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39 条记录 (耗时 0.04 秒)

    N-acyl-N′-benzyl-alkylendiamino derivatives
    22.
    发明授权
    N-acyl-N′-benzyl-alkylendiamino derivatives 失效

    公开(公告)号：US07411091B2

    公开(公告)日：2008-08-12

    申请号：US10580367

    申请日：2004-11-12

    申请人： Florian Thaler ,  Cibele Maria Sabido David ,  Laura Faravelli ,  Stefania Gagliardi ,  Elena Colombo ,  Patricia Salvati

    发明人： Florian Thaler ,  Cibele Maria Sabido David ,  Laura Faravelli ,  Stefania Gagliardi ,  Elena Colombo ,  Patricia Salvati

    IPC分类号： C07C233/05 ,  C61K31/16 ,  C07D207/00

    CPC分类号： C07D207/27 ,  C07C233/36

    摘要： This invention is related to compounds and use of N-Acyl-N′-benzyl-alkylendiamino derivatives of the following general formula (I), wherein A is a straight or branched C2-C8 alkyl chain; X is a methylene, oxygen, sulphur or a NR7 group; R1 is a straight or branched C1-C8 alkyl or C3-C8 alkenylene or C3-C8 alkynylene chain, optionally substituted with CF3, phenyl, phenoxy or naphthyl, the aromatic rings optionally substituted by one or more C1-C4 alkyl, halogens, trifluoromethyl, hydroxy or C1-C4 alkoxy groups; R2, R3 are independently hydrogen, a C1-C3 alkyl chain, halogen, trifluoromethyl, hydroxy or C1-C4 alkoxy groups; R4, R5 are independently hydrogen or C1-C6 alkyl; R6 is a hydrogen or a straight or branched C1-C8 alkyl or linked to R5 can form a five to seven membered lactam; R7 is hydrogen or C1-C6 alkyl; and the pharmaceutically acceptable salts thereof that are active as sodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role

    Substituted indole ligands for the ORL-1 receptor
    25.
    发明申请
    Substituted indole ligands for the ORL-1 receptor 审中-公开
    用于ORL-1受体的取代的吲哚配体

    公开(公告)号：US20090275555A1

    公开(公告)日：2009-11-05

    申请号：US11794654

    申请日：2005-12-28

    申请人： Silvano Ronzoni ,  Stefania Gagliardi

    发明人： Silvano Ronzoni ,  Stefania Gagliardi

    IPC分类号： A61K31/454 ,  C07D401/06 ,  A61K31/55 ,  C07D401/14 ,  A61K31/497

    CPC分类号： C07D405/14 ,  C07D401/06 ,  C07D401/14

    摘要： New ligands for the ORL-1 receptor are described, useful for antagonising the activity of said receptors in a patient in need thereof, and for preventing and treating illnesses dependent on the activation of this receptor. The new compounds conform to structural formula (I) wherein R1, R2, R3, R4 are further defined in the description.

    摘要翻译： 描述了ORL-1受体的新配体，其可用于拮抗有需要的患者中所述受体的活性，以及​​用于预防和治疗依赖于该受体活化的疾病。 新化合物符合结构式（I），其中R1，R2，R3，R4在描述中进一步定义。

    N-acyl-n'-benzyl-alkylendiamino derivatives
    27.
    发明申请
    N-acyl-n'-benzyl-alkylendiamino derivatives 失效

    公开(公告)号：US20070142455A1

    公开(公告)日：2007-06-21

    申请号：US10580367

    申请日：2004-11-12

    申请人： Florian Thaler ,  Cibele Sabido David ,  Laura Faravelli ,  Stefania Gagliardi ,  Elena Colombo ,  Patricia Salvati

    发明人： Florian Thaler ,  Cibele Sabido David ,  Laura Faravelli ,  Stefania Gagliardi ,  Elena Colombo ,  Patricia Salvati

    IPC分类号： A61K31/4015 ,  A61K31/16 ,  C07C235/36

    CPC分类号： C07D207/27 ,  C07C233/36

    摘要： This invention is related to compounds and use of N-Acyl-N′-benzyl-alkylendiamino derivatives of the following general formula (I), wherein A is a straight or branched C2-C8 alkyl chain; X is a methylene, oxygen, sulphur or a NR7 group; R1 is a straight or branched C1-C8 alkyl or C3-C8 alkenylene or C3-C8 alkynylene chain, optionally substituted with CF3, phenyl, phenoxy or naphthyl, the aromatic rings optionally substituted by one or more C1-C4 alkyl, halogens, trifluoromethyl, hydroxy or C1-C4 alkoxy groups; R2, R3 are independently hydrogen, a C1-C3 alkyl chain, halogen, trifluoromethyl, hydroxy or C1-C4 alkoxy groups; R4, R5 are independently hydrogen or C1-C6 alkyl; R6 is a hydrogen or a straight or branched C1-C8 alkyl or linked to R5 can form a five to seven membered lactam; R7 is hydrogen or C1-C6 alkyl; and the pharmaceutically acceptable salts thereof that are active as sodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.