公开(公告)号：US09724509B2

公开(公告)日：2017-08-08

申请号：US13701654

申请日：2011-06-06

Applicant: Xin Su ,  Dwight E. Nelson

Inventor： Xin Su ,  Dwight E. Nelson

IPC: A61N1/36 ,  A61B5/0488 ,  A61B5/20 ,  A61B5/00 ,  A61B5/04 ,  A61B5/11 ,  A61N1/05

CPC classification number: A61N1/36007 ,  A61B5/0031 ,  A61B5/04001 ,  A61B5/04882 ,  A61B5/1116 ,  A61B5/205 ,  A61B5/4047 ,  A61B5/4836 ,  A61N1/0514

Abstract: In some examples, electrical stimulation is delivered to a patient such that selective termination of the stimulation causes a therapeutic effect in the patient after termination of the electrical stimulation to the patient. The electrical stimulation may be insufficient to produce a desired therapeutic effect in the patient during stimulation, but sufficient to induce a post-stimulation desired therapeutic effect following termination of the stimulation. In some examples, the electrical stimulation may be sub-threshold electrical stimulation. In some examples, the desired therapeutic effect may alleviate bladder dysfunction, bowel dysfunction, or other disorders. The stimulation may be selectively terminated in response to one or more therapy trigger events to induce the post-stimulation therapeutic effect.

公开(公告)号：US09289607B2

公开(公告)日：2016-03-22

申请号：US13817486

申请日：2011-08-16

Applicant: Xin Su ,  Gregory F. Molnar ,  Dwight E. Nelson

Inventor： Xin Su ,  Gregory F. Molnar ,  Dwight E. Nelson

IPC: A61N1/02 ,  A61N1/36 ,  A61M5/142 ,  A61M5/172 ,  G06F19/00 ,  A61K31/165

CPC classification number: A61N1/36007 ,  A61K31/165 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2205/054 ,  A61M2210/1085 ,  A61N1/36057 ,  A61N1/3606 ,  A61N1/36071 ,  A61N1/36171 ,  G06F19/00 ,  G06F19/3468 ,  G06F19/3481

Abstract: Systems (10), devices (16), and methods may be used for treating bladder dysfunction, such as urgency and pelvic pain. In one example, a method includes administering a pharmacological agent to a patient (14) in a dosage sufficient to desensitize a C-afferent nerve fiber of the patient. Additionally, the method includes delivering stimulation to activate a nerve fiber proximate to the C-afferent nerve fiber via an electrode (19A, 19B, 21A, 21B, 29A-29D) electrically coupled to an implantable medical device (16). In some examples, the nerve fiber may be different than the C-afferent nerve fiber, the stimulation of the nerve fiber may elicit an inhibitory physiological response related to voiding in the patient, and/or the stimulation substantially may not activate the C-afferent nerve fiber after desensitization of the nerve fiber via the administration of the pharmacological agent.

Abstract translation: 系统（10），装置（16）和方法可用于治疗膀胱功能障碍，如紧急和盆腔疼痛。 在一个实例中，一种方法包括以足以使患者的C型传入神经纤维脱敏的剂量向患者（14）施用药理学试剂。 另外，该方法包括递送刺激以通过电耦合到可植入医疗装置（16）的电极（19A，19B，21A，21B，29A-29D）激活靠近C型传入神经纤维的神经纤维。 在一些实例中，神经纤维可能与C传入神经纤维不同，神经纤维的刺激可能引起与患者排尿有关的抑制性生理反应，和/或刺激基本上不能激活C传入 神经纤维通过施用药理学神经纤维脱敏后。

公开(公告)号：US20140029463A1

公开(公告)日：2014-01-30

申请号：US14002113

申请日：2011-11-08

Applicant: Xin Su ,  Qiubin Gao ,  Rakesh Tamrakar ,  Zukang Shen ,  Shaohui Sun

Inventor： Xin Su ,  Qiubin Gao ,  Rakesh Tamrakar ,  Zukang Shen ,  Shaohui Sun

IPC: H04W24/10

CPC classification number: H04W24/10 ,  H04B7/0671 ,  H04B7/0689 ,  H04B7/0697 ,  H04L1/0003 ,  H04L1/0009 ,  H04L1/0026 ,  H04L1/003 ,  H04L1/06 ,  H04L5/0023 ,  H04L5/0048 ,  H04L5/0094

Abstract: Disclosed are a method for reporting channel quality information and a device thereof, the method comprising: according to configuration information of a CSI-RS, a user equipment measuring the CSI-RS to acquire a downlink channel transmission matrix; according to a PDSCH transmission scheme used as a basis when determining a Channel Quality Indicator (CQI), and according to the measured downlink channel transmission matrix, the user equipment determining the CQI of a frequency domain reporting unit; and the user equipment reporting the determined CQI to a network side. Through the present invention, the measurement and reporting of the channel quality information based on the CSI-RS is implemented based on transmission of non-PMI feedback.

Abstract translation: 公开了一种用于报告信道质量信息的方法及其装置，所述方法包括：根据CSI-RS的配置信息，测量CSI-RS的用户设备以获取下行链路信道传输矩阵; 根据在确定信道质量指示符（CQI）时作为基础的PDSCH传输方式，根据所测量的下行链路信道传输矩阵，确定频域报告单元的CQI的用户设备; 以及将所确定的CQI报告给网络侧的用户设备。 通过本发明，基于CSI-RS的信道质量信息的测量和报告是基于非PMI反馈的传输来实现的。

公开(公告)号：US20140016496A1

公开(公告)日：2014-01-16

申请号：US14002106

申请日：2011-10-13

Applicant: Xin Su ,  Qiubin Gao ,  Rakesh Tamrakar ,  Zukang Shen ,  Shaohui Sun

Inventor： Xin Su ,  Qiubin Gao ,  Rakesh Tamrakar ,  Zukang Shen ,  Shaohui Sun

IPC: H04W24/10

CPC classification number: H04W24/10 ,  H04B7/0626 ,  H04B7/0632 ,  H04L1/0026 ,  H04L1/20

Abstract: A method and a device for reporting channel quality information are provided by the present invention, the method comprising that: measuring, by a user equipment (UE), Channel State Information-Reference Signal (CSI-RS) according to the configuration information of the CSI-RS, to acquire a downlink channel transport matrix (101); determining, by the UE, Channel Quality Indicator (CQI) of a frequency domain reporting unit according to the number of CSI-RS ports and the corresponding transmission scheme of the Physical Downlink Shared Channel (PDSCH) used when determining the CQI, and the downlink channel transport matrix acquired by measurement (102); reporting, by the UE, the determined CQI to network side (103). The present invention can realize measurement and reporting of CSI-RS-based channel quality information on the basis of non-Precoding Matrix Indicator (PMI) feedback transmissions.

Abstract translation: 本发明提供一种用于报告信道质量信息的方法和装置，所述方法包括：通过用户设备（UE）根据所述信道质量信息的配置信息测量信道状态信息参考信号（CSI-RS） CSI-RS，以获取下行链路信道传输矩阵（101）; 由UE根据CSI-RS端口的数量和在确定CQI时使用的物理下行链路共享信道（PDSCH）的相应传输方案，确定频域报告单元的信道质量指示符（CQI），以及下行链路 通过测量（102）获取的信道传输矩阵; 由所述UE向所述网络侧报告所确定的CQI。 本发明可以基于非预编码矩阵指示（PMI）反馈传输来实现基于CSI-RS的信道质量信息的测量和报告。

公开(公告)号：US20130072998A1

公开(公告)日：2013-03-21

申请号：US13701603

申请日：2011-06-06

Applicant: Xin Su ,  Dwight E. Nelson

Inventor： Xin Su ,  Dwight E. Nelson

IPC: A61N1/36

CPC classification number: A61N1/36007 ,  A61B5/0031 ,  A61B5/04001 ,  A61B5/04882 ,  A61B5/1116 ,  A61B5/205 ,  A61B5/4047 ,  A61B5/4836 ,  A61N1/0514

Abstract: A medical system may include a control module and a therapy delivery module configured to generate and deliver electrical stimulation therapy to a patient. The control module may be configured to control the therapy delivery module to deliver electrical stimulation at a first stimulation intensity for a first time period, to deliver electrical stimulation at a second stimulation intensity for a second time period immediately following the first time period, and to deliver electrical stimulation at the first stimulation intensity for a third time period immediately following the second time period. The second stimulation intensity may be less than the first stimulation intensity. The electrical stimulation may elicit a first inhibitory physiological response during the first time period and a second inhibitory physiological response during the second time period. The second inhibitory physiological response may be greater than the first inhibitory physiological response.

Abstract translation: 医疗系统可以包括控制模块和治疗递送模块，其被配置为产生并向患者递送电刺激治疗。 控制模块可以被配置为控制治疗递送模块在第一时间段内以第一刺激强度递送电刺激，以在第一时间段之后的第二时间段中以第二刺激强度递送电刺激，以及 在第二时间段之后的第三时间段内以第一刺激强度递送电刺激。 第二刺激强度可能小于第一刺激强度。 电刺激可以在第一时间段期间引起第一抑制性生理反应，并在第二时间段期间引起第二抑制性生理反应。 第二抑制生理反应可能大于第一抑制生理反应。

公开(公告)号：US20120197337A1

公开(公告)日：2012-08-02

申请号：US13358100

申请日：2012-01-25

Applicant: Xin Su ,  Dwight E. Nelson

Inventor： Xin Su ,  Dwight E. Nelson

IPC: A61N1/36

CPC classification number: A61N1/36178 ,  A61N1/36007 ,  A61N1/36107 ,  A61N1/36135

Abstract: A medical device is configured to deliver a first stimulation therapy to a patient, and, upon detecting a trigger event, deliver a second stimulation therapy to the patient. In some examples, the first stimulation therapy includes bilateral stimulation in which stimulation is delivered at different times to two lateral sides of the patient and the second stimulation therapy includes substantially simultaneous bilateral stimulation therapy to two lateral sides of the patient. In some examples, the second stimulation therapy may elicit a stronger inhibitory physiological response related to incontinence (e.g., inhibition of bladder contractions) than the first stimulation therapy. The trigger event may include, for example, any one or more of detection of a physiological condition indicative of an increased possibility of an involuntary voiding event or an imminent involuntary voiding event, input from the patient, a predetermined time of day, or expiration of a timer.

Abstract translation: 医疗装置被配置为向患者递送第一刺激疗法，并且在检测到触发事件时向患者传送第二刺激疗法。 在一些实例中，第一刺激疗法包括双侧刺激，其中在不同时间将刺激递送到患者的两个侧面，并且第二刺激疗法包括对患者的两个侧面的基本上同时的双侧刺激治疗。 在一些实例中，与第一刺激疗法相比，第二刺激疗法可引起与失禁相关的更强抑制性生理反应（例如，抑制膀胱收缩）。 触发事件可以包括例如以下任何一种或多种：检测指示增加的非自愿排尿事件的可能性或迫在眉睫的非自愿排泄事件，从患者输入，一天的预定时间或期满 一个计时器

公开(公告)号：US20120197336A1

公开(公告)日：2012-08-02

申请号：US13358038

申请日：2012-01-25

Applicant: Xin Su

Inventor： Xin Su

IPC: A61N1/36

CPC classification number: A61N1/36007 ,  A61N1/36107 ,  A61N1/36171 ,  A61N1/36178

Abstract: In general, the disclosure is directed to devices, systems, and techniques for delivering electrical stimulation to a patient with varying pulse frequencies within each burst of pulses. The pulse frequency variation within each burst of pulses may be between approximately 20 Hz and 40 Hz. In some examples, the pulse frequency may be increased, decreased, or polynomially varied within each burst. In other examples, the frequency of intrinsic nerve impulses may be detected and used to deliver pulses with the detected frequency or an inverse of the detected frequency. Electrical stimulation therapy with intra-burst pulse frequency variation may alleviate bladder dysfunction, bowel dysfunction, pain or other disorders.

Abstract translation: 通常，本公开涉及用于在每个脉冲脉冲串内向具有变化的脉冲频率的患者递送电刺激的装置，系统和技术。 每个脉冲脉冲之间的脉冲频率变化可以在大约20Hz和40Hz之间。 在一些示例中，脉冲频率可以在每个脉冲串内增加，减少或多项式变化。 在其他示例中，内在神经冲动的频率可以被检测并用于传送具有检测到的频率或检测到的频率的逆的脉冲。 突发脉冲频率变化的电刺激治疗可缓解膀胱功能障碍，肠功能障碍，疼痛或其他疾病。

公开(公告)号：US09168374B2

公开(公告)日：2015-10-27

申请号：US13358038

申请日：2012-01-25

Applicant: Xin Su

Inventor： Xin Su

IPC: A61N1/18 ,  A61N1/36

CPC classification number: A61N1/36007 ,  A61N1/36107 ,  A61N1/36171 ,  A61N1/36178

Abstract: In general, the disclosure is directed to devices, systems, and techniques for delivering electrical stimulation to a patient with varying pulse frequencies within each burst of pulses. The pulse frequency variation within each burst of pulses may be between approximately 20 Hz and 40 Hz. In some examples, the pulse frequency may be increased, decreased, or polynomially varied within each burst. In other examples, the frequency of intrinsic nerve impulses may be detected and used to deliver pulses with the detected frequency or an inverse of the detected frequency. Electrical stimulation therapy with intra-burst pulse frequency variation may alleviate bladder dysfunction, bowel dysfunction, pain or other disorders.

Abstract translation: 通常，本公开涉及用于在每个脉冲脉冲串内向具有变化的脉冲频率的患者递送电刺激的装置，系统和技术。 每个脉冲脉冲之间的脉冲频率变化可以在大约20Hz和40Hz之间。 在一些示例中，脉冲频率可以在每个脉冲串内增加，减少或多项式变化。 在其他示例中，内在神经冲动的频率可以被检测并用于传送具有检测到的频率或检测到的频率的逆的脉冲。 突发脉冲频率变化的电刺激治疗可缓解膀胱功能障碍，肠功能障碍，疼痛或其他疾病。

公开(公告)号：US08989861B2

公开(公告)日：2015-03-24

申请号：US13701603

申请日：2011-06-06

Applicant: Xin Su ,  Dwight E. Nelson

Inventor： Xin Su ,  Dwight E. Nelson

IPC: A61N1/36 ,  A61B5/0488 ,  A61B5/20 ,  A61B5/00 ,  A61B5/04 ,  A61B5/11 ,  A61N1/05

CPC classification number: A61N1/36007 ,  A61B5/0031 ,  A61B5/04001 ,  A61B5/04882 ,  A61B5/1116 ,  A61B5/205 ,  A61B5/4047 ,  A61B5/4836 ,  A61N1/0514

Abstract: A medical system may include a control module and a therapy delivery module configured to generate and deliver electrical stimulation therapy to a patient. The control module may be configured to control the therapy delivery module to deliver electrical stimulation at a first stimulation intensity for a first time period, to deliver electrical stimulation at a second stimulation intensity for a second time period immediately following the first time period, and to deliver electrical stimulation at the first stimulation intensity for a third time period immediately following the second time period. The second stimulation intensity may be less than the first stimulation intensity. The electrical stimulation may elicit a first inhibitory physiological response during the first time period and a second inhibitory physiological response during the second time period. The second inhibitory physiological response may be greater than the first inhibitory physiological response.

Abstract translation: 医疗系统可以包括控制模块和治疗递送模块，其被配置为产生并向患者递送电刺激治疗。 控制模块可以被配置为控制治疗递送模块以第一时间段的第一刺激强度递送电刺激，以在第一时间段之后的第二时间段中以第二刺激强度递送电刺激，以及 在第二时间段之后的第三时间段内以第一刺激强度递送电刺激。 第二刺激强度可能小于第一刺激强度。 电刺激可以在第一时间段期间引起第一抑制性生理反应，并在第二时间段期间引起第二抑制性生理反应。 第二抑制生理反应可能大于第一抑制生理反应。

公开(公告)号：US08846391B2

公开(公告)日：2014-09-30

申请号：US12822104

申请日：2010-06-23

Applicant: Xin Su ,  Lilly Kong ,  Wayne Hogrefe

Inventor： Xin Su ,  Lilly Kong ,  Wayne Hogrefe

IPC: C12Q1/70 ,  C07K14/005 ,  G01N33/569

CPC classification number: C07K14/005 ,  C12N2710/16622 ,  G01N33/56994

Abstract: The invention provides methods for sensitive and specific detection of anti-HSV-2 antibodies by depletion of cross-reactive (non-specific) antibodies in a biological sample that can lead to a false positive result. The invention also features compositions, including nucleic acids, polypeptides, and kits, for use in the methods of the invention.

Abstract translation: 本发明提供了通过消耗生物样品中可能导致假阳性结果的交叉反应性（非特异性）抗体来敏感和特异性检测抗HSV-2抗体的方法。 本发明还包括用于本发明方法的组合物，包括核酸，多肽和试剂盒。