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公开(公告)号:US20150343012A1
公开(公告)日:2015-12-03
申请号:US14414001
申请日:2013-07-12
Applicant: The University of Sheffield
Inventor: Steven J. Winder
IPC: A61K38/07 , A61K31/69 , A61K31/506
CPC classification number: A61K38/07 , A01K67/0275 , A01K2217/052 , A01K2217/054 , A01K2217/15 , A01K2227/105 , A01K2267/0306 , A61K31/198 , A61K31/4155 , A61K31/496 , A61K31/506 , A61K31/517 , A61K31/69 , A61K38/1709 , G01N33/5041 , G01N2333/9015 , G01N2800/10 , A61K2300/00
Abstract: The invention provides a compound capable of inhibiting ubiquitination for use in treating a disorder or symptom associated with reduced dystroglycan function in a subject.
Abstract translation: 本发明提供能够抑制泛素化用于治疗与受试者中降低的肌浆聚糖功能降低相关的病症或症状的化合物。
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公开(公告)号:US20140322254A1
公开(公告)日:2014-10-30
申请号:US14360680
申请日:2012-11-30
Applicant: University of Sheffield
Inventor: Jon Sayers , Peter Arymiuk , Andrew Heath
IPC: A61K39/39 , C07K14/435 , C07K14/005 , C07K14/22 , C07K14/195
CPC classification number: A61K39/39 , A61K2039/55516 , A61K2039/6068 , C07K14/005 , C07K14/195 , C07K14/22 , C07K14/435 , C07K2319/40
Abstract: The disclosure relates to an adjuvant polypeptide effective at enhancing the immune response to an antigen crosslinked to the adjuvant polypeptide.
Abstract translation: 本公开涉及对增强对与佐剂多肽交联的抗原的免疫应答有效的佐剂多肽。
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公开(公告)号:US20040181080A1
公开(公告)日:2004-09-16
申请号:US10808622
申请日:2004-03-24
Applicant: The University of Sheffield
Inventor: Mauro Francesco Alessio Adamo , Varinder Kumar Aggarwal
IPC: C07D301/03
CPC classification number: C07D301/14 , C07B2200/07 , C07D301/02 , C07D303/04
Abstract: A process for the epoxidation of an alkene, which process comprises reaction of an alkene with an oxidising agent in the presence of a catalyst, characterised in that the catalyst is an amine of formula (I), wherein T represents hydrogen or a moiety of formula (a); R1, R2, R3, R4, R5 and R6 each independently represents hydrogen, optionally substituted alkyl, an optionally substituted aryl group, heterocyclyl or an optionally substituted aralkyl group wherein substituents for the above mentioned groups are selected from up to three of alkyl, aryl, heterocycyl, hydroxy, alkoxy or a group NRsRt wherein Rs and Rt each independently represents hydrogen, alkyl or alkylcarbonyl and R7 represents hydrogen, alkyl, aryl or aralkyl; or T represents a moiety (a) wherein R1 together with R2 represents an optionally substituted alkylene chain comprising 2 to 6 carbon atoms the alkylene chain being optionally interrupted with an oxygen atom or a group NRp wherein Rp is hydrogen or alkyl, and wherein optional substituents for any carbon atom of the alkylene chain are selected from hydroxy, alkoxy, oxo or a group NRsRt wherein Rs and Rt each independently represents hydrogen, alkyl or alkylcarbonyl or substituents on any two adjacent carbon atoms of the chain together with the carbon atoms to which they are attached form an alicyclic, aryl or heterocyclic ring; and R3, R4, R5, R6 and R7 are as defined above. 1
Abstract translation: 一种烯烃的环氧化方法,该方法包括在催化剂存在下烯烃与氧化剂的反应,其特征在于催化剂是式(I)的胺,其中T表示氢或式 (一个); R 1,R 2,R 3,R 4,R 5和R 6各自独立地表示氢,任选取代的烷基,任选取代的芳基,杂环基或任选取代的芳烷基 基团,其中上述基团的取代基选自烷基,芳基,杂环基,羟基,烷氧基或基团NR s中的至多三个,其中R和R独立地表示氢, 烷基或烷基羰基,R 7表示氢,烷基,芳基或芳烷基; 或T表示部分(a),其中R 1与R 2一起代表任选取代的包含2至6个碳原子的亚烷基链,所述亚烷基链任选地被氧原子或基团NR中断,其中R p是氢或烷基,并且其中亚烷基链的任何碳原子的任选取代基选自羟基,烷氧基,氧代或基团,其中R和R各自独立地选自 独立地表示氢,烷基或烷基羰基或链上任何两个相邻碳原子上的取代基以及它们所连接的碳原子一起形成脂环族,芳基或杂环; R 3,R 4,R 5,R 6和R 7如上所定义。
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公开(公告)号:US20250161863A1
公开(公告)日:2025-05-22
申请号:US18832789
申请日:2023-01-26
Applicant: THE UNIVERSITY OF SHEFFIELD
Inventor: Peter HANDFORD-STYRING , George Richard Michael DOWSON
IPC: B01D53/053
Abstract: A method for refining carbon dioxide from an input mixed gas stream comprising carbon dioxide, the method comprising; introducing a compressed first portion of the input mixed gas stream into a first adsorption vessel containing carbon dioxide sorbent material to provide a first compressed gas mixture within the first adsorption vessel; venting, from the first adsorption vessel, a carbon dioxide depleted fraction of the first compressed gas mixture; venting, from the first adsorption vessel, an intermediate fraction of the first compressed gas mixture; venting, from the first adsorption vessel, a carbon dioxide enriched fraction of the first compressed gas mixture, wherein the intermediate fraction of the first compressed gas mixture has a concentration of carbon dioxide higher than that of the input gas mixture but lower than that of the enriched fraction of the first compressed gas mixture; collecting the carbon dioxide enriched fraction of the first compressed gas mixture; introducing the intermediate fraction of the first compressed gas mixture and a compressed second portion of the input mixed gas stream into a second adsorption vessel containing carbon dioxide sorbent material to provide a second compressed gas mixture within the second adsorption vessel; venting, from the second adsorption vessel, a carbon dioxide depleted fraction of the second compressed gas mixture; venting, from the second adsorption vessel, a carbon dioxide enriched fraction of the second compressed gas mixture; and collecting the carbon dioxide enriched fraction of the second compressed gas mixture.
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公开(公告)号:US20240288520A1
公开(公告)日:2024-08-29
申请号:US18573551
申请日:2023-06-23
Applicant: THE UNIVERSITY OF SHEFFIELD
Inventor: James M Wild , Madhwesha Rama Rao
CPC classification number: G01R33/3621 , G01R33/3635 , G01R33/62
Abstract: A passive filter circuit, for simultaneous dual-nuclear magnetic resonance quadrature transmit-receive that is configured to apply to an input a quadrature phase shift of a first polarity at a Larmor frequency of a first nucleus and a quadrature phase difference of a second polarity, that is opposite the first polarity, at the Larmor frequency of a second nucleus
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公开(公告)号:US20240207884A1
公开(公告)日:2024-06-27
申请号:US18514787
申请日:2023-11-20
Applicant: THE UNIVERSITY OF SHEFFIELD
Inventor: Chris SCRAGGS , George SLEATH
CPC classification number: B05C5/0254 , B05D1/26 , B05D1/40
Abstract: An applicator for the deposition of sealant onto a surface of a workpiece is disclosed having at least one inlet for depositing sealant on to a surface or a nozzle-receiving space for receiving a nozzle comprising at least one inlet for depositing sealant on to a surface; at least one sealant-contacting surface for contacting sealant deposited onto the surface through the inlet as the applicator is moved across the surface, thereby forming a film of sealant on said surface; at least one spacer for contacting a surface onto which sealant is to be deposited and for maintaining the sealant-contacting surface in spaced relationship with the surface; and at least one inlet reservoir for receiving sealant from at least one inlet, the inlet reservoir being configured to provide a covered space when the applicator is in contact with a surface onto which sealant is to be deposited.
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公开(公告)号:US20230157625A1
公开(公告)日:2023-05-25
申请号:US17532715
申请日:2021-11-22
Applicant: DC Medical Inc. , THE UNIVERSITY OF SHEFFIELD , Sheffield Teaching Hospitals NHS Foundation Trust
Inventor: Gordon SCARTH , Jack MONDRY , Byunggaun PARK , Hyunseon GONG , Timothy James HEALEY , Dilichukwu ANUMBA
CPC classification number: A61B5/4343 , A61B5/01 , A61B5/25 , A61B5/053 , A61B5/742 , A61B5/6823 , A61B5/7221 , A61B5/7246 , A61B5/7275 , A61B5/7475 , A61B5/14539 , A61B2560/0223
Abstract: A system for providing information for diagnosing preterm birth risk includes: two or more transmit electrodes, contacting cervical tissues, for applying a plurality of first signals at different frequencies to the cervical tissues, two or more detect electrodes, contacting the cervical tissues, for detecting a plurality of second signals generated in response to the first signals, the second signals corresponding to the first signals, and a source configured to generate a plurality of signals. The system obtains a plurality of impedances of the cervical tissues based on the first and the second signals and applies data quality requirements for diagnosing the preterm birth risk. The data quality requirements include checking at least one of signal generation, signal reception, impedance calculation, quality of the first signals, quality of the second signals, and the impedances. The system includes a diagnosis engine configured to receive data including impedances that satisfy the data quality requirements, classify the data into different groups, each representing different status, based on correlation between the data, patient’s information and the preterm birth risk, and output information for diagnosing the preterm birth risk.
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公开(公告)号:US11612626B2
公开(公告)日:2023-03-28
申请号:US16790459
申请日:2020-02-13
Applicant: Virttu Biologies Limited , The University of Sheffield
Inventor: Joe Conner , Munitta Muthana , Claire Elizabeth Lewis
IPC: A01N63/00 , A61K35/763 , A61K41/00 , C12N5/0786 , A61K35/15 , A61K9/19 , A61M37/00 , A61K9/00 , A61K47/69 , A61K33/26 , A61K9/50 , C12N7/00
Abstract: A monocyte, monocyte derived cell or macrophage infected with an oncolytic herpes simplex virus is disclosed together with uses of such infected cells in the treatment of diseases such as cancer.
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公开(公告)号:US20230028019A1
公开(公告)日:2023-01-26
申请号:US17756480
申请日:2020-11-25
Applicant: THE UNIVERSITY OF SHEFFIELD
Inventor: Bazbek DAVLETOV , Charlotte Michelle LEESE
IPC: C07K14/33 , C07K14/705 , C12N9/52
Abstract: The present invention provides novel neurotoxins and compositions comprising the same. The neurotoxins are useful in therapy, particularly for preventing, regulating or reducing neuropathic pain or sweating. Methods and kits for producing the neurotoxins are also provided.
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公开(公告)号:US20230001146A1
公开(公告)日:2023-01-05
申请号:US17779872
申请日:2020-11-24
Applicant: THE UNIVERSITY OF SHEFFIELD
Inventor: Julian Philip George GUNN , Paul David Morris
Abstract: A guiding device for a vascular catheter that is inserted over a guidewire. The guiding device comprising a tapered component for passing through a bore of the vascular catheter and extending from a distal end thereof. The tapered component has an aperture through which the guidewire may pass so that the tapered component (12) may move along the guidewire. A pushing means extends from the tapered component and is configured to extend beyond a proximal end of the vascular catheter. The tapered component comprises a first section, a second section and the third section. The first section is disposed between the proximal end of the tapered component and the second section, the second section is disposed between the first section and the third section, and the third section is disposed between the second section and a distal end of the tapered component. The first section is a cylinder and the second and the third sections are conical. The taper of the second section differs from the taper of the third section.
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