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    ARTIFICIAL GRAFT DEVICES AND RELATED SYSTEMS AND METHODS
    4.
    发明申请
    ARTIFICIAL GRAFT DEVICES AND RELATED SYSTEMS AND METHODS 审中-公开
    人工晶体装置及相关系统及方法

    公开(公告)号：US20160302911A1

    公开(公告)日：2016-10-20

    申请号：US15108276

    申请日：2014-12-22

    Applicant: NEOGRAFT TECHNOLOGIES, INC.

    Inventor： Lorenzo SOLETTI

    IPC: A61F2/06 ,  A61L27/18 ,  A61L27/28 ,  A61L27/54 ,  A61L27/50 ,  A61L27/58 ,  A61L27/56

    CPC classification number: A61F2/06 ,  A61F2/062 ,  A61F2/064 ,  A61F2210/0004 ,  A61F2250/0019 ,  A61F2250/003 ,  A61F2250/0067 ,  A61L27/18 ,  A61L27/28 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/42 ,  A61L2420/08 ,  A61L2430/36 ,  C08L67/04

    Abstract: In some aspects, a graft device can include a biodegradable inner layer, an outer layer, a first end portion, a second end portion, and a lumen therebetween. The biodegradable inner layer typically includes an inner surface and an outer surface. The outer layer typically includes a fiber matrix surrounding the outer surface of the inner layer. The graft device can include a reinforced end portion. At least 10% or at least 50% of the graft device can remain after 90 days of implantation. In some cases, at least 10% or at least 50% of the graft device can remain after 180 days of implantation. The graft device can include a kink-resisting element. The graft device can include at least one layer with a dynamic compliance less than or equal to at least one of: 20%/100 mmHg or 5%/100 mmHg.

    Abstract translation: 在一些方面，移植装置可以包括可生物降解的内层，外层，第一端部，第二端部和其间的内腔。 可生物降解内层通常包括内表面和外表面。 外层通常包括围绕内层的外表面的纤维基质。 移植装置可以包括加强的端部。 移植装置的至少10％或至少50％可以在植入90天后保留。 在一些情况下，移植装置的至少10％或至少50％可以在植入180天后保留。 移植装置可以包括抗皱元件。 移植装置可包括至少一层具有小于或等于20％/ 100mmHg或5％/ 100mmHg中至少之一的动态顺应性的层。

    Artificial Graft Devices and Related Systems and Methods
    5.
    发明申请
    Artificial Graft Devices and Related Systems and Methods 审中-公开

    公开(公告)号：US20180368966A1

    公开(公告)日：2018-12-27

    申请号：US15977894

    申请日：2018-05-11

    Applicant: Neograft Technologies, Inc.

    Inventor： Lorenzo SOLETTI

    IPC: A61F2/06 ,  A61L27/28 ,  A61L27/18 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58

    Abstract: In some aspects, a graft device can include a biodegradable inner layer, an outer layer, a first end portion, a second end portion, and a lumen therebetween. The biodegradable inner layer typically includes an inner surface and an outer surface. The outer layer typically includes a fiber matrix surrounding the outer surface of the inner layer. The graft device can include a reinforced end portion. At least 10% or at least 50% of the graft device can remain after 90 days of implantation. In some cases, at least 10% or at least 50% of the graft device can remain after 180 days of implantation. The graft device can include a kink-resisting element. The graft device can include at least one layer with a dynamic compliance less than or equal to at least one of: 20%/100 mmHg or 5%/100 mmHg.

    SELF-DIAGNOSTIC GRAFT PRODUCTION SYSTEMS AND RELATED METHODS
    7.
    发明申请
    SELF-DIAGNOSTIC GRAFT PRODUCTION SYSTEMS AND RELATED METHODS 审中-公开
    自诊断GRAFT生产系统及相关方法

    公开(公告)号：US20160325480A1

    公开(公告)日：2016-11-10

    申请号：US15108970

    申请日：2014-12-30

    Applicant: NEOGRAFT TECHNOLOGIES, INC.

    Inventor： Lorenzo SOLETTI ,  Jon MCGRATH ,  J. Christopher FLAHERTY

    IPC: B29C47/92 ,  B29D23/00 ,  A61F2/06

    CPC classification number: B29C48/92 ,  A61F2/06 ,  A61F2240/001 ,  A61F2250/003 ,  B29D23/00 ,  D01D5/0061 ,  D01D5/0084 ,  G01N21/952

    Abstract: In some aspects, a system for producing a graft device can include a rotating assembly, a polymer delivery assembly, a controller and a diagnostic assembly. The rotating assembly can be constructed and arranged to rotate a tubular conduit. The polymer delivery assembly can be constructed and arranged to receive a polymer and deliver a fiber matrix comprising the polymer about the tubular conduit. The controller can be constructed and arranged to control the polymer delivery assembly and the rotating assembly. The diagnostic assembly can be constructed and arranged to detect an undesired state of at least one of the system or the graft device. Methods for producing a graft device are also provided.

    Abstract translation: 在一些方面，用于生产移植装置的系统可以包括旋转组件，聚合物输送组件，控制器和诊断组件。 旋转组件可以被构造和布置成旋转管状导管。 聚合物递送组件可以被构造和布置成接收聚合物并且将围绕管状导管的包含聚合物的纤维基质递送。 控制器可以被构造和布置成控制聚合物输送组件和旋转组件。 可以构造和布置诊断组件以检测系统或移植装置中的至少一个的不期望的状态。 还提供了用于生产移植装置的方法。

    GRAFT DEVICES WITH SPINES AND RELATED SYSTEMS AND METHODS
    8.
    发明申请
    GRAFT DEVICES WITH SPINES AND RELATED SYSTEMS AND METHODS 审中-公开
    旋转装置与相关系统和方法

    公开(公告)号：US20160262868A1

    公开(公告)日：2016-09-15

    申请号：US15023265

    申请日：2014-09-18

    Applicant: NEOGRAFT TECHNOLOGIES, INC.

    Inventor： Lorenzo SOLETTI ,  John SPIRIDIGLIOZZI ,  Mohammed S. El-KURDI ,  Jon MCGRATH ,  J. Christopher FLAHERTY

    IPC: A61F2/07

    CPC classification number: A61F2/07 ,  A61F2/06 ,  A61F2/885 ,  A61F2002/072 ,  A61L27/507 ,  D01D5/0007

    Abstract: A graft device for a mammalian patient tubular conduit comprises a fiber matrix surrounding the tubular conduit and a spine comprising a first support portion and a second support portion. At least one of the first support portion or the second support portions can be constructed and arranged to rotate relative to the other to receive the tubular conduit. The first support portion can comprise a first set of projections and the second support portion can comprise a second set of projections that interdigitiate with the first set of projections. Tools for creating the spine and for applying the spine are also provided.

    Abstract translation: 用于哺乳动物患者管状导管的移植装置包括围绕管状导管的纤维基质和包括第一支撑部分和第二支撑部分的脊柱。 第一支撑部分或第二支撑部分中的至少一个可被构造和布置为相对于另一个旋转以接收管状导管。 第一支撑部分可以包括第一组突起，并且第二支撑部分可以包括与第一组突起相互交叉的第二组突起。 还提供了用于创建脊柱和应用脊椎的工具。

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