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    METHODS OF FORMING RADIOPAQUE PEPTIDES AND MEDICAL HYDROGELS FORMED THEREFROM
    2.
    发明申请
    METHODS OF FORMING RADIOPAQUE PEPTIDES AND MEDICAL HYDROGELS FORMED THEREFROM 有权

    公开(公告)号：US20250059237A1

    公开(公告)日：2025-02-20

    申请号：US18804679

    申请日：2024-08-14

    Applicant: Boston Scientific Scimed, Inc.

    Inventor： Joseph Thomas Delaney, JR. ,  Rick Dorn ,  Yen-Hao Hsu ,  Cristian Parisi

    IPC: C07K14/00 ,  C07K1/06 ,  C07K1/10 ,  C07K1/107

    Abstract: In various aspects, the present disclosure pertains to methods of forming an iodinated peptide compound that comprises: (a) forming a multifunctional precursor compound comprising (i) a residue of an amine-protected peptide that comprises two or more amino acid residues with primary-amine-containing side groups and (ii) a multifunctional moiety linked to the amine-protected peptide residue through an amide group or an ester group; (b) reacting the multifunctional precursor compound in an amide coupling reaction or an esterification coupling reaction with an iodinated compound to form an iodinated, amine-protected peptide compound comprising n iodinated moieties that are covalently attached to the amine-protected peptide residue through a residue of the multifunctional moiety; and (c) deprotecting the iodinated, amine-protected peptide compound to form the iodinated peptide compound.

    CATALYST-FREE RADIOPAQUE MEDICAL HYDROGELS AND SYSTEMS FOR FORMING SAME
    3.
    发明公开
    CATALYST-FREE RADIOPAQUE MEDICAL HYDROGELS AND SYSTEMS FOR FORMING SAME 审中-公开

    公开(公告)号：US20240316220A1

    公开(公告)日：2024-09-26

    申请号：US18614277

    申请日：2024-03-22

    Applicant: Boston Scientific Scimed, Inc.

    Inventor： Yen-Hao Hsu ,  Joseph Thomas Delaney, JR. ,  Cristian Parisi

    IPC: A61K49/04 ,  A61K49/00 ,  A61M5/19

    CPC classification number: A61K49/0442 ,  A61K49/0073 ,  A61K49/0438 ,  A61M5/19

    Abstract: In some aspects, the present disclosure pertains to systems for forming a crosslinked polymer composition, the systems comprising (a) an iodinated multifunctional compound comprising either a plurality of electron-rich dienophile-containing moieties or a plurality of electron-poor diene-containing moieties and (b) a multifunctional multi-arm polymer comprising either a plurality of electron-poor diene-containing moieties in the case where the iodinated multifunctional compound comprises a plurality of electron-rich dienophile-containing moieties or a plurality of electron-rich dienophile-containing moieties in the case where the iodinated multifunctional compound comprises a plurality of electron-poor diene-containing moieties, wherein the crosslinked polymer composition is formed by a cycloaddition reaction occurring between the iodinated multifunctional compound and the multifunctional multi-arm polymer. Other aspects of the present disclosure pertain to crosslinked networks formed by such systems and to methods of treatment using such systems.

    RADIOPAQUE POLYSACCHARIDE HYDROGELS AND METHODS OF MAKING THE SAME
    5.
    发明公开
    RADIOPAQUE POLYSACCHARIDE HYDROGELS AND METHODS OF MAKING THE SAME 审中-公开

    公开(公告)号：US20240335568A1

    公开(公告)日：2024-10-10

    申请号：US18627837

    申请日：2024-04-05

    Applicant: Boston Scientific Scimed, Inc.

    Inventor： Yen-Hao Hsu ,  Joseph Thomas Delaney, JR. ,  Cristian Parisi ,  Heather Cirka ,  Alexis Compton

    IPC: A61K49/04

    CPC classification number: A61K49/0438 ,  A61K49/0457 ,  A61K49/0495

    Abstract: In some aspects, the present disclosure pertains to radiopaque hydrogel compositions that comprise a radiopaque polysaccharide that comprises a plurality of radiopaque moieties that are covalently linked to a carboxylic-acid-containing polysaccharide along a backbone of the carboxylic-acid-containing polysaccharide. In some aspects, the present disclosure pertains to radiopaque hydrogel compositions that comprise a carboxylate-anion-containing polysaccharide that is ionically crosslinked by multivalent cations. In other aspects, the present disclosure pertains to kits that contain such radiopaque hydrogel compositions, to methods of treatment that comprise administering such radiopaque hydrogel compositions to patients, and to methods of making such radiopaque hydrogel compositions.

    SYNTHETIC METHODS PERTAINING TO TERT-BUTYL-BENZENE-BASED COMPOUNDS
    8.
    发明申请
    SYNTHETIC METHODS PERTAINING TO TERT-BUTYL-BENZENE-BASED COMPOUNDS 审中-公开
    对叔丁基苯基化合物的合成方法

    公开(公告)号：US20130190525A1

    公开(公告)日：2013-07-25

    申请号：US13748046

    申请日：2013-01-23

    Applicant: Boston Scientific Scimed, Inc.

    Inventor： Joseph Thomas Delaney, JR. ,  Kasyap Seethamraju ,  Paul Vincent Grosso

    IPC: C07C41/01 ,  C07C67/08

    CPC classification number: C07C41/01 ,  C07C41/16 ,  C07C67/08 ,  C07C43/164 ,  C07C69/76

    Abstract: According to some aspects, the present disclosure pertains to methods of forming dimethyl 5-tert-butylisophthalate which comprise comprising converting 5-tert-butylisophthalic acid into dimethyl 5-tert-butylisophthalate in synthesis procedures that comprises methanol and a dehydrating agent as chemical reagents. In other aspects, the present disclosure pertains to methods of forming 5-tert-butyl-1,3-bis(1-methoxy-1-methylethyl)benzene that comprise deprotonating 5-tert-butyl-1,3-bis(1-hydroxy-1-methylethyl)benzene with a Brønsted-Lowry superbase and methylating the deprotonated 5-tert-butyl-1,3-bis(1-hydroxy-1-methylethyl)benzene to form the 5-tert-butyl-1,3-bis(1-methoxy-1-methylethyl)benzene.

    Abstract translation: 根据一些方面，本公开涉及形成5-叔丁基间苯二甲酸二甲酯的方法，其包括在包含甲醇和脱水剂作为化学试剂的合成方法中将5-叔丁基间苯二甲酸转化为5-叔丁基间苯二甲酸二甲酯。 在其它方面，本公开涉及形成5-叔丁基-1,3-双（1-甲氧基-1-甲基乙基）苯的方法，其包括将5-叔丁基-1,3-双（1- 羟基-1-甲基乙基）苯与Brnnsted-Lowry超级碱基进行甲基化，将去质子化的5-叔丁基-1,3-双（1-羟基-1-甲基乙基）苯甲基化，形成5-叔丁基-1,3 - 双（1-甲氧基-1-甲基乙基）苯。

    REACTIVE POLYMERS AND HYDROGELS FORMED FROM THE SAME
    10.
    发明申请
    REACTIVE POLYMERS AND HYDROGELS FORMED FROM THE SAME 有权

    公开(公告)号：US20250032408A1

    公开(公告)日：2025-01-30

    申请号：US18781571

    申请日：2024-07-23

    Applicant: Boston Scientific Scimed, Inc.

    Inventor： Joseph Thomas Delaney, JR. ,  Cristian Parisi ,  Yen-Hao Hsu ,  Rick Dorn

    IPC: A61K9/06 ,  A61K47/34 ,  A61L27/52 ,  C08G65/332 ,  C08G65/333

    Abstract: In some aspects, the present disclosure provides reactive polymers that comprise one or more hydrophilic polymer segments having a plurality of hydrophilic polymer segment ends and a plurality of reactive moieties covalently linked to at least a portion of the hydrophilic polymer segment ends. The reactive moieties are 3,4-substituted-2,5-pyrrolidinedione moieties in which the 3-carbon and the 4-carbon form part of at least one ring in addition to the 2,5-pyrrolidinedione ring, and the 2,5-pyrrolidinedione ring nitrogen atom of each of the 3,4-substituted-2,5-pyrrolidinedione moieties is linked to one of the hydrophilic polymer segment ends. In other aspects, the present disclosure provides systems for forming hydrogel compositions and methods of treatment that employ such reactive polymers and methods of synthesizing such reactive polymers.

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