公开(公告)号：US20130130297A1

公开(公告)日：2013-05-23

申请号：US13697233

申请日：2011-05-09

申请人： Michael Ott

发明人： Michael Ott

IPC分类号： C12N5/071

CPC分类号： C12N5/067 ,  C12N2501/60 ,  C12N2510/00

摘要： The present invention relates to a method for producing cells having a mature hepatocyte phenotype, comprising (a) providing a cell population comprising precursor cells of mature hepatocytes, wherein said cell population is obtained from a subject or derived from a cell line; and (b) introducing into said precursor cells a group of differentiation factors and/or the nucleic acid sequences encoding said differentiation factors, said group consisting of (i) one or more member(s) of the Foxa subfamily, (ii) HNF-4α and (iii) C/EBPα, thereby differentiating said precursor cells into cells having a mature hepatocyte phenotype.

摘要翻译： 本发明涉及一种生产具有成熟肝细胞表型的细胞的方法，其包括（a）提供包含成熟肝细胞前体细胞的细胞群，其中所述细胞群体来自受试者或衍生自细胞系; 和（b）向所述前体细胞中引入一组分化因子和/或编码所述分化因子的核酸序列，所述组由以下组成：（i）一个或多个Foxa亚家族成员，（ii）HNF- 4α和（iii）C /EBPα，从而将所述前体细胞分化成具有成熟肝细胞表型的细胞。

公开(公告)号：US20130028783A1

公开(公告)日：2013-01-31

申请号：US13639113

申请日：2010-04-12

申请人： Michael Ott ,  Sebastian Piegert

发明人： Michael Ott ,  Sebastian Piegert

IPC分类号： B23K35/24 ,  C22C19/05 ,  C22C30/00

CPC分类号： F01D5/005 ,  B23K35/30 ,  F05D2230/238 ,  Y02T50/67

摘要： A solder alloy including a base material, a solder, and an additive is provided. The solder alloy has the following formula: (1−x−y)*base material+x*solder+y*additive, where 0.2≦x≦0.8 and 0≦y

摘要翻译： 提供了包括基材，焊料和添加剂的焊料合金。 焊料合金具有以下公式：（1-x-y）*基材+ x *焊料+ y *添加剂，其中0.2＆nlE; x＆nlE; 0.8和0＆nlE; y <0.8以及（y <1-x）。 基材包括铬，镍，铝和钨。 焊料包括铬，钴，铝，钨，锗和/或镓和镍。 添加剂可以包括硼，锆和碳。

公开(公告)号：US20120310997A1

公开(公告)日：2012-12-06

申请号：US13152739

申请日：2011-06-03

申请人： Agustin Da Fieno Delucchi ,  Michael Ott ,  Chris Shoring ,  Elliot Lewis ,  Nabanita Majumdar ,  Atul Shenoy ,  Matios Bedrosian

发明人： Agustin Da Fieno Delucchi ,  Michael Ott ,  Chris Shoring ,  Elliot Lewis ,  Nabanita Majumdar ,  Atul Shenoy ,  Matios Bedrosian

IPC分类号： G06F17/30

CPC分类号： G06F8/61 ,  G06F9/454

摘要： A customer relationship management (CRM) application provides a user interface to detect language selection and create a default organization application using the selected language. The CRM application can enable a user to configure a subsequent organization application utilizing settings inherited from the default organization application. The CRM application can further enable the user to provide a second base language selection for the subsequent organization application installation and create the second organization application according to the language selection in hosted and/or on-premise environments.

摘要翻译： 客户关系管理（CRM）应用程序提供用户界面来检测语言选择，并使用所选择的语言创建默认组织应用程序。 CRM应用程序可以使用户能够使用继承自默认组织应用程序的设置来配置后续组织应用程序。 CRM应用程序还可以使用户为后续组织应用程序安装提供第二基本语言选择，并根据托管和/或内部部署环境中的语言选择创建第二组织应用程序。

公开(公告)号：US20120264805A1

公开(公告)日：2012-10-18

申请号：US13088086

申请日：2011-04-15

申请人： Amar Sharma ,  Tobias Cantz ,  Michael Ott ,  Nidhi Narain

发明人： Amar Sharma ,  Tobias Cantz ,  Michael Ott ,  Nidhi Narain

IPC分类号： A61K31/713 ,  C12N15/63 ,  A61P1/16 ,  A61K31/7105

CPC分类号： A61K9/127 ,  A61K31/7105 ,  A61K31/713 ,  C12N15/1135 ,  C12N15/88 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2799/025

摘要： Small inhibitory RNA (siRNA) molecules, which e.g. are purified and/or isolated, as an active in a medicament, which siRNA molecules are inhibitory RNA molecules that through RNA interference (RNAi) reduce or prevent expression of the p53 upregulated modulator of apoptosis (PUMA). The siRNA molecules can be administered as a medicament to a patient suffering from an impaired liver function or from liver damage for the treatment of a functionally impaired liver, for delaying a deterioration of liver function and/or for prevention of liver failure, especially in patients who suffer from a critical impairment of damage to the liver, e.g. for delaying the complete failure of liver function.

摘要翻译： 小抑制性RNA（siRNA）分子，例如 被纯化和/或分离，作为药物中的活性物质，siRNA分子是通过RNA干扰（RNAi）减少或阻止p53上调凋亡调节剂（PUMA）的表达的抑制性RNA分子。 siRNA分子可作为药物施用于患有肝功能受损或肝损伤的患者，用于治疗功能障碍的肝，延缓肝功能的恶化和/或预防肝衰竭，特别是在患者中 谁患有肝损伤的严重损害，例如 延缓肝功能完全失败。

公开(公告)号：US07967183B2

公开(公告)日：2011-06-28

申请号：US10588024

申请日：2005-01-28

申请人： Dirk Goldschmidt ,  Matthias Oechsner ,  Michael Ott ,  Uwe Paul ,  Ursula Pickert ,  Eckart Schumann ,  Beate Seiler ,  Robert Singer ,  Jan Steinbach ,  Andreas Volek ,  Volker Vosberg

发明人： Dirk Goldschmidt ,  Matthias Oechsner ,  Michael Ott ,  Uwe Paul ,  Ursula Pickert ,  Eckart Schumann ,  Beate Seiler ,  Robert Singer ,  Jan Steinbach ,  Andreas Volek ,  Volker Vosberg

IPC分类号： B23K31/02

CPC分类号： F01D5/005 ,  B23K1/0008 ,  B23K1/0018 ,  B23K1/002 ,  B23K1/005 ,  B23K2101/001 ,  B23P6/007

摘要： The invention relates to a method for repairing components comprising a base material with an oriented microstructure, wherein the repair point comprises a correspondingly oriented microstructure as the surrounding base material. According to the inventive method, solder is applied in the region of a point which is to be repaired and is soldered to the component by means of a heating effect produced by a device. A temperature gradient, i.e., approximately a temperature characteristic, is produced during the heating effect, said temperature characteristic ranging from a high to a low temperature in the region of the point which is to be repaired.

摘要翻译： 本发明涉及一种用于修复包括具有定向微结构的基材的部件的方法，其中所述修复点包括相应定向的微结构作为周围的基材。 根据本发明的方法，焊料被施加在要修复的点的区域中，并且通过由器件产生的加热效应被焊接到部件上。 在加热效果期间产生温度梯度，即近似温度特性，所述温度特性在要修复的点的区域中从高温到低温。

公开(公告)号：US20100129544A1

公开(公告)日：2010-05-27

申请号：US12596547

申请日：2008-03-27

申请人： Michael Ott ,  Jan Steinbach ,  Steffen Walter

发明人： Michael Ott ,  Jan Steinbach ,  Steffen Walter

IPC分类号： C23C18/12

CPC分类号： C23G5/00 ,  B23K1/206 ,  B23K9/235 ,  B23K26/60 ,  C23C18/06 ,  C23C18/122 ,  C23C18/1275 ,  C23C18/1295 ,  F01D5/005 ,  F01D25/002 ,  F05D2230/90 ,  F05D2300/2261 ,  F05D2300/611 ,  Y02T50/67 ,  Y02T50/672

摘要： A process for the gentle cleaning of partially corroded or oxidized surfaces with fluoride ions is provided. The parts of the surface which are not corroded or oxidized are coated with polymer-based ceramics before the start of the cleaning process. The coating process includes applying a precursor of the polymer-based ceramic and then ceramicizing the precursor.

摘要翻译： 提供了用氟离子温和清洗部分腐蚀或氧化的表面的方法。 在开始清洁过程之前，未被腐蚀或氧化的表面部分涂覆有基于聚合物的陶瓷。 涂覆方法包括施加聚合物基陶瓷的前体，然后使前体陶瓷化。

公开(公告)号：US20100083820A1

公开(公告)日：2010-04-08

申请号：US12575154

申请日：2009-10-07

申请人： Edward R. Doyner ,  Michael Ott

发明人： Edward R. Doyner ,  Michael Ott

IPC分类号： F41H5/08 ,  F21L4/00 ,  F21L4/02 ,  F41H5/26 ,  F41H5/02

CPC分类号： F41H5/08

摘要： Various embodiments of the present invention relate to protective shields, and more particularly, to ballistic shields. For the purposes of describing and claiming the present invention the term “ballistic shield” is intended to refer to a shield designed to minimize the chances of a fatality or serious injury in the event of a bullet strike, shrapnel strike, or the like (but not necessarily to be impenetrable to all types of strikes under all conditions).

摘要翻译： 本发明的各种实施例涉及防护罩，更具体地涉及防弹罩。 为了描述和要求本发明的目的，术语“弹道防护罩”旨在表示设计成在发生子弹撞击，弹片击打等的情况下最小化死亡或严重伤害的机会的屏蔽（但是 不一定在所有条件下都不可穿越各种罢工）。

公开(公告)号：US20100000976A1

公开(公告)日：2010-01-07

申请号：US11989214

申请日：2005-07-22

申请人： Michael Ott ,  Uwe Paul ,  Robert Singer ,  Andreas Volek

发明人： Michael Ott ,  Uwe Paul ,  Robert Singer ,  Andreas Volek

IPC分类号： B23K15/00 ,  B23K31/02 ,  B23K26/34

CPC分类号： B23P6/007 ,  B23K1/0018 ,  B23K1/002 ,  B23K1/0056 ,  B23K2101/001

摘要： In one aspect, a repair method for repairing components comprising a base material with a directed microstructure is provided. The repair is performed in such a way that the repaired location correspondingly has a directed microstructure like the surrounding base material. A solder is applied in the region of a location to be repaired and is soldered to the component via heat exposure, a temperature gradient, i.e., for instance a temperature variation from a higher temperature to a lower temperature, is thereby produced in the region of the location to be repaired.

摘要翻译： 在一个方面，提供了一种用于修复包括具有定向微结构的基材的部件的修复方法。 以这样的方式进行修复，即修理的位置相应地具有像周围的基材的定向微观结构。 在要修复的位置的区域中施加焊料，并且通过热暴露将其焊接到部件，从而在以下区域中产生温度梯度，即例如从较高温度到较低温度的温度变化 要修理的位置。

公开(公告)号：US20090107003A1

公开(公告)日：2009-04-30

申请号：US12083753

申请日：2006-10-06

申请人： Brigitte Heinecke ,  Michael Ott

发明人： Brigitte Heinecke ,  Michael Ott

IPC分类号： F26B3/00

CPC分类号： F01D5/005 ,  C23G5/00 ,  F01D25/002 ,  Y02T50/67

摘要： There is described a method for cleaning components that comprise cracks that are polluted with oxides, in particular gas turbine part. In said method, the components to be cleaned are exposed in a cleaning chamber at high temperature to a cleaning gas containing gaseous halogen compounds, which ionize to form halide ions. A cleaning gas is used containing 18 to 30% by volume hydrogen halide.

摘要翻译： 描述了一种用于清洁包含被氧化物，特别是燃气轮机部分污染的裂纹的部件的方法。 在所述方法中，要清洁的部件在高温清洗室中暴露于含有气态卤素化合物的清洁气体，该气态卤素化合物电离以形成卤离子。 使用含有18至30体积％卤化氢的清洁气体。

公开(公告)号：US07345207B2

公开(公告)日：2008-03-18

申请号：US10547732

申请日：2004-03-04

申请人： Eckhard Stroefer ,  Neven Lang ,  Hans Hasse ,  Thomas Grützner ,  Michael Ott

发明人： Eckhard Stroefer ,  Neven Lang ,  Hans Hasse ,  Thomas Grützner ,  Michael Ott

IPC分类号： G07C45/78 ,  C08G8/04

CPC分类号： C07C45/002 ,  C07C45/82 ,  C07C47/04

摘要： Process for preparing high-concentration formaldehyde solutions having a CH2O content of ≧50% by weight from an aqueous formaldehyde solution having a lower CH2O content by evaporation of part of this solution (partial evaporation), in which the aqueous formaldehyde solution is heated to an evaporation temperature T at which the gas phase becomes enriched in water relative to the liquid phase and the gas phase formed is taken off continuously or discontinuously, wherein the evaporation temperature T obeys the relationship: T[° C.]

摘要翻译： 通过蒸发具有较低CH 2 O 2含量的甲醛水溶液制备CH 2 O 2含量> 50重量％的高浓度甲醛溶液的方法 该部分溶液（部分蒸发），其中甲醛水溶液被加热到气相相对于液相富集水的蒸发温度T，形成的气相连续或不连续地取出，其中 蒸发温度T遵循以下关系：<？in-line-formula description =“In-line Formulas”end =“lead”？> T [°C。] <°C] <？in-line-formula description =“In-line Formulas”end =“tail”？> <？in-line-formula description =“In-line Formulas”end =“lead”？>其中T < （c）= A + Bx（c / 100）+ Cx（c / 100）2 + Dx（c / 100）3 < line-formula description =“In-line Formulas”end =“tail”？> A = + 68.759，B = + 124.77，C = -12.851，D = -10.095，其中c是瞬时CH 2， / 在蒸发期间甲醛水溶液的重量百分比为20〜99重量％。