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公开(公告)号：US12016969B2
公开(公告)日：2024-06-25
申请号：US17165485
申请日：2021-02-02
Applicant: Boston Scientific Scimed, Inc.
Inventor： Joseph T. Delaney, Jr. , Mark W. Boden , John Murphy , Viktoria Molnar , Tatyana Dyndikova , Allison Zipp , Kolbein K Kolste
CPC classification number: A61L27/16 , A61L27/18 , A61L27/3839 , A61L27/50
Abstract: Described herein are injectable in vivo crosslinking materials for use as soft tissue filler comprising (a) a reactive multi-arm polymer that comprises a plurality of hydrophilic polymeric arms, at least a portion of the hydrophilic polymeric arms comprising one or more reactive end groups and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end groups of the reactive multi-arm polymer. Also described herein are systems and methods that are based on such materials.
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公开(公告)号：US20240076266A1
公开(公告)日：2024-03-07
申请号：US18451579
申请日：2023-08-17
Applicant: Boston Scientific Scimed, Inc.
Inventor： Joseph Thomas Delaney, JR. , Yen-Hao Hsu , Tatyana Dyndikova
IPC: C07C273/18
CPC classification number: C07C273/1872
Abstract: In various aspects, the present disclosure pertains to systems for forming hydrogels that comprise an iodinated polyamino compound and a reactive multi-arm polymer that comprises a plurality of hydrophilic polymer arms having reactive end groups that are reactive with amino groups of the iodinated polyamino compound. Other aspects of the present disclosure pertain to medical hydrogels that are formed by crosslinking the iodinated polyamino compound and the reactive multi-arm polymer of such systems. Further aspects of the present disclosure pertain to medical procedures that can be performed using such systems. Still other aspects of the present disclosure pertain to methods of making iodinated polyamino compounds.
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Patent Agency Ranking
公开(公告)号：US11807720B2
公开(公告)日：2023-11-07
申请号：US16999787
申请日：2020-08-21
Applicant: Boston Scientific Scimed Inc.
Inventor： Joseph T. Delaney, Jr. , Paul V. Grosso , John Kummailil , Tatyana Dyndikova , Carey Rehder
CPC classification number: C08G73/0233 , C08J3/24 , A61L27/52
Abstract: In some aspects, the present disclosure pertains to a multi-arm polymer comprising a core and a plurality of polyoxazoline segments (or arms) having a first end that is covalently attached to the core and a second end comprising a moiety that comprises a reactive group. In some aspects, systems are provided that comprise a first composition comprising such a multi-arm polymer and a second composition comprising a multifunctional compound that comprises functional groups that are reactive with the reactive groups of the multi-arm polymer. In some aspects, systems are provided that comprise crosslinked reaction products of such a multi-arm polymer and such a multifunctional compound.
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公开(公告)号：US20230241295A1
公开(公告)日：2023-08-03
申请号：US18103932
申请日：2023-01-31
Applicant: Boston Scientific Scimed, Inc.
Inventor： Joseph Thomas Delaney, JR. , Yen-Hao Hsu , Tatyana Dyndikova
IPC: A61L31/14 , A61L31/04 , A61M5/19 , C07C233/66
CPC classification number: A61L31/145 , A61L31/041 , A61M5/19 , C07C233/66
Abstract: In some aspects, the present disclosure pertains to systems for forming hydrogels that comprise (a) a first composition that comprises a polyiodinated polyamino compound that comprises a polyamino moiety linked to a polyiodinated aromatic moiety by an amide group or ester group and (b) a second composition that comprises a reactive multi-arm polymer that comprises a plurality of hydrophilic polymer arms having reactive end groups that are reactive with amino groups of the polyiodinated polyamino compound. Other aspects of the present disclosure pertain to medical hydrogels and methods of making medical hydrogels that are based on such compositions. Further aspects of the present disclosure pertain to methods of making polyiodinated polyamino compounds.
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公开(公告)号：US20220204655A1
公开(公告)日：2022-06-30
申请号：US17556408
申请日：2021-12-20
Applicant: Boston Scientific Scimed, Inc.
Inventor： Joseph T. Delaney, JR. , Kolbein Kolste , Tatyana Dyndikova
Abstract: The present disclosure pertains to iodinated polysaccharide compounds that comprise a polysaccharide backbone that comprises a plurality of carboxyl groups and a plurality of iodinated side groups. The present disclosure also pertains iodinated polysaccharide compounds in which at least a portion of carboxyl groups that are present in a carboxyl-containing polysaccharide chain are functionalized with a plurality of iodinated side groups. Other aspects of the present disclosure pertain to methods of forming iodinated polysaccharide compounds, medical compositions comprising iodinated polysaccharide compounds, medical procedures comprising introducing such medical compositions into or between tissue of a patient, and medical kits that comprise such medical compositions.
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公开(公告)号：US20210236690A1
公开(公告)日：2021-08-05
申请号：US17165485
申请日：2021-02-02
Applicant: Boston Scientific Scimed, Inc.
Inventor： Joseph T. Delaney, Jr. , Mark W. Boden , John Murphy , Viktoria Molnar , Tatyana Dyndikova , Allison Zipp , Kolbein K Kolste
Abstract: Described herein are injectable in vivo crosslinking materials for use as soft tissue filler comprising (a) a reactive multi-arm polymer that comprises a plurality of hydrophilic polymeric arms, at least a portion of the hydrophilic polymeric arms comprising one or more reactive end groups and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end groups of the reactive multi-arm polymer. Also described herein are systems and methods that are based on such materials.
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公开(公告)号：US20210061950A1
公开(公告)日：2021-03-04
申请号：US16999809
申请日：2020-08-21
Applicant: Boston Scientific Scimed Inc.
Inventor： Joseph T. Delaney, Jr. , Carey Rehder , Tatyana Dyndikova , John Kummailil
Abstract: In some aspects, the present disclosure pertains to multi-arm polymers that comprise a core, a plurality of polymer segments having a first end that is covalently attached to the core and a second end comprising a moiety that comprises a reactive group, wherein the polymer segments comprise one or more free-radical-polymerizable monomers. In some aspects, systems are provided that comprise a first composition comprising such a multi-arm polymer and a second composition comprising a multifunctional compound that comprises functional groups that are reactive with the reactive groups of the multi-arm polymer. In some aspects, systems are provided that comprise crosslinked reaction products of such a multi-arm polymer and such a multifunctional compound.
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