摘要:
The invention relates to a combination of substances (component I) inducing necrosis in tumors or inflamed tissue with other nontoxic substances ("prodrugs", component II). The enzymes set free by necrotic processes then cleave the nontoxic "prodrug" into the toxic "drug", which leads to massive tumor cell death and/or remission of inflammation.
摘要:
The supporting body of an instrument is joined to a casing by means of ribs fitting into guideways angularly spaced around a centerline of the supporting body. Thereby, small clearances between the ribs and guideways in a direction parallel to the casing wall surfaces are effective in limiting play at right angles to the casing walls, where much greater clearances must be provided. The casing may expand or shrink freely without exerting strains on the supporting body that could interfere with the proper function of the instrument, due to the large radial clearances between the ribs and guideways.
摘要:
A device is provided for clamping and centering two parts to be welded together, such as a flange or edge against a pipe or two pipes against each other, or a pipe against a pipe, so that the parts can be welded together in a clamped position. The device comprises a clamping tool which is in the form of a portable, manually operable unit. The tool preferably has clamping tongs with interchangeable clamping pins for interior clamping.
摘要:
A mining auger includes an auger shaft having a front end, a conical end ring affixed to the front end of the auger and having a forwardly oriented face and a peripheral edge zone; a plurality of tool holders affixed to the peripheral edge zone in a circumferential distribution and each having a forwardly oriented face; and a cutting tool bit carried in each tool holder. Each cutting tool bit projects forwardly beyond a peripheral edge of the conical end ring and has a longitudinal axis extending at an inclined orientation with respect to an imaginary frontal plane which is perpendicular to the auger axis and which generally coincides with the mine wall face during operation. At least some of the tool holders carry a shearing tool bit each having an axis extending from the forwardly oriented face of the conical end ring in the direction of the frontal plane and further, each shearing tool bit has a tip which is at a significant distance from the forwardly oriented face of the respective tool holder.
摘要:
A method for forming a longitudinal edge region of a transport/drive belt having at least two layers of a thermoplastic material and at least one layer of a woven fabric web includes positioning a mat at one longitudinal edge of the transport/drive belt. The method further includes transferring heat and pressure to the transport/drive belt so as to melt and merge at least a region of the at least two layers of thermoplastic material without adding any additional material, solidifying the at least two layers of thermoplastic material, and removing the mat.
摘要:
To leach the metal, crushed ore must be dumped in relatively thin layers of a height of approx. 5 m to 10 m. A conveying and stacking system, including a movable conveyor belt system, traveling tripper and stacker is used for this. The movable conveyor belt system is formed by a plurality of individual belts, the so-called grasshoppers. Provisions are made in the dumping technology for a high block for the end device in the conveying chain, the stacker with its swingable stacker boom, to always discharge an arc-shaped layer of ore, after which the device moves back by the amount of the next layer to be discharged in an arc-shaped pattern. This process is repeated until the stacker has moved back by the effective length of a grasshopper. Conveying is then stopped, one grasshopper is removed from the conveyor belt system and dumping of the ore is then continued. To enable this technology to be used, the stacker must be provided with a material pickup area, which is as long as a grasshopper. Furthermore, the material pickup must take place laterally from the direction of conveying of the stacker to ensure that the stacker is not hindered during the moving back. A transfer grasshopper is provided for this purpose, which stands in the direction of conveying at an angle of approx. 30° to 60° in relation to the main direction of conveying of the stacker. To enable the individual devices of the system to perform the movement intended for them, they are equipped with individually driven and steerable caterpillar-type chassis.
摘要:
A movable belt conveyor system for a leach pad for use for sulfidic copper ore, where favorable conditions are to be generated for leaching out the copper by a slight compaction of the ore piled up into a dump for the microbiological leaching technology. The movable belt conveyor system of a length of up to several km is composed of a plurality of smaller belt segments, comprising a tail segment (70), standard segments (711-n) and a head segment (72), as well as a traveling tripper (8). To prevent the loading by these individual components from being excessively compacted by the weight of the device during multiple travel over the dump during the moving process, the belt drives with the driving drum are accommodated in the tail element (70), which is supported on the soil next to the leach pad. In addition, the traveling tripper (8) is designed as an independent unit with the belt drums, additional belt drives and the belt-tensioning means, which unit is autarchically displaceable on a caterpillar-type moving gear (85) of its own. Due to the moving of the belt on the caterpillar-type moving gears of the standard segments (711-n), on the head segment (72) and on the traveling tripper (8) as well as due to the absorption of the weight of the tail segment (70) by the transfer carriage (6), the surface pressure acting locally on the dump is reduced and the compaction of the ore on the dump due to being traveled over by the belt conveyor system remains low. Traveling over with a moving device, which frequently happens with the use of a moving caterpillar, is eliminated.
摘要:
Substrate-spacer-prodrug compounds (pro-prodrugs) suited for site specific delivery of drugs, a process of preparing them and their use are described.
摘要:
The invention relates to a pharmacological composition comprising a polyelectrolyte complex, in particular a polyacid with an average particle size of less than 15 .mu.m and an active agent, among which are active peptides, proteins, enzymes, enzyme inhibitors, antigens, cytostatics, antiinflamatory agents, antibiotics and vaccines. The said composition ensures that the active agent is converted in a non-deleterious manner into a form which can be administered. In addition, the biodistribution, bioavailability and absorption of the pharmaceutical are beneficially affected.