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公开(公告)号：US20210054357A1
公开(公告)日：2021-02-25
申请号：US17091479
申请日：2020-11-06
Applicant: Codexis, Inc.
Inventor： Oscar Alvizo , David Elgart , Robert Kevin Orr , James Nicholas Riggins , Anna Fryszkowska , Katrina W. Lexa , Xiang Yi , Da Duan , Courtney Dianne Moffett , Nikki Dellas , Vesna Mitchell
Abstract: The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.
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公开(公告)号：US12012620B2
公开(公告)日：2024-06-18
申请号：US17635163
申请日：2020-09-03
Applicant: Codexis, Inc.
Inventor： Da Duan , Auric Anthony Sowell-Kantz , Aksiniya Lyubenova Petkova , Jovana Nazor , Nandhitha Subramanian , Oscar Alvizo
IPC: C12N9/08
CPC classification number: C12N9/0065
Abstract: The present invention provides engineered peroxidase enzymes, polypeptides having peroxidase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing peroxidase enzymes are also provided. The present invention further provides compositions comprising the peroxidase enzymes and methods of using the engineered peroxidase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds.
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公开(公告)号：US20240158766A1
公开(公告)日：2024-05-16
申请号：US18413338
申请日：2024-01-16
Applicant: Codexis, Inc.
Inventor： Da Duan , Auric Anthony Sowell-Kantz , Aksiniya Lyubenova Petkova , Oscar Alvizo
IPC: C12N9/12
CPC classification number: C12N9/1229 , C12Y207/04003
Abstract: The present invention provides engineered adenylate kinase (AdK) enzymes, polypeptides having AdK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing AdK enzymes are also provided. The present invention further provides compositions comprising the AdK enzymes and methods of using the engineered AdK enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号：US20240076647A1
公开(公告)日：2024-03-07
申请号：US18503542
申请日：2023-11-07
Applicant: Codexis, Inc.
Inventor： Da Duan , Oscar Alvizo , Jovana Nazor , Harvinder Chagger Maniar , James Nicholas Riggins , Jonathan Vroom , Santhosh Sivaramakrishnan , Hao Yang , Anna Fryszkowska , Mark A. Huffman , Joshua N. Kolev , Iman Farasat , Agustina Rodriguez-Granillo , Deeptak Verma
IPC: C12N9/88
Abstract: The present invention provides engineered deoxyribose-phosphate aldolase polypeptides useful under industrial process conditions for the production of pharmaceutical and fine chemical compounds.
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公开(公告)号：US11845968B2
公开(公告)日：2023-12-19
申请号：US17592869
申请日：2022-02-04
Applicant: Codexis, Inc.
Inventor： Da Duan , Oscar Alvizo , Jovana Nazor , Harvinder Chagger Maniar , James Nicholas Riggins , Jonathan Vroom , Santhosh Sivaramakrishnan , Hao Yang , Anna Fryszkowska , Mark A. Huffman , Joshua N. Kolev , Iman Farasat , Agustina Rodriguez-Granillo , Deeptak Verma
CPC classification number: C12N9/88 , C12N15/63 , C12P21/02 , C12Y401/02004
Abstract: The present invention provides engineered deoxyribose-phosphate aldolase polypeptides useful under industrial process conditions for the production of pharmaceutical and fine chemical compounds.
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Patent Agency Ranking
公开(公告)号：US11746369B2
公开(公告)日：2023-09-05
申请号：US17239953
申请日：2021-04-26
Applicant: Codexis, Inc.
Inventor： Jeffrey C. Moore , Jack Liang , Jonathan Penfield , Jovana Nazor , Nikki Dellas , Vesna Mitchell , Da Duan , Iman Farasat , Agustina Rodriguez-Granillo , Grant Murphy , Nicholas Marshall
CPC classification number: C12P41/002 , C12N9/0004 , C12N9/0006 , C12N15/70 , C12Y101/01002 , C12Y120/01001
Abstract: The present invention provides engineered ketoreductase and phosphite dehydrogenase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase and phosphite dehydrogenase enzymes, as well as polynucleotides encoding the engineered ketoreductase and phosphite dehydrogenase enzymes, host cells capable of expressing the engineered ketoreductase and phosphite dehydrogenase enzymes, and methods of using the engineered ketoreductase and phosphite dehydrogenase enzymes to synthesize a chiral catalyst used in the synthesis of antiviral compounds, such as nucleoside inhibitors. The present invention further provides methods of using the engineered enzymes to deracemize a chiral alcohol in a one-pot, multi-enzyme system.
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公开(公告)号：US11643642B2
公开(公告)日：2023-05-09
申请号：US16616041
申请日：2018-05-23
Applicant: Codexis, Inc.
Inventor： Rama Voladri , Christopher Michael Micklitsch , Oscar Alvizo , Jovana Nazor , Da Duan , Judy Victoria Antonio Viduya , Stephan Jenne , Chihui An , Keith Allen Canada , Paul N. Devine , Iman Farasat , Anna Fryszkowska , Katrina W. Lexa , Robert Kevin Orr
IPC: C12N9/84
CPC classification number: C12N9/84 , C12Y305/01011
Abstract: The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.
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公开(公告)号：US20220010316A1
公开(公告)日：2022-01-13
申请号：US17490215
申请日：2021-09-30
Applicant: Codexis, Inc.
Inventor： Scott J. Novick , Nikki Dellas , Vesna Mitchell , Da Duan , Jovana Nazor , Oscar Alvizo , Auric Anthony Sowell-Kantz , Jeffrey C. Moore , Mark A. Huffman , Agustina Rodriguez-Granillo , Deeptak Verma , Nicholas M. Marshall , Jay H. Russell , Keith A. Canada
IPC: C12N15/63
Abstract: The present invention provides engineered purine nucleoside phosphorylase (PNP) enzymes, polypeptides having PNP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PNP enzymes are also provided. The present invention further provides compositions comprising the PNP enzymes and methods of using the engineered PNP enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号：US11034948B2
公开(公告)日：2021-06-15
申请号：US16460062
申请日：2019-07-02
Applicant: Codexis, Inc.
Inventor： Scott J. Novick , Xiang Yi , Nikki Dellas , Oscar Alvizo , Jovana Nazor , Da Duan , Vesna Mitchell , Jonathan Vroom , Santhosh Sivaramakrishnan , Nandhitha Subramanian , Jeffrey C. Moore , Mark Huffman , Agustina Rodriguez-Granillo , Deeptak Verma , Grant Murphy , Nicholas M. Marshall , Jay Russell , Keith A. Canada
Abstract: The present invention provides engineered phosphopentomutase (PPM) enzymes, polypeptides having PPM activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PPM enzymes are also provided. The present invention further provides compositions comprising the PPM enzymes and methods of using the engineered PPM enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
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公开(公告)号：US20200339973A1
公开(公告)日：2020-10-29
申请号：US16927129
申请日：2020-07-13
Applicant: Codexis, Inc.
Inventor： Oscar Alvizo , David Elgart , Robert Kevin Orr , James Nicholas Riggins , Anna Fryszkowska , Katrina W. Lexa , Xiang Yi , Da Duan , Courtney Dianne Moffett , Nikki Dellas , Vesna Mitchell
Abstract: The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.
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