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公开(公告)号：US10647812B2
公开(公告)日：2020-05-12
申请号：US15579629
申请日：2016-06-06
Applicant: THE UNIVERSITY OF ROCHESTER
Inventor： Mitchell Anthamatten , Yuan Meng
Abstract: Described are shape-memory polymers that have a composite prepolymer crosslinked with a stoichiometric amount of a multifunctional crosslinker, the composite prepolymer having a branched or telechelic prepolymer having a low polydispersity reacted with a non-crystalline chain extender. Also described are methods of making shape-memory polymers by reacting a branched or telechelic prepolymer having a low polydispersity with a non-crystalline chain extender to form a composite prepolymer, and crosslinking a stoichiometric amount of a multifunctional crosslinker with the composite prepolymer, thereby forming the shape-memory polymer.
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公开(公告)号：US20180171288A1
公开(公告)日：2018-06-21
申请号：US15819843
申请日：2017-11-21
Applicant: THE UNIVERSITY OF ROCHESTER
Inventor： Mark Noble , Brett Stevens , Hsing-Yu Chen , Jennifer Stripay , Christopher Folts , Nicole Scott
IPC: C12N5/00 , G01N33/574 , C12N9/10 , C07K16/30 , A61P35/00
CPC classification number: C12N5/0093 , A61K31/135 , A61K31/137 , A61K31/138 , A61K31/175 , A61K31/495 , A61K31/675 , A61K45/06 , A61P35/00 , C07K16/30 , C12N5/0693 , C12N9/104 , C12Y203/02 , G01N33/57415 , G01N33/57423 , G01N33/5743 , G01N33/57438 , G01N33/57446 , G01N33/57492 , A61K2300/00
Abstract: Compositions and methods of treating a subject with cancer are described. The methods include administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a compound with the dual characteristics or restoring function of the c-Cbl ubiquitin ligase in cancer cells and in also worsening sublethal lysosomal dysfunction, preferably in combination with an agent capable of making cancer cells more oxidized. The pharmaceutical composition can be administered with an additional therapeutic agent or agents such as an agent that represents an accepted standard of care for the treatment of a particular type being treated. The methods can be used for treating a wide variety of different kinds of cancers, such as brain tumors, breast cancers, melanomas, breast cancers and lymphomas. The compositions and methods have the characteristics of enabling simultaneous regulation of multiple proteins known to be critical in cancer cell function, of targeting cancer stem cells and of enhancing sensitivity of cancer cells to the effects of tamoxifen and other anticancer agents.
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![Substituted pyrrolo[2,3-b]pyridines as MLK inhibitors](/abs-image/US/2017/11/14/US09814704B2/abs.jpg.150x150.jpg)
公开(公告)号：US09814704B2
公开(公告)日：2017-11-14
申请号：US15172355
申请日：2016-06-03
Applicant: The University of Rochester
Inventor： Harris A. Gelbard , Stephen Dewhurst , Val S. Goodfellow , Colin J. Loweth , Torsten Wiemann
IPC: C07D471/04 , A61K31/437 , A61K45/06 , C07D487/04 , A61K31/438 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/5377 , A61K31/553 , C07D471/10 , A61K31/444
CPC classification number: A61K31/437 , A61K31/438 , A61K31/444 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/5377 , A61K31/553 , A61K45/06 , C07D471/04 , C07D471/10 , C07D487/04 , A61K2300/00
Abstract: Provided are compounds having an inhibitory effect on Mixed Lineage Kinases. The compounds include substituted pyrrolo[2,3-b]pyridines having Formula IX Also provided are pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by Mixed Lineage Kinase inhibition. Also provided are methods of treatment neuropsychiatric disorders which comprise the inhibition of Mixed Lineage Kinases.
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公开(公告)号：US12023875B2
公开(公告)日：2024-07-02
申请号：US16630962
申请日：2018-07-13
Applicant: THE UNIVERSITY OF ROCHESTER
Inventor： Mitchell Anthamatten
CPC classification number: B29C67/246 , C08G18/246 , C08G18/4277 , C08G18/792 , B29K2075/00 , C08G2120/00 , C08G2280/00
Abstract: Disclosed are methods of using reaction injection molding to mold stimuli-responsive thermosets such as urethane linked poly(caprolactone) networks from polyols and polyisocyanates, as well as polymers prepared by such methods.
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公开(公告)号：US20230295146A1
公开(公告)日：2023-09-21
申请号：US18017759
申请日：2021-07-03
Applicant: The University of Rochester
Inventor： Michael Becker , Rakesh Singh , Richard Moore , Laura Calvi
IPC: C07D417/02 , A61K45/06
CPC classification number: C07D417/02 , A61K45/06
Abstract: The present disclosure provides compounds that are inhibitors of interleukin-1 receptor-associated kinases 1 and 4 (IRAK1 and IRAK4) and their use in the treatment of medical disorders such as autoimmune disorders, cancer, and pain disorders.
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Patent Agency Ranking
公开(公告)号：US11438704B2
公开(公告)日：2022-09-06
申请号：US16592368
申请日：2019-10-03
Applicant: The University of Rochester
Abstract: A method, system and devices to selectively control modal vibrations in an elastic panel with a number of force actuators distributed throughout the surface of the elastic panel to excite/depress the response of one or more vibrational resonant modes included in a prescribed subset. The force actuators are disposed such that prescribed modal excitation/depression may be realized when the actuators are driven by a common source signal.
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公开(公告)号：US20200223156A1
公开(公告)日：2020-07-16
申请号：US16630962
申请日：2018-07-13
Applicant: THE UNIVERSITY OF ROCHESTER
Inventor： Mitchell ANTHAMATTEN
Abstract: Disclosed are methods of using reaction injection molding to mold stimuli-responsive thermosets such as urethane linked poly(caprolactone) networks from polyols and polyisocyanates, as well as polymers prepared by such methods.
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公开(公告)号：US20180143194A1
公开(公告)日：2018-05-24
申请号：US15563667
申请日：2016-04-04
Applicant: THE UNIVERSITY OF ROCHESTER , EMORY UNIVERSITY
Inventor： John Linforth DAISS , Edward M. SCHWARZ , Kohei NISHITANI , Sandeep SOIN , Frances Eun-Hyung LEE
IPC: G01N33/569 , G01N33/50 , G01N33/536 , C07K16/12
CPC classification number: G01N33/56938 , C07K16/1271 , C07K2317/14 , G01N33/5091 , G01N33/536
Abstract: Provided herein are compositions and methods for detecting and/or diagnosing a Staphylococcus aureus (S. aureus) infection in a subject. It is a surprising finding of the present invention that an S. aureus infection may be detected by using one or more antigens selected from the group consisting of an IsdA antigen, IsdB antigen, CHIPS antigen, and a SCIN antigen. In some embodiments, these S. aureus antigens are used to detect antibodies secreted by the plasmablasts from the subject.
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公开(公告)号：US20160317509A1
公开(公告)日：2016-11-03
申请号：US15172355
申请日：2016-06-03
Applicant: The University of Rochester
Inventor： Harris A. Gelbard , Stephen Dewhurst , Val S. Goodfellow , Colin J. Loweth , Torsten Wiemann
IPC: A61K31/437 , A61K31/496 , A61K31/506 , A61K31/444
CPC classification number: A61K31/437 , A61K31/438 , A61K31/444 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/5377 , A61K31/553 , A61K45/06 , C07D471/04 , C07D471/10 , C07D487/04 , A61K2300/00
Abstract: Provided are compounds having an inhibitory effect on Mixed Lineage Kinases. Also provided are pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by Mixed Lineage Kinase inhibition. Also provided are methods of treatment of neuropsychiatric disorders which comprise the inhibition of Mixed Lineage Kinases.
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30.发明申请SPATIALLY INHOMOGENOUSLY FUNCTIONALIZED POROUS MEDIA AND METHOD FOR USE IN SELECTIVE REMOVAL OF CONTAMINANTS 有权空间不均匀多功能多孔介质和选择性去除污染物的方法公开(公告)号：US20150337291A1
公开(公告)日：2015-11-26
申请号：US14725968
申请日：2015-05-29
Applicant: The University of Rochester
Inventor： Lewis Rothberg , Barbara Stwertka
IPC: C12N15/10 , C08F222/38 , C08F222/02
CPC classification number: C12N15/1006 , C08F222/02 , C08F222/38 , Y10T428/249978 , Y10T428/2982
Abstract: Compositions and methods for separating double-stranded nucleic acids out of a mixture comprising single-stranded nucleic acids and/or dNTPs and/or enzymes. The method uses spatially inhomogeneously functionalized nanoporous materials. For example, the compositions and methods of the present invention can be used to purify DNA amplification reaction products.
Abstract translation: 从包含单链核酸和/或dNTP和/或酶的混合物中分离双链核酸的组合物和方法。 该方法使用空间不均匀的官能化纳米多孔材料。 例如，本发明的组合物和方法可用于纯化DNA扩增反应产物。
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