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32 条记录 (耗时 0.021 秒)

    Compounds and methods for the modulation of CD154
    21.
    发明授权
    Compounds and methods for the modulation of CD154 有权
    用于调节CD154的化合物和方法

    公开(公告)号：US07271152B2

    公开(公告)日：2007-09-18

    申请号：US10476237

    申请日：2002-05-03

    申请人： Lisa Alaimo ,  Veronica Alves ,  Patrick Andre ,  David Phillips ,  Sri R. Prasad ,  Denisa D. Wagner

    发明人： Lisa Alaimo ,  Veronica Alves ,  Patrick Andre ,  David Phillips ,  Sri R. Prasad ,  Denisa D. Wagner

    IPC分类号： A61K38/04

    CPC分类号： A61K38/57 ,  A61K31/00 ,  A61K38/12 ,  A61K2300/00

    摘要： The present invention relates to compounds that are capable of modulating CD154 mobilization and that are useful for stabilizing the thrombotic process and reducing the activation of cells involved in an inflammatory response. The present invention also relates to methods useful for identifying such compounds. The present invention also relates to the treatment of platelets for transfusion with metalloproteinase inhibitors to treat or prevent inflammation. The present invention also includes compositions and methods to treat injury and disease related to such biological processes.

    摘要翻译： 本发明涉及能够调节CD154动员并且可用于稳定血栓形成过程并减少参与炎性反应的细胞活化的化合物。 本发明还涉及用于鉴定这些化合物的方法。 本发明还涉及用金属蛋白酶抑制剂输血的血小板治疗或预防炎症。 本发明还包括治疗与这种生物过程相关的损伤和疾病的组合物和方法。

    Thermal actuator
    24.
    发明授权
    Thermal actuator 失效
    热致动器

    公开(公告)号：US6046666A

    公开(公告)日：2000-04-04

    申请号：US91776

    申请日：1998-08-17

    申请人： Leif Ingvarsson ,  Patrick Andre

    发明人： Leif Ingvarsson ,  Patrick Andre

    IPC分类号： F16K20060101 ,  F16K31/68 ,  G05D23/13 ,  G05D23/19 ,  H01H37/36 ,  F24F11/053 ,  H01H37/40 ,  H01H37/44

    CPC分类号： G05D23/1921

    摘要： A known thermal actuator includes a capsule, which contains a diaphragm controlling the position of a stem. A thermal expansion substance like wax is contained in the capsule which operates as a thermostat in a thermostatically controlled valve such as a thermostatically controlled mixing valve. The stem of the actuator is connected with a valve body movable between two valve seats for a hot and cold medium, respectively, and the capsule is placed in the area of the mixed medium for transmitting the heat of the mixed medium to the thermal expansion substance. In order to present a simple and more effective actuator that can react promptly at changes of temperature and which does not require an extra temperature sensor, the capsule includes an oblong cuplike sensor body, the surface of which is at least partly deformed in such a way that its thermal transmittance area is increased.

    摘要翻译： PCT No.PCT / SE95 / 01580 Sec。 371日期1998年8月17日第 102（e）日期1998年8月17日PCT 1995年12月22日PCT PCT。 第WO97 / 23740号公报 日期1997年7月3日已知的热致动器包括胶囊，其包含控制杆的位置的隔膜。 在诸如恒温控制的混合阀的恒温控制阀中作为恒温器的胶囊中包含蜡等热膨胀物质。 致动器的杆分别与可在两个用于热和冷介质的阀座之间移动的阀体连接，并且将胶囊放置在混合介质的区域中，以将混合介质的热传递到热膨胀物质 。 为了呈现一种能够在温度变化时迅速反应并且不需要额外温度传感器的简单且更有效的致动器，该胶囊包括长方形杯状传感器体，其表面至少部分地以这种方式变形 其热传导率增加。

    Support tube for a cold-shrink sleeve for joining electric cables
    28.
    发明申请
    Support tube for a cold-shrink sleeve for joining electric cables 审中-公开
    用于连接电缆的冷缩套管的支撑管

    公开(公告)号：US20080209724A1

    公开(公告)日：2008-09-04

    申请号：US12070724

    申请日：2008-02-20

    申请人： Patrick Andre

    发明人： Patrick Andre

    IPC分类号： H01R43/20 ,  H01R43/04 ,  B23P11/02

    CPC分类号： H02G15/1826 ,  G06F16/40 ,  Y10T29/49217 ,  Y10T29/4987

    摘要： A process for manufacturing an electrical cable joint by means of a shrink sleeve supported by a tube including supporting the shrink sleeve, in an expanded state, with the tube, where the tube is an open tube fitted on its two longitudinal edges with mutual engagement means. The mutual engagement means are engaged with one another while the tube is supporting the shrink sleeve. The mutual engagement means are then disengaged and the tube is removing from the shrink sleeve, allowing the shrink sleeve to shrink onto the joint.

    摘要翻译： 一种用于通过由管支承的收缩套管制造电缆接头的方法，包括以膨胀状态支撑收缩套管，其中管是其两个纵向边缘上的相互接合装置 。 相互接合装置彼此接合，同时管子支撑收缩套筒。 然后，相互接合装置脱离，并且管从收缩套筒移除，使收缩套筒收缩到接头上。

    METHODS FOR DIAGNOSING AND TREATING HEMOSTATIC DISORDERS BY MODULATING P-SELECTIN ACTIVITY
    29.
    发明申请
    METHODS FOR DIAGNOSING AND TREATING HEMOSTATIC DISORDERS BY MODULATING P-SELECTIN ACTIVITY 审中-公开
    通过调节P-选择素活性来诊断和治疗嗜酸粒细胞性疾病的方法

    公开(公告)号：US20080193949A1

    公开(公告)日：2008-08-14

    申请号：US12030576

    申请日：2008-02-13

    申请人： Denisa D. Wagner ,  Patrick Andre ,  Daqing W. Hartwell ,  Ingrid Hrachovinova

    发明人： Denisa D. Wagner ,  Patrick Andre ,  Daqing W. Hartwell ,  Ingrid Hrachovinova

    IPC分类号： G01N33/566

    CPC分类号： G01N33/86 ,  A61K38/178 ,  A61K48/00 ,  C07K2319/30 ,  G01N2333/70564

    摘要： The present invention identifies P-selectin as a modulator of hemostasis. Accordingly, the present invention relates to methods for the identification and use of modulators of P-selectin activity as modulators of hemostasis. The invention also relates to methods and compositions for the diagnosis and treatment of hemostatic disorders, including, but not limited to, hemorrhagic disorders and thrombotic disorders. The present invention describes methods for the diagnostic evaluation and prognosis of various hemostatic conditions, and for the identification of subjects exhibiting a predisposition to such conditions. In addition, the present invention provides methods for the diagnostic monitoring of patients undergoing clinical evaluation for the treatment of a hemostatic or vascular disorders, and for monitoring the efficacy of compounds in clinical trials.

    摘要翻译： 本发明鉴定了P-选择蛋白作为止血调节剂。 因此，本发明涉及用于鉴定和使用P-选择蛋白活性的调节剂作为止血调节剂的方法。 本发明还涉及用于诊断和治疗止血障碍的方法和组合物，包括但不限于出血性疾病和血栓形成障碍。 本发明描述了用于各种止血条件的诊断评估和预后的方法，以及用于鉴定表现出对这些病症倾向的受试者。 此外，本发明提供了用于诊断监测临床评估用于治疗止血或血管疾病以及用于监测化合物在临床试验中的功效的患者的诊断监测方法。

    Methods of treatment with Syk inhibitors
    30.
    发明申请
    Methods of treatment with Syk inhibitors 有权
    Syk抑制剂治疗方法

    公开(公告)号：US20050232969A1

    公开(公告)日：2005-10-20

    申请号：US11107324

    申请日：2005-04-15

    申请人： Patrick Andre ,  David Phillips ,  Charles Homcy

    发明人： Patrick Andre ,  David Phillips ,  Charles Homcy

    IPC分类号： A61F2/02 ,  A61K31/473 ,  A61K31/4745 ,  A61K31/52

    CPC分类号： A61K31/473 ,  A61K31/4745 ,  A61K31/52 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L2300/434

    摘要： The present invention provides novel compositions and methods for inhibiting restenosis, thrombosis, and/or inflammation in a patient undergoing a vascular intervention. More particularly, the present invention provides intravascular devices coated with one or more spleen tyrosine kinase (Syk) inhibitors. Methods for inhibiting restenosis, thrombosis, and/or inflammation in a patient by treatment with such intravascular devices are also provided. In addition, the present invention provides methods for treating sickle cell disease using Syk inhibitors.

    摘要翻译： 本发明提供了用于在经历血管干预的患者中抑制再狭窄，血栓形成和/或炎症的新型组合物和方法。 更具体地，本发明提供涂覆有一种或多种脾脏酪氨酸激酶（Syk）抑制剂的血管内装置。 还提供了通过用这种血管内装置治疗来抑制患者再狭窄，血栓形成和/或炎症的方法。 此外，本发明提供了使用Syk抑制剂治疗镰状细胞病的方法。