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公开(公告)号：US20160318901A1
公开(公告)日：2016-11-03
申请号：US15106284
申请日：2014-12-16
发明人： Eva Maria BECKER-PELSTER , Philipp BUCHGRABER , Anja BUCHMÜLLER , Karen ENGEL , Volker GEISS , Andreas GÖLLER , Herbert HIMMEL , Raimund KAST , Andreas KNORR , Dieter LANG , Gorden REDLICH , Carsten SCHMECK , Hanna TINEL , Frank WUNDER
IPC分类号： C07D401/14 , A61K45/06 , A61K31/5377 , A61K31/541 , C07D413/14 , A61K31/506 , C07D491/107
CPC分类号： C07D401/14 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D413/14 , C07D417/14 , C07D491/107
摘要： The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.
摘要翻译： 本申请涉及新的取代的哌啶基四氢喹啉，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/ /或预防糖尿病性微血管病，四肢糖尿病性溃疡，特别是促进糖尿病足溃疡的伤口愈合，糖尿病性心力衰竭，糖尿病性冠状动脉微血管性心脏病，外周和心脏血管疾病，血栓栓塞性疾病和局部缺血，周围循环障碍，雷诺 现象，CREST综合征，微循环障碍，间歇性跛行，外周和自主神经病变。
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公开(公告)号：US20160318866A1
公开(公告)日：2016-11-03
申请号：US15106285
申请日：2014-12-16
发明人： Eva Maria BECKER-PELSTER , Philipp BUCHGRABER , Anja BUCHMÜLLER , Karen ENGEL , Mark Jean GNOTH , Herbert HIMMEL , Raimund KAST , Joerg KELDENICH , Jürgen KLAR , Andreas KNORR , Dieter LANG , Niels LINDNER , Carsten SCHMECK , Rudolf SCHOHE-LOOP , Hanna TINEL , Hubert TRÜBEL , Frank WUNDER
IPC分类号： C07D211/10 , C07D211/42 , C07D211/22 , A61K45/06 , C07D401/14 , C07D413/14 , C07D405/14 , C07D211/60 , A61K31/4545
CPC分类号： C07D211/10 , A61K31/4545 , A61K45/06 , C07D211/16 , C07D211/22 , C07D211/42 , C07D211/60 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14
摘要： The invention relates to novel substituted bipiperidinyl derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardiac vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.
摘要翻译： 本发明涉及新的取代的二哌啶基衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/ /或预防糖尿病性微血管病，四肢糖尿病溃疡，特别是用于促进糖尿病足溃疡的伤口愈合，糖尿病性心力衰竭，糖尿病性冠状动脉微血管性心脏病，外周和心脏血管疾病，血栓栓塞性疾病和局部缺血，外周循环障碍，雷诺 现象，CREST综合征，微循环障碍，间歇性跛行，外周和自主神经病变。
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公开(公告)号：US20200253961A1
公开(公告)日：2020-08-13
申请号：US16758802
申请日：2018-10-17
发明人： Marie-Pierre COLLIN-KROEPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FUERSTNER , Elisabeth POOK , Hanna TINEL , Carsten SCHMECK , Pierre WASNAIRE , Heiko SCHIRMER , Klemens LUSTIG
IPC分类号： A61K31/496 , A61K45/06 , A61P9/12 , A61K31/4196 , C07D403/06 , C07D403/14 , C07D413/14 , A61K31/422 , A61K31/454 , A61K31/55 , A61K31/541 , C07D417/14 , C07D487/10
摘要： The present invention relates to novel amine substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20200061063A1
公开(公告)日：2020-02-27
申请号：US16373487
申请日：2019-04-02
发明人： Chantal FÜRSTNER , Jens ACKERSTAFF , Alexander STRAUB , Heinrich MEIER , Hanna TINEL , Katja ZIMMERMANN , Adrian TERSTEEGEN , Dmitry ZUBOV , Raimund KAST , Jens SCHAMBERGER , Martina SCHÄFER , Kirsten BÖRNGEN
IPC分类号： A61K31/513 , C07D413/14 , C07D401/04 , C07D403/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D471/04 , A61K45/06 , C07D405/14 , C07D417/14 , A61K31/538 , A61K31/506 , A61K31/536
摘要： The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.
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公开(公告)号：US20180297994A1
公开(公告)日：2018-10-18
申请号：US15735138
申请日：2016-06-06
发明人： Henrik TELLER , Alexander STRAUB , Markus BRECHMANN , Thomas MÜLLER , Mark MEININGHAUS , Katrin NOWAK-REPPEL , Hanna TINEL , Klaus MÜNTER , Daniela FLIEGNER , Thomas MONDRITZKI , Melissa BOULTADAKIS ARAPINIS , Tobias MARQUARDT , Alexandros VAKALOPOULOS , Anne-Sophie REBSTOCK , Matthias Beat WITTWER
IPC分类号： C07D471/04 , A61P9/04 , A61K45/06 , A61K31/4545 , A61K31/4375 , A61K31/496 , A61K31/5377 , C07D519/00 , A61K31/513
CPC分类号： C07D471/04 , A61K31/4375 , A61K31/4545 , A61K31/496 , A61K31/513 , A61K31/5377 , A61K45/06 , A61P9/04 , C07D519/00
摘要： The present application relates to positive allosteric modulators of the muscarinic M2 receptor, especially to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of cardiovascular disorders and/or renal disorders.
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公开(公告)号：US20180256576A1
公开(公告)日：2018-09-13
申请号：US15912185
申请日：2018-03-05
发明人： Chantal FÜRSTNER , Jens ACKERSTAFF , Alexander STRAUB , Heinrich MEIER , Hanna TINEL , Katja ZIMMERMANN , Adrian TERSTEEGEN , Dmitry ZUBOV , Raimund KAST , Jens SCHAMBERGER , Martina SCHÄFER , Kirsten BÖRNGEN
IPC分类号： A61K31/513 , C07D403/04 , C07D417/14 , A61K31/506 , A61K31/536 , A61K31/538 , A61K45/06 , C07D401/04 , C07D471/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04
CPC分类号： A61K31/513 , A61K31/506 , A61K31/536 , A61K31/538 , A61K45/06 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04
摘要： The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.
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公开(公告)号：US20180251447A1
公开(公告)日：2018-09-06
申请号：US15969222
申请日：2018-05-02
发明人： Marie-Pierre COLLIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FÜRSTNER , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Anja BUCHMÜLLER , Hanna TINEL , Karoline DRÖBNER , Thomas MONDRITZKI , Heiko SCHIRMER , Axel KRETSCHMER , Carsten SCHMECK , Pierre WASNAIRE , Hana CERNECKA
IPC分类号： C07D401/14 , A61K45/06 , A61K31/4439
摘要： The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20170267648A1
公开(公告)日：2017-09-21
申请号：US15611467
申请日：2017-06-01
发明人： Chantal FÜRSTNER , Jens ACKERSTAFF , Alexander STRAUB , Heinrich MEIER , Hanna TINEL , Katja ZIMMERMANN , Dmitry ZUBOV , Jens SCHAMBERGER
IPC分类号： C07D239/557 , C07D403/04 , C07D403/10 , C07D239/54 , C07D413/04 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/12 , A61K31/513 , A61K9/20 , A61K9/08 , A61K9/00 , C07D417/14 , C07D403/14 , A61K45/06 , C07D403/12 , C07D413/14
CPC分类号： C07D239/557 , A61K9/0053 , A61K9/08 , A61K9/20 , A61K31/513 , A61K45/06 , C07D239/54 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present application relates to novel substituted uracil derivatives, to a method for the production thereof, to the use thereof either alone or in combination for treating and/or preventing diseases, and to the use thereof for producing pharmaceuticals for the treatment and/or prevention of diseases.
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公开(公告)号：US20160304491A1
公开(公告)日：2016-10-20
申请号：US15106283
申请日：2014-12-16
发明人： Eva Maria BECKER-PELSTER , Philipp BUCHGRABER , Anja BUCHMÜLLER , Karen ENGEL , Volker GEISS , Andreas GÖLLER , Herbert HIMMEL , Raimund KAST , Andreas KNORR , Dieter LANG , Gorden REDLICH , Carsten SCHMECK , Hanna TINEL , Frank WUNDER
IPC分类号： C07D401/14 , A61K31/506 , A61K31/4725 , C07D495/10 , C07D491/107 , C07D413/14 , A61K31/5377 , A61K45/06 , A61K31/541
CPC分类号： C07D401/14 , A61K31/4725 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D413/14 , C07D491/107 , C07D495/10
摘要： The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.
摘要翻译： 本申请涉及新的取代的哌啶基四氢喹啉，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/ /或预防糖尿病性微血管病，四肢糖尿病性溃疡，特别是促进糖尿病足溃疡的伤口愈合，糖尿病性心力衰竭，糖尿病性冠状动脉微血管性心脏病，外周和心脏血管疾病，血栓栓塞性疾病和局部缺血，外周循环障碍，雷诺 现象，CREST综合征，微循环障碍，间歇性跛行，外周和自主神经病变。
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公开(公告)号：US20160297771A1
公开(公告)日：2016-10-13
申请号：US15034499
申请日：2014-11-05
发明人： Chantal FÜRSTNER , Jens ACKERSTAFF , Alexander STRAUB , Heinrich MEIER , Hanna TINEL , Katja ZIMMERMANN , Adrian TERSTEEGEN , Dmitry ZUBOV , Raimund KAST , Jens SCHAMBERGER , Martina SCHÄFER
IPC分类号： C07D239/557 , C07D413/14 , C07D417/10 , C07D409/06 , C07D403/10 , C07D413/10
CPC分类号： C07D239/557 , A61K31/513 , C07D403/10 , C07D409/06 , C07D413/10 , C07D413/14 , C07D417/10
摘要： The present application relates to novel substituted uracil derivatives of formula (I), to a method for the production thereof, to the use thereof either alone or in combination for treating and/or preventing diseases, and to the use thereof for producing pharmaceuticals for the treatment and/or prevention of diseases.
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