , A61F2/06 , A61F2/885 , A61F2002/072 , A61L27/507 , D01D5/0007
Abstract: A graft device for a mammalian patient tubular conduit comprises a fiber matrix surrounding the tubular conduit and a spine comprising a first support portion and a second support portion. At least one of the first support portion or the second support portions can be constructed and arranged to rotate relative to the other to receive the tubular conduit. The first support portion can comprise a first set of projections and the second support portion can comprise a second set of projections that interdigitiate with the first set of projections. Tools for creating the spine and for applying the spine are also provided.
Abstract translation: 用于哺乳动物患者管状导管的移植装置包括围绕管状导管的纤维基质和包括第一支撑部分和第二支撑部分的脊柱。 第一支撑部分或第二支撑部分中的至少一个可被构造和布置为相对于另一个旋转以接收管状导管。 第一支撑部分可以包括第一组突起，并且第二支撑部分可以包括与第一组突起相互交叉的第二组突起。 还提供了用于创建脊柱和应用脊椎的工具。
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公开(公告)号：US20170258609A1
公开(公告)日：2017-09-14
申请号：US15414216
申请日：2017-01-24
Applicant: Neograft Technologies, Inc.
Inventor： Jon MCGRATH , Mohammed S. EL-KURDI , Lorenzo SOLETTI , J. Christopher FLAHERTY
CPC classification number: A61F2/82 , A61B17/00008 , A61B17/11 , A61B17/135 , A61B2017/00778 , A61B2017/00969 , A61B2017/1107 , A61B2017/1132 , A61B2017/22097 , A61L27/3625 , A61L27/3687 , A61L27/3691 , A61L27/507
Abstract: Methods and devices for treating a vessel for use in a medical procedure are disclosed. A vein or other vessel can be modified in situ, prior to harvesting. Subsequently, at least a portion of the vessel is removed, and subsequently implanted to treat a patient, typically in a bypass procedure in which the vessel portion fluidly connects a source of oxygenated blood to an occluded artery.
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公开(公告)号：US20170043360A1
公开(公告)日：2017-02-16
申请号：US15228339
申请日：2016-08-04
Applicant: Neograft Technologies, Inc.
Inventor： Lorenzo SOLETTI , Mohammed S. EL-KURDI , Jon MCGRATH , Andrew ZIEGLER , J. Christopher FLAHERTY , William R. WAGNER , David VORP
CPC classification number: B05B5/12 , A61B90/00 , A61F2/022 , A61F2/04 , A61F2/06 , A61F2/07 , A61F2002/043 , A61F2002/046 , A61F2002/047 , A61F2002/048 , A61F2240/001 , A61L27/3625 , B05B5/0255 , D01D5/0084 , D01D13/02
Abstract: A cartridge device is provided for applying a fiber matrix to a tubular member such as a saphenous vein graft. The cartridge includes a housing, a tubular member holder, a rotational drive, and a polymer delivery assembly. The housing defines a chamber which surrounds the tubular member holder. The rotational drive rotates the tubular member during the fiber application process.
Abstract translation: 提供了用于将纤维基质施加到诸如隐静脉移植物的管状构件上的药筒装置。 盒包括壳体，管状构件保持器，旋转驱动器和聚合物输送组件。 壳体限定围绕管状构件保持器的腔室。 旋转驱动器在纤维施加过程中旋转管状构件。
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