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    N-acyl-n'-benzyl-alkylendiamino derivatives
    1.
    发明申请
    N-acyl-n'-benzyl-alkylendiamino derivatives 失效

    公开(公告)号：US20070142455A1

    公开(公告)日：2007-06-21

    申请号：US10580367

    申请日：2004-11-12

    申请人： Florian Thaler ,  Cibele Sabido David ,  Laura Faravelli ,  Stefania Gagliardi ,  Elena Colombo ,  Patricia Salvati

    发明人： Florian Thaler ,  Cibele Sabido David ,  Laura Faravelli ,  Stefania Gagliardi ,  Elena Colombo ,  Patricia Salvati

    IPC分类号： A61K31/4015 ,  A61K31/16 ,  C07C235/36

    CPC分类号： C07D207/27 ,  C07C233/36

    摘要： This invention is related to compounds and use of N-Acyl-N′-benzyl-alkylendiamino derivatives of the following general formula (I), wherein A is a straight or branched C2-C8 alkyl chain; X is a methylene, oxygen, sulphur or a NR7 group; R1 is a straight or branched C1-C8 alkyl or C3-C8 alkenylene or C3-C8 alkynylene chain, optionally substituted with CF3, phenyl, phenoxy or naphthyl, the aromatic rings optionally substituted by one or more C1-C4 alkyl, halogens, trifluoromethyl, hydroxy or C1-C4 alkoxy groups; R2, R3 are independently hydrogen, a C1-C3 alkyl chain, halogen, trifluoromethyl, hydroxy or C1-C4 alkoxy groups; R4, R5 are independently hydrogen or C1-C6 alkyl; R6 is a hydrogen or a straight or branched C1-C8 alkyl or linked to R5 can form a five to seven membered lactam; R7 is hydrogen or C1-C6 alkyl; and the pharmaceutically acceptable salts thereof that are active as sodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.

    N-acyl-N′-benzyl-alkylendiamino derivatives
    2.
    发明授权
    N-acyl-N′-benzyl-alkylendiamino derivatives 失效

    公开(公告)号：US07411091B2

    公开(公告)日：2008-08-12

    申请号：US10580367

    申请日：2004-11-12

    申请人： Florian Thaler ,  Cibele Maria Sabido David ,  Laura Faravelli ,  Stefania Gagliardi ,  Elena Colombo ,  Patricia Salvati

    发明人： Florian Thaler ,  Cibele Maria Sabido David ,  Laura Faravelli ,  Stefania Gagliardi ,  Elena Colombo ,  Patricia Salvati

    IPC分类号： C07C233/05 ,  C61K31/16 ,  C07D207/00

    CPC分类号： C07D207/27 ,  C07C233/36

    摘要： This invention is related to compounds and use of N-Acyl-N′-benzyl-alkylendiamino derivatives of the following general formula (I), wherein A is a straight or branched C2-C8 alkyl chain; X is a methylene, oxygen, sulphur or a NR7 group; R1 is a straight or branched C1-C8 alkyl or C3-C8 alkenylene or C3-C8 alkynylene chain, optionally substituted with CF3, phenyl, phenoxy or naphthyl, the aromatic rings optionally substituted by one or more C1-C4 alkyl, halogens, trifluoromethyl, hydroxy or C1-C4 alkoxy groups; R2, R3 are independently hydrogen, a C1-C3 alkyl chain, halogen, trifluoromethyl, hydroxy or C1-C4 alkoxy groups; R4, R5 are independently hydrogen or C1-C6 alkyl; R6 is a hydrogen or a straight or branched C1-C8 alkyl or linked to R5 can form a five to seven membered lactam; R7 is hydrogen or C1-C6 alkyl; and the pharmaceutically acceptable salts thereof that are active as sodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role