公开(公告)号：US20050009107A1

公开(公告)日：2005-01-13

申请号：US10921218

申请日：2004-08-19

申请人： Daniel Soppet ,  Yi Li ,  Craig Rosen ,  Steven Ruben

发明人： Daniel Soppet ,  Yi Li ,  Craig Rosen ,  Steven Ruben

IPC分类号： A61K48/00 ,  C07K14/72 ,  C12N15/12 ,  G01N33/53 ,  C12N5/06 ,  C12P21/04

CPC分类号： C07K14/723 ,  A61K48/00 ,  C12N2799/026

摘要： Human G-protein parathyroid hormone (PTH) receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the PTH receptor receptor polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the PTH receptor receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host. Disclosed embodiments of the invention also include antibodies that bind Human G-Protein parathyroid hormone (PTH) receptor polypeptides and methods for making and using such antibodies.

摘要翻译： 公开了人类G蛋白甲状旁腺激素（PTH）受体多肽和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及在治疗上使用激动剂和拮抗剂治疗与PTH受体受体多肽的低表达和过表达相关的病症的方法。 还公开了用于检测PTH受体受体核酸序列中的突变并检测衍生自宿主的样品中受体的可溶形式水平的诊断方法。 本发明的公开的实施方案还包括结合人类G蛋白甲状旁腺激素（PTH）受体多肽的抗体以及制备和使用这些抗体的方法。

公开(公告)号：US5958400A

公开(公告)日：1999-09-28

申请号：US766620

申请日：1996-12-13

申请人： Steven Ruben ,  Haodong Li ,  Mark D. Adams

发明人： Steven Ruben ,  Haodong Li ,  Mark D. Adams

IPC分类号： G01N33/50 ,  A61K31/70 ,  A61K31/7088 ,  A61K38/00 ,  A61K45/00 ,  A61K48/00 ,  A61P3/10 ,  A61P7/00 ,  A61P7/04 ,  A61P9/00 ,  A61P29/00 ,  A61P31/00 ,  A61P31/12 ,  A61P35/00 ,  A61P35/02 ,  A61P37/02 ,  A61P43/00 ,  C07H21/04 ,  C07K14/54 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  C12R1/19 ,  G01N33/15 ,  G01N33/566 ,  A61K38/20 ,  C12N15/24 ,  C12N15/63

CPC分类号： C07K14/5412 ,  A61K38/00 ,  A61K48/00

摘要： Polynucleotides which encode the polypeptide IL-6SV, as well as such polypeptides, antibodies and antagonist inhibitors against the polypeptide and the use of the polypeptide as a pharmaceutical for treating cancer, auto-immune diseases, platelet reducing conditions, anemias, bone marrow and organ transplantation.

摘要翻译： 编码多肽IL-6SV的多核苷酸，以及针对多肽的多肽，抗体和拮抗剂抑制剂以及多肽作为治疗癌症的药物，自身免疫疾病，血小板减少病症，贫血，骨髓和器官的用途 移植。

公开(公告)号：US07358231B1

公开(公告)日：2008-04-15

申请号：US11606949

申请日：2006-12-01

申请人： Ian McCaffey ,  Kim Alving ,  Bruno Domon ,  Steven Ruben

发明人： Ian McCaffey ,  Kim Alving ,  Bruno Domon ,  Steven Ruben

IPC分类号： A61K31/00 ,  C07K1/00

CPC分类号： C07K14/4748 ,  G01N33/57438

摘要： The present invention provides a method for diagnosing and detecting diseases associated with pancreas. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in pancreatic diseases (PCAST) and antibodies binds to PCAST. The present invention provides that PCAST is used as targets for screening agents that modulates the PCAST activities. Further the present invention provides methods for treating diseases associated with pancreas.

摘要翻译： 本发明提供了诊断和检测与胰腺相关疾病的方法。 本发明提供在胰腺疾病（PCAST​​）中差异表达的一种或多种蛋白质或其片段，肽或核酸分子，并且抗体结合PCAST​​。 本发明提供PCAST​​作为调节PCAST​​活性的筛选试剂的靶标。 此外，本发明提供了治疗与胰腺相关疾病的方法。

公开(公告)号：US20070292411A1

公开(公告)日：2007-12-20

申请号：US11745734

申请日：2007-05-08

申请人： Theodora Salcedo ,  Viktor Roschke ,  Steven Ruben ,  Craig Rosen

发明人： Theodora Salcedo ,  Viktor Roschke ,  Steven Ruben ,  Craig Rosen

IPC分类号： A61K39/395 ,  A61P43/00 ,  C07K16/28 ,  C12N5/06 ,  C12N5/12 ,  C12P21/08 ,  G01N33/53

CPC分类号： G01N33/57411 ,  A61K2039/505 ,  C07K16/2878 ,  C07K2317/73 ,  G01N33/57419

摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptors. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TRAIL receptor antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor.

摘要翻译： 本发明涉及免疫特异性结合TRAIL受体的抗体和相关分子。 这样的抗体具有例如用于预防和治疗癌症和其它增殖性疾病的用途。 本发明还涉及编码抗TRAIL受体抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症和其它过度增殖性疾病的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段 或其变体，或免疫特异性结合TRAIL受体的相关分子。

公开(公告)号：US20070224121A1

公开(公告)日：2007-09-27

申请号：US11676830

申请日：2007-02-20

申请人： Paul Young ,  Steven Ruben

发明人： Paul Young ,  Steven Ruben

IPC分类号： A61K38/00 ,  C07H21/04 ,  C07K14/00 ,  C07K16/18 ,  C12N15/00 ,  C12N5/06 ,  C12P1/04 ,  G01N33/53

CPC分类号： C07K14/475 ,  A61K38/00 ,  C07K14/47 ,  G01N33/574 ,  G01N33/6893 ,  G01N33/74 ,  G01N2800/085 ,  G01N2800/323 ,  Y02A50/401 ,  Y02A50/411 ,  Y02A50/465 ,  Y02A50/475 ,  Y02A50/58

摘要： The present invention relates to a novel human protein called Connective Tissue Growth Factor-4, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.

摘要翻译： 本发明涉及称为结缔组织生长因子-4的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。 还提供了用于产生该人蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与该新型人蛋白相关的疾病的诊断和治疗方法。

公开(公告)号：US20070154918A1

公开(公告)日：2007-07-05

申请号：US11608978

申请日：2006-12-11

申请人： David LaFleur ,  Steven Ruben ,  Craig Rosen ,  Paul Moore ,  Yanggu Shi ,  Hla Kyaw ,  Ying-Fei Wei

发明人： David LaFleur ,  Steven Ruben ,  Craig Rosen ,  Paul Moore ,  Yanggu Shi ,  Hla Kyaw ,  Ying-Fei Wei

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

CPC分类号： C12Q1/6883 ,  A61K35/13 ,  A61K38/00 ,  C07K14/47 ,  G01N33/6893 ,  Y02A50/465

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

公开(公告)号：US20070042361A1

公开(公告)日：2007-02-22

申请号：US10472963

申请日：2002-03-26

申请人： Craig Rosen ,  Steven Ruben

发明人： Craig Rosen ,  Steven Ruben

IPC分类号： C12Q1/68 ,  G01N33/574 ,  A61K38/17

CPC分类号： C07K14/47 ,  A61K38/00 ,  Y02A50/393 ,  Y02A50/395

摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating cancer and other hyperproliferative diseases and disorders. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

摘要翻译： 本发明涉及人分泌多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗癌症及其它过度增殖性疾病和病症。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

公开(公告)号：US20070041963A1

公开(公告)日：2007-02-22

申请号：US11001793

申请日：2004-12-02

申请人： Craig Rosen ,  Steven Ruben

发明人： Craig Rosen ,  Steven Ruben

IPC分类号： C12Q1/68 ,  C07H21/04 ,  A61K39/395 ,  A61K48/00 ,  C07K14/47 ,  C07K16/18

CPC分类号： C07K14/47

摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

公开(公告)号：US20070032414A1

公开(公告)日：2007-02-08

申请号：US10472964

申请日：2002-03-26

申请人： Craig Rosen ,  Steven Ruben

发明人： Craig Rosen ,  Steven Ruben

IPC分类号： C12Q1/68 ,  G01N33/53 ,  A61K38/17

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  G01N2800/32

摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating cardiovascular diseases, disorders, and/or conditions related thereto. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

摘要翻译： 本发明涉及人分泌的多肽，以及编码所述多肽的分离的核酸分子，其可用于诊断和治疗与之有关的心血管疾病，病症和/或病症。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞和用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

公开(公告)号：US20070031842A1

公开(公告)日：2007-02-08

申请号：US10670186

申请日：2003-09-25

申请人： Craig Rosen ,  Steven Ruben

发明人： Craig Rosen ,  Steven Ruben

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C07K14/705 ,  C07K14/47 ,  C07K16/18 ,  C12N9/00

CPC分类号： C07K14/47 ,  A61K38/17

摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating immune disorders and diseases. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

摘要翻译： 本发明涉及人分泌的多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗免疫疾病和疾病。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。