公开(公告)号：US20100158930A1

公开(公告)日：2010-06-24

申请号：US12446382

申请日：2007-10-19

Applicant: Bing Zhu ,  Shifang Yang ,  Junsheng Cui

Inventor： Bing Zhu ,  Shifang Yang ,  Junsheng Cui

IPC: A61K39/00 ,  C07H21/00 ,  A61P37/04 ,  A61P31/12 ,  A61P31/14

CPC classification number: A61K39/12 ,  A61K2039/585 ,  A61K2039/6031 ,  C07K14/005 ,  C07K14/4725 ,  C07K2319/00 ,  C12N7/00 ,  C12N2710/20022 ,  C12N2710/20034

Abstract: The present invention provides a fusion protein comprising an immunostimulatory polypeptide and a mutant E7 protein of a human papilloma virus. The present invention also provides a gene encoding the fusion protein, expression vectors containing the gene, a pharmaceutical composition comprising the fusion protein, a method for treating or preventing a human papilloma virus related disease by using the fusion protein and uses of the fusion protein in the preparation of a medicament for the treatment or prevention of the human papilloma virus related disease.

Abstract translation: 本发明提供了包含免疫刺激多肽和人乳头瘤病毒的突变E7蛋白的融合蛋白。 本发明还提供了编码融合蛋白的基因，含有该基因的表达载体，包含该融合蛋白的药物组合物，通过使用融合蛋白治疗或预防人乳头状瘤病毒相关疾病的方法以及融合蛋白的用途 制备用于治疗或预防人乳头状瘤病毒相关疾病的药物。

公开(公告)号：US07725171B1

公开(公告)日：2010-05-25

申请号：US11848606

申请日：2007-08-31

Applicant: Bing Zhu ,  Jay Snell ,  Laleh Jalali ,  Katie Hoberman ,  Elizabeth Bacon

Inventor： Bing Zhu ,  Jay Snell ,  Laleh Jalali ,  Katie Hoberman ,  Elizabeth Bacon

IPC: A61B5/04

CPC classification number: A61B5/0452 ,  A61N1/365

Abstract: A method and system are provided for tracking ST shift data. The system includes an implantable medical device having an input configured to receive cardiac signals. Each cardiac signal has an associated heart rate and includes a segment of interest. The implantable medical device further includes a processor configured to determine segment variations of the segment of interest in the cardiac signals. The processor determines a heart rate associated with each of the segment variations with each heart rate falling within a corresponding heart rate range. The implantable medical device also includes a memory configured to store a group of histograms for a corresponding group of heart rate ranges. The histograms store distributions for the segment variations within corresponding heart rate ranges.

Abstract translation: 提供了一种跟踪ST移位数据的方法和系统。 该系统包括具有被配置为接收心脏信号的输入的可植入医疗装置。 每个心脏信号具有相关的心率并且包括感兴趣的部分。 可植入医疗装置还包括被配置为确定心脏信号中感兴趣区段的区段变化的处理器。 每个心率落在对应的心率范围内，处理器确定与每个区段变化相关联的心率。 可植入医疗装置还包括被配置为存储用于相应心率范围组的一组直方图的存储器。 直方图存储在相应的心率范围内的段变化的分布。

公开(公告)号：US20080280821A1

公开(公告)日：2008-11-13

申请号：US10577535

申请日：2003-11-03

Applicant: Bing Zhu

Inventor： Bing Zhu

IPC: A61K38/16 ,  C07K14/00 ,  C07H21/00 ,  A61P35/00 ,  C12N15/63 ,  C12N1/00

CPC classification number: C07K14/4703 ,  A61K38/00 ,  C07K14/70575

Abstract: The present invention discloses a recombinant protein having an anti-cancer effect, its encoding gene and uses thereof. The recombinant protein having an anti-cancer effect provided by the present invention is one selected from the group consisting of: 1) a protein having the amino acid sequence of SEQ ID No:2 shown in the sequence listing; 2) a protein derived from SEQ ID No:2, which has a sequence homology of more than 90% with SEQ ID No:2 and which has the same activity as that of SEQ ID No:2; 3) a protein derived from SEQ ID No:2, which is obtained by adding or deleting 15 or less amino acid residues at the N-terminus of the amino acid sequence of SEQ ID No:2, and which has the same activity as that of SEQ ID No:2; 4) a protein derived from SEQ ID No:2, which is obtained by adding or deleting 15 or less amino acid residues at the C-terminus of the amino acid sequence of SEQ ID No:2, and which has the same activity as that of SEQ ID No:2; 5) a protein derived from SEQ ID No:2, which is obtained by substitution, deletion, or addition of one or several amino acid residues in the amino acid sequence of SEQ ID No:2, and which has the same activity as that of SEQ ID No:2. The medicament containing above recombinant protein as active component has significant selective inhibitory effect on tumor cells, and does not induce apoptosis of normal tissue cells, and has important applicable value.

Abstract translation: 本发明公开了具有抗癌作用的重组蛋白，其编码基因及其用途。 本发明提供的具有抗癌效果的重组蛋白质选自：1）具有序列表所示的SEQ ID No：2的氨基酸序列的蛋白质; 2）衍生自SEQ ID No：2的蛋白质，其与SEQ ID No：2具有大于90％的序列同源性，并且具有与SEQ ID No：2具有相同的活性; 3）衍生自SEQ ID No：2的蛋白质，其通过在SEQ ID No：2的氨基酸序列的N末端添加或缺失15个或更少的氨基酸残基而获得，并且具有与该序列具有相同的活性 SEQ ID No：2; 4）衍生自SEQ ID No：2的蛋白质，其通过在SEQ ID No：2的氨基酸序列的C末端添加或缺失15个或更少的氨基酸残基获得，并且具有与SEQ ID No：2具有相同的活性 SEQ ID No：2; 5）衍生自SEQ ID No：2的蛋白质，其通过在SEQ ID No：2的氨基酸序列中的一个或几个氨基酸残基的取代，缺失或添加获得，并且具有与 SEQ ID No：2。 含有上述重组蛋白作为活性成分的药物对肿瘤细胞具有显着的选择性抑制作用，不诱导正常组织细胞凋亡，具有重要的适用价值。

公开(公告)号：US06200771B1

公开(公告)日：2001-03-13

申请号：US09173375

申请日：1998-10-15

Applicant: Li Liu ,  Rifat Pamukcu ,  W. Joseph Thompson ,  Gary A. Piazza ,  Han Li ,  Bing Zhu

Inventor： Li Liu ,  Rifat Pamukcu ,  W. Joseph Thompson ,  Gary A. Piazza ,  Han Li ,  Bing Zhu

IPC: C12Q144

CPC classification number: G01N33/5011 ,  A61K31/00 ,  A61K31/165 ,  A61K31/192 ,  A61K31/365 ,  A61K31/4192 ,  A61K38/00 ,  C12Q1/26 ,  C12Q1/44 ,  G06F19/00 ,  G06Q50/24 ,  Y02A90/22

Abstract: A method for identifying compounds useful for the treatment of neoplasia involves acertaining whether such compounds exhibit an ability to inhibit a PDE that is characterized by cGMP specificity, cooperative kinetic behavior and insensitivity to phosphorylation.

Abstract translation: 用于鉴定可用于治疗瘤形成的化合物的方法涉及是否具有抑制以cGMP特异性，协同动力学行为和对磷酸化不敏感为特征的PDE的能力。

公开(公告)号：US10146570B2

公开(公告)日：2018-12-04

申请号：US15118844

申请日：2015-09-25

Applicant: INTEL CORPORATION ,  Kai Wang ,  Bing Zhu ,  Peng Zou ,  Manohar Castelino

Inventor： Kai Wang ,  Bing Zhu ,  Peng Zou ,  Manohar Castelino

IPC: G06F9/455 ,  G06F9/50

Abstract: Memory security technologies are described. An example processing device includes a processor core and a memory controller coupled to the processor core and a memory. The processor core can determine that an exit condition to transfer control of a resource for a processor core from a first virtual machine monitor (VMM) to a second VMM has occurred. The processor core can also determine whether a control virtual machine control structure (VMCS) link pointer is valid. The processor core can also determine whether a reason value corresponding to the control VMCS link pointer is set. The processor core can also determine whether the reason value is set to zero. The processor core can also determining whether an exception bit corresponding to a specific exception type of a reason value is set. The processor core can also transfer a control of the resource from the first VMM to the second VMM.

公开(公告)号：US09436576B2

公开(公告)日：2016-09-06

申请号：US13993257

申请日：2012-06-29

Applicant: Bing Zhu ,  Peng Zou ,  Madhukar Tallam ,  Luhai Chen ,  Kai Wang

Inventor： Bing Zhu ,  Peng Zou ,  Madhukar Tallam ,  Luhai Chen ,  Kai Wang

IPC: G06F11/00 ,  G06F11/34 ,  G06F11/07

CPC classification number: G06F11/3466 ,  G06F11/0712 ,  G06F11/0778

Abstract: Methods and apparatus are disclosed to capture error conditions in lightweight virtual machine managers. A disclosed example method includes defining a shared memory structure between the VMM and a virtual machine (VM), when the VM is spawned by the VMM, installing an abort handler on the VM associated with a vector value, in response to detecting an error, transferring VMM state information to the shared memory structure, and invoking the abort handler on the VM to transfer contents of the shared memory structure to a non-volatile memory.

Abstract translation: 公开了在轻量级虚拟机管理器中捕获错误状况的方法和装置。 所公开的示例性方法包括当VM由VMM产生时，在VMM与虚拟机（VM）之间定义共享存储器结构，响应于检测到错误，在与向量值相关联的VM上安装中止处理程序， 将VMM状态信息传送到共享存储器结构，并且调用VM上的中止处理程序以将共享存储器结构的内容传送到非易失性存储器。

公开(公告)号：US09144919B2

公开(公告)日：2015-09-29

申请号：US13514780

申请日：2009-12-21

Applicant: Ke Cui ,  Hepeng Zhang ,  Shuo Teng ,  Bing Zhu ,  Juergen Wiker

Inventor： Ke Cui ,  Hepeng Zhang ,  Shuo Teng ,  Bing Zhu ,  Juergen Wiker

IPC: B27C5/10 ,  B25F5/00 ,  B23C1/20

CPC classification number: B27C5/10 ,  B23C1/20 ,  B25F5/003 ,  Y10T409/306608 ,  Y10T409/307952 ,  Y10T409/308176

Abstract: A power tool having a depth adjustment mechanism includes a motor housing, a support base for supporting the motor housing, and a depth adjustment member coupled to the support base and movable between two positions. The depth adjustment member in a first position contacts a surface portion of the motor housing and in a second position is distanced from the surface portion of the motor housing such that the movement of the depth adjustment member from the first position to the second position is in a direction parallel to a plane that is substantially tangent to the surface portion of the motor housing.

Abstract translation: 具有深度调节机构的动力工具包括马达壳体，用于支撑马达壳体的支撑基座以及联接到支撑基座并可在两个位置之间移动的深度调节构件。 第一位置的深度调节构件接触电动机壳体的表面部分，并且在第二位置远离电动机壳体的表面部分，使得深度调节构件从第一位置到第二位置的移动位于 平行于与马达壳体的表面部分基本相切的平面的方向。

公开(公告)号：US20130195575A1

公开(公告)日：2013-08-01

申请号：US13514780

申请日：2009-12-21

Applicant: Ke Cui ,  Hepeng Zhang ,  Shuo Teng ,  Bing Zhu ,  Juergen Wiker

Inventor： Ke Cui ,  Hepeng Zhang ,  Shuo Teng ,  Bing Zhu ,  Juergen Wiker

IPC: B27C5/10

CPC classification number: B27C5/10 ,  B23C1/20 ,  B25F5/003 ,  Y10T409/306608 ,  Y10T409/307952 ,  Y10T409/308176

Abstract: A power tool having a depth adjustment mechanism includes a motor housing, a support base for supporting the motor housing, and a depth adjustment member coupled to the support base and movable between two positions. The depth adjustment member in a first position contacts a surface portion of the motor housing and in a second position is distanced from the surface portion of the motor housing such that the movement of the depth adjustment member from the first position to the second position is in a direction parallel to a plane that is substantially tangent to the surface portion of the motor housing.

Abstract translation: 具有深度调节机构的动力工具包括马达壳体，用于支撑马达壳体的支撑基座以及联接到支撑基座并可在两个位置之间移动的深度调节构件。 第一位置的深度调节构件接触电动机壳体的表面部分，并且在第二位置远离电动机壳体的表面部分，使得深度调节构件从第一位置到第二位置的移动位于 平行于与马达壳体的表面部分基本相切的平面的方向。

公开(公告)号：US07756572B1

公开(公告)日：2010-07-13

申请号：US11740175

申请日：2007-04-25

Applicant: Mohssen Fard ,  Xiaoyi Min ,  Peter Boileau ,  Jong Gill ,  Bing Zhu ,  Jay Snell ,  Laleh Jalali ,  Josh Reiss ,  Gene Bornzin

Inventor： Mohssen Fard ,  Xiaoyi Min ,  Peter Boileau ,  Jong Gill ,  Bing Zhu ,  Jay Snell ,  Laleh Jalali ,  Josh Reiss ,  Gene Bornzin

IPC: A61B5/0468

CPC classification number: A61N1/36585 ,  A61B5/0452 ,  A61B5/0468 ,  A61B5/14532 ,  A61N1/36557

Abstract: Techniques are described for efficiently detecting and distinguishing among cardiac ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. In one example, a preliminary indication of an episode of cardiac ischemia is detected based on shifts in ST segment elevation within the IEGM. In response, the implanted device then records additional IEGM data for transmission to an external system. The external system analyzes the additional IEGM data to confirm the detection of cardiac ischemia using a more sophisticated analysis procedure exploiting additional detection parameters. In particular, the external system uses detection parameters capable of distinguishing hypoglycemia, hyperglycemia and hyperkalemia from cardiac ischemia, such as QTmax and QTend intervals. Alternatively, the more sophisticated analysis procedure may be performed by the device itself, if it is so equipped. Other examples described herein pertain instead to the detection of atrial fibrillation.

Abstract translation: 描述了基于心脏电图（IEGM）信号来有效检测和区分心脏缺血，低血糖或高血糖的技术。 在一个实例中，基于IEGM内的ST段抬高的移动来检测心脏缺血发作的初步指示。 作为响应，植入的装置然后记录附加的IEGM数据以传输到外部系统。 外部系统使用更复杂的分析程序利用额外的检测参数来分析额外的IEGM数据，以确认心脏缺血的检测。 特别地，外部系统使用能够区分低血糖，高血糖和高血钾从心脏缺血的检测参数，例如QTmax和QTend间期。 或者，如果装置如此装备，则可以由装置本身执行更复杂的分析程序。 本文描述的其它实例代替心房颤动的检测。

公开(公告)号：US20050244914A1

公开(公告)日：2005-11-03

申请号：US11176073

申请日：2005-07-07

Applicant: Li Liu ,  Bing Zhu ,  Han Li ,  W. Thompson ,  Rifat Pamukcu ,  Gary Piazza

Inventor： Li Liu ,  Bing Zhu ,  Han Li ,  W. Thompson ,  Rifat Pamukcu ,  Gary Piazza

IPC: A61K31/519 ,  C12Q1/42 ,  C12Q1/44 ,  C12Q1/48 ,  G01N33/574

CPC classification number: C12Q1/44 ,  A61K31/519 ,  C12Q1/485 ,  G01N33/574

Abstract: This invention provides pharmaceutical compositions containing compounds for the treatment of neoplasia in mammals. The phosphodiesterase inhibitory activity of a compound is determined along with COX inhibitory activity. Growth inhibitory and apoptosis inducing effects on cultured tumor cells are also determined. Compounds that exhibit phosphodiesterase inhibiton, growth inhibition and apoptosis induction, but prefereably not substantial prostaglandin inhibitory activity, are desirable for the treatment of neoplasia.

Abstract translation: 本发明提供含有用于治疗哺乳动物瘤形成的化合物的药物组合物。 确定化合物的磷酸二酯酶抑制活性与COX抑制活性。 还测定了对培养的肿瘤细胞的生长抑制和凋亡诱导作用。 表现出磷酸二酯酶抑制，生长抑制和细胞凋亡诱导但优先不是实质性前列腺素抑制活性的化合物对于治疗瘤形成是理想的。