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公开(公告)号:US20240209343A1
公开(公告)日:2024-06-27
申请号:US18395294
申请日:2023-12-22
申请人: Codexis, Inc.
发明人: Rachelle Copeland , David Elgart , Jason Fell , Jovana Nazor , Leland Ken Wong , Zhe Rui
IPC分类号: C12N9/00 , C12Q1/6813
CPC分类号: C12N9/93 , C12Q1/6813 , C12Y605/01003
摘要: The present disclosure relates to engineered RNA ligase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered RNA ligase polypeptides. The present disclosure also provides methods of using the engineered RNA ligase polypeptides or compositions thereof for molecular biological, diagnostic, and other purposes.
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公开(公告)号:US11965192B2
公开(公告)日:2024-04-23
申请号:US17537941
申请日:2021-11-30
申请人: Codexis, Inc.
发明人: Jovana Nazor , Vesna Mitchell , David Elgart , Katrina W. Lexa , Nikki Dellas , Robert Kevin Orr , Oscar Alvizo , Ravi David Garcia , Judy Victoria Antonio Viduya , Courtney Dianne Moffett
CPC分类号: C12N9/84 , C07K14/62 , C12P21/02 , C12Y305/01011
摘要: The present invention provides engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.
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公开(公告)号:US11591588B2
公开(公告)日:2023-02-28
申请号:US17091479
申请日:2020-11-06
申请人: Codexis, Inc.
发明人: Oscar Alvizo , David Elgart , Robert Kevin Orr , James Nicholas Riggins , Anna Fryszkowska , Katrina W. Lexa , Xiang Yi , Da Duan , Courtney Dianne Moffett , Nikki Dellas , Vesna Mitchell
摘要: The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.
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公开(公告)号:US20210254041A1
公开(公告)日:2021-08-19
申请号:US17242181
申请日:2021-04-27
申请人: Codexis, Inc.
发明人: Gjalt W. Huisman , Nicholas J. Agard , David Elgart , Xiyun Zhang
摘要: The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof. In some embodiments, the engineered TAL polypeptides have been optimized to provide enhanced catalytic activity while reducing sensitivity to proteolysis and increasing tolerance to acidic pH levels. The invention also provides methods for utilization of the compositions comprising the engineered TAL polypeptides for therapeutic and industrial purposes.
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公开(公告)号:US20200071688A1
公开(公告)日:2020-03-05
申请号:US16689503
申请日:2019-11-20
申请人: Codexis, Inc.
发明人: Gjalt W. Huisman , Nicholas J. Agard , David Elgart , Xiyun Zhang
摘要: The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof. In some embodiments, the engineered TAL polypeptides have been optimized to provide enhanced catalytic activity while reducing sensitivity to proteolysis and increasing tolerance to acidic pH levels. The invention also provides methods for utilization of the compositions comprising the engineered TAL polypeptides for therapeutic and industrial purposes.
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公开(公告)号:US20190211320A1
公开(公告)日:2019-07-11
申请号:US16367640
申请日:2019-03-28
申请人: Codexis, Inc.
发明人: Gjalt W. Huisman , Nicholas J. Agard , David Elgart , Xiyun Zhang
CPC分类号: C12N9/88 , A61K31/122 , A61K38/51 , C12P7/42 , C12P13/225 , C12Q1/527 , C12Y403/01023 , A61K2300/00
摘要: The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof. In some embodiments, the engineered TAL polypeptides have been optimized to provide enhanced catalytic activity while reducing sensitivity to proteolysis and increasing tolerance to acidic pH levels. The invention also provides methods for utilization of the compositions comprising the engineered TAL polypeptides for therapeutic and industrial purposes.
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公开(公告)号:US10287567B2
公开(公告)日:2019-05-14
申请号:US15432429
申请日:2017-02-14
申请人: Codexis, Inc.
发明人: Gjalt W. Huisman , Nicholas J. Agard , David Elgart , Xiyun Zhang
摘要: The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof. In some embodiments, the engineered TAL polypeptides have been optimized to provide enhanced catalytic activity while reducing sensitivity to proteolysis and increasing tolerance to acidic pH levels. The invention also provides methods for utilization of the compositions comprising the engineered TAL polypeptides for therapeutic and industrial purposes.
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公开(公告)号:US20150299689A1
公开(公告)日:2015-10-22
申请号:US14688126
申请日:2015-04-16
申请人: Codexis, Inc.
发明人: Gjalt W. Huisman , Nicholas J. Agard , David Elgart , Xiyun Zhang
IPC分类号: C12N9/88 , C12P7/42 , C12P13/22 , A61K38/51 , A61K31/122
CPC分类号: C12N9/88 , A61K31/122 , A61K38/51 , C12P7/42 , C12P13/225 , C12Q1/527 , C12Y403/01023 , A61K2300/00
摘要: The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof. In some embodiments, the engineered TAL polypeptides have been optimized to provide enhanced catalytic activity while reducing sensitivity to proteolysis and increasing tolerance to acidic pH levels. The invention also provides methods for utilization of the compositions comprising the engineered TAL polypeptides for therapeutic and industrial purposes.
摘要翻译: 本发明提供了工程化的酪氨酸氨裂解酶(TAL)多肽及其组合物。 在一些实施方案中,工程化TAL多肽已被优化以提供增强的催化活性,同时降低对蛋白水解的敏感性并增加对酸性pH水平的耐受性。 本发明还提供了用于治疗和工业目的的包含工程化TAL多肽的组合物的利用方法。
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公开(公告)号:US20140017733A1
公开(公告)日:2014-01-16
申请号:US13914475
申请日:2013-06-10
申请人: Codexis, Inc.
发明人: Nicholas John Agard , David Elgart , Jie Yang , Goutami Banerjee , Jeanne Bonomo Benoit , Dipnath Baidyaroy
IPC分类号: C12P19/14
CPC分类号: C12P19/14 , C12N9/2402 , C12N9/248 , C12N9/2482 , C12P7/14 , C12P7/16 , C12P19/02 , C12Y302/01008 , C12Y302/01037 , Y02E50/16
摘要: The present invention provides fungal xylanase and/or xylosidase enzymes suitable for use in saccharification reactions. The present invention provides xylanase and xylosidase enzymes suitable for use in saccharification reactions. The present application further provides genetically modified fungal organisms that produce xylanase(s) and/or xylosidase(s), as well as enzyme mixtures exhibiting enhanced hydrolysis of cellulosic material to fermentable sugars, enzyme mixtures produced by the genetically modified fungal organisms, and methods for producing fermentable sugars from cellulose using such enzyme mixtures. In some embodiments, the xylanase and xylosidase enzyme(s) are M. thermophila enzymes.
摘要翻译: 本发明提供了适用于糖化反应的真菌木聚糖酶和/或木糖苷酶。 本发明提供适用于糖化反应的木聚糖酶和木糖酶。 本申请还提供了生产木聚糖酶和/或木糖苷酶的遗传修饰的真菌生物,以及表现出纤维素材料水解为可发酵糖的酶混合物,由遗传修饰的真菌生物体产生的酶混合物和方法 用于使用这种酶混合物从纤维素生产可发酵糖。 在一些实施方案中,木聚糖酶和木糖苷酶是嗜热嗜热乳杆菌酶。
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公开(公告)号:US12018295B2
公开(公告)日:2024-06-25
申请号:US17345404
申请日:2021-06-11
申请人: Codexis, Inc.
发明人: Mathew G. Miller , Vesna Mitchell , Jovana Nazor , Donald S. Baskerville , Nikki Dellas , David Elgart , Jonathan Vroom , Sandy M. Gomes , Nandhitha Subramanian , Ericka Bermudez
CPC分类号: C12N9/1252
摘要: The present invention provides engineered DNA polymerase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered DNA polymerase polypeptides. The invention also provides methods for use of the compositions comprising the engineered DNA polymerase polypeptides for diagnostic and other purposes.
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