公开(公告)号：US20170369557A1

公开(公告)日：2017-12-28

申请号：US15612938

申请日：2017-06-02

Applicant: Dyax Corp.

Inventor： Robert Charles Ladner ,  Edward H. Cohen ,  Horacio G. Nastri ,  Kristin L. Rookey ,  Rene Hoet ,  Hendricus Renerus Jacobus Mattheus Hoogenboom

IPC: C07K16/00 ,  C40B40/02 ,  C12N15/10 ,  C12N15/66 ,  C40B40/08

Abstract: Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.

公开(公告)号：US09845340B2

公开(公告)日：2017-12-19

申请号：US14626188

申请日：2015-02-19

Applicant: Dyax Corp.

Inventor： Daniel T. Dransfield ,  Aaron K. Sato ,  Robert Charles Ladner

IPC: C07K7/08 ,  A61K49/00 ,  B82Y5/00 ,  C07K14/475 ,  A61K51/08 ,  C07K14/00 ,  A61K47/60 ,  A61K47/54 ,  A61K47/66

CPC classification number: C07K7/08 ,  A61K47/543 ,  A61K47/60 ,  A61K47/665 ,  A61K49/0043 ,  A61K49/0056 ,  A61K51/08 ,  B82Y5/00 ,  C07K14/00 ,  C07K14/4753

Abstract: A polypeptide or multimeric polypeptide construct having the ability to bind to cMet or a complex comprising cMet and HGF, and methods for use are disclosed.

公开(公告)号：US20170240887A1

公开(公告)日：2017-08-24

申请号：US15402724

申请日：2017-01-10

Applicant: Dyax Corp.

Inventor： Hendricus Renerus Jacobus Mattheus Hoogenboom ,  Jurgen Mullberg ,  Robert Charles Ladner

IPC: C12N15/10 ,  C12N15/85

CPC classification number: C12N15/1082 ,  C07K16/00 ,  C07K2317/56 ,  C12N15/1058 ,  C12N15/625 ,  C12N15/85 ,  C12N2800/108 ,  C12N2830/002 ,  C12N2830/50 ,  C12N2830/55 ,  C12N2830/85 ,  C12N2840/203 ,  C40B30/04 ,  G01N33/56983

Abstract: Disclosed is a method that includes: (i) providing a plurality of initial nucleic acid cassettes that include: a) a first coding region encoding a first immunoglobulin variable domain, b) a second coding region encoding a second immunoglobulin variable domain, and c) a ribosomal binding site disposed between the first and second coding regions for translation of the second polypeptide in a first expression system, wherein the first and second coding regions are in the same translational orientation; (ii) modifying each nucleic acid cassette of the plurality in a single reaction mixture so that it is functional in a second expression system, wherein the first and second region remain physically attached during the modifying; (iii) introducing each modified nucleic acid cassette into a mammalian cell to produce a mixture of transfected cells; and (iv) expressing each modified nucleic acid cassette in the transfected cells.

公开(公告)号：US09670481B2

公开(公告)日：2017-06-06

申请号：US14048526

申请日：2013-10-08

Applicant: Dyax Corp.

Inventor： Robert Charles Ladner ,  Shannon Hogan ,  Kristin L. Rookey

IPC: C40B30/04 ,  C12N15/10 ,  B03C1/01 ,  B03C1/28 ,  G01N33/569

CPC classification number: C12N15/1037 ,  B03C1/01 ,  B03C1/288 ,  C40B30/04 ,  G01N33/56983 ,  G01N2500/10

Abstract: Disclosed are methods for identifying desired members from a display libraries, including bacteriophage display libraries. Display library members can be amplified in the presence of a target compound so that cycles of selection can be rapidly completed.

公开(公告)号：US09629934B2

公开(公告)日：2017-04-25

申请号：US14019241

申请日：2013-09-05

Applicant: Dyax Corp.

Inventor： Aaron K. Sato ,  Daniel J. Sexton ,  Daniel T. Dransfield ,  Robert Charles Ladner

IPC: C07K14/00 ,  A61K49/22 ,  A61K47/48 ,  A61K51/08 ,  C07K7/08 ,  C07K14/52 ,  C07K14/71 ,  A61K38/00

CPC classification number: A61K49/221 ,  A61K38/00 ,  A61K47/62 ,  A61K49/223 ,  A61K51/088 ,  C07K7/08 ,  C07K14/001 ,  C07K14/52 ,  C07K14/71 ,  C07K2319/00 ,  Y02A50/411 ,  Y02A50/58

Abstract: The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD

公开(公告)号：US20160222108A1

公开(公告)日：2016-08-04

申请号：US14979165

申请日：2015-12-22

Applicant: DYAX CORP. ,  BIOGEN HEMOPHILIA INC.

Inventor： Christopher TenHoor ,  Arumugam Muruganandam ,  Robert Charles Ladner ,  Clive Wood ,  Alan J. Bitonti ,  James M. McGivney ,  Kevin A. McDonnell ,  Liming Liu ,  Jennifer Dumont ,  Aaron K. Sato ,  Malini Viswanathan

IPC: C07K16/28

Abstract: This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.

公开(公告)号：US10829541B2

公开(公告)日：2020-11-10

申请号：US15612938

申请日：2017-06-02

Applicant: Dyax Corp.

Inventor： Robert Charles Ladner ,  Edward H. Cohen ,  Horacio G. Nastri ,  Kristin L. Rookey ,  Rene Hoet ,  Hendricus Renerus Jacobus Mattheus Hoogenboom

IPC: C40B50/06 ,  C07K16/00 ,  C12N15/10 ,  C12N15/66 ,  C40B40/02 ,  C40B40/08

Abstract: Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.

公开(公告)号：US20200231962A1

公开(公告)日：2020-07-23

申请号：US16748441

申请日：2020-01-21

Applicant: Dyax Corp.

Inventor： Robert Charles Ladner ,  Shannon Hogan ,  Kristin L. Rookey

IPC: C12N15/10 ,  B03C1/01 ,  B03C1/28 ,  G01N33/569

Abstract: Disclosed are methods for identifying desired members from a display libraries, including bacteriophage display libraries. Display library members can be amplified in the presence of a target compound so that cycles of selection can be rapidly completed.

公开(公告)号：US10683342B2

公开(公告)日：2020-06-16

申请号：US15177199

申请日：2016-06-08

Applicant: Dyax Corp.

Inventor： Robert Charles Ladner

IPC: C40B40/08 ,  C07K16/00 ,  C40B40/02 ,  C40B40/10

Abstract: Provided are compositions and methods for preparing and identifying antibodies having CDR3s that vary in sequence and in length from very short to very long which in certain embodiments may bind to a carbohydrate moiety or the active site of an enzyme. Libraries coding for antibodies with the CDR3s are also provided. The libraries can be provided by modifying a pre-existing nucleic acid library.

公开(公告)号：US10604753B2

公开(公告)日：2020-03-31

申请号：US15797927

申请日：2017-10-30

Applicant: Dyax Corp.

Inventor： Robert Charles Ladner

IPC: C40B40/10 ,  C12N15/10 ,  C07K16/00 ,  C40B40/02 ,  C40B40/08

Abstract: Focused libraries of vectors or genetic packages that display, display and express, or comprise a member of a diverse family of antibody peptides, polypeptides or proteins and collectively display, display and express, or comprise at least a portion of the focused diversity of the family. The libraries have length and sequence diversities that mimic that found in native human antibodies.