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21.发明申请Methods For The Preparation of Lysine By Fermentation Of Corynebacterium Glutamicum 有权通过发酵谷氨酸棒杆菌制备赖氨酸的方法公开(公告)号：US20100015674A1
公开(公告)日：2010-01-21
申请号：US12533677
申请日：2009-07-31
申请人： Oskar Zelder , Corinna Klopprogge , Hartwig Schroder , Stefan Häfner , Burkhard Kröger , Patrick Kiefer , Elmar Heinzle , Christoph Wittmann
发明人： Oskar Zelder , Corinna Klopprogge , Hartwig Schroder , Stefan Häfner , Burkhard Kröger , Patrick Kiefer , Elmar Heinzle , Christoph Wittmann
IPC分类号： C12P13/08
摘要： The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.
摘要翻译： 本发明的特征在于通过使酶编码基因（即果糖-1,6-二磷酸酶）失调来增加精细化学品例如来自微生物例如棒状杆菌的赖氨酸的生产方法。 在优选的实施方案中，本发明提供了通过增加果糖-1,6-二磷酸酶活性的表达来增加谷氨酸棒杆菌中赖氨酸的产生的方法。 本发明还提供了通过调节向草酰乙酸（OAA）的碳通量来生产赖氨酸的新方法。 在优选的实施方案中，本发明提供了通过使用果糖或蔗糖作为碳源来生产赖氨酸的方法。
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22.发明授权Method for the production by fermentation of sulphur-containing fine chemicals (metF) 有权含硫精细化学品（metF）发酵生产方法公开(公告)号：US07282357B2
公开(公告)日：2007-10-16
申请号：US10525907
申请日：2003-08-26
摘要： The invention relates to methods for the fermentative production of sulfur-containing fine chemicals, in particular L-methionine, by using bacteria which express a nucleotide sequence coding for a methionine synthase (metF) gene.
摘要翻译： 本发明涉及通过使用表达编码甲硫氨酸合成酶（metF）基因的核苷酸序列的细菌来发酵生产含硫精细化学物质，特别是L-甲硫氨酸的方法。
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23.发明授权公开(公告)号：US07238502B2
公开(公告)日：2007-07-03
申请号：US10525674
申请日：2003-08-26
摘要： The invention relates to methods for the fermentative production of sulfur-containing fine chemicals, in particular L-methionine, by using bacteria which express a nucleotide sequence coding for a methionine synthase (metA) gene.
摘要翻译： 本发明涉及通过使用表达编码甲硫氨酸合成酶（metA）基因的核苷酸序列的细菌来发酵生产含硫精细化学品，特别是L-甲硫氨酸的方法。
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24.发明授权公开(公告)号：US08048651B2
公开(公告)日：2011-11-01
申请号：US12533677
申请日：2009-07-31
申请人： Oskar Zelder , Corinna Klopprogge , Hartwig Schroder , Stefan Haefner , Burkhard Kröger , Patrick Kiefer , Elmar Heinzle , Christoph Wittmann
发明人： Oskar Zelder , Corinna Klopprogge , Hartwig Schroder , Stefan Haefner , Burkhard Kröger , Patrick Kiefer , Elmar Heinzle , Christoph Wittmann
IPC分类号： C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P23/00 , C12N9/16 , C12N15/70 , C12N1/20 , C12N15/74 , C07H21/04
摘要： The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.
摘要翻译： 本发明的特征在于通过使酶编码基因（即果糖-1,6-二磷酸酶）失调来增加精细化学品例如来自微生物例如棒状杆菌的赖氨酸的生产方法。 在优选的实施方案中，本发明提供了通过增加果糖-1,6-二磷酸酶活性的表达来增加谷氨酸棒杆菌中赖氨酸的产生的方法。 本发明还提供了通过调节向草酰乙酸（OAA）的碳通量来生产赖氨酸的新方法。 在优选的实施方案中，本发明提供了通过使用果糖或蔗糖作为碳源来生产赖氨酸的方法。
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25.发明授权Method for producing methionine using a microorganism with reduced expression activity of a negative regulator of methionine biosynthesis 有权使用具有降低甲硫氨酸生物合成负调节子的表达活性的微生物生产甲硫氨酸的方法公开(公告)号：US08389251B2
公开(公告)日：2013-03-05
申请号：US13018119
申请日：2011-01-31
申请人： Markus Pompejus , Burkhard Kröger , Hartwig Schröder , Oskar Zelder , Gregor Haberhauer , Stefan Haefner , Corrinna Klopprogge
发明人： Markus Pompejus , Burkhard Kröger , Hartwig Schröder , Oskar Zelder , Gregor Haberhauer , Stefan Haefner , Corrinna Klopprogge
CPC分类号： C07K14/34
摘要： Isolated nucleic acid molecules, designated MR nucleic acid molecules, which encode novel MR proteins from Corynebacterium glutamicum are described which are involved in biosynthesis of a fine chemical, e.g., methionine biosynthesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MR nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides methods of producing methionine from microorganisms, e.g., C. glutamicum, which involve culturing recombinant microorganisms which overexpress or underexpress at least one MR molecule of the invention under conditions such that methionine is produced. Also featured are methods of producing a fine chemical, e.g., methionine, which involve culturing recombinant microorganisms having selected MR genes deleted or mutated under conditions such that the fine chemical, e.g., methionine, is produced.
摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型MR蛋白质的分离的核酸分子，称为MR核酸分子，其涉及精细化学品的生物合成，例如甲硫氨酸生物合成。 本发明还提供反义核酸分子，含有MR核酸分子的重组表达载体和已经引入表达载体的宿主细胞。 本发明还提供了从微生物例如谷氨酸棒杆菌制备甲硫氨酸的方法，其涉及在产生甲硫氨酸的条件下培养过表达或低表达本发明的至少一种MR分子的重组微生物。 还特征在于生产精细化学品的方法，例如甲硫氨酸，其涉及在产生精细化学物质例如甲硫氨酸的条件下培养具有选择的MR基因缺失或突变的重组微生物。
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26.发明授权公开(公告)号：US07410766B2
公开(公告)日：2008-08-12
申请号：US11506167
申请日：2006-08-17
CPC分类号： C12N9/1205 , C07K14/34 , C12N9/00 , C12N9/1223 , C12P1/04 , C12P13/04 , C12R1/15 , C12Y207/01069
摘要： Isolated nucleic acid molecules, designated PTS nucleic acid molecules, which encode novel PTS proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated PTS proteins, mutated PTS proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of PTS genes in this organism.
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27.发明授权Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport 有权编码参与膜合成和膜转运的蛋白质的谷氨酸棒杆菌基因公开(公告)号：US06696561B1
公开(公告)日：2004-02-24
申请号：US09602787
申请日：2000-06-23
IPC分类号： C12N1531
CPC分类号： C12Q1/689 , C07K14/34 , C12N9/00 , C12N9/18 , G01N33/56911
摘要： Isolated nucleic acid molecules, designated MCT nucleic acid molecules, which encode novel MCT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MCT proteins, mutated MCT proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MCT genes in this organism.
摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型MCT蛋白质的分离的核酸分子，命名为MCT核酸分子。 本发明还提供反义核酸分子，含有MCT核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 本发明还进一步提供了分离的MCT蛋白，突变的MCT蛋白，融合蛋白，抗原肽和基于该生物体中MCT基因的遗传工程改进从谷氨酸棒球菌生产所需化合物的方法。
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28.发明授权Corynebacterium glutamicum genes encoding proteins involved in homeostasis and adaptation 有权编码参与体内平衡和适应的蛋白质的谷氨酸棒杆菌基因公开(公告)号：US06831165B1
公开(公告)日：2004-12-14
申请号：US09602777
申请日：2000-06-23
IPC分类号： C07H2104
摘要： Isolated nucleic acid molecules, designated HA nucleic acid molecules, which encode novel HA proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HA nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated HA proteins, mutated HA proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of HA genes in this organism.
摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型HA蛋白质的分离的核酸分子，命名为HA核酸分子。 本发明还提供反义核酸分子，含有HA核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 本发明还进一步提供分离的HA蛋白，突变的HA蛋白，融合蛋白，抗原肽以及用于基于该生物体中HA基因的遗传工程改进谷氨酸棒球菌产生所需化合物的方法。
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29.发明授权Polynucleotides encoding a 6-phosphogluconolactonase polypeptide from corynebacterium glutamicum 有权编码来自谷氨酸棒杆菌的6-磷酸葡萄糖聚糖酶多肽的多核苷酸公开(公告)号：US07270984B1
公开(公告)日：2007-09-18
申请号：US09602740
申请日：2000-06-23
CPC分类号： C12N9/18 , C07K14/34 , C07K2319/00 , C12N9/00 , C12N9/90 , C12P7/18 , C12P7/40 , C12P7/6409 , C12P7/6427 , C12P7/6463 , C12P7/6472 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12P13/222 , C12P13/225 , C12P13/227 , C12P13/24 , C12P19/00 , C12P19/34 , C12Y301/01031
摘要： Isolated nucleic acid molecules, designated sugar metabolism and oxidative phosphorylation (SMP) nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum, are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SMP proteins, mutated SMP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SMP genes in this organism.
摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型SMP蛋白质的分离的核酸分子，称为糖代谢和氧化磷酸化（SMP）核酸分子。 本发明还提供了反义核酸分子，含有SMP核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 本发明还基于该生物体中的SMP基因的遗传工程，进一步提供了分离的SMP蛋白，突变的SMP蛋白，融合蛋白，抗原肽和用于从谷氨酸棒球菌（C.GM）生产所需化合物的方法。
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30.发明申请CORYNEBACTERIUM GLUTAMICUM GENES ENCODING REGULATORY PROTEINS INVOLVED IN THE PRODUCTION OF METHIONINE 有权CORYNEBACTERIUM GLUTAMICUM GENES编码参与甲磺酸生产的法规蛋白质公开(公告)号：US20110229937A1
公开(公告)日：2011-09-22
申请号：US13018119
申请日：2011-01-31
申请人： Markus Pompejus , Burkhard Kröger , Hartwig Schröder , Oskar Zelder , Gregor Haberhauer , Stefan Haefner , Corrinna Klopprogge
发明人： Markus Pompejus , Burkhard Kröger , Hartwig Schröder , Oskar Zelder , Gregor Haberhauer , Stefan Haefner , Corrinna Klopprogge
CPC分类号： C07K14/34
摘要： Isolated nucleic acid molecules, designated MR nucleic acid molecules, which encode novel MR proteins from Corynebacterium glutamicum are described which are involved in biosynthesis of a fine chemical, e.g., methionine biosynthesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MR nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides methods of producing methionine from microorganisms, e.g., C. glutamicum, which involve culturing recombinant microorganisms which overexpress or underexpress at least one MR molecule of the invention under conditions such that methionine is produced. Also featured are methods of producing a fine chemical, e.g., methionine, which involve culturing recombinant microorganisms having selected MR genes deleted or mutated under conditions such that the fine chemical, e.g., methionine, is produced.
摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型MR蛋白质的分离的核酸分子，称为MR核酸分子，其涉及精细化学品的生物合成，例如甲硫氨酸生物合成。 本发明还提供反义核酸分子，含有MR核酸分子的重组表达载体和已经引入表达载体的宿主细胞。 本发明还提供了从微生物例如谷氨酸棒杆菌制备甲硫氨酸的方法，其涉及在产生甲硫氨酸的条件下培养过表达或低表达本发明的至少一种MR分子的重组微生物。 还特征在于生产精细化学品的方法，例如甲硫氨酸，其涉及在产生精细化学物质例如甲硫氨酸的条件下培养具有选择的MR基因缺失或突变的重组微生物。
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