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    Molecular topological fractionation of macromolecules
    1.
    发明授权
    Molecular topological fractionation of macromolecules 有权
    大分子的分子拓扑分馏

    公开(公告)号：US07416698B2

    公开(公告)日：2008-08-26

    申请号：US10510060

    申请日：2003-05-14

    申请人： Patrick B. Smith ,  David M. Meunier ,  Scott A. Baker ,  Robert K. Prud'homme

    发明人： Patrick B. Smith ,  David M. Meunier ,  Scott A. Baker ,  Robert K. Prud'homme

    IPC分类号： G01N30/02

    CPC分类号： G01N30/32 ,  G01N30/0005 ,  G01N30/02 ,  G01N30/461 ,  G01N30/52 ,  G01N33/44 ,  G01N2030/001 ,  G01N2030/324 ,  G01N2030/525 ,  G01N2030/528 ,  B01D15/34

    摘要： A process for characterizing a sample comprising a population of linear macromolecules of interest (104) and a population of long chain branched macromolecules of interest (103), the process including four steps. The first step is to provide a flow through separating medium (100) and a liquid eluant (101) in which the macromolecules of interest dissolve, the separating medium defining flow through channels (102), the eluant flow rate and the average diameter of the channels being in a range so that the linear macromolecules of interest elute before the long chain branched macromolecules of interest (105) (106). The second step is to introduce a sample into the liquid eluant. The third step is to flow the liquid eluant under pressure through the channels (102) of the separating medium (100). The fourth step is to differentiate the linear macromolecules of interest (104) from the long chain branched macromolecules of interest (103) based on their successive elution volumes established in the third step such as by determining the refractive index of the successive elution volumes or by subjecting the successive elution volumes to size exclusion chromatography.

    摘要翻译： 用于表征包含一组目标线性大分子（104）和一组感兴趣的长链支化大分子（103）的样品的方法，该方法包括四个步骤。 第一步是提供流过分离介质（100）和其中感兴趣的大分子的液体洗脱液（101）的流动，分离介质限定流过通道（102），洗脱液流速和平均直径 通道在一定范围内，使得目标线性大分子在感兴趣的长链支化大分子（105）（106）之前洗脱。 第二步是将样品引入液体洗脱液。 第三步骤是使液体洗脱液在压力下流过分离介质（100）的通道（102）。 第四步是基于其在第三步骤中建立的连续洗脱体积，例如通过确定连续洗脱体积的折射率或通过测定连续洗脱体积的折射率，或通过测定连续洗脱体积的折射率来区分感兴趣的线性大分子（104）与目标长链支化大分子（103） 对连续的洗脱体积进行排阻层析。

    DETERMINATION OF THE HYDRODYNAMIC RADII AND/OR CONTENT OF CONSTITUENTS OF A MIXTURE BY ANALYSIS OF THE TAYLOR DISPERSION OF THE MIXTURE IN A CAPILLARY TUBE
    3.
    发明申请
    DETERMINATION OF THE HYDRODYNAMIC RADII AND/OR CONTENT OF CONSTITUENTS OF A MIXTURE BY ANALYSIS OF THE TAYLOR DISPERSION OF THE MIXTURE IN A CAPILLARY TUBE 审中-公开
    通过分析毛细管中混合物的水分散度来确定混合物的水动力RADII和/或内容物

    公开(公告)号：US20110264380A1

    公开(公告)日：2011-10-27

    申请号：US13055350

    申请日：2009-03-13

    申请人： Hervé Cottet ,  Rachid Matmour ,  Jean Philippe Biron ,  Michel Martin

    发明人： Hervé Cottet ,  Rachid Matmour ,  Jean Philippe Biron ,  Michel Martin

    IPC分类号： G06F19/00 ,  G01N33/00

    CPC分类号： B01J19/0053 ,  B01J2208/00955 ,  G01N15/1459 ,  G01N33/442 ,  G01N2015/0092 ,  G01N2030/001

    摘要： A method for analysing a mixture M comprising (i) a first monodisperse species, and (ii) a second species having a response coefficient which is distinct from the response coefficient of the first species (i) on at least one detection device, said method comprising the following steps: (A) the mixture M is injected at the inlet of a capillary tube and forced to be transported in said tube by the flow of a carrier liquid induced by a positive hydrodynamic and/or hydrostatic pressure between the inlet and the outlet of the capillary, whereby a phenomenon of Taylor dispersion of the species of the mixture M occurs in the tube; (B) by using a detection device able to detect simultaneously both species (i) and (ii) and placed in the region of the outlet of the capillary tube, a signal reflecting the Taylor dispersion obtained in step (A) is measured; (C) the signal obtained in step (B) is analysed, so as to determine specific contributions of species (i) and (ii) and thereby establishing at least one of the followings: —the content of species (i) and/or (ii) in the mixture M; and/or, —the mean hydrodynamic radius of the species (ii) or the hydrodynamic radius of species (i).

    摘要翻译： 一种用于分析混合物M的方法，包括（i）第一单分散物质和（ii）具有与至少一种检测装置上的第一物质（i）的响应系数不同的响应系数的第二物质，所述方法 包括以下步骤：（A）混合物M在毛细管的入口处被注入，并且被迫通过由正的流体动力学和/或静水压力引起的载体流在所述管内被输送到入口和 毛细管的出口，由此在管中发生混合物M的种类的泰勒分散现象; （B）通过使用能够同时检测物质（i）和（ii）并且放置在毛细管的出口的区域中的检测装置，测量反映步骤（A）中获得的泰勒色散的信号; （C）分析步骤（B）中获得的信号，以便确定物种（i）和（ii）的具体贡献，从而建立以下至少一个： - 物种（i）和/或 （ii）在混合物M中; 和/或 - 物种（ii）的平均流体动力学半径或物质（i）的流体动力学半径。

    Size separation of particles contained within a material by the use of nonaqueous hydrodynamic chromatography
    4.
    发明授权
    Size separation of particles contained within a material by the use of nonaqueous hydrodynamic chromatography 失效
    通过使用非水性流体动力学色谱法在材料中包含的颗粒的尺寸分离

    公开(公告)号：US5183604A

    公开(公告)日：1993-02-02

    申请号：US825353

    申请日：1992-01-24

    申请人： Martin A. Langhorst ,  Joseph B. Henry

    发明人： Martin A. Langhorst ,  Joseph B. Henry

    IPC分类号： G01N15/02 ,  G01N30/00

    CPC分类号： G01N30/0005 ,  G01N15/02 ,  G01N2030/001 ,  G01N2030/885

    摘要： A method is disclosed for determining the distribution according to size of particles which make up a noncontinuous phase dispersed within a matrix which is not completely soluble in an aqueous solution. The method involves dissolving the matrix containing the particles in an essentially nonaqueous liquid causing the particles to be suspended. The suspension is then eluted through a separating medium which sorts the particles according to size. A detector monitors the effluent from the separating medium and creates a record of the data. This record is then compared to data obtained from known standards in order to estimate the size distribution in the sample.

    摘要翻译： 公开了一种根据构成分散在不完全溶于水溶液的基体内的非连续相的颗粒尺寸来确定分布的方法。 该方法包括将含有颗粒的基质溶解在基本上非水性的液体中，导致颗粒被悬浮。 然后将悬浮液通过分离介质洗脱，根据尺寸对颗粒进行排序。 检测器监测来自分离介质的流出物，并创建数据记录。 然后将该记录与从已知标准获得的数据进行比较，以估计样品中的尺寸分布。

    Molecular topological fractionation of macromolecules
    7.
    发明申请
    Molecular topological fractionation of macromolecules 有权
    大分子的分子拓扑分馏

    公开(公告)号：US20050176154A1

    公开(公告)日：2005-08-11

    申请号：US10510060

    申请日：2003-05-14

    申请人： Patrick Smith ,  David Meunier ,  Scott Baker ,  Robert Prud'homme

    发明人： Patrick Smith ,  David Meunier ,  Scott Baker ,  Robert Prud'homme

    IPC分类号： G01N30/88 ,  G01Q60/00 ,  B01J20/281 ,  G01N30/00 ,  G01N30/02 ,  G01N30/32 ,  G01N30/46 ,  G01N30/52 ,  G01N30/62 ,  G01N30/74 ,  G01N30/86 ,  G01N33/44 ,  G01Q80/00 ,  G01Q90/00 ,  G01N33/00

    CPC分类号： G01N30/32 ,  G01N30/0005 ,  G01N30/02 ,  G01N30/461 ,  G01N30/52 ,  G01N33/44 ,  G01N2030/001 ,  G01N2030/324 ,  G01N2030/525 ,  G01N2030/528 ,  B01D15/34

    摘要： A process for characterizing a sample comprising a population of linear macromolecules of interest (104) and a population of long chain branched macromolecules of interest (103), the process including four steps. The first step is to provide a flow through separating medium (100) and a liquid eluant (101) in which the macromolecules of interest dissolve, the separating medium defining flow through channels (102), the eluant flow rate and the average diameter of the channels being in a range so that the linear macromolecules of interest elute before the long chain branched macromolecules of interest (105) (106). The second step is to introduce a sample into the liquid eluant. The third step is to flow the liquid eluant under pressure through the channels (102) of the separating medium (100). The fourth step is to differentiate the linear macromolecules of interest (104) from the long chain branched macromolecules of interest (103) based on their successive elution volumes established in the third step such as by determining the refractive index of the successive elution volumes or by subjecting the successive elution volumes to size exclusion chromatography.

    摘要翻译： 用于表征包含一组目标线性大分子（104）和一组感兴趣的长链支化大分子（103）的样品的方法，该方法包括四个步骤。 第一步是提供流过分离介质（100）和其中感兴趣的大分子的液体洗脱液（101）的流动，分离介质限定流过通道（102），洗脱液流速和平均直径 通道在一定范围内，使得目标线性大分子在感兴趣的长链支化大分子（105）（106）之前洗脱。 第二步是将样品引入液体洗脱液。 第三步骤是使液体洗脱液在压力下流过分离介质（100）的通道（102）。 第四步是基于其在第三步骤中建立的连续洗脱体积，例如通过确定连续洗脱体积的折射率或通过测定连续洗脱体积的折射率，或通过测定连续洗脱体积的折射率来区分感兴趣的线性大分子（104）与目标长链支化大分子（103） 对连续的洗脱体积进行排阻层析。

    Size separation of particles contained within a material by the use of nonaqueous hydrodynamic chromatography
    8.
    发明授权
    Size separation of particles contained within a material by the use of nonaqueous hydrodynamic chromatography 失效
    通过使用非水性流体动力学色谱法在材料中包含的颗粒的尺寸分离

    公开(公告)号：US5372721A

    公开(公告)日：1994-12-13

    申请号：US139324

    申请日：1993-10-19

    申请人： Martin A. Langhorst ,  Joseph B. Henry

    发明人： Martin A. Langhorst ,  Joseph B. Henry

    IPC分类号： G01N15/02 ,  G01N30/00 ,  B01D15/08

    CPC分类号： G01N30/0005 ,  G01N15/02 ,  G01N2030/001 ,  G01N2030/885

    摘要： A method is disclosed for determining the distribution according to size of particles which make up a noncontinuous phase dispersed within a matrix which is not completely soluble in an aqueous solution. The method involves dissolving the matrix containing the particles in an essentially nonaqueous liquid causing the particles to be suspended. The suspension is then eluted through a separating medium which sorts the particles according to size. A detector monitors the effluent from the separating medium and creates a record of the data. This record is then compared to data obtained from known standards in order to estimate the size distribution in the sample.

    摘要翻译： 公开了一种根据构成分散在不完全溶于水溶液的基体内的非连续相的颗粒尺寸来确定分布的方法。 该方法包括将含有颗粒的基质溶解在基本上非水性的液体中，导致颗粒被悬浮。 然后将悬浮液通过分离介质洗脱，根据尺寸对颗粒进行排序。 检测器监测来自分离介质的流出物，并创建数据记录。 然后将该记录与从已知标准获得的数据进行比较，以估计样品中的尺寸分布。