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公开(公告)号：US20050196745A1
公开(公告)日：2005-09-08
申请号：US11015256
申请日：2004-12-16
IPC分类号： B01J19/00 , B01L3/00 , C40B60/14 , G01N35/10 , C12Q1/00 , C12Q1/68 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： B01L3/5085 , B01J19/0046 , B01J2219/00317 , B01J2219/00367 , B01J2219/00378 , B01J2219/00527 , B01J2219/00536 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00635 , B01J2219/00659 , B01J2219/0072 , B01L2300/0893 , C40B60/14 , G01N2035/1039 , Y10T436/111666 , Y10T436/143333 , Y10T436/2575
摘要： An apparatus and method is provided for preparing and using a very large and diverse array of compounds on a substrate having rapidly accessible locations. The substrate contains cells in which the compounds of the array are located. Surrounding the cells is a non-wetable surface that prevents the solution in one cell from moving to adjacent cells. The compounds are delivered to the individual cells of the array by a micropipette attached to an X-Y translation stage.
摘要翻译： 提供了一种用于在具有快速可及位置的基底上制备和使用非常大且多样化的化合物阵列的装置和方法。 底物含有阵列化合物所在的细胞。 围绕细胞是不可润湿的表面，其防止一个细胞中的溶液移动到相邻的细胞。 通过连接到X-Y平台的微量移液管将化合物递送到阵列的各个细胞。
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公开(公告)号：US20050176058A1
公开(公告)日：2005-08-11
申请号：US11100917
申请日：2005-04-06
CPC分类号： B01L3/5085 , B01J19/0046 , B01J2219/00317 , B01J2219/00367 , B01J2219/00378 , B01J2219/00527 , B01J2219/00536 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00635 , B01J2219/00659 , B01J2219/0072 , B01L2300/0893 , C40B60/14 , G01N2035/1039 , Y10T436/111666 , Y10T436/143333 , Y10T436/2575
摘要： An apparatus and method is provided for preparing and using a very large and diverse array of compounds on a substrate having rapidly accessible locations. The substrate contains cells in which the compounds of the array are located. Surrounding the cells is a non-wetable surface that prevents the solution in one cell from moving to adjacent cells. The compounds are delivered to the individual cells of the array by a micropipette attached to an X-Y translation stage.
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公开(公告)号：US20050186592A1
公开(公告)日：2005-08-25
申请号：US10997142
申请日：2004-11-24
申请人： James Winkler , Stephen Fodor , Christopher Buchko , Debra Ross , Lois Aldwin , Douglas Modlin
发明人： James Winkler , Stephen Fodor , Christopher Buchko , Debra Ross , Lois Aldwin , Douglas Modlin
IPC分类号： B01J19/00 , C07B61/00 , C07H21/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/10 , C12Q1/68 , C08F2/46 , C08J3/28 , G01N33/53
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00364 , B01J2219/00367 , B01J2219/00369 , B01J2219/00378 , B01J2219/00389 , B01J2219/00416 , B01J2219/0043 , B01J2219/00432 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00686 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07H21/00 , C07K1/045 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1072 , Y10S436/809 , Y10T436/143333 , Y10T436/25 , Y10T436/255 , Y10T436/2575
摘要： A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.
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公开(公告)号：US20050186683A1
公开(公告)日：2005-08-25
申请号：US10997136
申请日：2004-11-24
申请人： James Winkler , Stephen Fodor , Christopher Buchko , Debra Ross , Lois Aldwin , Douglas Modlin
发明人： James Winkler , Stephen Fodor , Christopher Buchko , Debra Ross , Lois Aldwin , Douglas Modlin
IPC分类号： B01J19/00 , C07B61/00 , C07H21/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/10 , G01N1/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00364 , B01J2219/00367 , B01J2219/00369 , B01J2219/00378 , B01J2219/00389 , B01J2219/00416 , B01J2219/0043 , B01J2219/00432 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00686 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07H21/00 , C07K1/045 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1072 , Y10S436/809 , Y10T436/143333 , Y10T436/25 , Y10T436/255 , Y10T436/2575
摘要： A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.
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公开(公告)号：US20050124000A1
公开(公告)日：2005-06-09
申请号：US10997740
申请日：2004-11-24
申请人： James Winkler , Stephen Fodor , Christopher Buchko , Debra Ross , Lois Aldwin , Douglas Modlin
发明人： James Winkler , Stephen Fodor , Christopher Buchko , Debra Ross , Lois Aldwin , Douglas Modlin
IPC分类号： B01J19/00 , C07B61/00 , C07H21/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/10 , B05D3/00 , C12M1/34 , C12Q1/68 , G01N33/53
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00364 , B01J2219/00367 , B01J2219/00369 , B01J2219/00378 , B01J2219/00389 , B01J2219/00416 , B01J2219/0043 , B01J2219/00432 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00686 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07H21/00 , C07K1/045 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1072 , Y10S436/809 , Y10T436/143333 , Y10T436/25 , Y10T436/255 , Y10T436/2575
摘要： A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.
摘要翻译： 一种用于在基底（401）上形成大量聚合物阵列的方法和装置。 根据本发明的优选方面，衬底与其中具有通道（409）的通道块（407）接触。 所选择的试剂通过通道输送，基底通过旋转阶段（403）旋转，并且重复该过程以在基底上形成聚合物阵列。 该方法可以与光导方法组合。
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6.发明授权Methods for immobilizing anti-thrombogenic material onto a medical device or into a coating thereon 有权将抗血栓形成材料固定在医疗装置上或其上的涂层中的方法公开(公告)号：US08263170B2
公开(公告)日：2012-09-11
申请号：US12683404
申请日：2010-01-06
申请人： Eugene T. Michal , Ni Ding , Christopher Buchko
发明人： Eugene T. Michal , Ni Ding , Christopher Buchko
CPC分类号： A61L31/10 , A61L31/16 , A61L33/0029 , A61L33/0088 , A61L2300/42 , A61L2420/08
摘要： The present invention is directed to a medical device having a polymerized base coat layer for the immobilization of an anti-thrombogenic material, such as heparin, thereon. The binding coat layer is comprised of various chemically functional groups which are stable and allow for the immobilization of the anti-thrombogenic material thereto. Methods for immobilizing the anti-thrombogenic material within the base coat layer posited on a surface of the medical device are also provided.
摘要翻译： 本发明涉及一种具有用于固定抗血栓形成材料如肝素的聚合底涂层的医疗装置。 粘合涂层由各种化学官能团组成，它们是稳定的并允许将抗血栓形成材料固定在其上。 还提供了将抗凝血栓塞材料固定在医疗装置表面上的底涂层内的方法。
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