公开(公告)号：US20170281730A1

公开(公告)日：2017-10-05

申请号：US15488764

申请日：2017-04-17

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Jacques F. Banchereau ,  Maria Virginia Pascual

IPC: A61K38/20 ,  A61K38/17 ,  G01N33/68 ,  C07K16/24 ,  C07K14/545

Abstract: The present invention includes compositions and methods for treating arthritic joints found in patients with autoinflammation, e.g., systemic onset juvenile idiopathic arthritis, by administering at the site of inflammation a therapeutically effective amount of at least one agent that reduces or blocks the bioavailability of interleukin-1β.

公开(公告)号：US20160067310A1

公开(公告)日：2016-03-10

申请号：US14942841

申请日：2015-11-16

Applicant: Baylor Research Institute

Inventor： Jacques F. Banchereau ,  Maria Virginia Pascual

IPC: A61K38/20

CPC classification number: A61K38/2006 ,  A61K38/1709 ,  C07K14/545 ,  C07K16/245 ,  G01N33/6869 ,  Y10S514/825

Abstract: The present invention includes compositions and methods for treating arthritic joints found in patients with autoinflammation, e.g., systemic onset juvenile idiopathic arthritis, by administering at the site of inflammation a therapeutically effective amount of at least one agent that reduces or blocks the bioavailability of interleukin-1β.

Abstract translation: 本发明包括用于治疗患有自身炎症的患者的关节炎关节的组合物和方法，例如全身性发作的幼年特发性关节炎，通过在炎症部位施用治疗有效量的至少一种降低或阻断白介素 - 1＆bgr

公开(公告)号：US20160022792A1

公开(公告)日：2016-01-28

申请号：US14819909

申请日：2015-08-06

Applicant: Baylor Research Institute

Inventor： Gerard Zurawski ,  Jacques F. Banchereau ,  Anne-Laure Flamar ,  Peter Klucar ,  Keiko Akagawa ,  Sandra Zurawski ,  SangKon Oh

IPC: A61K39/00 ,  C07K14/435 ,  C07K16/28

CPC classification number: A61K39/0011 ,  A61K2039/6056 ,  C07K14/435 ,  C07K16/2878 ,  C07K2319/00 ,  C07K2319/33 ,  C07K2319/91 ,  Y02A50/39 ,  Y02A50/466

Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.

Abstract translation: 本发明包括用于表达，分泌和使用用作例如疫苗和抗原递送载体的用于将抗原递送至抗原呈递细胞的组合物和方法。 在一个实施方案中，载体是抗CD40抗体或其片段，以及与抗-CD40抗体或其片段（包括人源化抗体）连接的一个或多个抗原肽。

公开(公告)号：US20150133469A1

公开(公告)日：2015-05-14

申请号：US14384891

申请日：2013-03-13

Applicant: BAYLOR RESEARCH INSTITUTE ,  MEDICAL RESEARCH COUNCIL ,  IMPERIAL COLLEGE HEATHCARE NHS TRUST

Inventor： Anne O'Garra ,  Chloe Bloom ,  Matthew Paul Reddoch Berry ,  Robert Wilkinson ,  Jacques F. Banchereau ,  Damien Chaussabel ,  Maria Virginia Pascual

IPC: C12Q1/68 ,  A61K31/133 ,  A61K31/455 ,  A61K31/496 ,  A61K31/4965

CPC classification number: C12Q1/6883 ,  A61K31/133 ,  A61K31/455 ,  A61K31/496 ,  A61K31/4965 ,  C12Q1/68 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/48 ,  G01N33/68 ,  G01N33/6893 ,  G01N2333/35 ,  G01N2800/26 ,  G01N2800/52

Abstract: The present invention includes methods for early detection of a treatment response in a patient suspected of being infected with Mycobacterium tuberculosis. Changes in the blood transcriptome are detectable within two weeks of the initiation of antituberculosis therapy.

Abstract translation: 本发明包括在怀疑感染结核分枝杆菌的患者中早期检测治疗反应的方法。 在抗结核治疗开始后两周内，血液转录组的变化是可检测的。

公开(公告)号：US11806390B2

公开(公告)日：2023-11-07

申请号：US17301704

申请日：2021-04-12

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Gerard Zurawski ,  Jacques F. Banchereau ,  Anne-Laure Flamar ,  Peter Klucar ,  Keiko Akagawa ,  Sandra Zurawski ,  SangKon Oh

IPC: A61K39/00 ,  A61K39/385 ,  C07K14/005 ,  C07K16/00 ,  G01N33/68 ,  C07K16/28 ,  C07K14/435

CPC classification number: A61K39/001129 ,  A61K39/385 ,  C07K14/005 ,  C07K14/435 ,  C07K16/00 ,  C07K16/2878 ,  G01N33/6863 ,  A61K39/00 ,  A61K2039/6056 ,  A61K2039/627 ,  A61K2039/64 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/77 ,  C07K2317/80 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/33 ,  C07K2319/40 ,  C07K2319/91 ,  C12N2740/16222 ,  C12N2740/16322 ,  C12N2760/16122 ,  C12N2770/24222 ,  C12N2770/24234 ,  Y02A50/30

Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.

公开(公告)号：US20230134568A1

公开(公告)日：2023-05-04

申请号：US17818276

申请日：2022-08-08

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Jacques F. Banchereau ,  Maria Virginia Pascual

IPC: A61K38/20 ,  C07K16/24 ,  A61K38/17 ,  C07K14/545 ,  A61P19/02 ,  A61K39/395 ,  G01N33/68

Abstract: The present invention includes compositions and methods for treating arthritic joints found in patients with autoinflammation, e.g., systemic onset juvenile idiopathic arthritis, by administering at the site of inflammation a therapeutically effective amount of at least one agent that reduces or blocks the bioavailability of interleukin-1β.

公开(公告)号：US20210308242A1

公开(公告)日：2021-10-07

申请号：US17301704

申请日：2021-04-12

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Gerard ZURAWSKI ,  Jacques F. Banchereau ,  Anne-Laure FLAMAR ,  Peter KLUCAR ,  Keiko AKAGAWA ,  Sandra ZURAWSKI ,  SangKon OH

IPC: A61K39/00 ,  C07K16/28 ,  C07K14/435

Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.

公开(公告)号：US20210221904A1

公开(公告)日：2021-07-22

申请号：US17301118

申请日：2021-03-25

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Gerard ZURAWSKI ,  Jacques F. Banchereau ,  Anne-Laure FLAMAR ,  Yves Levy ,  Monica Montes

IPC: C07K16/28 ,  C07K14/005 ,  A61K39/385 ,  G01N33/68 ,  C07K16/00

Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.

公开(公告)号：US10683361B2

公开(公告)日：2020-06-16

申请号：US16143995

申请日：2018-09-27

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Jacques F. Banchereau ,  Gerard Zurawski ,  Sandra Zurawski ,  SangKon Oh

IPC: A61K39/395 ,  C07K16/28 ,  C07K14/005 ,  A61K39/00

Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccine and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.

公开(公告)号：US20190085088A1

公开(公告)日：2019-03-21

申请号：US16143995

申请日：2018-09-27

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Jacques F. Banchereau ,  Gerard Zurawski ,  Sandra Zurawski ,  SangKon Oh

IPC: C07K16/28 ,  C07K14/005 ,  A61K39/00

Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccine and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.