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53 条记录 (耗时 0.042 秒)

    Selective administration of drug with ocular therapeutic system
    26.
    发明授权
    Selective administration of drug with ocular therapeutic system 失效
    用眼部治疗系统选择性给药

    公开(公告)号：US4186184A

    公开(公告)日：1980-01-29

    申请号：US32498

    申请日：1979-04-23

    申请人： Alejandro Zaffaroni

    发明人： Alejandro Zaffaroni

    IPC分类号： A61F9/00 ,  A61K9/00 ,  A61K9/22 ,  A61M31/00

    CPC分类号： A61F9/0017 ,  A61K9/0051

    摘要： A method for administering a drug to a preselected tissue compartment of the eye for advantageously controlling the concentration of drug in the tissue compartment is disclosed. The method comprises (1) placing an ocular therapeutic system in the eye, and (2) orienting the drug releasing portal of the system towards the preselected tissue compartment for controlled administration of drug thereto.

    摘要翻译： 公开了一种将药物施用于眼睛的预选组织隔室以有利地控制组织隔室中的药物浓度的方法。 该方法包括（1）将眼部治疗系统放置在眼睛中，以及（2）将系统的药物释放入口朝向预选的组织室定向以控制其给予药物。

    Osmotic releasing device having a plurality of release rate patterns
    27.
    发明授权
    Osmotic releasing device having a plurality of release rate patterns 失效
    渗透释放装置具有多个释放速率模式

    公开(公告)号：US4036227A

    公开(公告)日：1977-07-19

    申请号：US536006

    申请日：1974-12-23

    申请人： Alejandro Zaffaroni ,  Alan S. Michaels ,  Felix Theeuwes

    发明人： Alejandro Zaffaroni ,  Alan S. Michaels ,  Felix Theeuwes

    IPC分类号： A61F6/14 ,  A61F9/00 ,  A61K9/00 ,  A61M37/00

    CPC分类号： A61K9/0004 ,  A61F6/14 ,  A61F6/144 ,  A61F9/0017

    摘要： An osmotic device for releasing a useful agent at different release rate patterns from the device in a selected environment is disclosed. The device is comprised of a wall surrounding and forming a compartment as a means for containing a useful agent and having a passageway for releasing the agent. The wall is comprised in at least a part of a material permeable to an external fluid and impermeable to the agent. A layer of a pattern rate controlling material that erodes in a selected environment for changing the release rate pattern of the device is carried on the semipermeable wall distant from the compartment. The agent is soluble in the fluid and exhibits an osmotic pressure gradient across the semipermeable wall against the fluid, or the agent has limited solubility and is admixed with an osmotically effective solute soluble in the fluid that exhibits an osmotic pressure gradient across the semipermeable wall against the fluid. In operation, agent is released from the device at different release rate patterns by the pattern rate controlling material eroding at a controlled rate to increase the amount of fluid available to the semipermeable wall for imbibition, which fluid is imbibed through the wall into the compartment producing a solution of the soluble agent or a solution of the osmotically effective solute containing the agent which is released through the passageway to the exterior of the device at a rate controlled by the permeability of the semipermeable wall and the osmotic pressure gradient across the wall of the device.

    摘要翻译： 公开了一种用于在所选环境中从设备以不同释放速率模式释放有用试剂的渗透装置。 该装置包括围绕并形成隔室的壁，作为用于容纳有用试剂并具有用于释放试剂的通道的装置。 所述壁包括在对外部流体可渗透并且对所述试剂不可渗透的材料的至少一部分中。 在选择的环境中侵蚀以改变装置的释放速率图案的图案速率控制材料层被承载在远离隔室的半透壁上。 该试剂可溶于流体并且表现出跨越半透性壁抵抗流体的渗透压梯度，或者该试剂具有有限的溶解度，并且与可溶于流体的渗透压有效溶质混合，该溶质表现出穿过半透壁的渗透压梯度，抵抗 流体。 在操作中，通过模式速率控制材料以受控的速率以不同的释放速率模式从设备释放试剂，以增加半渗透壁可用于吸入的流体的量，该流体通过壁被吸入隔室产生 将可溶性试剂或含有该试剂的渗透有效溶质的溶液的溶液以通过该通道释放的渗透压力通过半透壁的渗透率和穿过该壁的渗透压梯度 设备。

    Pharmaceutical aerosol compositions comprising putrescine prostaglandins
    28.
    发明授权
    Pharmaceutical aerosol compositions comprising putrescine prostaglandins 失效
    包含腐胺前列腺素的药物气溶胶组合物

    公开(公告)号：US4014989A

    公开(公告)日：1977-03-29

    申请号：US618581

    申请日：1975-10-01

    申请人： Alejandro Zaffaroni

    发明人： Alejandro Zaffaroni

    IPC分类号： C07C405/00 ,  A61K9/00 ,  A61K31/205 ,  A61K31/215

    CPC分类号： A61K9/0073 ,  C07C405/00

    摘要： Novel compounds of the formulae: ##STR1## wherein R.sub.2 and R.sub.6 are hydrogen when Z.sub.2 is a single bond and when Z.sub.2 is a double bond R.sub.2 and R.sub.6 are absent; R.sub.3 is a keto, ##STR2## R.sub.7 is OH or OR.sub.9 ; R.sub.8 is H or OH; R.sub.9 is acyl or alkoxyalkyl; R.sub.10 is H or ##STR3## Z.sub.1 is --CH.sub.2 CH.sub.2 -- or cis --CH=CH--; Z.sub.2 is a single bond or a double bond; Z.sub.3 is a single bond or a double bond when R.sub.4 and R.sub.5 are hydrogen; Z.sub.4 is --CH.sub.2 CH.sub.2 -- or trans --CH=CH--; Z.sub.5 is --CH.sub.2 CH.sub.2 -- or cis --CH=CH--; n is 2 to 5, m is 1 to 3, and x is 1 to 2. The compounds are useful for regulating blood pressure, for stimulating smooth muscles, for inhibiting gastric secretion and inhibiting platelet aggregation and they possess improved biological stability and enhanced membrane permeability to serve as an in vivo reservoir of the prostaglandin to ensure the biological availability of the prostaglandin.

    摘要翻译： 下式的新型化合物：其中当Z 2为单键时，R 2和R 6为氢，当Z 2为双键时R 2和R 6为不存在; R3是酮，R7是OH或OR9; R8是H或OH; R9是酰基或烷氧基烷基; R 10为H或Z 1为-CH 2 CH 2 - 或顺式-CH = CH-; Z2是单键或双键; 当R4和R5是氢时，Z3是单键或双键; Z4是-CH2CH2-或反式-CH = CH-; Z 5是-CH 2 CH 2 - 或顺式-CH = CH-; n为2至5，m为1至3，x为1至2.该化合物可用于调节血压，刺激平滑肌，抑制胃分泌和抑制血小板聚集，具有改善的生物稳定性和增强膜 渗透性用作前列腺素的体内储库，以确保前列腺素的生物利用度。

    Comestibles containing non-nutritive flavoring
    29.
    发明授权
    Comestibles containing non-nutritive flavoring 失效
    包含非营养调味料的食物

    公开(公告)号：US3998974A

    公开(公告)日：1976-12-21

    申请号：US584550

    申请日：1975-06-06

    申请人： Alejandro Zaffaroni

    发明人： Alejandro Zaffaroni

    IPC分类号： A23L27/00 ,  A61K47/48 ,  C07D303/22 ,  C07D303/24 ,  C07H15/10 ,  A23L1/226

    CPC分类号： C07D303/22 ,  A23L27/75 ,  A61K47/48176 ,  A61K47/48215 ,  A61K47/4823 ,  C07D303/24 ,  C07H15/10

    摘要： Nonnutritive flavor imparting compounds of the general formula (F--Z).sub.n C wherein F is an active flavor imparting agent, C is a controlling agent for transporting and essentially restricting absorption of the compound (F--Z).sub.n C in a biological environment, Z is a covalent bond for bonding F to C and n is at least one. The nonnutritive flavor imparting compounds are useful for imparting flavor and taste to foods, beverages, confections and medicinals without any substantial absorption of the flavor imparting compounds in the environment of use.

    摘要翻译： 非营养风味赋予通式（FZ）nC的化合物，其中F是活性香料赋予剂，C是用于在生物环境中输送和基本上限制化合物（FZ）nC的吸收的控制剂，Z是用于 将F键合到C，n是至少一个。 非营养风味赋予化合物可用于赋予食品，饮料，甜食和药物风味和味道，而在使用环境中没有任何明显吸收赋予香味的化合物。