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公开(公告)号：US20250059330A1
公开(公告)日：2025-02-20
申请号：US18929889
申请日：2024-10-29
Applicant: Alcon Inc.
Inventor： Steve Yun Zhang , Daqing Wu , Junhao Ge , Richard Charles Breitkopf , Xinming Qian , Zach Munoz , Matthew D. Nelson , Augustine Twum Kumi , Weihong Lang , Ying Zheng , Feng Jing , Frank Chang
IPC: C08G77/442 , B29D11/00 , C08G77/12 , C08G77/14 , C08G77/20 , C08G77/388 , C08G77/392 , C08L83/10 , G02B1/04 , G02C7/04
Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.
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公开(公告)号：US12171871B2
公开(公告)日：2024-12-24
申请号：US17392448
申请日：2021-08-03
Applicant: ALCON INC.
Inventor： Junhao Ge , Steve Yun Zhang , Daqing Wu , Jing Cheng , Yuan Chang , Feng Jing , Jang-Shing Chiou , Stephen Raymond Perreault
Abstract: The present invention relates to a method to load a water insoluble phospholipid as nanoparticles to load into a hydrogel contact lens in autoclaving process during the hydrogel contact lens manufacturing process without an extra manufacturing step and without swelling the hydrogel contact lens with an organic solvent. The phospholipid nanoparticles loaded in hydrogel contact lens subsequently releases to the eye upon wearing.
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公开(公告)号：US12162987B2
公开(公告)日：2024-12-10
申请号：US18465610
申请日：2023-09-12
Applicant: Alcon Inc.
Inventor： Steve Yun Zhang , Daqing Wu , Junhao Ge , Richard Charles Breitkopf , Xinming Qian , Zach Munoz , Matthew D. Nelson , Augustine Twum Kumi , Weihong Lang , Ying Zheng , Feng Jing , Frank Chang
IPC: C08G77/442 , B29D11/00 , C08G77/12 , C08G77/14 , C08G77/20 , C08G77/388 , C08G77/392 , C08L83/10 , G02B1/04 , G02C7/04
Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.
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Patent Agency Ranking
公开(公告)号：US11802182B2
公开(公告)日：2023-10-31
申请号：US17742559
申请日：2022-05-12
Applicant: Alcon Inc.
Inventor： Steve Yun Zhang , Daqing Wu , Junhao Ge , Richard Charles Breitkopf , Xinming Qian , Zach Munoz , Matthew D. Nelson , Augustine Twum Kumi , Weihong Lang , Ying Zheng , Feng Jing , Frank Chang
IPC: C08G77/442 , C08G77/20 , C08G77/388 , C08G77/392 , C08G77/14 , C08L83/10 , G02B1/04 , C08G77/12 , B29D11/00 , G02C7/04
CPC classification number: C08G77/442 , B29D11/00134 , C08G77/12 , C08G77/14 , C08G77/20 , C08G77/388 , C08G77/392 , C08L83/10 , G02B1/043 , G02C7/04 , C08G2210/00 , C08L2201/10 , G02B2207/109
Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.
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公开(公告)号：US11542353B2
公开(公告)日：2023-01-03
申请号：US16872628
申请日：2020-05-12
Applicant: Alcon Inc.
Inventor： Weihong Lang , Junhao Ge , Steve Yun Zhang , Daqing Wu
IPC: C08F271/02 , B29D11/00 , C08K5/1545 , C08K5/17 , B29K83/00 , B29K105/00 , G02B1/04
Abstract: The invention provides a method for producing photochromic silicone hydrogel (SiHy) contact lenses based on thermal cast-molding technology in a relatively efficient and consistent manner. The method is characterized by selecting a high radical-reactive hydrophilic acrylic monomer while eliminating any low radical-reactive hydrophilic N-vinyl amide monomer in a lens formulation (polymerizable composition), by selecting a weight ratio of low-radical-reactive hydrophilic N-vinyl amide monomer to a high radical-reactive hydrophilic acrylic monomer in a lens formulation if the low radical-reactive hydrophilic N-vinyl amide monomer is needed, and/or by using a relatively high temperature thermal initiator in a lens formulation, to control the lens properties (e.g., water content, elastic modulus, etc.) and lens processability (capability of dry-delensing from molds) of thermally cast-molded SiHy contact lenses while minimizing loss in photochromic ability of resultant SiHy contact lenses.
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公开(公告)号：US11534994B2
公开(公告)日：2022-12-27
申请号：US17146181
申请日：2021-01-11
Applicant: Alcon Inc.
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC: B29D11/00 , G02B1/18 , G02B1/04 , G02C7/04 , G02B1/10 , C08J7/04 , C08L83/04 , C08G77/388 , C08J5/00 , C09D5/16 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , C09D177/06
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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公开(公告)号：US11433629B2
公开(公告)日：2022-09-06
申请号：US16429776
申请日：2019-06-03
Applicant: Alcon Inc.
Inventor： Weihong Lang , Wei Liang , Ying Zheng , Karen Belinda Sentell , Richard Charles Breitkopf , Daqing Wu , Steve Yun Zhang
IPC: B29D11/00 , G02B1/04 , B29K83/00 , B29K105/00
Abstract: The invention provides a contact lens manufacturing method for cast-molding of silicone hydrogel contact lenses having enhanced oxygen permeability without adversely affecting desirable lens mechanical properties (e.g., modulus). A method of the invention comprises adding a small amount of a radical scavenger (e.g., H-TEMPO) in a polymerizable composition for cast-molding of SiHy contact lenses) to provide the resultant polymerizable composition with a bi-phase curing profile at a curing temperature of from about 45° C. to about 100° C. With such a bi-phase curing profile, the resultant polymerizable composition can be thermally cured at the curing temperature to form a SiHy contact lens having an oxygen permeability higher than that for a polymerizable composition having the substantially identical composition excepting being free of any radical scavenger.
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公开(公告)号：US11365288B2
公开(公告)日：2022-06-21
申请号：US17038293
申请日：2020-09-30
Applicant: Alcon Inc.
Inventor： Steve Yun Zhang , Daqing Wu , Junhao Ge , Richard Charles Breitkopf , Xinming Qian , Zach Munoz , Matthew D. Nelson , Augustine Twum Kumi , Weihong Lang , Ying Zheng , Feng Jing , Frank Chang
IPC: C08G77/442 , C08G77/20 , C08G77/388 , C08G77/392 , C08G77/14 , C08L83/10 , G02B1/04 , C08G77/12 , B29D11/00 , G02C7/04
Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.
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