公开(公告)号：US20250074840A1

公开(公告)日：2025-03-06

申请号：US18753413

申请日：2024-06-25

Applicant: University of Rhode Island Board of Trustees

Inventor： Jimmie Oxley ,  James L. Smith ,  Taylor Busby ,  Athina Kominia

IPC: C06B45/10 ,  A62D3/38

Abstract: A plasticized pyrotechnic material can be easily portioned and formed or molded into a desired shape and burns at a high temperature (>2000° C.) but does not detonate. The plasticized pyrotechnic material may preferably include a combination of about 70-99% by weight of a pyrotechnic composition and about 1-30% by weight of a plasticizer composition comprising various low to mid molecular weight polyisobutylenes. The pyrotechnic material comprises inorganic oxidizers (e.g. metal oxides, oxohalide salts, nitrates, nitrites, chlorates/perchlorates) and metal or metal oxides powders mixed intimately. The plasticizer may include a small amount of a fluoropolymer, such as polytetrafluoroethylene (PTFE) and may also include up to 1-2% by weight of a processed oil, such as a mineral oil or motor oil. Some embodiments may also include a biocide precursor molecule.

公开(公告)号：US20240343859A1

公开(公告)日：2024-10-17

申请号：US18628340

申请日：2024-04-05

Applicant: University of Rhode Island Board of Trustees ,  Yale University

Inventor： Matthew Kiesewetter ,  Kassie Picard ,  Jinal Pothupitiya ,  W. Mark Saltzman

IPC: C08G63/08 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58

CPC classification number: C08G63/08 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58

Abstract: Embodiments of the present invention comprises one or more of an article composed of a copolymer, a copolymer made from a process, and a process for the preparation of a copolymer composition by metal free enzyme ring-opening polymerization of a monomer composition comprising i) an ethylene brassylate monomer; ii) a 1-4 dioxan-2-one (DO); iii) lipase B from Candida antarctica (Novozyme® 435) and at an elevated temperature, processing the monomer reactants i) and ii) to a copolymer via ring-opening polymerization under solvent-free conditions and a nitrogen atmosphere in the absence of a metal and the presence of the lipase to produce a random EB-co-DO copolymer.

公开(公告)号：US11981557B2

公开(公告)日：2024-05-14

申请号：US17232624

申请日：2021-04-16

Applicant: Southern Methodist University ,  University of Rhode Island Board of Trustees

Inventor： Y. M. Nuwan D. Y. Bandara ,  Buddini I. Karawdeniya ,  Jugal Saharia ,  Min Jun Kim ,  Jason Rodger Dwyer

IPC: B81B1/00 ,  B82Y15/00 ,  B82Y40/00 ,  C25F3/02 ,  G01N27/12 ,  G01N33/487

CPC classification number: B81B1/002 ,  B82Y40/00 ,  C25F3/02 ,  G01N27/127 ,  G01N33/48721 ,  B01J2219/00864 ,  B82Y15/00

Abstract: The present invention includes one or more nanopores in a SixNy membrane comprising a monoprotic surface termination, methods of making, and methods of using the one or more nanopores, where the one or more nanopores are a chemically-tuned controlled dielectric breakdown (CT-CDB) nanopore membrane, wherein the CT-CDB allows for long-term stability of measurements in the presence of only electrolyte (open pore current stability) and ability to support many molecular detection events. In addition, the CT-CBD has pore that unclog spontaneously, in response to voltage cessation or application, or both.

公开(公告)号：US20240148911A1

公开(公告)日：2024-05-09

申请号：US18349851

申请日：2023-07-10

Applicant: UNIVERSITY OF RHODE ISLAND BOARD OF TRUSTEES ,  YALE UNIVERSITY

Inventor： Yana K. RESHETNYAK ,  Oleg A. ANDREEV ,  Donald M. ENGELMAN

IPC: A61K49/00 ,  A61B5/00 ,  A61K49/04 ,  A61K49/22 ,  C07K14/00 ,  C07K19/00 ,  C09B69/10 ,  C09K11/06 ,  G01N33/58

CPC classification number: A61K49/0056 ,  A61B5/0082 ,  A61K49/0034 ,  A61K49/04 ,  A61K49/221 ,  A61K49/227 ,  C07K14/001 ,  C07K19/00 ,  C09B69/107 ,  C09K11/06 ,  G01N33/582 ,  A61B5/0071 ,  C09K2211/1466

Abstract: The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided.

公开(公告)号：US11932558B1

公开(公告)日：2024-03-19

申请号：US17190248

申请日：2021-03-02

Applicant: University of Rhode Island Board of Trustees

Inventor： William B. Euler ,  Angela Thach ,  Lasanthi Sumathirathne ,  Benjamin B. Cromwell ,  Mara Dubnicka

IPC: C02F1/461 ,  C02F1/467 ,  C02F101/34 ,  C02F101/38 ,  C25B1/04 ,  C25B1/27 ,  C25B3/07 ,  C25B3/26 ,  C25B11/095 ,  H10N30/857

CPC classification number: C02F1/46109 ,  C02F1/4672 ,  C25B1/04 ,  C25B1/27 ,  C25B3/07 ,  C25B3/26 ,  C25B11/095 ,  H10N30/857 ,  C02F2001/46133 ,  C02F2101/345 ,  C02F2101/38 ,  C02F2201/46115

Abstract: A piezoelectric polymer used as a piezocatalyst, and methods of manufacture and use therefor. A preferred piezoelectric polymer is poly(vinylidene difluoride) (PVDF) due to its piezoelectric response and good flexibility. The polymer can be doped with a metal, metal salt, metal carbonyl, metal oxide such as ZnO, Co2O3, or TiO2, or ion such as Cr3+, Co2+, or Zn2+. The dopant can be chosen so that when the polymer is PVDF the dopant increases the amount of β-phase PVDF and/or γ-phase PVDF relative to α-phase PVDF, thereby increasing the piezocatalytic response of the polymer. The compound to be decomposed can be adsorbed on the surface of the piezoelectric polymer. Applications include wastewater treatment, CO2 capture and reduction, hydroformylation, water splitting, and ammonia synthesis.

公开(公告)号：US20240066096A1

公开(公告)日：2024-02-29

申请号：US18325884

申请日：2023-05-30

Applicant: UNIVERSITY OF RHODE ISLAND BOARD OF TRUSTEES ,  YALE UNIVERSITY

Inventor： Yana K. RESHETNYAK ,  Oleg A. ANDREEV ,  Anna MOSHNIKOVA ,  Donald M. Engelman

IPC: A61K38/16 ,  A61K38/19 ,  A61K38/20

CPC classification number: A61K38/16 ,  A61K38/195 ,  A61K38/20 ,  A61K47/00 ,  A61K2121/00 ,  C07K2319/33

Abstract: The invention features methods and compositions for eliciting an anti-tumor response in a subject comprising administering to the subject a pHLIP● construct comprising an antibody recruiting molecule linked to one or more pHLIP● peptides by a non-cleavable linker compound. The construct increases the amount of the antibody recruiting molecule on the surface of a diseased cell.

公开(公告)号：US20230372551A1

公开(公告)日：2023-11-23

申请号：US18027337

申请日：2021-09-21

Applicant: MEMORIAL SLOAN-KETTERING CANCER CENTER ,  MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES ,  SLOAN-KETTERING INSTITUTE OF CANCER RESEARCH ,  UNIVERSITY OF RHODE ISLAND BOARD OF TRUSTEES ,  PHLIP, INC.

Inventor： Jason S. LEWIS ,  Yana K. RESHETNYAK ,  Lukas M. CARTER ,  David BAUER

IPC: A61K51/08 ,  C07K14/00

CPC classification number: A61K51/088 ,  C07K14/001 ,  A61K2123/00

Abstract: The present disclosure provides compounds, complexes, compositions, and methods for the detection of cancer. Specifically, the compounds, complexes, compositions of the present technology include pH (low) insertion peptides. Also disclosed herein are methods of using the complexes and compositions of the present technology in diagnostic imaging to detect cancer in a subject.

公开(公告)号：US11572417B2

公开(公告)日：2023-02-07

申请号：US16870829

申请日：2020-05-08

Applicant: University of Rhode Island Board of Trustees

Inventor： Teresa L. Mako ,  Mindy Levine ,  Jason Dwyer

IPC: C08B15/00 ,  G01N21/78 ,  G01N31/22 ,  G01N21/25 ,  G01N21/17

Abstract: The invention provides a mild procedure for the functionalization of cellulose and other substrates with a detection reagent such as N-(1-naphthyl)ethylenediamine and is able to achieve much higher functionalization density than previously reported. A paper-based device created using cellulose functionalized according to the invention allowed for much lower detection limits for nitrite in various kinds of water samples than have been seen using paper-based devices. In addition, grafting of N-(1-naphthyl)ethylenediamine to cellulose improved the stability of the N-(1-naphthyl)ethylenediamine in the presence of moisture and light.

公开(公告)号：US20220259433A1

公开(公告)日：2022-08-18

申请号：US17588674

申请日：2022-01-31

Applicant: University of Rhode Island Board of Trustees

Inventor： Sumeru Nayak ,  Sumanta Das

IPC: C08L91/00 ,  C08K3/04 ,  C09D7/61 ,  C09D5/10 ,  C09D191/00

Abstract: A composition and method of synthesizing a composition from organic oils and industrial byproducts for use as a corrosion inhibitor coating is disclosed. The synthesis of a rapid setting ionomer is the result of iron-induced polymerization of oleic and linoleic acids, where an alkaline ionomeric reaction is facilitated with a small fraction of pure aluminum leaf at room temperature. At least one alkaline reagent is employed with at least one metallic additive to form metal complex ionomers that form a solid polymer. The resulting ionomer is stirred and applied on the substrate as a surface coating and it starts setting in less than thirty minutes.

公开(公告)号：US20220248983A1

公开(公告)日：2022-08-11

申请号：US17590032

申请日：2022-02-01

Applicant: University of Rhode Island Board of Trustees

Inventor： Daniel Roxbury ,  Mohammad Moein Safaee ,  Mitchell Gravely

IPC: A61B5/1455 ,  A61B5/145 ,  A61F13/00 ,  C08K3/04 ,  C08L71/02 ,  C08L67/04

Abstract: An optical core-shell microfibrous textile incorporates single-walled carbon nanotubes (SWCNTs) for the real-time optical monitoring of hydrogen peroxide concentrations and other biochemicals in in vitro wounds. The environmentally sensitive and non-photo-bleachable fluorescence of SWCNTs enable continuous analyte monitoring without a decay in signal over time. The microfibrous textiles spatially resolve chemical indicator concentrations using a camera and are integrated into commercial wound bandages without significant degradation in their optical properties.