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公开(公告)号：US20120042400A1
公开(公告)日：2012-02-16
申请号：US12927919
申请日：2010-11-29
申请人： Avi J. Ashkenazi , Austin Gurney
发明人： Avi J. Ashkenazi , Austin Gurney
IPC分类号： A01K67/027 , C07K19/00 , C07K16/28 , C12N15/12 , C12N15/63 , G01N33/566 , C12N1/21 , C12N5/10 , C12P21/02 , A61K38/17 , A61K39/395 , C12N5/071 , C07K14/705 , C12N1/19
CPC分类号： C07K14/70578
摘要： Novel polypeptides, designated RTD, which are capable of binding Apo-2 ligand are provided. Compositions including RTD chimeras, nucleic acid encoding RTD, and antibodies to RTD are also provided.
摘要翻译： 提供了能够结合Apo-2配体的命名为RTD的新型多肽。 还提供了包括RTD嵌合体，编码RTD的核酸和RTD抗体的组合物。
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公开(公告)号：US20070238150A1
公开(公告)日：2007-10-11
申请号：US10187595
申请日：2002-07-01
申请人： Kevin Baker , Jian Chen , Luc Desnoyers , Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Victoria Smith , Colin Watanabe , William Wood , Zemin Zhang
发明人： Kevin Baker , Jian Chen , Luc Desnoyers , Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Victoria Smith , Colin Watanabe , William Wood , Zemin Zhang
CPC分类号： C07K14/47 , A01K2217/075 , A01K2227/105 , A61K38/00 , C07K14/4748 , C07K14/705 , C07K14/82 , C07K16/28 , C07K2319/30 , C12Q1/6816 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5082 , G01N33/5308 , G01N33/574 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/57484 , G01N33/57488 , G01N33/57492 , G01N2500/00 , C12Q2563/131 , C12Q2527/137
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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23.发明申请公开(公告)号：US20070224185A1
公开(公告)日：2007-09-27
申请号：US11537235
申请日：2006-09-29
申请人： Kevin Baker , Maureen Beresini , Laura DeForge , Luc Desnoyers , Ellen Filvaroff , Wei-Qiang Gao , Mary Gerritsen , Audrey Goddard , Paul Godowski , Austin Gurney , Steven Sherwood , Victoria Smith , Timothy Stewart , Daniel Tumas , Colin Watanabe , William Wood , Zemin Zhang
发明人： Kevin Baker , Maureen Beresini , Laura DeForge , Luc Desnoyers , Ellen Filvaroff , Wei-Qiang Gao , Mary Gerritsen , Audrey Goddard , Paul Godowski , Austin Gurney , Steven Sherwood , Victoria Smith , Timothy Stewart , Daniel Tumas , Colin Watanabe , William Wood , Zemin Zhang
IPC分类号： A61K39/395 , C07K14/47 , C07K16/30 , G01N33/53
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K39/0011 , C07K1/00 , C07K14/00 , C07K14/47 , C07K14/4703 , C07K14/705 , C07K14/70578 , C07K14/82 , C07K16/18 , C07K17/00 , C07K2317/24 , C07K2319/00 , C07K2319/30 , C12N5/06 , C12N9/00 , C12N9/001 , C12N9/1051 , C12N15/00 , C12N2799/026 , C12P21/02 , C12P21/06 , C12Q1/68 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5008 , G01N33/5011 , G01N33/5014 , G01N33/502 , G01N33/5044 , G01N33/505 , G01N33/5061 , G01N33/53 , G01N33/574 , G01N33/57484 , G01N33/68 , G01N33/6845 , G01N2800/042 , Y10S530/828 , Y10S530/866
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US20070105191A1
公开(公告)日：2007-05-10
申请号：US10448580
申请日：2003-05-29
申请人： Luc Desnoyers , Audrey Goddard , Paul Godowski , Austin Gurney , William Wood , Filvaroff Ellen
发明人： Luc Desnoyers , Audrey Goddard , Paul Godowski , Austin Gurney , William Wood , Filvaroff Ellen
IPC分类号： C12N9/00 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： G01N33/68 , A61K38/00 , C07K14/47 , C07K2317/24 , C07K2319/00 , C07K2319/30 , G01N33/57484
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20070088151A1
公开(公告)日：2007-04-19
申请号：US11642816
申请日：2006-12-19
IPC分类号： C07K16/18
CPC分类号： C07K14/47 , A61K38/00 , C07K14/705 , C07K2317/24 , C07K2319/00 , G01N33/5005 , G01N33/5008 , G01N33/5064 , G01N33/57484 , G01N33/68
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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26.发明申请公开(公告)号：US20070087007A1
公开(公告)日：2007-04-19
申请号：US11607709
申请日：2006-11-30
申请人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin Gurney , Mary Napier , Daniel Tumas , William Wood
发明人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin Gurney , Mary Napier , Daniel Tumas , William Wood
IPC分类号： A61K39/395
CPC分类号： C07K14/47 , A61K38/00 , A61K39/395 , C07K14/705 , C07K16/28 , C07K2317/24 , C07K2319/00 , C07K2319/30 , G01N33/57484 , G01N33/6893 , G01N2800/7095 , Y02A50/54
摘要： The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer, and nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing such antigens PRO301, PRO362 or PRO245.
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27.发明申请Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity 审中-公开成纤维细胞生长因子-19（FGF-19）核酸和多肽以及用于治疗肥胖症的方法公开(公告)号：US20070042395A1
公开(公告)日：2007-02-22
申请号：US11339772
申请日：2006-01-25
申请人： David Botstein , Audrey Goddard , Austin Gurney , Kenneth Hillan , David Lawrence , Margaret Roy
发明人： David Botstein , Audrey Goddard , Austin Gurney , Kenneth Hillan , David Lawrence , Margaret Roy
CPC分类号： C12Q1/6883 , C07K14/50 , C07K2317/24 , C07K2319/00 , C12Q2600/158
摘要： The present invention is directed to novel polypeptides belonging to the fibroblast growth factor family and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Furthermore, methods of treating obesity are provided.
摘要翻译： 本发明涉及属于成纤维细胞生长因子家族的新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 此外，提供了治疗肥胖症的方法。
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公开(公告)号：US20070041964A1
公开(公告)日：2007-02-22
申请号：US11488375
申请日：2006-07-17
申请人： David Botstein , Robert Cohen , Audrey Goddard , Austin Gurney , Kenneth Hillan , David Lawrence , Arnold Levine , Diane Pennica , Margaret Roy , William Wood
发明人： David Botstein , Robert Cohen , Audrey Goddard , Austin Gurney , Kenneth Hillan , David Lawrence , Arnold Levine , Diane Pennica , Margaret Roy , William Wood
IPC分类号： A61K39/395 , C07K16/40 , C07K16/42
CPC分类号： C07K14/47 , C07K14/475 , C07K16/18 , C07K16/22 , C07K16/30 , C07K16/32 , C07K2317/73 , C07K2317/74 , C12Q1/6886 , C12Q2600/136
摘要： Wnt-1-Induced Secreted Proteins (WISPs) are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and methods for producing the polypeptides.
摘要翻译： 提供了Wnt-1诱导的分泌蛋白（WISP），其基因至少被Wnt-1诱导。 还提供了编码那些多肽的核酸分子，以及包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的多肽的嵌合多肽分子，与多肽结合的抗体，以及用于产生多肽的方法。
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公开(公告)号：US20060275864A9
公开(公告)日：2006-12-07
申请号：US10970823
申请日：2004-10-20
申请人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Jennie Mather , James Pan , Nicholas Paoni , Margaret Roy , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
发明人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Jennie Mather , James Pan , Nicholas Paoni , Margaret Roy , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
CPC分类号： C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20060246540A1
公开(公告)日：2006-11-02
申请号：US11240891
申请日：2005-09-29
申请人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , Austin Gurney , Ivar Kljavin , Jennie Mather , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , Timothy Stewart , Daniel Tumas , Colin Watanabe , P. Williams , William Wood , Zemin Zhang
发明人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , Austin Gurney , Ivar Kljavin , Jennie Mather , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , Timothy Stewart , Daniel Tumas , Colin Watanabe , P. Williams , William Wood , Zemin Zhang
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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