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72 条记录 (耗时 0.018 秒)

    Molecular topological fractionation of macromolecules
    24.
    发明授权
    Molecular topological fractionation of macromolecules 有权
    大分子的分子拓扑分馏

    公开(公告)号：US07416698B2

    公开(公告)日：2008-08-26

    申请号：US10510060

    申请日：2003-05-14

    申请人： Patrick B. Smith ,  David M. Meunier ,  Scott A. Baker ,  Robert K. Prud'homme

    发明人： Patrick B. Smith ,  David M. Meunier ,  Scott A. Baker ,  Robert K. Prud'homme

    IPC分类号： G01N30/02

    CPC分类号： G01N30/32 ,  G01N30/0005 ,  G01N30/02 ,  G01N30/461 ,  G01N30/52 ,  G01N33/44 ,  G01N2030/001 ,  G01N2030/324 ,  G01N2030/525 ,  G01N2030/528 ,  B01D15/34

    摘要： A process for characterizing a sample comprising a population of linear macromolecules of interest (104) and a population of long chain branched macromolecules of interest (103), the process including four steps. The first step is to provide a flow through separating medium (100) and a liquid eluant (101) in which the macromolecules of interest dissolve, the separating medium defining flow through channels (102), the eluant flow rate and the average diameter of the channels being in a range so that the linear macromolecules of interest elute before the long chain branched macromolecules of interest (105) (106). The second step is to introduce a sample into the liquid eluant. The third step is to flow the liquid eluant under pressure through the channels (102) of the separating medium (100). The fourth step is to differentiate the linear macromolecules of interest (104) from the long chain branched macromolecules of interest (103) based on their successive elution volumes established in the third step such as by determining the refractive index of the successive elution volumes or by subjecting the successive elution volumes to size exclusion chromatography.

    摘要翻译： 用于表征包含一组目标线性大分子（104）和一组感兴趣的长链支化大分子（103）的样品的方法，该方法包括四个步骤。 第一步是提供流过分离介质（100）和其中感兴趣的大分子的液体洗脱液（101）的流动，分离介质限定流过通道（102），洗脱液流速和平均直径 通道在一定范围内，使得目标线性大分子在感兴趣的长链支化大分子（105）（106）之前洗脱。 第二步是将样品引入液体洗脱液。 第三步骤是使液体洗脱液在压力下流过分离介质（100）的通道（102）。 第四步是基于其在第三步骤中建立的连续洗脱体积，例如通过确定连续洗脱体积的折射率或通过测定连续洗脱体积的折射率，或通过测定连续洗脱体积的折射率来区分感兴趣的线性大分子（104）与目标长链支化大分子（103） 对连续的洗脱体积进行排阻层析。

    Method for preparing ceramic articles
    25.
    发明授权
    Method for preparing ceramic articles 失效
    陶瓷制品的制备方法

    公开(公告)号：US06197843B1

    公开(公告)日：2001-03-06

    申请号：US08846764

    申请日：1997-04-30

    申请人： Gene D Rose ,  Robert K Prud'homme ,  Gordon D McCann ,  Donald L Schmidt ,  Iihan A Aksay ,  Rajeev Garg

    发明人： Gene D Rose ,  Robert K Prud'homme ,  Gordon D McCann ,  Donald L Schmidt ,  Iihan A Aksay ,  Rajeev Garg

    IPC分类号： C08J328

    CPC分类号： C04B35/634 ,  B33Y10/00 ,  B33Y70/00 ,  C04B35/111 ,  C04B35/622 ,  C08K3/34 ,  G03F7/0047

    摘要： A process for preparation of ceramic objects which comprises: (a) applying a layer of a high-solids photocurable ceramic composition, to a substrate, the composition comprising: (1) at least 10 percent by volume of water; (2) at least 0.05 percent by weight of photocurable compounds which are soluble or dispersible in water; and (3) at least 45 volume percent dispersed ceramic particles; and (b) subjecting the composition to sufficient ultraviolet radiation to react the compounds or polymers sufficiently to form a layer of the photocurable compounds or polymers, which is water-insoluble and non-dispersible in water, having the ceramic particles dispersed therein.

    摘要翻译： 一种制备陶瓷物体的方法，包括：（a）将高固体可光固化的陶瓷组合物层施加到基底上，所述组合物包含：（1）至少10体积％的水; （2）至少0.05重量％的可溶于或可分散在水中的光固化化合物; 和（3）至少45体积％的分散陶瓷颗粒; 和（b）使组合物经受足够的紫外线辐射以使化合物或聚合物充分反应以形成其中分散有陶瓷颗粒的水不溶性且不可分散在水中的光固化性化合物或聚合物层。

    Compositions for fracturing subterranean formations
    26.
    发明授权
    Compositions for fracturing subterranean formations 失效
    压裂地层的组成

    公开(公告)号：US5869435A

    公开(公告)日：1999-02-09

    申请号：US403078

    申请日：1995-03-13

    申请人： Robert M. Kelly ,  Saad A. Khan ,  Pascal Leduc ,  Akash Tayal ,  Robert K. Prud'homme

    发明人： Robert M. Kelly ,  Saad A. Khan ,  Pascal Leduc ,  Akash Tayal ,  Robert K. Prud'homme

    IPC分类号： C09K8/62 ,  C09K8/68 ,  E21B43/267 ,  E21B43/26

    CPC分类号： E21B43/267 ,  C09K8/62 ,  C09K8/685 ,  Y10S507/921 ,  Y10S507/922 ,  Y10S507/923

    摘要： A method of fracturing a subterranean formation which surrounds a well bore comprises the steps of providing a fracturing fluid, and injecting the fracturing fluid into the well bore at a pressure sufficient to form fractures in the subterranean formation which surrounds the well bore. The pressure is then released from the fracturing fluid, after which the fluid may be removed from the well and the well placed into production. The fracturing fluid comprises an aqueous liquid, a polysaccharide soluble or dispersible in the aqueous liquid in an amount sufficient to increase the viscosity of the aqueous liquid, an enzyme breaker which degrades said polysaccharide at a temperature above 180.degree. F. Fracturing fluid compositions and enzyme breaker systems useful for carrying out the invention are also disclosed.

    摘要翻译： 压裂围绕井眼的地下地层的方法包括提供压裂流体的步骤，以及足以在围绕井眼的地层中形成裂缝的压力将压裂流体注入井眼。 然后压力从压裂液中释放出来，然后可以将流体从井中移出并将井放入生产中。 压裂流体包含含水液体，可溶于或分散在含水液体中的多糖，其量足以增加水性液体的粘度，该酶在大于180°F的温度下降解所述多糖。压裂液组合物和酶 还公开了可用于实施本发明的断路器系统。

    Process and apparatuses for preparing nanoparticle compositions with amphiphilic copolymers and their use
    30.
    发明授权
    Process and apparatuses for preparing nanoparticle compositions with amphiphilic copolymers and their use 有权
    用两亲共聚物制备纳米颗粒组合物的方法和设备及其用途

    公开(公告)号：US08137699B2

    公开(公告)日：2012-03-20

    申请号：US10472071

    申请日：2002-03-29

    申请人： Brian K Johnson ,  Robert K Prud'homme

    发明人： Brian K Johnson ,  Robert K Prud'homme

    IPC分类号： A61K9/50 ,  B29B9/00

    CPC分类号： A61K9/5138 ,  A01N25/04 ,  A01N43/70 ,  A61K9/5146 ,  A61K9/5192 ,  A61K47/34 ,  B01F1/00 ,  B01F7/22 ,  B01F15/00123 ,  B01F15/00344 ,  B01F15/00357 ,  B01F15/00376 ,  B01F15/00396 ,  B01J13/0021 ,  A01N2300/00

    摘要： This invention discloses a process for making nanopanticles of amphiphilic copolymers by flash precipitation. Nanoparticles may be of amphiphilic copolymer alone or may contain an additive target molecule, preferably an organic active. The inclusion of additive target molecules in amphiphilic copolymer nanoparticles can alter their water solubility characteristics, fluid dynamics, and/or stability. Changing an additive target molecule's solubility and stability in an nanoparticle can make a water insoluble compound suitable for pharmaceutical administration as well as specifically target the molecule to a specific area of a patient's body. The process affords the production of nanoparticles at high absolute active content, at high yield, high productivity, and high processing rates while using unusually low amounts of amphiphilic copolymers. Furthermore, the resulting particles exhibit sufficient stability for post processing as desired. The invention also discloses two apparatuses for the production of nanoparticles of amphiphilic copolymers by flash precipitation.

    摘要翻译： 本发明公开了一种通过闪蒸沉淀制备两亲性共聚物的纳米颗粒的方法。 纳米颗粒可以单独使用两亲性共聚物，也可以含有添加剂目标分子，优选为有机活性物质。 在两亲共聚物纳米颗粒中包含添加剂靶分子可以改变其水溶性特征，流体动力学和/或稳定性。 改变添加剂目标分子在纳米颗粒中的溶解度和稳定性可以使得适合于药物给药的水不溶性化合物以及将该分子特异性地靶向患者身体的特定区域。 该方法以高绝对活性含量，高产率，高生产率和高加工速率生产纳米颗粒，同时使用异常少量的两亲性共聚物。 此外，所得到的颗粒根据需要显示出足够的后处理稳定性。 本发明还公开了通过闪蒸沉淀生产两亲性共聚物的纳米颗粒的两种装置。