公开(公告)号：US20170057908A1

公开(公告)日：2017-03-02

申请号：US15229026

申请日：2016-08-04

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Simon C. JONES ,  Victoria K. DAVIS ,  Christopher M. BATES ,  Nebojsa MOMCILOVIC ,  Brett M. SAVOIE ,  Michael A. WEBB ,  Thomas F. MILLER, III ,  Robert H. GRUBBS ,  Jennifer M. MURPHY

IPC: C07C209/68

CPC classification number: H01M10/0568 ,  C07C209/68 ,  H01M10/0525 ,  H01M10/054 ,  H01M10/0569 ,  H01M2300/0025

Abstract: Processes and reaction mixtures including non-aqueous solvent mixtures are presented. Non-aqueous solvent mixtures including fluoride salt and non-aqueous solvent combinations are provided that possess high fluoride ion concentrations useful for a range of applications, including organic synthesis. Further non-aqueous solvent mixtures are provided including a salt possessing a non-fluoride anion and a non-aqueous solvent that, when contacted with aqueous fluoride-containing reagents, extract fluoride ions to form non-aqueous fluoride-ion solutions possessing high fluoride-ion concentrations. The salts include an organic cation that does not possess a carbon in the β-position or does not possess a carbon in the β-position having a bound hydrogen. This salt structure facilitates its ability to be made anhydrous without decomposition. Example anhydrous fluoride salts include (2,2-dimethylpropyl)trimethylammonium fluoride and bis(2,2-dimethylpropyl)dimethylammonium fluoride. The combination of these fluoride salts with at least one fluorine-containing non-aqueous solvent (e.g., bis(2,2,2-trifluoroethyl)ether; (BTFE)) promotes solubility of the salt within the non-aqueous solvents.

Abstract translation: 提出了包括非水溶剂混合物的方法和反应混合物。 提供包括氟化物盐和非水溶剂组合的非水溶剂混合物，其具有用于一系列应用的高氟离子浓度，包括有机合成。 提供了另外的非水溶剂混合物，包括具有非氟化物阴离子的盐和非水溶剂，当与含氟化物的试剂接触时，提取氟离子以形成具有高氟化物浓度的非氟化物离子溶液， 离子浓度。 所述盐包括在β-位上不具有碳或在具有结合氢的β位上不具有碳的有机阳离子。 该盐结构有助于其无分解的能力。 例如无水氟化物盐包括（2,2-二甲基丙基）三甲基氟化铵和二（2,2-二甲基丙基）二甲基氟化铵。 这些氟化物盐与至少一种含氟非水溶剂（例如双（2,2,2-三氟乙基）醚;（BTFE））的组合促进盐在非水溶剂中的溶解度。

公开(公告)号：US20170022231A1

公开(公告)日：2017-01-26

申请号：US15074545

申请日：2016-03-18

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Choon Woo LEE ,  Robert H. GRUBBS ,  Pablo E. GUZMAN ,  Tonia S. AHMED ,  T. Patrick MONTGOMERY

IPC: C07F15/00 ,  B01J31/12 ,  C07C67/475 ,  C08F12/08 ,  C07C67/30 ,  C07D313/00

CPC classification number: C07F15/0046 ,  B01J31/122 ,  B01J31/28 ,  B01J2231/543 ,  B01J2531/821 ,  C07B2200/09 ,  C07C67/293 ,  C07C67/30 ,  C07C67/333 ,  C07C67/475 ,  C07C2601/10 ,  C07D313/00 ,  C08F2500/25 ,  C08G61/08 ,  C08G2261/3322 ,  C08G2261/418 ,  C07C69/74 ,  C07C69/16 ,  C07C69/78 ,  C07C69/76

Abstract: This invention relates generally to olefin metathesis catalyst compounds, to the preparation of such compounds, and the use of such catalysts in the metathesis of olefins and olefin compounds, more particularly, in the use of such catalysts in (E)-selective olefin metathesis reactions. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.

Abstract translation: 本发明一般涉及烯烃复分解催化剂化合物，这些化合物的制备，以及这些催化剂在烯烃和烯烃化合物的复分解中的用途，更具体地说，在（E）选择性烯烃复分解反应中使用这种催化剂 。 本发明在催化，有机合成，聚合物化学，工业和精细化学品化学领域具有实用价值。

公开(公告)号：US20150284313A1

公开(公告)日：2015-10-08

申请号：US14684262

申请日：2015-04-10

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Vanessa M. MARX ,  Scott C. VIRGIL ,  Robert H. GRUBBS

IPC: C07C67/333 ,  C07C6/04

CPC classification number: C07C67/333 ,  C07C1/2078 ,  C07C6/04 ,  C07C2531/22 ,  C07D405/04 ,  C07F15/0046 ,  C07C11/02

Abstract: Described herein are compounds and methods for catalyzing metathesis reactions. The compounds described herein are ruthenium complexes bearing cyclic alkyl amino carbene (CAAC) ligands. The ruthenium complexes bearing cyclic alkyl amino carbene ligands may be used for catalyzing metathesis reactions, such as ethenolysis and alkenolysis reactions.

Abstract translation: 本文描述了用于催化复分解反应的化合物和方法。 本文所述的化合物是带有环烷基氨基卡宾（CAAC）配体的钌络合物。 带有环状烷基氨基卡宾配体的钌络合物可用于催化复分解反应，如乙烯分解和烯解作用反应。

公开(公告)号：US20130296511A1

公开(公告)日：2013-11-07

申请号：US13779190

申请日：2013-02-27

Applicant: California Institute Of Technology ,  Materia, Inc.

Inventor： Thay UNG ,  Yann SCHRODI ,  Mark S. TRIMMER ,  Andrew HEJL ,  Daniel SANDERS ,  Robert H. GRUBBS

IPC: C07F15/00 ,  C08F132/08 ,  C07C67/333

CPC classification number: C08G61/02 ,  C07C67/333 ,  C07D493/10 ,  C07F15/0046 ,  C08F132/08 ,  C08G61/06 ,  C08G2261/11 ,  C08G2261/3325 ,  C08G2261/418

Abstract: The invention provides novel organometallic complexes useful as olefin metathesis catalysts. The complexes have an N-heterocyclic carbene ligand and a chelating carbene ligand associated with a Group 8 transition metal center. The molecular structure of the complexes can be altered so as to provide a substantial latency period. The complexes are particularly useful in catalyzing ring closing metathesis of acyclic olefins and ring opening metathesis polymerization of cyclic olefins.

公开(公告)号：US20230135901A1

公开(公告)日：2023-05-04

申请号：US18147417

申请日：2022-12-28

Applicant: Honda Motor Co., Ltd. ,  California Institute of Technology

Inventor： Qingmin XU ,  Christopher J. BROOKS ,  Kaoru OMICHI ,  Ryan K. MCKENNEY ,  Simon JONES ,  Victoria DAVIS ,  Stephen MUNOZ ,  Jeongmin KIM ,  Keith BILLINGS ,  Thomas MILLER, III ,  Robert H. GRUBBS ,  William WOLF ,  Nam Hawn CHOU

IPC: H01M10/0569 ,  H01M4/36 ,  H01M4/38 ,  H01M4/58 ,  H01M10/05 ,  H01M10/0568 ,  H01M10/36

Abstract: The present disclosure relates to fluoride ion batteries and structures of metal based electrode materials for various fluoride ion batteries. The structures of the metal based electrode materials comprise one or more shells or interfaces, enabling the electrodes to operate at room temperature with a liquid electrolyte.

公开(公告)号：US20210332011A1

公开(公告)日：2021-10-28

申请号：US17055970

申请日：2019-05-14

Applicant: California Institute of Technology

Inventor： Jiaming LI ,  Xu CHEN ,  Tonia S. AHMED ,  Brian STOLTZ ,  Robert H. GRUBBS

IPC: C07C405/00 ,  B01J23/46

Abstract: This invention relates generally to the synthesis of Δ12-Prostaglandin J product using stereoretentive ruthenium olefin metathesis catalysts supported by dithiolate ligands. Δ12-Prostaglandin J products were generated with excellent selectivity (>99% Z) and in moderate to high/good yields (47% to 80% yield; 58% to 80% yield).

公开(公告)号：US20200038851A1

公开(公告)日：2020-02-06

申请号：US16341635

申请日：2017-10-17

Applicant: Umicore AG & Co. KG ,  California Institute of Technology

Inventor： Adam M. JOHNS ,  Jessica R. HERRON ,  Richard L. PEDERSON ,  Bryan A. FIAMENGO ,  Jennifer A. BEERMAN ,  Tzu-Pin LIN ,  Crystal K. CHU ,  Robert H. GRUBBS

IPC: B01J31/24 ,  B01J31/22 ,  C07F15/00

Abstract: This invention relates generally to olefin metathesis catalyst compounds, to the preparation of such compounds, compositions comprising such compounds, methods of using such compounds, articles of manufacture comprising such compounds, and the use of such compounds in the metathesis of olefins and olefin compounds. The invention has utility in the fields of catalysts, organic synthesis, polymer chemistry, and industrial and fine chemicals industry.

公开(公告)号：US20170018801A1

公开(公告)日：2017-01-19

申请号：US15065317

申请日：2016-03-09

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Robert H. GRUBBS ,  Christopher M. BATES ,  Alice CHANG ,  Brendon MCNICHOLAS ,  Simon C. JONES

IPC: H01M10/0565 ,  H01M14/00 ,  H01M10/0525 ,  C08G61/02

CPC classification number: H01M10/0565 ,  C08G61/02 ,  C08G61/08 ,  C08G81/00 ,  C08G2261/126 ,  C08G2261/1426 ,  C08G2261/143 ,  C08G2261/148 ,  C08G2261/149 ,  C08G2261/3324 ,  C08G2261/3325 ,  C08G2261/418 ,  C08G2261/516 ,  C08G2261/792 ,  C08L65/00 ,  C08L87/005 ,  H01M10/0525 ,  H01M14/005 ,  H01M2008/1095 ,  H01M2300/0082

Abstract: Provided herein are copolymer electrolytes and electrocatalyst platforms, including brush block copolymers, triblock brush copolymers and pentablock brush copolymers. The copolymers described have beneficial chemical, physical and electrical properties including high ionic conductivity and mechanical strength. In embodiments, for example, the provided copolymer electrolytes and electrocatalyst platforms are doped with lithium salts or mixed with ionic liquids to form ion gels. In some embodiments, the copolymers provided herein self-assemble into physically cross-linked polymer networks with additional useful properties. The provided copolymers have low dispersity in the polymer side chains and do not require post-polymerization modifications.

Abstract translation: 本文提供了共聚物电解质和电催化剂平台，包括刷嵌段共聚物，三嵌段刷共聚物和五嵌段刷共聚物。 所述的共聚物具有有益的化学，物理和电学性能，包括高离子导电性和机械强度。 在实施方案中，例如，所提供的共聚物电解质和电催化剂平台掺杂有锂盐或与离子液体混合以形成离子凝胶。 在一些实施方案中，本文提供的共聚物自组装成具有额外有用性质的物理交联的聚合物网络。 所提供的共聚物在聚合物侧链中具有低分散性，并且不需要后聚合修饰。

公开(公告)号：US20160185821A1

公开(公告)日：2016-06-30

申请号：US14802244

申请日：2015-07-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Shane L. MANGOLD ,  Robert H. GRUBBS

IPC: C07K7/08 ,  C07D307/79 ,  C07K7/06 ,  C07C271/22

CPC classification number: C07K7/08 ,  C07C269/06 ,  C07C277/08 ,  C07C319/20 ,  C07D207/16 ,  C07D209/20 ,  C07D233/64 ,  C07D307/79 ,  C07K7/06 ,  C07C271/22 ,  C07C279/14 ,  C07C323/59

Abstract: The invention relates generally to the synthesis of modified amino acids and modified peptides in the presence of cyclometalated catalysts. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.

Abstract translation: 本发明一般涉及在环金属化催化剂存在下合成修饰的氨基酸和修饰的肽。 本发明在催化，有机合成，聚合物化学，工业和精细化学品化学领域具有实用价值。

公开(公告)号：US20150299236A1

公开(公告)日：2015-10-22

申请号：US14649725

申请日：2013-12-12

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Lauren E. ROSEBRUGH ,  Myles B. HERBERT ,  Vanessa M. MARX ,  Benjamin K. KEITZ ,  Robert H. GRUBBS

IPC: C07F15/00 ,  C07C2/34 ,  C07C29/00 ,  C07C67/293 ,  C07D313/00 ,  C07C45/67 ,  B01J31/22 ,  C08F110/14

CPC classification number: C07F15/0046 ,  B01J31/2265 ,  B01J31/2278 ,  B01J2231/20 ,  B01J2231/32 ,  B01J2531/821 ,  C07C2/34 ,  C07C29/00 ,  C07C45/673 ,  C07C67/293 ,  C07D313/00 ,  C08F110/14 ,  C08G61/08 ,  C08G2261/418

Abstract: A novel chelated ruthenium-based metathesis catalyst bearing an N-2,6-diisopropylphenyl group is reported and displays near-perfect selectivity for the Z-olefin (>95%), as well as unparalleled TONs of up to 7,400, in a variety of homodimerization and industrially relevant metathesis reactions. This derivative and other new catalytically-active species were synthesized using an improved method employing sodium carboxylates to induce the salt metathesis and C—H activation of these chelated complexes. All of these new ruthenium-based catalysts are highly Z-selective in the homodimerization of terminal olefins.

Abstract translation: 报道了一种新型的具有N-2,6-二异丙基苯基的螯合钌基复分解催化剂，并显示了Z-烯烃（> 95％）的近乎完美的选择性，以及多达7400种无与伦比的TON 的同型二聚化和工业相关复分解反应。 该衍生物和其他新的催化活性物质使用羧酸钠诱导盐复分解和这些螯合络合物的C-H活化的改进方法合成。 所有这些新的钌基催化剂在末端烯烃的同二聚化中是高度Z选择性的。