公开(公告)号：US09804141B2

公开(公告)日：2017-10-31

申请号：US14280175

申请日：2014-05-16

Applicant: 1ST DETECT CORPORATION

Inventor： Guido Fridolin Verbeck, IV ,  David Rafferty ,  James Wylde ,  Michael Spencer

IPC: G01N33/22 ,  G01N1/44 ,  G01N1/28 ,  G01N33/00 ,  G01N1/40 ,  G01N1/02 ,  G01N1/38

CPC classification number: G01N33/227 ,  G01N1/28 ,  G01N1/4022 ,  G01N1/4044 ,  G01N1/44 ,  G01N33/0057 ,  G01N2001/022 ,  G01N2001/383 ,  Y10T436/147777 ,  Y10T436/173076 ,  Y10T436/173845 ,  Y10T436/25375

Abstract: Methods, devices, and systems are disclosed for releasing a sample from a carrier medium. A method of releasing a sample from a carrier medium comprises treating a sample on a carrier medium with a first organic reagent, wherein when the sample contains at least one inorganic salt, the first organic reagent binds to a cation of the inorganic salt to produce both a first volatile compound and an isolated anion of the inorganic salt; treating the sample on the carrier medium with a second organic reagent, wherein the second organic reagent reacts with the isolated anion to produce a second volatile compound; and releasing the treated sample from the carrier medium, wherein when the first and the second volatile compounds are produced, the releasing step releases at least one of the first and second volatile compounds from the carrier medium.

公开(公告)号：US09214321B2

公开(公告)日：2015-12-15

申请号：US13794530

申请日：2013-03-11

Applicant: 1st Detect Corporation

Inventor： David Rafferty

IPC: H01J49/42 ,  H01J49/04 ,  H01J49/00

CPC classification number: H01J49/0031 ,  H01J49/424 ,  H01J49/4295

Abstract: A mass spectrometer for analyzing a sample utilizing an ion trap comprises an entrance end cap defining an entrance aperture configured to receive the sample entering the ion trap; a ring electrode defining a ring cavity configured to generate, based on a radio frequency (RF) voltage applied to the ring electrode, an electric field configured to trap the sample received through the entrance aperture; an exit end cap defining an exit aperture configured to receive sample ions exiting the ion trap; and an end cap controller configured to generate a bias control voltage for applying a DC bias potential to at least one of the entrance end or the exit end cap, wherein a value of the bias control voltage is based on an operational parameter of the mass spectrometer.

Abstract translation: 用于使用离子阱来分析样品的质谱仪包括入口端盖，其限定入口孔，所述入口孔配置成接收进入离子阱的样品; 限定环形腔的环形电极，其被配置为基于施加到所述环形电极的射频（RF）电压产生被配置为捕获通过所述入口孔接收的样品的电场; 出口端盖，其限定出口孔，其配置成接收离开离子阱的离子样品离子; 以及端帽控制器，其被配置为产生用于将DC偏置电位施加到所述入口端或出口端帽中的至少一个的偏置控制电压，其中所述偏置控制电压的值基于所述质谱仪的操作参数 。

公开(公告)号：US20150228468A1

公开(公告)日：2015-08-13

申请号：US14600851

申请日：2015-01-20

Applicant: 1st Detect Corporation

Inventor： James Wylde ,  David Rafferty ,  Michael Spencer

IPC: H01J49/06 ,  H01J49/26

CPC classification number: H01J49/067 ,  H01J49/06 ,  H01J49/26 ,  H01J49/4265

Abstract: Systems and methods for automatic gain control in mass spectrometers are disclosed. An exemplary system may include a mass spectrometer, comprising a lens configured to receive a supply of ions, and a mass analyzer. The mass analyzer may include an ion trap for trapping the supplied ions. The mass analyzer may also include an ion detector for detecting ions that exit the ion trap. The lens may focus the ions non-uniformly based on mass of the ions to compensate for space charge effects reflected in a measurement output of the mass spectrometer.

Abstract translation: 公开了用于质谱仪中自动增益控制的系统和方法。 示例性系统可以包括质谱仪，其包括被配置为接收离子供应的透镜和质量分析器。 质量分析器可以包括用于捕获所提供的离子的离子阱。 质量分析器还可以包括用于检测离子离子的离子的离子检测器。 透镜可以基于离子质量不均匀地聚焦离子，以补偿在质谱仪的测量输出中反映的空间电荷效应。

公开(公告)号：US09082599B2

公开(公告)日：2015-07-14

申请号：US14082555

申请日：2013-11-18

Applicant: 1st DETECT CORPORATION

Inventor： David Rafferty ,  Michael Spencer

IPC: H01J3/00 ,  H01J49/42 ,  H01J49/02

CPC classification number: H01J49/02 ,  H01J49/424 ,  H01J49/4255

Abstract: An ion trap for a mass spectrometer is disclosed. The ion trap includes a ring electrode and first and second electrodes which are arranged on opposite sides of the ring electrode. The ring electrode and the first and second electrodes are configured to generate an electric field based on the received RF signal. The first electrode defines a first aperture and the second electrode defines a second aperture, the first aperture and the second aperture being asymmetric relative to each other and configured to generate a hexapole field.

Abstract translation: 公开了用于质谱仪的离子阱。 离子阱包括环形电极和布置在环形电极的相对侧上的第一和第二电极。 环形电极和第一和第二电极被配置为基于所接收的RF信号产生电场。 第一电极限定第一孔，并且第二电极限定第二孔，第一孔和第二孔相对于彼此是不对称的并且被配置成产生六极场。

公开(公告)号：US08975573B2

公开(公告)日：2015-03-10

申请号：US13794779

申请日：2013-03-11

Applicant: 1st Detect Corporation

Inventor： David Rafferty ,  James Wylde ,  Michael Spencer ,  Warren Mino

IPC: H01J49/00

CPC classification number: H01J49/0009

Abstract: Systems and methods are disclosed for calibrating mass spectrometers. In accordance with one implementation, a system comprises a calibrant chamber within a housing of a mass spectrometer. The system also comprises a permeation tube enclosed within the calibrant chamber, wherein the tube contains a calibrant chemical that continuously outgasses the calibrant chemical. The outgassed calibrant chemical may be introduced to the mass spectrometer for analysis. The system may also comprise a heating block to control the temperature of the calibrant chemical. The system may further comprise a valve that introduces a known amount of the calibrant chemical into the calibrant chamber. In accordance with the present disclosure, systems and methods are provided for calibrating a mass spectrometer abundance scale.

Abstract translation: 公开了用于校准质谱仪的系统和方法。 根据一个实施方案，系统包括在质谱仪的壳体内的校准室。 该系统还包括封闭在校准物室内的渗透管，其中管含有连续排出校准物质的校准物质。 可以将去气的校准物质引入质谱仪进行分析。 该系统还可以包括加热块以控制校准物质的温度。 该系统还可以包括将已知量的校准物质引入校准物室的阀。 根据本公开，提供了用于校准质谱仪丰度标度的系统和方法。