Cyclic Peptide Isolation by Spray Drying
    22.
    发明申请
    Cyclic Peptide Isolation by Spray Drying 审中-公开
    循环肽通过喷雾干燥分离

    公开(公告)号:US20080227693A1

    公开(公告)日:2008-09-18

    申请号:US12064896

    申请日:2006-08-29

    IPC分类号: A61K38/12 C07K1/14 C07K7/64

    CPC分类号: C07K7/56 C07K1/14

    摘要: Methods for isolation of a synthetic cyclic peptide by spray drying, including spray drying at elevated temperatures, products made by the methods, and synthetic cyclic peptides preparations with defined characteristics, including an essentially amorphous acid addition salt of Ac-Nle-cyclo(-Asp-His-D-Phe-Arg-Trp-Lys)-OH in the form of a fine powder with a particle diameter of about 2 to about 20 microns.

    摘要翻译: 通过喷雾干燥分离合成环肽的方法,包括在高温下的喷雾干燥,通过该方法制备的产物和具有确定特征的合成环肽制剂,包括Ac-Nle-cyclo(-Asp)的基本无定形酸加成盐 -His-D-Phe-Arg-Trp-Lys)-OH,其粒径为约2至约20微米。

    QRS onset and offset detection with adaptive temporal windowing
    23.
    发明授权
    QRS onset and offset detection with adaptive temporal windowing 有权
    QRS开始和偏移检测与自适应时间窗口

    公开(公告)号:US08855752B2

    公开(公告)日:2014-10-07

    申请号:US12721836

    申请日:2010-03-11

    申请人: Steven R. Johnson

    发明人: Steven R. Johnson

    IPC分类号: A61B5/0472

    CPC分类号: A61B5/0472

    摘要: A heart monitor computes ST segment deviation as the difference in the value of an electrocardiogram signal at the ST and PQ points of a heartbeat. The ST point is found based on slope criteria and temporal criteria. The maximum (positive) slope of the QRS (maxQRS) is located. Within a preset window after the maxQRS point, the processor searches for a sample at which the second finite difference is less than a threshold that is a function of average QRS amplitude. If such a qualifying sample is found, the processor examines its location relative to the location of an adaptive window that is centered on a sample that is an adaptively determined distance from the peak of the R wave. If the qualifying point is within the adaptive window, it is chosen as the ST point. If the qualifying point is after the adaptive window, the ST point is set at the end of the adaptive window. Finally, if the qualifying point is before the adaptive window, the ST point is selected at the beginning of the adaptive window. The adaptive window is then updated according to an exponential average filter based upon the distance between the ST point and the R wave peak.

    摘要翻译: 心脏监测器计算ST段偏差作为心跳的ST和PQ点的心电图信号的值的差异。 ST点是基于斜率标准和时间标准。 QRS(maxQRS)的最大(正)斜率位于。 在maxQRS点之后的预设窗口内,处理器搜索第二有限差小于作为平均QRS幅度的函数的阈值的样本。 如果找到这样的合格样本,则处理器相对于以R波的峰值为自适应地确定距离的采样为中心的自适应窗口的位置检查其位置。 如果限定点在自适应窗口内,则将其选为ST点。 如果限定点在自适应窗口之后,ST点被设置在自适应窗口的末尾。 最后,如果限定点在自适应窗口之前,则在自适应窗口的开头选择ST点。 然后根据基于ST点和R波峰之间的距离的指数平均滤波器来更新自适应窗口。

    Wellcare management methods and systems
    24.
    发明申请
    Wellcare management methods and systems 有权
    保健管理方法和系统

    公开(公告)号:US20130090940A1

    公开(公告)日:2013-04-11

    申请号:US13317149

    申请日:2011-10-11

    IPC分类号: G06Q50/22

    CPC分类号: G06Q50/22

    摘要: Methods and systems related to wellcare management are disclosed. The methods comprise enrolling wellcare providers and consumers, offering wellcare plans, and providing automated payment processing and collection in connection with the wellcare plans. The methods also allow the wellcare management systems to interface with the wellcare provider's practice management software administered by a third party. Preferably, the wellcare plan providers are veterinarians, particularly independent veterinarians. Systems employing the methods over one or more computer networks are also disclosed, as are articles comprising computer readable media.

    摘要翻译: 披露与养护管理相关的方法和系统。 这些方法包括招募保健提供者和消费者,提供保健计划,并提供与保健计划相关的自动支付处理和收集。 这些方法还允许养护管理系统与由第三方管理的养护提供者的实践管理软件进行交互。 优选地,保健计划提供者是兽医,特别是独立的兽医。 还公开了在一个或多个计算机网络上采用该方法的系统,以及包括计算机可读介质的文章。

    Modular conveyer belt
    25.
    发明授权
    Modular conveyer belt 有权
    模块化输送带

    公开(公告)号:US08113340B1

    公开(公告)日:2012-02-14

    申请号:US12613061

    申请日:2009-11-05

    IPC分类号: B65G17/38

    摘要: A modular member for a conveyer belt is provided that includes an elongated main base, at least one attaching rod and a plurality of hooks. The at least one attaching rod is coupled proximate a first side of the main base. The plurality of aligned hooks are coupled proximate a second side of the main base. Each hook includes a slot defined by an inner surface. The slot of each hook is configured to receive an attaching rod of another modular member. The inner surface that defines the slot of at least one hook has an attaching rod relief cutout section. The attaching rod relief cutout section limits wear between the attaching rod of another modular member that is received in the slot of the at least one hook and the inner surface of the slot of the at least one hook.

    摘要翻译: 提供了一种用于输送带的模块化构件,其包括细长主基座,至少一个附接杆和多个钩。 所述至少一个附接杆在所述主底座的第一侧附近联接。 多个对准的钩子靠近主底座的第二侧联接。 每个钩包括由内表面限定的槽。 每个钩的槽被构造成接收另一个模块构件的连接杆。 限定至少一个钩的狭槽的内表面具有附接杆释放部分。 附接杆释放切口部分限制了容纳在至少一个钩的槽中的另一模块化构件的附接杆与至少一个钩的槽的内表面之间的磨损。

    Header with integral antenna for implantable medical devices
    26.
    发明申请
    Header with integral antenna for implantable medical devices 审中-公开
    带可植入医疗器械的集成天线的头部

    公开(公告)号:US20100019985A1

    公开(公告)日:2010-01-28

    申请号:US12219566

    申请日:2008-07-24

    IPC分类号: H01Q1/40

    摘要: Antenna assemblies for an implantable medical device are disclosed. The implantable medical device comprises a hermetically sealed housing, typically formed of titanium materials, and electronics, including a transceiver, disposed therein. An antenna is disposed in an air, gas or plastic dielectric filled compartment within a header, which is attached to the housing. The header is premolded so as to create the compartment. The antenna is then placed within the compartment, which is then sealed.

    摘要翻译: 公开了一种用于可植入医疗装置的天线组件。 该植入式医疗装置包括通常由钛材料形成的气密密封的壳体,以及设置在其中的包括收发器的电子装置。 天线设置在头部内的空气,气体或塑料电介质填充的隔间中,该隔板连接到外壳。 标题被预先翻转,以便创建隔间。 然后将天线放置在隔间内,然后密封。

    Reshaping of paths without respect to control points
    27.
    发明授权
    Reshaping of paths without respect to control points 失效
    改变路径,而不是控制点

    公开(公告)号:US06459439B1

    公开(公告)日:2002-10-01

    申请号:US09037720

    申请日:1998-03-09

    IPC分类号: G06T320

    CPC分类号: G06T11/203

    摘要: The inventive mechanisms convert a path, which represents a graphical object, into a plurality of line segments. Thus, the path can be reshaped without respect to existing Bezier control points. The first mechanism allows a user to ‘pull’ a segment of a path. A user selects a specific place on the path, pulls the selected place along with a portion of the path on either side of the place to a desired location. The second mechanism allows a user to ‘push’ a segment of a path, by using an arbitrary shape and sculpting the path. The arbitrary shape is used in a manner similar in which a sculptor would use a putty knife and sculpts away part of the path, by pushing that shape into the path. The path is being repelled from the shape, as the shape is being pushed. The third mechanism allows a user to reshape an area or region of the path. The user selects a specific point in space and modify any parts of the path that lie within that region of space.

    摘要翻译: 本发明的机构将表示图形对象的路径转换成多个线段。 因此,路径可以重新整形,而不会影响现有的贝塞尔控制点。 第一种机制允许用户“拉”路径的一段,用户选择路径上的特定位置,将所选位置与位置任意一侧的路径的一部分一起拉到所需位置,第二个 机制允许用户通过使用任意形状和雕刻路径来“推”路径的一段。 任意形状的使用方式类似于雕塑家将使用油灰刀,并通过将该形状推入路径来雕刻路径的一部分。 由于形状被推动,路径被排除了形状。 第三种机制允许用户重新形成路径的区域或区域。 用户选择空间中的特定点,并修改位于该空间区域内的路径的任何部分。

    Workpiece holding apparatus for spindle finishing machines and the like
    28.
    发明授权
    Workpiece holding apparatus for spindle finishing machines and the like 失效
    用于主轴精加工机的工件保持装置等

    公开(公告)号:US4205487A

    公开(公告)日:1980-06-03

    申请号:US889961

    申请日:1978-03-24

    IPC分类号: B24B31/00 B24B41/06 B24B31/08

    摘要: A workpiece holding apparatus for spindle finishing machines and the like, the apparatus including a plurality of radially arranged workpiece holders mounted for rotation about a first axis and including cooperating gear elements for rotating each of the holders about its respective longitudinal axis in response to rotation of the entire assemblage of holders about the first mentioned axis; a cam arrangement is provided whereby each of the holders may be actuated between a first condition securing workpieces on the holders and a second condition permitting workpieces to be removed, such as after a finishing operation has been completed.

    摘要翻译: 一种用于主轴精加工机械等的工件保持装置,该装置包括多个径向布置的工件保持器,其安装成围绕第一轴线旋转,并且包括用于响应于第一轴线的旋转而围绕其相应的纵向轴线旋转每个保持器的协作齿轮元件 关于第一个提到的轴的持有者的整个组合; 提供了一种凸轮装置,其中每个保持器可以在固定保持器上的工件的第一状态和允许工件被移除的第二状态之间,诸如在完成操作完成之后被致动。

    System and methods for the selective updating of heart signal parameter time series
    29.
    发明授权
    System and methods for the selective updating of heart signal parameter time series 有权
    选择性更新心脏信号参数时间序列的系统和方法

    公开(公告)号:US08560055B2

    公开(公告)日:2013-10-15

    申请号:US12702777

    申请日:2010-02-09

    IPC分类号: A61B5/0456 A61B5/0468

    摘要: A heart rate monitor generates an ST deviation time series by employing a recursive filter that is preferably an exponential average filter whose output is a weighted sum of the then existing ST time series value and current ST deviation values of analyzable beats. Beats are detected in segments of data. ST deviation is measured for analyzable beats. The ST deviation time series is updated only if certain criteria are met. A first criterion for updating the time series is that at least half of the beats within a segment must be normal sinus rhythm beats. A second criterion for updating the time series is that (i) the average RR interval of the segment is between ¾ and 1.5 times the average RR interval of the previous segment; or (ii) both (a) the number of abnormal beats in the current segment is less than 2, and (b) the number of premature ventricular contractions within the current segment is less than 2.

    摘要翻译: 心率监视器通过采用递归滤波器来产生ST偏差时间序列,该递归滤波器优选地是指数平均滤波器,其输出是当时存在的ST时间序列值和可分析节拍的当前ST偏差值的加权和。 在数据段中检测到节拍。 对可分析节拍测量ST偏差。 仅当符合某些标准时才更新ST偏差时间序列。 更新时间序列的第一个标准是片段中至少一半的节拍必须是正常的窦性心律拍子。 用于更新时间序列的第二个标准是(i)段的平均RR间隔在前一段的平均RR间隔的¾和1.5倍之间; 或(ii)(a)当前段的异常搏动次数小于2,(b)当前段内过早心室收缩数小于2。

    Method and apparatus for controlling signal power level in free space communication
    30.
    发明授权
    Method and apparatus for controlling signal power level in free space communication 有权
    用于控制自由空间通信中的信号功率电平的方法和装置

    公开(公告)号:US06643466B1

    公开(公告)日:2003-11-04

    申请号:US09675003

    申请日:2000-09-29

    IPC分类号: H04B1000

    摘要: In the method and apparatus for controlling the power level of a laser signal in free space communication, a communication terminal transmits an output laser beam into free space and also receives information, through a channel that is not free space laser based, about the power of the output laser beam measured at a distance and at different times. The terminal determines whether a drop in the power of the output laser beam measured at the distance is due to atmospheric effects based on the received information. The terminal increases the power level of the output laser beam to a desired level if the power drop is determined to be due to atmospheric effects. On the other hand, the terminal lowers the power of the output laser beam to a predetermined level if the power drop is determined to be due to blockage thus avoiding harm to accidental observers that might intrude into the path of the laser beams.

    摘要翻译: 在用于控制自由空间通信中的激光信号的功率电平的方法和装置中,通信终端将输出激光束发射到自由空间中,并且通过不是以自由空间激光为基础的信道来接收信息, 在一段距离和不同时间测量输出激光束。 终端确定在距离处测量的输出激光束的功率的下降是否是由于基于所接收的信息的大气影响。 如果确定功率降是由于大气效应,则端子将输出激光束的功率电平增加到期望的水平。 另一方面,如果断电被确定为由于阻塞而导致输出激光束的功率降低到预定水平,从而避免对可能侵入到激光束路径中的意外观测器的危害。