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21.发明授权公开(公告)号：US09932635B2
公开(公告)日：2018-04-03
申请号：US14119843
申请日：2012-05-24
申请人： David T. Wong , Fang Wei , Wei Liao
发明人： David T. Wong , Fang Wei , Wei Liao
IPC分类号： C12Q1/68 , C12N15/10 , G01N33/50 , G01N33/543 , G01N33/569 , G01N33/49
CPC分类号： C12Q1/6881 , C12N15/1013 , C12Q1/6806 , G01N33/49 , G01N33/5005 , G01N33/5076 , G01N33/54326 , G01N33/56966 , C12Q2563/131 , C12Q2563/143 , C12Q2563/161
摘要： The molecules harbored in exosomes play important roles in biological science. A highly desirable goal for exosome research is the rapid, simple, simultaneous tracking and quantification of exosome harbored molecules. Disclosed herein are methods and devices for inducing the release and measurement of biomolecules harbored in exosomes. The disclosed method, Electric Field Induced Release and Measurement (EFIRM) technique, uses an electrical field to simultaneously disrupt exosomes to release the contents and measure the harbored exosomal RNA/proteins. The exosome vesicle contents can be released within minutes. This provides a potential on-site method for the detection of exosome-harbored biomolecules.
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22.发明申请公开(公告)号：US20120196764A1
公开(公告)日：2012-08-02
申请号：US13379341
申请日：2010-06-25
申请人： Lei Zhang , David T. Wong
发明人： Lei Zhang , David T. Wong
CPC分类号： G01N33/57488 , C12Q1/6886 , C12Q2600/158 , G01N33/57438
摘要： The present invention relates to the identification of pancreatic cancer biomarkers for the detection of early pancreatic cancer. The present invention also provides methods of diagnosing pancreatic cancer and distinguishing between pancreatic cancer and chronic pancreatitis. The present invention additionally provides kits that find use in the practice of the methods of the invention.
摘要翻译： 本发明涉及用于检测早期胰腺癌的胰腺癌生物标志物的鉴定。 本发明还提供诊断胰腺癌和区分胰腺癌和慢性胰腺炎的方法。 本发明另外提供可用于实施本发明方法的试剂盒。
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公开(公告)号：USD561546S1
公开(公告)日：2008-02-12
申请号：US29250807
申请日：2006-12-01
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公开(公告)号：US4647591A
公开(公告)日：1987-03-03
申请号：US785411
申请日：1985-10-07
申请人： Arthur Cherkin , James F. Flood , David T. Wong
发明人： Arthur Cherkin , James F. Flood , David T. Wong
IPC分类号： A61K31/135 , A61K31/195
CPC分类号： A61K31/135
摘要： Fluoxetine can be employed to improve memory in mammals and to treat amnesia.
摘要翻译： 氟西汀可用于改善哺乳动物的记忆和治疗遗忘。
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公开(公告)号：USD562094S1
公开(公告)日：2008-02-19
申请号：US29250804
申请日：2006-12-01
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公开(公告)号：USD503581S1
公开(公告)日：2005-04-05
申请号：US29185161
申请日：2003-06-25
申请人： David T. Wong , Vincent M. L. Ng
设计人： David T. Wong , Vincent M. L. Ng
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公开(公告)号：US5789402A
公开(公告)日：1998-08-04
申请号：US471121
申请日：1995-06-06
申请人： James E. Audia , David J. Hibschman , Joseph H. Krushinski, Jr. , Thomas E. Mabry , Jeffrey S. Nissen , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson , David T. Wong
发明人： James E. Audia , David J. Hibschman , Joseph H. Krushinski, Jr. , Thomas E. Mabry , Jeffrey S. Nissen , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson , David T. Wong
IPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D491/20 , C07D495/10 , C07D513/04 , A61K31/55 , C07D401/00 , C07D405/00 , C07D409/00
CPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D495/10 , C07D513/04
摘要： A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1.sub.A receptor. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.
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公开(公告)号：US5538992A
公开(公告)日：1996-07-23
申请号：US442734
申请日：1995-05-17
申请人： David T. Wong , Juan I. Oguiza
发明人： David T. Wong , Juan I. Oguiza
IPC分类号： A61K31/445 , A61K31/13 , A61K31/135 , A61K31/138 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/41 , A61K31/435 , A61K31/475 , A61K31/495 , A61K31/535 , A61K31/54 , A61K31/55 , A61K45/06 , A61P9/12
CPC分类号： A61K45/06 , A61K31/135 , A61K31/38 , A61K31/40
摘要： The power of fluoxetine, venlafaxine, milnacipran and duloxetine to increase the availability of serotonin, norepinephrine and dopamine, particularly serotonin, is augmented by administration in combination with a drug which is a serotonin 1A receptor antagonist.
摘要翻译： 氟西汀，文拉法辛，米那普仑和度洛西汀增加5-羟色胺，去甲肾上腺素和多巴胺，特别是5-羟色胺的可用性的功效通过与作为血清素1A受体拮抗剂的药物组合施用而增加。
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公开(公告)号：US5532250A
公开(公告)日：1996-07-02
申请号：US442609
申请日：1995-05-17
申请人： David T. Wong , Juan I. Oguiza
发明人： David T. Wong , Juan I. Oguiza
IPC分类号： A61K31/445 , A61K31/13 , A61K31/135 , A61K31/138 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/41 , A61K31/435 , A61K31/475 , A61K31/495 , A61K31/535 , A61K31/54 , A61K31/55 , A61K45/06 , A61P9/12
CPC分类号： A61K45/06 , A61K31/135 , A61K31/38 , A61K31/40
摘要： The power of fluoxetine, venlafaxine, milnacipran and duloxetine to increase the availability of serotonin, norepinephrine and dopamine, particularly serotonin, is augmented by administration in combination with a drug which is a serotonin 1A receptor antagonist.
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公开(公告)号：US4585861A
公开(公告)日：1986-04-29
申请号：US688946
申请日：1985-01-04
IPC分类号： C07D253/06 , A61K31/33 , A61K31/495 , A61K31/53 , A61P25/00 , A61P25/08 , C07D241/16 , C07D241/18 , C07D253/07 , C07D401/04 , C07D403/04 , C07D413/04 , C07D491/04 , C07D491/10 , C07D491/113
CPC分类号： C07D491/10 , C07D241/16 , C07D241/18 , C07D253/07 , C07D401/04 , C07D403/04
摘要： This invention relates to certain amino-5,6-diaryl-1,2,4-triazines and -pyrazines useful as activators of GABA and benzodiazepine binding.
摘要翻译： 本发明涉及可用作GABA和苯并二氮杂结合活化剂的某些氨基-5,6-二芳基-1,2,4-三嗪和吡嗪。
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