公开(公告)号：US20070088204A1

公开(公告)日：2007-04-19

申请号：US11548781

申请日：2006-10-12

Applicant: Jeremy Albrecht ,  Charles Hart ,  John Brustad ,  Gary Johnson ,  Jennifer Ko ,  Donald Gadberry

Inventor： Jeremy Albrecht ,  Charles Hart ,  John Brustad ,  Gary Johnson ,  Jennifer Ko ,  Donald Gadberry

IPC: A61B1/32

CPC classification number: A61B17/0293 ,  A61B17/02 ,  A61B17/0218 ,  A61B17/3423 ,  A61B17/3431 ,  A61B17/3439 ,  A61B17/3462 ,  A61B17/3496 ,  A61B17/3498 ,  A61B90/40 ,  A61B2017/00477 ,  A61B2017/00526 ,  A61B2017/0225 ,  A61B2017/0287 ,  A61B2017/3419 ,  A61B2017/347 ,  A61B2050/005 ,  A61B2050/0051

Abstract: An incrementally adjustable wound retractor, which provides access to a body cavity, includes an inner ring having a diameter greater than the desired diameter of the wound incision, an outer ring having an annular axis and a diameter greater than the desired diameter of the wound incision, and a flexible sleeve disposed in a generally cylindrical form between the inner and outer rings. The outer ring includes first and second circular tubes spaced apart axially with each including a lumen having a rigid, noncompliant split hoop positioned therein. The outer ring may be rolled over itself and around the annular axis to retract the sleeve with sufficient force to stretch the incision to the desired diameter. A gel cap seal may be coupled to the outer ring outside of the biological body to seal the opening produced by the wound retractor between the body cavity and outside the body cavity.

Abstract translation: 提供进入体腔的增量可调的伤口牵开器包括直径大于所述伤口切口所需直径的内环，具有环形轴线的外环和直径大于伤口切口的期望直径的内环 以及在内环和外环之间以大致圆柱形的形式设置的柔性套管。 外环包括轴向间隔开的第一和第二圆形管，每个管包括具有定位在其中的刚性的，不一致的分割箍的内腔。 外环可以自身滚动并围绕环形轴线以足够的力使套筒缩回以将切口拉伸到期望的直径。 凝胶帽密封件可以联接到生物体外部的外环，以密封由卷绕牵开器在体腔和体腔外部产生的开口。

公开(公告)号：US20060229637A1

公开(公告)日：2006-10-12

申请号：US11423741

申请日：2006-06-13

Applicant: Charles Hart ,  John Brustad ,  Nabil Hilal ,  Henry Kahle

Inventor： Charles Hart ,  John Brustad ,  Nabil Hilal ,  Henry Kahle

IPC: A61F11/00

CPC classification number: A61B17/3498 ,  A61B17/3423 ,  A61B17/3462 ,  A61B2017/3464

Abstract: A surgical access device, such as a trocar, includes a pendent valve having an elongate structure extending from a proximal end to a septum valve disposed at a distal end. In operation, the elongate structure follows the angle of the instrument to pre-position the septum valve into the path of the instrument where it is not significantly challenged during instrument insertion or manipulation. The pendant valve can be made to float at both the proximal end and the distal end of the elongate structure, to further reduce the vulnerability of the septum valve. Since the valve is less vulnerable to instrument insertion, it can be formed to minimize friction and maximize the functional range of the access device.

Abstract translation: 手术进入装置，例如套管针，包括具有从近端延伸到设置在远端的隔膜阀的细长结构的侧悬阀。 在操作中，细长结构遵循仪器的角度，以将隔膜阀预先定位到仪器的路径中，在仪器插入或操纵期间，隔膜阀不会受到严重的挑战。 悬挂阀可以制成在细长结构的近端和远端两侧浮动，以进一步降低隔膜阀的脆弱性。 由于阀门不易受仪器插入的影响，因此可以形成最小化摩擦力并最大化进入设备的功能范围。

公开(公告)号：US20060217681A1

公开(公告)日：2006-09-28

申请号：US11383927

申请日：2006-05-17

Applicant: Charles Hart ,  John Brustad

Inventor： Charles Hart ,  John Brustad

IPC: A61M31/00

CPC classification number: A61B17/3421 ,  A61B1/3132 ,  A61B17/3417 ,  A61B17/3474 ,  A61B90/30 ,  A61B2017/00685 ,  A61B2017/320044 ,  A61B2017/3405 ,  A61B2017/3484 ,  A61B2017/349 ,  A61B2090/08021 ,  A61B2090/373 ,  A61M25/02 ,  A61M25/04 ,  A61M2025/0286

Abstract: A trocar system for providing access across a body wall includes a trocar and an anchor provided in the form of a first helix. The anchor is adapted for placement in an operative position wherein the anchor extends at least partially through the body wall. A second helix formed on the trocar is size and configured to engage the first helix of the anchor so that rotation of the trocar relative to the anchor moves the second helix along the first helix. In this manner, the trocar is drawn into the anchor as it moves into the body wall. A proximal force applied to the anchor resists tenting of the abdominal wall. The anchor also holds the layers of the body wall together thereby resisting peritoneal separation.

Abstract translation: 用于提供通过身体壁的通路的套针针系统包括以第一螺旋形式设置的套针针和锚。 锚固件适于放置在操作位置，其中锚固件至少部分延伸穿过主体壁。 形成在套针针上的第二螺旋是尺寸并且构造成接合锚固件的第一螺旋，使得套管针相对于锚的旋转沿着第一螺旋移动第二螺旋。 以这种方式，套管针在移动到体壁时被拉入锚中。 施加到锚的近侧力抵抗腹壁的隆起。 锚固体还将体壁的层保持在一起，从而抵抗腹膜分离。

公开(公告)号：US20060149306A1

公开(公告)日：2006-07-06

申请号：US11330661

申请日：2006-01-12

Applicant: Charles Hart ,  Scott Taylor

Inventor： Charles Hart ,  Scott Taylor

IPC: A61M29/00

CPC classification number: A61B17/3423 ,  A61B17/0293 ,  A61B17/3462 ,  A61B17/3498 ,  A61B90/50 ,  A61B2017/00265 ,  A61B2017/3405 ,  A61B2017/3482 ,  A61B2017/3484 ,  A61B2017/3486 ,  A61B2017/3492

Abstract: A surgical access device is adapted to facilitate access through an incision in a body wall having an inner surface and an outer surface, and into a body cavity of a patient. The device includes first and second retention members adapted to be disposed in proximity to the outer surface and the inner surface of the body wall, respectively. A membrane extending between the two retention members forms a throat which is adapted to extend through the incision and form a first funnel extending from the first retention member into the throat, and a second funnel extending from the second retention member into the throat. The throat of the membrane has characteristics for forming an instrument seal in the presence of an instrument and a zero seal in the absence of an instrument. The first retention member may include a ring with either a fixed or variable diameter. The ring can be formed in first and second sections, each having two ends. Couplings can be disposed between the ends to accommodate variations in the size of the first retention member. The first retention member can also be formed as an inflatable toroid, a self-expanding foam, or a circumferential spring. A plurality of inflatable chambers can also provide the surgical access device with a working channel adapted for disposition across the body wall. A first retention member with a plurality of retention stations functions with a plurality of tethers connected to the membrane to change the shape of the membrane and the working channel. A stabilizing platform can be used to support the access device generally independent of any movement of the body wall.

Abstract translation: 外科进入装置适于通过具有内表面和外表面的体壁中的切口并进入患者的体腔中。 该装置包括适于分别设置在靠近体壁的外表面和内表面的第一和第二保持构件。 在两个保持构件之间延伸的膜形成喉部，其适于延伸穿过切口并形成从第一保持构件延伸到喉部中的第一漏斗，以及从第二保持构件延伸到喉部的第二漏斗。 膜的喉部具有在没有仪器的情况下在仪器存在下形成仪器密封件的特性和零密封。 第一保持构件可包括具有固定或可变直径的环。 环可以形成在第一和第二部分中，每个具有两个端部。 联接器可以设置在端部之间以适应第一保持构件的尺寸的变化。 第一保持构件也可以形成为充气环形，自膨胀泡沫或圆周弹簧。 多个可充气室还可以为外科进入装置提供适于跨越身体壁布置的工作通道。 具有多个保持站的第一保持构件具有连接到膜的多个系绳以改变膜和工作通道的形状。 可以使用稳定平台来支撑大体独立于体壁的任何运动的进入装置。

公开(公告)号：US20060052669A1

公开(公告)日：2006-03-09

申请号：US10539641

申请日：2004-01-20

Applicant: Charles Hart

Inventor： Charles Hart

IPC: A61B1/32

CPC classification number: A61B17/0218 ,  A61B1/32 ,  A61B17/0293 ,  A61B2017/0212 ,  A61B2017/2931

Abstract: A positionable internal retraction device is provided comprising a malleable ring member and a web-like structure. The retraction device operates to temporarily reposition tissues and organs from an operative site to provide a clear access and visual path for the surgeon. The ring member may be elongated, twisted, folded, bent or deformed to provide an appropriate insertion profile and subsequent functional shape. The retraction device may be shaped for both open and minimally invasive surgeries. The retraction device is atraumatic and may be used for retraction of delicate tissues and organs. The ring member may have different bending biases. The web-like structure may be constructed of any elastic material that can stretch and recover from the shaping and reshaping of the ring member. In another aspect of the invention, the ring member further comprises an internal lumen defining a wall, which may be of any geometric shape providing a desired bending bias. The ring member may further include a reinforcement member placed within the lumen and made of a “shape memory” material that allows the reinforcement member to return to its desired shape or condition after being bent. The reinforcement member may be placed in some sections of the ring member to keep these sections substantially straight. Each of the ring member, the reinforcement member and the internal wall may have a cross-section or profile of any geometric shape to provide a desired bending bias in a preferred plane. In yet another aspect of the invention, the ring member further comprises a second lumen and a second reinforcement member placed within the second lumen to provide a desired bending bias.

Abstract translation: 提供了一种可定位的内部回缩装置，其包括可延展的环构件和网状结构。 缩回装置用于暂时从手术部位重新定位组织和器官，以为外科医生提供清晰的通路和视觉路径。 环形构件可以是细长的，扭曲的，折叠的，弯曲的或变形的，以提供适当的插入轮廓和随后的功能形状。 缩回装置可以成形为开放和微创手术。 收缩装置无创伤，可用于收缩精细的组织和器官。 环件可能具有不同的弯曲偏差。 网状结构可以由能够从环构件的成形和整形拉伸和恢复的任何弹性材料构成。 在本发明的另一方面，环形构件还包括限定壁的内腔，所述壁可具有提供期望的弯曲偏压的任何几何形状。 环构件还可以包括放置在内腔内并由“形状记忆”材料制成的加强构件，其允许加强构件在弯曲之后返回到其期望的形状或状态。 加强构件可以放置在环构件的一些部分中，以使这些部分保持基本上直线。 环形构件，加强构件和内壁中的每一个可以具有任何几何形状的横截面或轮廓，以在优选平面中提供期望的弯曲偏压。 在本发明的另一方面，环形构件还包括放置在第二内腔内的第二内腔和第二加强构件，以提供期望的弯曲偏压。

公开(公告)号：US20050288558A1

公开(公告)日：2005-12-29

申请号：US11218412

申请日：2005-09-01

Applicant: Richard Ewers ,  John Brustad ,  Edward Pingleton ,  Nabil Hilal ,  Payam Adlparvar ,  Scott Taylor ,  Gary Dulak ,  Michael Dunn ,  Norman Morales ,  Charles Hart ,  Robert Bowes

Inventor： Richard Ewers ,  John Brustad ,  Edward Pingleton ,  Nabil Hilal ,  Payam Adlparvar ,  Scott Taylor ,  Gary Dulak ,  Michael Dunn ,  Norman Morales ,  Charles Hart ,  Robert Bowes

IPC: A61B17/02 ,  A61B17/34 ,  A61B1/32

CPC classification number: A61B1/32 ,  A61B17/0293 ,  A61B17/3423 ,  A61B17/3431 ,  A61B2017/3484

Abstract: A surgical wound retractor is adapted to dilate a wound stretchable to a desired diameter, the retractor includes a first ring having a diameter greater than that desired for the wound and being adapted for disposition interiorly of the wound. A second ring has a diameter greater than that desired for the wound and is adapted for disposition exteriorly of the wound. A plurality of retraction elements are disposed in a generally cylindrical relationship to each other, between the first ring and the second ring. These elements extend through the wound to exert a radial retraction force on the wound which is dependent on the distance separating the first ring and the second ring. Retraction elements, both distensible and non-distensible are contemplated with appropriate attachment means at the rings to provide for variations in the retraction force. With a suitable retraction sleeve, a third ring can be provided to form a circumferential retainer to vary the retraction force. Rings can also be made inflatable or self-expanding to vary the retraction force. An associated method includes the step of rolling the second ring circumferentially of the third ring to form the circumferential retainer.

Abstract translation: 外科伤口牵开器适于将可拉伸至期望直径的伤口扩张，牵开器包括直径大于伤口所需直径的第一环，并适于在伤口内部配置。 第二环的直径大于伤口所需的直径，并且适于在伤口的外部配置。 多个退回元件在第一环和第二环之间以大致圆柱形的关系设置。 这些元件延伸穿过伤口以在伤口上施加径向缩回力，这取决于分离第一环和第二环的距离。 缩回元件，可扩张和不扩张两者都可以在环上使用适当的附接装置来设计，以提供收缩力的变化。 利用合适的缩回套筒，可以提供第三环以形成圆周保持器以改变收回力。 环也可以制成充气或自膨胀以改变收缩力。 相关联的方法包括在第三环周向滚动第二环以形成周向保持器的步骤。

公开(公告)号：US20050241647A1

公开(公告)日：2005-11-03

申请号：US10516198

申请日：2003-06-03

Applicant: Eric Nguyen ,  Donald Gadberry ,  Gary Johnson ,  Charles Hart ,  John Brustad ,  Robert Bowes ,  Jeremy Albrecht ,  Ghassan Sakakine ,  Henry Kahle

Inventor： Eric Nguyen ,  Donald Gadberry ,  Gary Johnson ,  Charles Hart ,  John Brustad ,  Robert Bowes ,  Jeremy Albrecht ,  Ghassan Sakakine ,  Henry Kahle

IPC: A61B17/02 ,  A61B17/34 ,  A61B19/08 ,  A61F13/00 ,  A61L31/00

CPC classification number: A61B17/0293 ,  A61B17/0206 ,  A61B17/0218 ,  A61B17/3423 ,  A61B17/3498 ,  A61B2017/00889 ,  A61B2017/00938 ,  A61B2017/0225 ,  A61B2017/3419 ,  A61B2017/3435

Abstract: An incrementally adjustable wound retractor (100), having a first ring (102) with a diameter greater than the desired diameter of the wound incision. A second ring (104), having an annular axis and a diameter greater than the desired diameter of the wound incision. A flexible sleeve (106), disposed in a generally cylindrical form between the first and second rings (102, 104), the second ring may be rolled over itself and around the annular axis to provide a sleeve with a radical retraction force sufficient to stretch the incision to the desired diameter.

Abstract translation: 一种增量可调的伤口牵开器（100），具有直径大于所述伤口切口所需直径的第一环（102）。 第二环（104），其具有环形轴线和直径大于所述伤口切口的期望直径。 柔性套筒（106）以大致圆柱形的形式设置在第一和第二环（102,104）之间，第二环可绕其自身并围绕环形轴线滚动以提供具有足以拉伸的自由基缩回力的套筒 切口至所需直径。

公开(公告)号：US20050192605A1

公开(公告)日：2005-09-01

申请号：US10664698

申请日：2004-02-06

Applicant: Charles Hart ,  Donald Gadberry ,  Eduardo Chi-Sing ,  Mark Ashby ,  Luis Urquidi ,  Robert Jones

Inventor： Charles Hart ,  Donald Gadberry ,  Eduardo Chi-Sing ,  Mark Ashby ,  Luis Urquidi ,  Robert Jones

IPC: A61B17/00 ,  A61B17/02 ,  A61B17/122 ,  A61B17/28 ,  A61B17/08

CPC classification number: A61B17/02 ,  A61B17/122 ,  A61B17/1227 ,  A61B2017/00858 ,  A61B2017/00862 ,  A61B2017/0243 ,  A61B2017/2825

Abstract: A surgical instrument (10) is adapted to contact tissue of a patient, and to provide traction with the tissue in order to inhibit migration of the instrument relative to the tissue. The instrument may include a pair of opposing jaws (16, 18) with at least one of the jaws (16, 18) comprising a substrate having a particular surface facing the tissue, and a plurality of discrete elements (26, 28) disposed on the particular surface for increasing the traction of the instrument relative to the tissue. These discrete elements (26, 28) may include a multiplicity of granules, bristles, or projections, and may be formed of materials having various properties such as hydrophilic characteristics. The discrete elements in the form of bristles can be oriented too so that the column strength of each bristle provides increased traction in a predetermined direction.

Abstract translation: 手术器械（10）适于接触患者的组织，并提供对组织的牵引，以便抑制器械相对于组织的移动。 仪器可以包括一对相对的夹爪（16,18），其中至少一个钳口（16,18）包括具有面向组织的特定表面的衬底，以及多个分立元件（26,28），其设置在 用于增加器械相对于组织的牵引力的特定表面。 这些离散元件（26,28）可以包括多个颗粒，刷毛或凸起，并且可以由具有各种性质如亲水特性的材料形成。 刷毛形式的离散元件也可以被定向，使得每个刷毛的柱强度在预定方向上提供增加的牵引力。

公开(公告)号：US20050113936A1

公开(公告)日：2005-05-26

申请号：US10976506

申请日：2004-10-29

Applicant: John Brustad ,  Nabil Hilal ,  Gary Johnson ,  Charles Hart

Inventor： John Brustad ,  Nabil Hilal ,  Gary Johnson ,  Charles Hart

IPC: A61B17/00 ,  A61B17/02 ,  A61B17/06 ,  A61B17/064 ,  A61B17/122 ,  A61F2/00 ,  A61F2/02 ,  A61F2/04 ,  A61F2/06 ,  A61F2/24 ,  B05D3/00 ,  C09D20060101

CPC classification number: A61B17/064 ,  A61B17/02 ,  A61B17/06166 ,  A61B17/122 ,  A61B2017/00345 ,  A61B2017/00858 ,  A61F2002/0086 ,  A61L27/30 ,  A61L31/082 ,  A61L2400/12 ,  A61L2400/18

Abstract: The invention is directed to nanostructure surface treatments, coatings or modifications formed from nanoscale building blocks. The nanostructure surface treatments, modifications or coatings have hydrophobic, hydrophilic and surface adherence properties. The nanoscale building blocks have orientation, geometry, packing density and composition that may be adjusted to control the unique surface characteristics of the desired treatment, coating or modification. Applications of this nanostructure technology include surgical clips, staples, retractors, sutures and manipulators where an improvement in traction, retention or occlusion is desired without excessive material or tissue deformation or where high compressive forces would be undesirable, dangerous or ineffective. In one aspect, a nanostructure surface treatment for a medical device having an external surface is disclosed, wherein the treatment is applied on the external surface to provide a hydrophobic or a hydrophilic surface. With this aspect, the treatment comprises titanium dioxide and provides nanoscopic structures having nearly vertical sidewalls. The treated surface of the device has contact angles greater than or equal to 150 degrees. The vertical sidewalls provide a negative capillary effect and have a width of about 200 nm. The vertical sidewalls attach to a wet surface by the negative capillary effect. The van der Waals forces of the vertical sidewalls enable the treated surface to attach to a dry surface. The treatment may be vapor deposited and cured on the device, or the treatment may be laser blasted on the device.

Abstract translation: 本发明涉及纳米结构表面处理，由纳米级结构单元形成的涂层或改性。 纳米结构表面处理，改性或涂层具有疏水性，亲水性和表面附着性。 纳米级结构单元具有取向，几何形状，填充密度和组成，可以调节以控制所需处理，涂层或改性的独特表面特性。 该纳米结构技术的应用包括手术夹，钉，牵开器，缝合线和操纵器，其中希望改善牵引力，保持力或闭塞，而不会产生过多的材料或组织变形，或者高压缩力是不希望的，危险的或无效的。 一方面，公开了一种具有外表面的医疗器械的纳米结构表面处理，其中将处理施加在外表面上以提供疏水或亲水表面。 在这方面，处理包括二氧化钛并提供具有近似垂直侧壁的纳米结构。 该设备的被处理表面具有大于或等于150度的接触角。 垂直侧壁提供负毛细管效应并具有约200nm的宽度。 垂直侧壁通过负毛细管效应附着在潮湿的表面上。 垂直侧壁的范德华力使得经处理的表面附着在干燥的表面上。 处理可以在装置上气相沉积和固化，或者可以在装置上激光喷射处理。

公开(公告)号：US20050031694A1

公开(公告)日：2005-02-10

申请号：US10910938

申请日：2004-08-03

Applicant: Debra Gilbertson ,  Charles Hart

Inventor： Debra Gilbertson ,  Charles Hart

IPC: A61K38/00 ,  A61K38/18 ,  A61K38/19 ,  C07K14/52 ,  A61K9/14

CPC classification number: C04B38/06 ,  A61K38/177 ,  A61K38/18 ,  A61K38/1866 ,  A61K38/22 ,  C04B2111/00224 ,  C04B2111/00612 ,  C07K14/52 ,  C07K2319/00 ,  C12N2799/022 ,  C04B20/008 ,  C04B35/2641 ,  C04B35/50 ,  C04B35/64 ,  C04B38/0054 ,  C04B38/007 ,  C04B41/4578 ,  A61K2300/00

Abstract: Methods for promoting growth of bone, ligament, or cartilage in a mammal are disclosed. The methods comprise administering to said mammal a composition comprising a pharmacologically effective amount of zvegf4 in combination with a pharmaceutically acceptable delivery vehicle. Also disclosed are methods for promoting proliferation or differentiation of osteoblasts, osteoclasts, chondrocytes, or bone marrow stem cells comprising culturing the cells in an effective amount of zvegf4.