-
公开(公告)号:US12123052B2
公开(公告)日:2024-10-22
申请号:US17130394
申请日:2020-12-22
Applicant: Cepheid
Inventor: Joseph H. Smith , David H. Persing , Alan Wortman , Ronald Chang , David Swenson
IPC: C12Q1/686 , B01L3/00 , B01L7/00 , C12Q1/6848 , C12Q1/6851 , C12Q1/689
CPC classification number: C12Q1/686 , B01L3/502738 , B01L7/52 , C12Q1/6848 , C12Q1/6851 , C12Q1/689 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2400/0644 , C12Q1/6848 , C12Q2565/629 , C12Q2547/101 , C12Q2537/149 , C12Q1/6848 , C12Q2565/629 , C12Q2565/101 , C12Q2527/107 , C12Q1/6851 , C12Q2565/629 , C12Q2537/149 , C12Q2537/143 , C12Q1/686 , C12Q2565/629 , C12Q2537/149 , C12Q2537/143
Abstract: The invention provides methods and apparatus for carrying out multiple amplification reactions in a single reaction chamber by successive cycles of loading reaction mixture, amplifying, and removing spent reaction mixture in a fluidly closed reaction system. In particular, the present invention allows amplification of a plurality of target polynucleotides from a single sample by carrying out under closed-loop control successive amplifications of different target polynucleotides from different portions of the sample.
-
公开(公告)号:USD978369S1
公开(公告)日:2023-02-14
申请号:US29751420
申请日:2020-09-21
Applicant: Cepheid
Designer: Ronald Chang , Gregory Mote , Steven M. Montgomery
-
公开(公告)号:USD973655S1
公开(公告)日:2022-12-27
申请号:US29720274
申请日:2020-01-10
Applicant: Cepheid
Designer: Ronald Chang , Stephen M. Montgomery , Gregory E. Mote
-
公开(公告)号:US20210285025A1
公开(公告)日:2021-09-16
申请号:US17130394
申请日:2020-12-22
Applicant: Cepheid
Inventor: Joseph H. Smith , David H. Persing , Alan Wortman , Ronald Chang , David Swenson
IPC: C12Q1/686 , C12Q1/6851 , C12Q1/6848 , B01L3/00 , B01L7/00 , C12Q1/689
Abstract: The invention provides methods and apparatus for carrying out multiple amplification reactions in a single reaction chamber by successive cycles of loading reaction mixture, amplifying, and removing spent reaction mixture in a fluidly closed reaction system. In particular, the present invention allows amplification of a plurality of target polynucleotides from a single sample by carrying out under closed-loop control successive amplifications of different target polynucleotides from different portions of the sample.
-
公开(公告)号:US20210187505A1
公开(公告)日:2021-06-24
申请号:US17132143
申请日:2020-12-23
Applicant: Cepheid
Inventor: Douglas B. Dority , Ronald Chang
Abstract: A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least one external port. The fluid displacement region is fluidicly coupled with at least one external port of the body. The body is adjustable with respect to the plurality of chambers to place the at least one external port selectively in fluidic communication with the plurality of chambers. One or more of the chambers may be a processing chamber which includes two ports configured to selectively engage the at least one external port of the body, and a fluid processing material such as an enrichment material or a depletion material. In some embodiments, one or more chambers may include a separation channel, and an electric field may be applied across the separation channel.
-
公开(公告)号:US10907202B2
公开(公告)日:2021-02-02
申请号:US15849125
申请日:2017-12-20
Applicant: Cepheid
Inventor: Joseph H. Smith , David H. Persing , Alan Wortman , Ronald Chang , David Swenson
IPC: C12Q1/686 , C12Q1/6851 , C12Q1/6848 , B01L3/00 , B01L7/00 , C12Q1/689
Abstract: The invention provides methods and apparatus for carrying out multiple amplification reactions in a single reaction chamber by successive cycles of loading reaction mixture, amplifying, and removing spent reaction mixture in a fluidly closed reaction system. In particular, the present invention allows amplification of a plurality of target polynucleotides from a single sample by carrying out under closed-loop control successive amplifications of different target polynucleotides from different portions of the sample.
-
公开(公告)号:USD907793S1
公开(公告)日:2021-01-12
申请号:US29647906
申请日:2018-05-16
Applicant: Cepheid
Designer: Ronald Chang , Steven M. Montgomery , Gregory Mote
-
公开(公告)号:US20200156067A1
公开(公告)日:2020-05-21
申请号:US16704733
申请日:2019-12-05
Applicant: Cepheid
Inventor: Douglas B. Dority , Ronald Chang
Abstract: A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least one external port. The fluid displacement region is fluidicly coupled with at least one external port of the body. The body is adjustable with respect to the plurality of chambers to place the at least one external port selectively in fluidic communication with the plurality of chambers. One or more of the chambers may be a processing chamber which includes two ports configured to selectively engage the at least one external port of the body, and a fluid processing material such as an enrichment material or a depletion material. In some embodiments, one or more chambers may include a separation channel, and an electric field may be applied across the separation channel.
-
公开(公告)号:US20160158753A1
公开(公告)日:2016-06-09
申请号:US14935166
申请日:2015-11-06
Applicant: Cepheid
Inventor: DOUGLAS B. DORITY , Ronald Chang
IPC: B01L3/00
CPC classification number: B01L3/502715 , B01L3/502 , B01L3/50273 , B01L3/502738 , B01L2200/06 , B01L2200/10 , B01L2200/16 , B01L2300/06 , B01L2300/0645 , B01L2300/0681 , B01L2300/0848 , B01L2300/0861 , B01L2300/0877 , B01L2300/123 , B01L2300/14 , B01L2400/0421 , B01L2400/0478 , B01L2400/0487 , B01L2400/0644 , G01N1/18 , G01N1/28 , G01N1/405 , Y10T436/255 , Y10T436/2575
Abstract: A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least one external port. The fluid displacement region is fluidicly coupled with at least one external port of the body. The body is adjustable with respect to the plurality of chambers to place the at least one external port selectively in fluidic communication with the plurality of chambers. One or more of the chambers may be a processing chamber which includes two ports configured to selectively engage the at least one external port of the body, and a fluid processing material such as an enrichment material or a depletion material. In some embodiments, one or more chambers may include a separation channel, and an electric field may be applied across the separation channel.
Abstract translation: 用于控制多个室之间的流体流动的流体控制和处理系统包括主体,其包括与流体位移区域流体连续耦合的流体处理区域。 流体位移区域是可减压的,以将流体吸入流体移动区域并且可加压以从流体位移区域排出流体。 身体至少包括一个外部端口。 流体处理区域与至少一个外部端口流体耦合。 流体位移区域与主体的至少一个外部端口流体耦合。 主体相对于多个室可调节以将至少一个外部端口选择性地与多个室流体连通。 一个或多个室可以是处理室,其包括构造成选择性地接合主体的至少一个外部端口的两个端口,以及诸如富集材料或耗尽材料的流体处理材料。 在一些实施例中,一个或多个腔室可以包括分离通道,并且可以跨越分离通道施加电场。
-
公开(公告)号:US20140206074A1
公开(公告)日:2014-07-24
申请号:US14218517
申请日:2014-03-18
Applicant: Cepheid
Inventor: Kurt E. Peterson , William McMillan , Farzad Pourahmadi , Ronald Chang , Douglas B. Dority
CPC classification number: B01L7/52 , B01L3/502 , B01L2200/10 , B01L2300/0654 , B01L2300/0681 , B01L2300/0858 , B01L2300/087 , B01L2300/123 , B01L2300/14 , B01L2300/168 , B01L2300/18 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12Q1/6844 , G01N33/5302 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
Abstract: A cartridge for conducting a chemical reaction includes a body having at least one flow path formed therein. The cartridge also includes a reaction vessel extending from the body for holding a reaction mixture for chemical reaction and optical detection. The vessel comprises a rigid frame defining the side walls of a reaction chamber. The frame includes at least one channel connecting the flow path to the chamber. The vessel also includes flexible films or sheets attached to opposite sides of the rigid frame to form opposing major walls of the chamber. In addition, at least two of the side walls are optically transmissive and angularly offset from each to permit real-time optical detection of analyte in the reaction chamber.
Abstract translation: 用于进行化学反应的药筒包括具有形成在其中的至少一个流路的主体。 药筒还包括从身体延伸的反应容器,用于保持用于化学反应和光学检测的反应混合物。 容器包括限定反应室侧壁的刚性框架。 该框架包括连接到该腔室的流动路径的至少一个通道。 容器还包括附接到刚性框架的相对侧的柔性膜或片,以形成腔室的相对的主壁。 此外,至少两个侧壁是光学透射的并且与每个侧壁成角度地偏移以允许对反应室中的分析物的实时光学检测。
-
-
-
-
-
-
-
-
-