Polymeric intraocular lens material having improved surface properties
    22.
    发明授权
    Polymeric intraocular lens material having improved surface properties 失效
    具有改善的表面性质的聚合物眼内透镜材料

    公开(公告)号:US5091204A

    公开(公告)日:1992-02-25

    申请号:US111132

    申请日:1987-10-21

    IPC分类号: A61L27/34

    摘要: A method of making an improved intraocular lens for implanting in the eye by coating a glass or polymeric lens substrate with a fluorocarbon polymer to produce a rigid, low-energy surface that will significantly reduce adhesion and damage to corneal endothelial tissues upon implantation. The preferred lens material is produced by exposing the lens substrate to a gas plasma of a fluorocarbon monomer.

    摘要翻译: 一种通过用氟碳聚合物涂覆玻璃或聚合物透镜基底以产生刚性的低能量表面来制造改进的眼内透镜以用于植入眼睛的方法,其将在植入时显着降低粘附和损伤角膜内皮组织。 优选的透镜材料通过将透镜基板暴露于氟碳单体的气体等离子体来制造。

    ADAPTIVE TISSUE ENGINEERING SCAFFOLD
    24.
    发明申请
    ADAPTIVE TISSUE ENGINEERING SCAFFOLD 审中-公开
    自适应组织工程SCAFFOLD

    公开(公告)号:US20110256628A1

    公开(公告)日:2011-10-20

    申请号:US13090999

    申请日:2011-04-20

    摘要: The embodiments described herein include porous scaffolds formed from a stimuli-responsive polymer. The stimuli-responsive polymer of the scaffold creates a “smart” scaffold that changes properties in response to an effective stimulus applied to the stimuli-responsive polymer. In a preferred embodiment, an effective stimulus applied to the scaffold initiates a phase transition event in the stimuli-responsive polymer that results in a change in the volume of the pores of the scaffold. The scaffolds can be used to capture appropriately sized objects (e.g., cells) by using the volume-change properties of the pores. Relatedly, the scaffolds can be used as tissue-engineering scaffolds by capturing cells in the pores and introducing the cell-loaded scaffold into a cell-growth environment (e.g., in vivo).

    摘要翻译: 本文所述的实施方案包括由刺激响应性聚合物形成的多孔支架。 支架的刺激响应聚合物产生“智能”支架,其响应于施加到刺激响应聚合物的有效刺激而改变特性。 在优选的实施方案中,施用于支架的有效刺激引发刺激响应聚合物中的相变事件,其导致支架孔的体积变化。 支架可用于通过使用孔的体积变化特性捕获适当大小的物体(例如细胞)。 相关地,支架可以通过捕获孔中的细胞并将细胞负载的支架引入细胞生长环境(例如,体内)而用作组织工程支架。

    Multiple-probe diagnostic sensor
    26.
    发明授权
    Multiple-probe diagnostic sensor 失效
    多探针诊断传感器

    公开(公告)号:US5976466A

    公开(公告)日:1999-11-02

    申请号:US869899

    申请日:1992-04-15

    摘要: There is disclosed a diagnostic sensor device comprising a plurality of sensor probes, a detection device, and a computer for analyzing the signals generated from each sensor probe by multivariate statistical analysis. The plurality of sensor probes comprise a substrate that allows transmission of a signal and a partially selective surface coating the substrate wherein the partially selective surface binds proteins from a biological fluid by multiple, noncovalent interactions, and with the proviso that the partially selective surfaces of each sensor probe in the diagnostic sensor device be different. The diagnostic sensor device can be used as a method for diagnosing disease states in humans and animals, wherein the disease states are characterized by altered protein character and behavior of a biological fluid.

    摘要翻译: 公开了一种诊断传感器装置,其包括多个传感器探针,检测装置和计算机,用于通过多变量统计分析来分析从每个传感器探针产生的信号。 多个传感器探针包括允许透射信号和部分选择性表面包被基质的基底,其中部分选择性表面通过多种非共价相互作用结合来自生物流体的蛋白,并且条件是每个 诊断传感器设备中的传感器探头不同。 诊断传感器装置可用作诊断人和动物疾病状态的方法,其中疾病状态的特征在于改变的生物流体的蛋白质特性和行为。

    Method of controlling the chemical structure of polymeric films by
plasma deposition and films produced thereby
    27.
    发明授权
    Method of controlling the chemical structure of polymeric films by plasma deposition and films produced thereby 失效
    通过等离子体沉积控制聚合物膜的化学结构的方法和由此制备的膜

    公开(公告)号:US5153072A

    公开(公告)日:1992-10-06

    申请号:US675531

    申请日:1991-03-25

    IPC分类号: B05D3/06 B05D7/24

    摘要: A method of controlling the chemical structure of polymeric thin films formed by plasma deposition and films produced by these methods, is disclosed. An important aspect of the method involves controlling the temperature of the substrate and the reactor so as to create a temperature differential between the substrate and reactor such that the precursor molecules are preferentially adsorbed or condensed onto the substrate either during plasma deposition or between plasma deposition steps. The polymeric thin films produced by the methods of this invention exhibit more defined and predictable chemical structures and properties than conventional plasma deposited films.

    摘要翻译: 公开了一种控制通过等离子体沉积形成的聚合物薄膜的化学结构的方法和通过这些方法生产的薄膜。 该方法的一个重要方面包括控制衬底和反应器的温度,以便在衬底和反应器之间产生温度差,使得前体分子在等离子体沉积期间或在等离子体沉积步骤之间优先吸附或冷凝到衬底上 。 通过本发明的方法制备的聚合物薄膜比常规的等离子体沉积膜显示更多的限定和可预测的化学结构和性能。

    Method of controlling the chemical structure of polymeric films by plasma
    28.
    发明授权
    Method of controlling the chemical structure of polymeric films by plasma 失效
    通过等离子体控制聚合物膜的化学结构的方法

    公开(公告)号:US5002794A

    公开(公告)日:1991-03-26

    申请号:US402181

    申请日:1989-08-31

    IPC分类号: B05D3/06 B05D7/24

    CPC分类号: C08J7/123 B05D1/62

    摘要: A method of controlling the chemical structure of thin films formed by plasma deposition and films produced by these methods, is disclosed. An important aspect of the method involves controlling the temperature of the substrate and the reactor so as to create a temperature differential between the substrate and reactor such that the precursor molecules are preferentially adsorbed or condensed onto the substrate either during plasma deposition or between plasma deposition steps. The thin films produced by the methods of this invention exhibit more defined and predictable chemical structures and properties than conventional plasma deposited films.

    摘要翻译: 公开了一种控制通过等离子体沉积形成的薄膜的化学结构的方法和通过这些方法制造的薄膜。 该方法的一个重要方面包括控制衬底和反应器的温度,以便在衬底和反应器之间产生温度差,使得前体分子在等离子体沉积期间或在等离子体沉积步骤之间优先吸附或冷凝到衬底上 。 通过本发明的方法生产的薄膜表现出比常规等离子体沉积膜更加确定和可预测的化学结构和性能。

    Process for radiation grafting hydrogels onto organic polymeric
substrates
    30.
    发明授权
    Process for radiation grafting hydrogels onto organic polymeric substrates 失效
    将水凝胶辐射接枝到有机聚合物基材上的方法

    公开(公告)号:US3939049A

    公开(公告)日:1976-02-17

    申请号:US459734

    申请日:1974-04-10

    CPC分类号: C08F291/18

    摘要: An improved process for radiation grafting of hydrogels onto organic polymeric substrates is provided comprising the steps of incorporating an effective amount of cupric or ferric ions in an aqueous graft solution consisting of N-vinyl-2 - pyrrolidone or mixture of N-vinyl-2 - pyrrolidone and other monomers, e.g., 2-hydroxyethyl methacrylate, 2-hydroxyethyl acrylate, propylene glycol acrylate, acrylamide, methacrylic acid and methacrylamide, immersing an organic polymeric substrate in the aqueous graft solution and thereafter subjecting the contacted substrate with ionizing radiation.

    摘要翻译: 提供了一种用于将水凝胶辐射接枝到有机聚合物基底上的改进方法,其包括以下步骤:将有效量的铜或铁离子掺入由N-乙烯基-2-吡咯烷酮或N-乙烯基-2-吡咯烷酮的混合物组成的接枝水溶液中, 吡咯烷酮和其它单体,例如甲基丙烯酸2-羟基乙酯,丙烯酸2-羟乙酯,丙二醇丙烯酸酯,丙烯酰胺,甲基丙烯酸和甲基丙烯酰胺,将有机聚合物基材浸入含水接枝溶液中,然后用电离辐射对接触的基材进行处理。