公开(公告)号：US09353091B2

公开(公告)日：2016-05-31

申请号：US14260504

申请日：2014-04-24

Applicant: AbbVie Inc.

Inventor： David A. Betebenner ,  John K. Pratt ,  David A. DeGoey ,  Pamela L. Donner ,  Charles A. Flentge ,  Douglas K. Hutchinson ,  Warren M. Kati ,  Allan C. Krueger ,  Kenton L. Longenecker ,  Clarence J. Maring ,  John T. Randolph ,  Todd W. Rockway ,  Michael D. Tufano ,  Rolf Wagner ,  Dachun Liu

IPC: A61K31/503 ,  C07D409/10 ,  C07C311/08 ,  C07D207/27 ,  C07D213/64 ,  C07D233/32 ,  C07D233/72 ,  C07D239/10 ,  C07D239/54 ,  C07D263/22 ,  C07D275/02 ,  C07D403/10 ,  C07D405/10 ,  A61K31/18 ,  A61K31/27 ,  A61K31/4166 ,  A61K31/421 ,  A61K31/4418 ,  A61K31/513 ,  A61K45/06 ,  C07D263/24

CPC classification number: C07D409/10 ,  A61K31/18 ,  A61K31/27 ,  A61K31/402 ,  A61K31/4166 ,  A61K31/421 ,  A61K31/425 ,  A61K31/4418 ,  A61K31/503 ,  A61K31/513 ,  A61K45/06 ,  C07C311/08 ,  C07D207/27 ,  C07D213/64 ,  C07D233/32 ,  C07D233/72 ,  C07D239/10 ,  C07D239/54 ,  C07D263/22 ,  C07D263/24 ,  C07D275/02 ,  C07D403/10 ,  C07D405/10 ,  Y02P20/55

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

Abstract translation: 本发明涉及：（a）特别是抑制HCV的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。

公开(公告)号：US20150225397A1

公开(公告)日：2015-08-13

申请号：US14604129

申请日：2015-01-23

Applicant: AbbVie Inc. ,  Reata Pharmaceuticals, Inc.

Inventor： Pamela Donner ,  Rolf Wagner ,  Jason Shanley ,  Howard Heyman ,  Allan Krueger ,  Hui-Ju Chen ,  Michael Rozema ,  David Grampovnik ,  Melean Visnick ,  Eric Anderson ,  Xin Jiang ,  Christopher F. Bender ,  Gary Louis Bolton ,  Bradley William Caprathe ,  Chitase Lee ,  William Howard Roark

IPC: C07D471/04 ,  C07D231/54 ,  C07D413/04 ,  C07D403/04 ,  C07D417/04 ,  C07D239/70 ,  C07D401/04

CPC classification number: C07D471/04 ,  C07D231/54 ,  C07D239/70 ,  C07D239/72 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04

Abstract: The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein R1, R2, R3, R4, R5, R6, m, n, X and Y are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use for the treatment and prevention of diseases such as those associated with oxidative stress and inflammation.

Abstract translation: 本申请涉及：（a）式（I）化合物及其盐，其中R 1，R 2，R 3，R 4，R 5，R 6，m，n，X和Y如说明书中所定义; （b）包含这些化合物和盐的组合物; 和（c）使用这些化合物，盐和组合物的方法，特别用于治疗和预防与氧化应激和炎症有关的疾病。

公开(公告)号：US20140073700A1

公开(公告)日：2014-03-13

申请号：US14023143

申请日：2013-09-10

Applicant: AbbVie Inc.

Inventor： Rolf Wagner ,  Hui-Ju Chen ,  Jason Shanley ,  Andrew Bogdan ,  Jasmina Marjanovic ,  Xiu Wang ,  Diana Donnelly-Roberts

IPC: C07C261/00

CPC classification number: C07C261/00 ,  C07J63/008

Abstract: The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein Y and Z are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use for the treatment and prevention of diseases such as those associated with oxidative stress and inflammation.

Abstract translation: 本申请涉及：（a）式（I）的化合物及其盐，其中Y和Z如说明书中所定义; （b）包含这些化合物和盐的组合物; 和（c）使用这些化合物，盐和组合物的方法，特别用于治疗和预防与氧化应激和炎症有关的疾病。

公开(公告)号：US20230285378A1

公开(公告)日：2023-09-14

申请号：US17941090

申请日：2022-09-09

Applicant: AbbVie Inc.

Inventor： Mary E. Bellizzi ,  David A. Betebenner ,  Jean-Christophe C. Califano ,  William A. Carroll ,  Daniel D. Caspi ,  David A. DeGoey ,  Pamela L. Donner ,  Charles A. Flentge ,  Yi Gao ,  Charles W. Hutchins ,  Douglas K. Hutchinson ,  Warren M. Kati ,  Tammie K. Jinkerson ,  Ryan G. Keddy ,  Allan C. Krueger ,  Wenke Li ,  Dachun Liu ,  Clarence J. Maring ,  Mark A. Matulenko ,  Christopher E. Motter ,  Lissa T. Nelson ,  Sachin V. Patel ,  John K. Pratt ,  John T. Randolph ,  Todd W. Rockway ,  Kathy Sarris ,  Michael D. Tufano ,  Seble H. Wagaw ,  Rolf Wagner ,  Kevin R. Woller

IPC: A61K31/454 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/00 ,  C07D491/113 ,  C07D403/14 ,  C07F7/02 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/4355 ,  A61K31/438 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/695 ,  A61K45/06 ,  A61K31/435

CPC classification number: A61K31/454 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/00 ,  C07D491/113 ,  C07D403/14 ,  C07F7/02 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/4355 ,  A61K31/438 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/695 ,  A61K45/06 ,  A61K31/435 ,  Y02P20/582

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：US20180022763A1

公开(公告)日：2018-01-25

申请号：US15588037

申请日：2017-05-05

Applicant: AbbVie Inc.

Inventor： Jaclyn Chau ,  Hui-Ju J. Chen ,  David A. DeGoey ,  John Hartung ,  Nathan Ide ,  Vikram Kalthod ,  Allan C. Krueger ,  Yi-Yin Ku ,  Tongmei Li ,  John T. Randolph ,  Rolf Wagner ,  Geoff T. Halvorsen ,  Christopher C. Marvin ,  Eric Voight ,  Brian S. Brown ,  Steven R. Martinez ,  Anurupa Shrestha ,  Howard R. Heyman

IPC: C07F9/08 ,  C07F9/6512 ,  C07H19/10

CPC classification number: C07F9/08 ,  C07F9/6512 ,  C07H19/10

Abstract: The present invention features compounds effective in inhibiting active against Hepatitis C virus (“HCV”) polymerase. The invention also features processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：US09676797B2

公开(公告)日：2017-06-13

申请号：US15254342

申请日：2016-09-01

Applicant: AbbVie Inc.

Inventor： Hui-Ju J. Chen ,  David A. DeGoey ,  John Hartung ,  Nathan Ide ,  Vikram Kalthod ,  Allan C. Krueger ,  Yi-Yin Ku ,  Tongmei Li ,  John T. Randolph ,  Rolf Wagner ,  Jaclyn Chau ,  Geoff T. Halvorsen ,  Christopher C. Marvin ,  Eric Voight

IPC: A61K31/675 ,  C07F9/02 ,  C07F9/08 ,  C07F9/6512

CPC classification number: C07F9/08 ,  C07F9/6512 ,  C07H19/10

Abstract: The present invention features compounds effective in inhibiting active against Hepatitis C virus (“HCV”) polymerase. The invention also features processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：US20170157105A1

公开(公告)日：2017-06-08

申请号：US15434789

申请日：2017-02-16

Applicant: AbbVie Inc.

Inventor： Mary E. Bellizzi ,  David A. Betebenner ,  Jean-Christophe C. Califano ,  William A. Carroll ,  Daniel D. Caspi ,  David A. DeGoey ,  Pamela L. Donner ,  Charles A. Flentge ,  Yi Gao ,  Charles W. Hutchins ,  Douglas K. Hutchinson ,  Tammie K. Jinkerson ,  Warren M. Kati ,  Ryan G. Keddy ,  Allan C. Krueger ,  Wenke Li ,  Dachun Liu ,  Clarence J. Maring ,  Mark A. Matulenko ,  Christopher E. Motter ,  Lissa T. Nelson ,  Sachin V. Patel ,  John K. Pratt ,  John T. Randolph ,  Todd W. Rockway ,  Kathy Sarris ,  Michael D. Tufano ,  Seble H. Wagaw ,  Rolf Wagner ,  Kevin R. Woller

IPC: A61K31/695

CPC classification number: A61K31/454 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/435 ,  A61K31/4355 ,  A61K31/438 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/695 ,  A61K45/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/00 ,  C07D491/113 ,  C07F7/02 ,  Y02P20/582

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：US20160368905A1

公开(公告)日：2016-12-22

申请号：US15141556

申请日：2016-04-28

Applicant: AbbVie Inc.

Inventor： David A. Betebenner ,  John K. Pratt ,  David A. DeGoey ,  Pamela L. Donner ,  Charles A. Flentge ,  Douglas K. Hutchinson ,  Warren M. Kati ,  Allan C. Krueger ,  Kenton L. Longenecker ,  Clarence J. Maring ,  John T. Randolph ,  Todd W. Rockway ,  Michael D. Tufano ,  Rolf Wagner ,  Dachun Liu

IPC: C07D409/10 ,  A61K31/513 ,  C07D213/64 ,  A61K31/4418 ,  C07C311/08 ,  A61K31/18 ,  C07D233/72 ,  A61K31/4166 ,  A61K31/27 ,  C07D263/24 ,  A61K31/421 ,  C07D239/10 ,  C07D207/27 ,  A61K31/402 ,  C07D405/10 ,  C07D403/10 ,  A61K45/06 ,  A61K31/425 ,  C07D275/02 ,  C07D239/54

CPC classification number: C07D409/10 ,  A61K31/18 ,  A61K31/27 ,  A61K31/402 ,  A61K31/4166 ,  A61K31/421 ,  A61K31/425 ,  A61K31/4418 ,  A61K31/503 ,  A61K31/513 ,  A61K45/06 ,  C07C311/08 ,  C07D207/27 ,  C07D213/64 ,  C07D233/32 ,  C07D233/72 ,  C07D239/10 ,  C07D239/54 ,  C07D263/22 ,  C07D263/24 ,  C07D275/02 ,  C07D403/10 ,  C07D405/10 ,  Y02P20/55

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

Abstract translation: 本发明涉及：（a）特别是抑制HCV的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。

公开(公告)号：US09139536B2

公开(公告)日：2015-09-22

申请号：US13838223

申请日：2013-03-15

Applicant: AbbVie Inc.

Inventor： Charles A. Flentge ,  Douglas K. Hutchinson ,  David A. Betebenner ,  David A. DeGoey ,  Pamela L. Donner ,  Warren M. Kati ,  Allan C. Krueger ,  Dachun Liu ,  Yaya Liu ,  Kenton L. Longenecker ,  Clarence J. Maring ,  Christopher E. Motter ,  John K. Pratt ,  John T. Randolph ,  Todd W. Rockway ,  Kent D. Stewart ,  Rolf Wagner ,  Shuang Chen ,  Yi Gao ,  Xiaochun Lou ,  Geoff G. Z. Zhang

IPC: A61K31/505 ,  C07D239/54 ,  C07D239/22 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  A61K31/513 ,  A61K45/06

CPC classification number: C07D239/54 ,  A61K31/513 ,  A61K45/06 ,  C07D239/22 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  A61K2300/00

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

Abstract translation: 本发明涉及：（a）特别是抑制HCV的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。

公开(公告)号：US20150065542A1

公开(公告)日：2015-03-05

申请号：US14534916

申请日：2014-11-06

Applicant: ABBVIE INC.

Inventor： Allan C. Krueger ,  Warren M. Kati ,  Clarence J. Maring ,  Rolf Wagner ,  Charles W. Hutchins

IPC: C07D403/14 ,  C07D409/14

CPC classification number: C07D403/14 ,  C07D409/14

Abstract: The present invention relates to anti-HCV compounds, compositions comprising the same and methods of using the same to treat HCV infection.

Abstract translation: 本发明涉及抗HCV化合物，包含其的组合物以及使用该化合物治疗HCV感染的方法。