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公开(公告)号：US20140187531A1
公开(公告)日：2014-07-03
申请号：US14195666
申请日：2014-03-03
Applicant: AbbVie Inc.
Inventor： Milan Bruncko , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Christopher L. Lynch , William J. McClellan , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Xilu Wang , Noah P. Tu , Michael D. Wendt , Alexander R. Shoemaker , Michael J. Mitten
IPC: C07D295/155 , C07D209/52 , C07D405/12 , C07D211/34 , C07D491/048 , C07D451/02 , C07D233/22 , C07D207/08 , C07D205/04
CPC classification number: C07D295/155 , C07C311/51 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/20 , C07D207/24 , C07D207/50 , C07D209/02 , C07D209/52 , C07D211/14 , C07D211/20 , C07D211/26 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/62 , C07D211/70 , C07D211/72 , C07D213/36 , C07D213/38 , C07D213/42 , C07D213/70 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/12 , C07D231/12 , C07D231/56 , C07D233/06 , C07D233/22 , C07D233/24 , C07D233/61 , C07D233/64 , C07D235/08 , C07D239/06 , C07D239/20 , C07D239/38 , C07D241/04 , C07D249/18 , C07D257/04 , C07D261/20 , C07D263/12 , C07D263/22 , C07D263/58 , C07D265/30 , C07D267/10 , C07D273/01 , C07D277/04 , C07D277/36 , C07D277/74 , C07D295/185 , C07D295/30 , C07D307/14 , C07D307/22 , C07D307/81 , C07D309/14 , C07D309/20 , C07D317/66 , C07D333/20 , C07D333/34 , C07D335/02 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/10 , C07D413/04 , C07D451/02 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/04 , C07D491/048 , C07D491/08 , C07D498/08
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
Abstract translation: 公开了抑制抗凋亡蛋白家族成员的活性的化合物，含有化合物的组合物和该化合物用于制备用于治疗疾病的药物的用途，其中发生表达一种或多种抗凋亡蛋白家族成员。
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22.发明申请公开(公告)号：US20140107119A1
公开(公告)日：2014-04-17
申请号：US14081940
申请日：2013-11-15
Applicant: AbbVie Inc.
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura A. Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
IPC: A61K31/5377 , A61K31/496 , C07D295/155 , A61K45/06 , C07D215/14 , C07D405/12 , C07D209/20 , C07D309/32 , C07D231/56
CPC classification number: C07D215/14 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/20 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/13 , C07D295/14 , C07D295/155 , C07D309/08 , C07D309/14 , C07D309/32 , C07D401/12 , C07D405/12 , C07D417/12 , C07D487/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
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23.发明申请BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES 审中-公开用于治疗癌症和免疫疾病的BCL-2-选择性病毒诱导剂公开(公告)号：US20140057889A1
公开(公告)日：2014-02-27
申请号：US14058159
申请日：2013-10-18
Applicant: AbbVie Inc.
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura A. Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt
IPC: A61K31/5377 , A61K31/496 , C07D413/06 , C07D401/06 , A61K45/06 , A61K31/407 , C07D403/06 , A61K31/501 , C07D241/04 , A61K31/495 , C07D405/06 , C07D487/04
CPC classification number: C07D401/12 , A61K31/407 , A61K31/495 , A61K31/496 , A61K31/501 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D209/32 , C07D211/58 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D241/04 , C07D249/04 , C07D295/125 , C07D295/14 , C07D295/155 , C07D309/04 , C07D309/14 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/12 , C07D471/04 , C07D487/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
Abstract translation: 公开了抑制抗凋亡Bcl-2或Bcl-xL蛋白活性的化合物，含有化合物的组合物和治疗疾病的方法，其中表达有抗凋亡Bcl-2蛋白。
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24.发明申请公开(公告)号：US20250019364A1
公开(公告)日：2025-01-16
申请号：US18883472
申请日：2024-09-12
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
IPC: C07D401/12 , A61K31/496 , C07D209/82 , C07D401/14 , C07D403/12 , C07D471/04 , C07D519/00
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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25.发明授权公开(公告)号：US11897864B2
公开(公告)日：2024-02-13
申请号：US17938835
申请日：2022-10-07
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
IPC: C07D401/12 , C07D401/14 , C07D519/00 , C07D471/04 , C07D209/82 , C07D403/12 , A61K31/496
CPC classification number: C07D401/12 , A61K31/496 , C07D209/82 , C07D401/14 , C07D403/12 , C07D471/04 , C07D519/00 , Y02A50/30
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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Patent Agency Ranking
26.发明公开公开(公告)号：US20230143532A1
公开(公告)日：2023-05-11
申请号：US17938835
申请日：2022-10-07
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
IPC: C07D401/12 , C07D401/14 , C07D519/00 , C07D471/04 , C07D209/82 , C07D403/12 , A61K31/496
CPC classification number: C07D401/12 , A61K31/496 , C07D209/82 , C07D401/14 , C07D403/12 , C07D471/04 , C07D519/00 , Y02A50/30
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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27.发明申请公开(公告)号：US20180251426A1
公开(公告)日：2018-09-06
申请号：US15783993
申请日：2017-10-13
Applicant: AbbVie, Inc.
Inventor： Milan Bruncko , Yujia Dai , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , William J. McClellan
IPC: C07D209/08 , A61K31/635 , C07D211/58 , C07D401/12 , C07D309/08 , C07D471/04 , C07D413/12 , C07D405/14 , C07D405/12 , C07D403/12 , C07D401/14 , C07D309/04 , C07D295/30 , C07D277/24 , C07D235/06 , C07D231/56 , C07D213/84 , C07D213/74 , C07D417/12
CPC classification number: C07D209/08 , A61K31/635 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D309/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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28.发明申请公开(公告)号：US20160304451A1
公开(公告)日：2016-10-20
申请号：US15048901
申请日：2016-02-19
Applicant: AbbVie Inc.
Inventor： Steven W. Elmore , Aaron R. Kunzer , Robert A. Mantei , Andrew J. Souers , Gerard M. Sullivan , Gary T. Wang , Le Wang , Michael D. Wendt
IPC: C07D209/08 , C07D401/12 , C07D405/12 , C07D405/14 , C07D403/12 , A61K31/635 , C07D413/12
CPC classification number: C07D209/08 , A61K31/635 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D309/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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29.发明授权公开(公告)号：US09303025B2
公开(公告)日：2016-04-05
申请号：US14582144
申请日：2014-12-23
Applicant: AbbVie Inc.
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , Cheol-Min Park , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt
IPC: C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D209/08 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D471/04 , C07D309/08
CPC classification number: C07D209/08 , A61K31/635 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D309/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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30.发明申请BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES 审中-公开用于治疗癌症和免疫疾病的BCL-2-选择性病毒诱导剂公开(公告)号：US20160009687A1
公开(公告)日：2016-01-14
申请号：US14726337
申请日：2015-05-29
Applicant: AbbVie Inc.
Inventor： Hong Ding , Steven W. Elmore , Lisa Hasvold , Laura A. Hexamer , Aaron R. Kunzer , William J. McClellan , Gerard M. Sullivan , Andrew J. Souers , Zhi-Fu Tao , Michael D. Wendt
IPC: C07D401/12 , C07D211/58 , C07D209/08 , C07D309/04 , C07D295/155
CPC classification number: C07D401/12 , A61K31/407 , A61K31/495 , A61K31/496 , A61K31/501 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D209/32 , C07D211/58 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D241/04 , C07D249/04 , C07D295/125 , C07D295/14 , C07D295/155 , C07D309/04 , C07D309/14 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/12 , C07D471/04 , C07D487/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
Abstract translation: 公开了抑制抗凋亡Bcl-2或Bcl-xL蛋白活性的化合物，含有化合物的组合物和治疗疾病的方法，其中表达有抗凋亡Bcl-2蛋白。
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