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公开(公告)号：US20240123095A1
公开(公告)日：2024-04-18
申请号：US18469762
申请日：2023-09-19
Applicant: Boston Scientific Scimed, Inc.
Inventor： Yen-Hao Hsu , Joseph Thomas Delaney, JR.
IPC: A61K51/04 , C07D491/18
CPC classification number: A61K51/0446 , C07D491/18
Abstract: In some aspects, the present disclosure pertains to a system for forming a radiopaque product that comprises an iodinated compound comprising one or more diene containing moieties and a multi-arm polymer comprising a plurality of dienophile containing moieties, wherein the diene containing moieties of the iodinated compound couple with the dienophile containing moieties of the multi-arm polymer through a Diels-Alder reaction. Other aspects of the disclosure pertain to crosslinked networks that are formed by combining such an iodinated compound with such a multi-arm polymer, whereupon the diene containing moieties couple with the dienophile containing moieties through a Diels-Alder reaction. Still other aspects of the disclosure pertain to methods of treatment comprising administering to a subject a mixture that comprises such an iodinated compound and such a multi-arm polymer, whereupon the diene containing moieties couple with the dienophile containing moieties by undergoing a Diels-Alder reaction after administration.
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公开(公告)号：US20220249676A1
公开(公告)日：2022-08-11
申请号：US17616576
申请日：2020-05-11
Applicant: Boston Scientific Scimed, Inc.
Inventor： Joseph Thomas Delaney, JR. , Sarah Melissa Gruba , Tatyana Dyndikova , Paul Vincent Grosso , Amanda Maxwell , Ajay Gupta , Andrew J. Ro , Douglas Pennington
Abstract: A chemotherapy agent comprising a chemotherapy group and a ligand secured to the chemotherapy group is disclosed, the ligand comprising a reactive group capable of bonding to a capture substrate. A method of removing chemotherapy agents from a patient is disclosed, the method comprising providing a chemotherapy agent containing a reactive group; providing a capture substrate in contact with a patient's bloodstream; administering the chemotherapy agent to the patient; and sequestering the chemotherapy agent on the capture substrate. A system for removing chemotherapy agents is also disclosed.
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公开(公告)号：US20210170069A1
公开(公告)日：2021-06-10
申请号：US17179971
申请日：2021-02-19
Applicant: Boston Scientific Scimed, Inc.
Inventor： Joseph Thomas Delaney, JR. , Patrick Willoughby , David Robert Wulfman , Andrew J. Ro , Niraj Gurung
Abstract: Aspects herein relate to biocompatible polyisobutylene-fiber composite materials and related methods. In one aspect a biocompatible composite material is included. The biocompatible composite material can include a network of fibers comprising one or more polymers to form a substrate and a continuous polyisobutylene matrix that is non-porous and completely surrounds the electrospun fibers. Other aspects are included herein.
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公开(公告)号：US20210022743A1
公开(公告)日：2021-01-28
申请号：US16935963
申请日：2020-07-22
Applicant: Boston Scientific Scimed, Inc.
Inventor： Joseph Thomas Delaney, JR. , Ajay Gupta , Daniel K. Tomaschko , Tatyana Dyndikova
IPC: A61B17/12 , C08J3/075 , C08J3/24 , A61K31/787
Abstract: A crosslinked embolic hydrogel is disclosed, the crosslinked embolic hydrogel comprising a hydrophilic polymer functionalized with first reactive groups and a crosslinking agent functionalized with second reactive groups; wherein the first and second reacting groups comprise a biorthogonally reactive pair that react to form the crosslinked embolic hydrogel. Methods and systems are also disclosed.
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公开(公告)号：US20190262131A1
公开(公告)日：2019-08-29
申请号：US16413104
申请日：2019-05-15
Applicant: Boston Scientific Scimed, Inc.
Inventor： David Robert Wulfman , Thomas A. Wrobel , Crystal Marie Anderson-Cunanan , Joseph Thomas Delaney, JR. , Patrick Willoughby , Mark W. Boden , Peter G. Edelman , Michael Eppihimer
Abstract: A prosthetic heart valve leaflet includes a plurality of electrospun fibers at least partially embedded in a polymer matrix. The plurality of fibers includes a first polyisobutylene urethane copolymer having a first predetermined weight average percentage of hard segment portions and the polymer matrix includes a second polyisobutylene urethane copolymer having a second predetermined weight average percentage of the hard segment portions, wherein the first predetermined weight average percentage of the hard segment portions is greater than the second predetermined weight average percentage of the hard segment portions.
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Patent Agency Ranking
公开(公告)号：US20250144251A1
公开(公告)日：2025-05-08
申请号：US18938832
申请日：2024-11-06
Applicant: Boston Scientific Scimed, Inc.
Inventor： Rick Dorn , Nicolas Ball-Jones , Joseph Thomas Delaney, JR.
Abstract: In some aspects, the present disclosure provides hydrogels that comprise a crosslinked reaction product of (a) a reactive multi-arm polymer that comprises a plurality of reactive moieties and (b) a multifunctional crosslinking compound which has plurality of complementary reactive moieties that are reactive with the reactive moieties of the reactive multi-arm polymer, the hydrogels comprising hydrolysable moieties as described herein that are dispersed throughout the hydrogels. Other aspects of the present disclosure pertain to reactive multi-arm polymers and multifunctional crosslinking compounds for forming such hydrogels and to crosslinkable systems for forming such hydrolysable hydrogels.
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公开(公告)号：US20250059323A1
公开(公告)日：2025-02-20
申请号：US18939927
申请日：2024-11-07
Applicant: Boston Scientific Scimed Inc.
Inventor： Joseph Thomas Delaney, JR. , Carey Rehder , Tatyana Dyndikova , John Kummailil
Abstract: In some aspects, the present disclosure pertains to multi-arm polymers that comprise a core, a plurality of polymer segments having a first end that is covalently attached to the core and a second end comprising a moiety that comprises a reactive group, wherein the polymer segments comprise one or more free-radical-polymerizable monomers. In some aspects, systems are provided that comprise a first composition comprising such a multi-arm polymer and a second composition comprising a multifunctional compound that comprises functional groups that are reactive with the reactive groups of the multi-arm polymer. In some aspects, systems are provided that comprise crosslinked reaction products of such a multi-arm polymer and such a multifunctional compound.
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公开(公告)号：US20250017956A1
公开(公告)日：2025-01-16
申请号：US18762216
申请日：2024-07-02
Applicant: Boston Scientific Scimed, Inc.
Inventor： Yen-Hao Hsu , Joseph Thomas Delaney, JR. , Rick Dorn , Cristian Parisi , Niraj Gurung , Claire Hobbs
IPC: A61K31/765 , A61K45/06 , C08J3/075 , C08K3/011
Abstract: Disclosed herein are radiopaque, reactive multi-arm polymers that comprise an iodine-containing core region, a plurality of polymer arms comprising a plurality of polymer segments linked to the iodine-containing core region, and a plurality of reactive moieties linked to the plurality of polymer segments. Also disclosed are methods of forming such radiopaque, reactive multi-arm polymers, systems for forming hydrogel compositions that comprise (a) such radiopaque, reactive multi-arm polymers and (b) multifunctional crosslinking compounds comprising a plurality of complementary reactive moieties that are reactive with the reactive moieties of the radiopaque, reactive multi-arm polymers, as well as reaction products of such systems and methods of treatment using such systems.
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公开(公告)号：US20250000954A1
公开(公告)日：2025-01-02
申请号：US18754776
申请日：2024-06-26
Applicant: Boston Scientific Scimed, Inc.
Inventor： Heather Cirka , Yen-Hao Hsu , Marc Plourde , Joseph Thomas Delaney, JR. , Cristian Parisi
Abstract: Systems for hydrogel hydrolysis as well as methods for hydrogel hydrolysis are disclosed. An example system may include a syringe barrel having a needle connector disposed thereon. A hydrogel hydrolysis material may be disposed in the syringe barrel. The hydrogel hydrolysis material may be configured to be injected into a hydrogel formed in the body of a patient in order to accelerate the hydrolysis of the hydrogel.
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公开(公告)号：US20240293572A1
公开(公告)日：2024-09-05
申请号：US18590582
申请日：2024-02-28
Applicant: Boston Scientific Scimed, Inc.
Inventor： Yen-Hao Hsu , Cristian Parisi , Joseph Thomas Delaney, JR.
CPC classification number: A61K47/6903 , A61K47/61 , A61K47/64
Abstract: In some aspects, the present disclosure provides therapeutic-agent-releasing polyamino compounds that comprise a polyamino moiety that is covalently linked to a residue of a hydroxyl-substituted therapeutic agent by an ester bond. In various embodiments, such therapeutic-agent-releasing polyamino compounds are used to form therapeutic-agent-releasing hydrogels. In other aspects, the present disclosure provides therapeutic-agent-releasing polysaccharides that comprise a plurality of hydroxyl-substituted therapeutic agent residues that are covalently linked to a carboxylic-acid-containing polysaccharide along a backbone of the carboxylic-acid-containing polysaccharide.
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