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21.发明申请PHARMACEUTICAL FORMULATIONS OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES WITH PROTEASE INHIBITORS 审中-公开替代酰基氨基哌啶衍生物与蛋白酶抑制剂的药物制剂公开(公告)号：US20150087652A1
公开(公告)日：2015-03-26
申请号：US14493515
申请日：2014-09-23
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Tao Wang , Zhongxing Zhang , Nicholas A. Meanwell , John F. Kadow , Zhiwei Yin , Qiufen May Xue , Alicia Regueiro-Ren , John D. Matiskella , Yasutsugu Ueda
IPC: A61K31/496 , A61K45/06
CPC classification number: C07D471/04 , A61K31/496 , A61K45/06 , C07D491/048
Abstract: This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
Abstract translation: 本发明提供具有药物和生物影响性质的化合物，其药物组合物和使用方法。 特别地，本发明涉及氮杂吲哚乙酰基哌嗪衍生物。 这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药，抗感染剂，免疫调节剂或HIV进入抑制剂组合使用。 更具体地说，本发明涉及艾滋病毒和艾滋病的治疗。
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22.发明申请C-19 MODIFIED TRITERPENOIDS WITH HIV MATURATION INHIBITORY ACTIVITY 审中-公开C-19修饰的TRAILRPENOIDS与HIV成熟抑制活性公开(公告)号：US20140221361A1
公开(公告)日：2014-08-07
申请号：US14172389
申请日：2014-02-04
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Jacob Swidorski , Brian Lee Venables , Zheng Liu , Ny Sin , Nicholas A. Meanwell , Alicia Regueiro-Ren
CPC classification number: C07J63/008 , A61K31/56 , A61K31/58 , A61K45/06
Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-19 modified triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I and II: These compounds are useful for the treatment of HIV and AIDS.
Abstract translation: 阐述了具有药物和生物影响特性的化合物，其药物组合物和使用方法。 特别地，具有独特抗病毒活性的C-19修饰的三萜类化合物作为HIV成熟抑制剂提供，如式I和II化合物所示：这些化合物可用于治疗HIV和AIDS。
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23.发明申请C-17 BICYCLIC AMINES OF TRITERPENOIDS WITH HIV MATURATION INHIBITORY ACTIVITY 有权具有HIV成熟活性的三唑类化合物的C-17双相氨基酸公开(公告)号：US20130296554A1
公开(公告)日：2013-11-07
申请号：US13799479
申请日：2013-03-13
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ny Sin , Zheng Liu , Jacob Swidorski , Sing-Yuen Sit , Jie Chen , Yan Chen , Nicholas A. Meanwell , Alicia Regueiro-Ren
IPC: C07D487/08 , C07D495/08 , C07D495/10 , C07D487/10 , C07D498/08 , C07D209/52 , C07D491/08
CPC classification number: C07D487/08 , C07D209/52 , C07D487/10 , C07D491/08 , C07D495/08 , C07D495/10 , C07D498/08 , C07J63/008
Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-17 bicyclic amines of triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III: These compounds are useful for the treatment of HIV and AIDS.
Abstract translation: 阐述了具有药物和生物影响特性的化合物，其药物组合物和使用方法。 特别地，具有独特抗病毒活性的三萜类化合物的C-17二环胺作为HIV成熟抑制剂提供，如式I，II和III化合物所示：这些化合物可用于治疗HIV和AIDS。
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公开(公告)号：US11358988B2
公开(公告)日：2022-06-14
申请号：US16711105
申请日：2019-12-11
Applicant: Bristol-Myers Squibb Company
Inventor： Kevin W. Gillman , Jason Goodrich , Kenneth M. Boy , Yunhui Zhang , Claudio Mapelli , Michael A. Poss , Paul Michael Scola , David R. Langley , Nicholas A. Meanwell
Abstract: The present disclosure provides compounds which are immunomodulators and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
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公开(公告)号：US20180221342A1
公开(公告)日：2018-08-09
申请号：US15749557
申请日：2016-07-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： David B. Frennesson , Piyasena Hewawasam , Omar D. Lopez , Van N. Nguyen , Mark G. Saulnier , Yong Tu , Alan Xiangdong Wang , Gan Wang , Ningning Xu , Roshan Yadavrao Nimje , Hasibur Rahaman , Samayamunthula Venkata Satya Arun Kumar Gupta , Nicholas A. Meanwell , Makonen Belema
IPC: A61K31/4178 , A61P31/14
CPC classification number: A61K31/4178 , A61K31/417 , A61K31/4184 , A61K31/4439 , A61K31/497 , A61K31/7056 , A61K38/21 , A61K45/06 , A61K2300/00 , A61P31/14
Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
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Patent Agency Ranking
公开(公告)号：US20160257645A1
公开(公告)日：2016-09-08
申请号：US15031352
申请日：2014-10-23
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Annapurna Pendri , Guo Li , John A. Bender , Zhong Yang , Alan Xiangdong Wang , Brett R. Beno , Robert A. Fridell , Makonen Belema , Nicholas A. Meanwell , Robert G. Gentles
IPC: C07C311/58 , C07D317/66 , C07D409/12 , C07D405/12 , C07D317/46 , C07D407/12 , C07D271/06 , C07D307/38 , C07D333/18 , C07D231/12 , C07D333/54 , C07D209/10 , C07D333/28 , C07D261/08 , C07D215/08 , C07D209/08 , C07D277/82 , C07D495/04 , C07D491/08 , C07D205/04 , C07D401/04 , C07D213/56 , C07D249/08 , C07D265/36
CPC classification number: C07C311/58 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D205/04 , C07D209/08 , C07D209/10 , C07D213/56 , C07D215/08 , C07D231/12 , C07D249/08 , C07D261/08 , C07D265/36 , C07D271/06 , C07D277/82 , C07D307/38 , C07D317/46 , C07D317/66 , C07D333/18 , C07D333/28 , C07D333/54 , C07D401/04 , C07D405/12 , C07D407/12 , C07D409/12 , C07D491/08 , C07D495/04
Abstract: Compounds of Formula I with activity against HIV, including pharmaceutical compositions and methods for using these compounds in treating human immunodeficiency virus (HIV) infection, are set forth: Formula: (I)
Abstract translation: 阐述了具有抗HIV活性的式I化合物，包括药物组合物和使用这些化合物治疗人类免疫缺陷病毒（HIV）感染的方法：式（I）
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公开(公告)号：US20150329543A1
公开(公告)日：2015-11-19
申请号：US14725318
申请日：2015-05-29
Applicant: Bristol-Myers Squibb Company
Inventor： Tao Wang , Zhongxing Zhang , Nicholas A. Meanwell , John F. Kadow , Zhiwei Yin , Qiufen May Xue , Alicia Regueiro-Ren , John D. Matiskella , Yasutsugu Ueda
IPC: C07D471/04
CPC classification number: C07D471/04 , A61K31/496 , A61K45/06 , C07D491/048
Abstract: This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
Abstract translation: 本发明提供具有药物和生物影响性质的化合物，其药物组合物和使用方法。 特别地，本发明涉及氮杂吲哚乙酰基哌嗪衍生物。 这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药，抗感染剂，免疫调节剂或HIV进入抑制剂组合使用。 更具体地说，本发明涉及艾滋病毒和艾滋病的治疗。
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公开(公告)号：US20150210684A1
公开(公告)日：2015-07-30
申请号：US14419559
申请日：2013-08-07
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Tao Wang , Zhongxing Zhang , John F. Kadow , Nicholas A. Meanwell , Edward H. Ruediger , Clint A. James , Daniel H. Deon , David J. Carini , Barry L. Johnson
IPC: C07D471/04 , A61K45/06 , A61K31/4545 , C07D401/06 , A61K31/454
CPC classification number: C07D471/04 , A61K31/454 , A61K31/4545 , A61K45/06 , C07D401/06
Abstract: Compounds of Formula I, including pharmaceutically acceptable salts thereof: formule (I): wherein A is selected from the group consisting of: formule (II) and wherein Z is selected from the group consisting of: formule (III): and. are useful as HIV attachment inhibitors.
Abstract translation: 式I化合物，包括其药学上可接受的盐：式（I）：其中A选自：结构（II），并且其中Z选自：基团（III）：和。 可用作HIV附着抑制剂。
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公开(公告)号：US20150025240A1
公开(公告)日：2015-01-22
申请号：US14249638
申请日：2014-04-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yasutsugu Ueda , Timothy P. Connolly , John F. Kadow , Nicholas A. Meanwell , Tao Wang , Chung-Pin H. Chen , Kap-Sun Yeung , Zhongxing Zhang , David Kenneth Leahy , Shawn K. Pack , Nachimuthu Soundararajan , Pierre Sirard , Kathia Levesque , Dominique Thoraval
IPC: C07F9/06 , C07F9/6561
CPC classification number: A61K31/675 , A61K31/497 , A61K31/519 , A61K45/06 , C07C215/10 , C07D471/04 , C07F9/062 , C07F9/5728 , C07F9/65515 , C07F9/65586 , C07F9/6561
Abstract: This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. wherein: X is C or N with the proviso that when X is N, R1 does not exist; W is C or N with the proviso that when W is N, R2 does not exist; V is C; E is hydrogen or a pharmaceutically acceptable salt thereof; and Y is selected from the group consisting of Also, this invention provides for intermediate Compounds II useful in making prodrug Compounds I. wherein: L and M are independently selected from the group consisting of C1-C6 alkyl, phenyl, benzyl, trialkylsilyl, -2,2,2-trichloroethoxy and 2-trimethylsilylethoxy.
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30.发明申请COMPOSITIONS HAVING C-17 AND C-3 MODIFIED TRITERPENOIDS WITH HIV MATURATION INHIBITORY ACTIVITY 审中-公开具有HIV成熟抑制活性的C-17和C-3修饰的TRIPRPENOIDS的组合物公开(公告)号：US20140343000A1
公开(公告)日：2014-11-20
申请号：US14339572
申请日：2014-07-24
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Alicia Regueiro-Ren , Zheng Liu , Jacob Swidorski , Ny Sin , Brian Lee Venables , Sing-Yuen Sit , Yan Chen , Jie Chen , Nicholas A. Meanwell
CPC classification number: A61K31/565 , A61K31/56 , A61K31/58 , A61K31/704 , A61K45/06 , C07J63/008
Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-17 and C-3 modified triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III: These compounds are useful for the treatment of HIV and AIDS.
Abstract translation: 阐述了具有药物和生物影响特性的化合物，其药物组合物和使用方法。 特别地，具有独特抗病毒活性的C-17和C-3修饰的三萜类化合物作为HIV成熟抑制剂提供，如式I，II和III化合物所示：这些化合物可用于治疗HIV和AIDS。
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