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132 条记录 (耗时 0.041 秒)

    Di-and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
    23.
    发明授权
    Di-and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone 失效
    二取代和三取代的哌啶，吡咯烷和六氢-1H-吖庚因促进生长激素的释放

    公开(公告)号：US5721250A

    公开(公告)日：1998-02-24

    申请号：US600646

    申请日：1996-02-13

    申请人： Gregori J. Morriello ,  Lihu Yang ,  Arthur A. Patchett

    发明人： Gregori J. Morriello ,  Lihu Yang ,  Arthur A. Patchett

    IPC分类号： A61K38/00 ,  C07K5/02 ,  C07K5/06 ,  C07K5/078 ,  C07K5/083 ,  A61K31/445 ,  C07D401/02 ,  C07D401/14 ,  C07D409/02

    CPC分类号： C07K5/0202 ,  C07K5/06034 ,  C07K5/06139 ,  C07K5/0808 ,  A61K38/00

    摘要： The present invention is directed to certain novel compounds identified as di- and tri-substituted piperidines, pyrrolidines, and hexahydro-1H-azepines of the general structural formula: ##STR1## wherein R.sub.1, R.sub.4, R.sub.5, A, X, Y, and n are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by growth hormone. Growth hormone releasing compositions containing such di and tri substituted piperidines, pyrrolidines, and hexahydro-1H-azepines as the active ingredient thereof are also disclosed.

    摘要翻译： 本发明涉及鉴定为二 - 和三 - 取代的哌啶，吡咯烷和六氢-1H-吖庚因的一些新化合物，其通式为：其中R1，R4，R5，A，X，Y和 n如本文所定义。 这些化合物促进人和动物中生长激素的释放。 这种性质可以用于促进食用动物的生长，使食用肉制品的生产更有效，并且在人类中，用于治疗以生长激素分泌不足为特征的生理或医学病症，例如生长激素缺乏的身材矮小 儿童，并治疗由生长激素改善的医疗状况。 还公开了含有这种二取代和三取代的哌啶，吡咯烷酮和六氢-1H-吖庚因作为其活性成分的生长激素释放组合物。

    Camphor compounds promote release of growth hormone
    24.
    发明授权
    Camphor compounds promote release of growth hormone 失效
    樟脑化合物促进生长激素的释放

    公开(公告)号：US5656606A

    公开(公告)日：1997-08-12

    申请号：US390328

    申请日：1995-02-17

    申请人： Ravi Nargund ,  Arthur A. Patchett

    发明人： Ravi Nargund ,  Arthur A. Patchett

    IPC分类号： C07D211/60 ,  C07D401/12 ,  C07D453/02 ,  A61K31/16 ,  A61K31/445 ,  A61K31/495 ,  A61K38/22

    CPC分类号： C07D401/12 ,  C07D211/60 ,  C07D453/02 ,  C07C2102/42

    摘要： The present invention is directed to certain novel compounds identified as camphor derivatives of the general structural formula: ##STR1## wherein A, X, Y, R.sup.2a, R.sup.4, and R.sup.5 are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.

    摘要翻译： 本发明涉及鉴定为以下通式结构式的樟脑衍生物的某些新化合物：其中A，X，Y，R 2a，R 4和R 5如本文所定义。 这些化合物促进人和动物中生长激素的释放。 这种性质可以用于促进食用动物的生长，使食用肉制品的生产更有效，并且在人类中，用于治疗以生长激素分泌不足为特征的生理或医学病症，例如生长激素缺乏的身材矮小 儿童，并且治疗通过生长激素的合成代谢作用改善的医疗状况。 还公开了含有这些化合物作为其活性成分的生长激素释放组合物。