公开(公告)号：US20240382307A1

公开(公告)日：2024-11-21

申请号：US18788468

申请日：2024-07-30

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Tamir S. Levi ,  Michael Bukin ,  Nikolai Gurovich ,  Ziv Yohanan

IPC: A61F2/24

Abstract: An implantable prosthetic valve including a plurality of leaflets and an annular frame that is radially expandable from a radially compressed state to a radially expanded state. The prosthetic valve also includes a skirt assembly comprising a reinforcing layer sandwiched between a first encapsulating layer and a second encapsulating layer, which are made of a thin elastomeric material. The reinforcing layer comprises a first set of yarns and a second set of yarns interwoven in a leno weave pattern, wherein the first and second sets of yarns are non-perpendicular and non-parallel to a longitudinal axis of the frame when the valve is in the radially expanded state. The first encapsulating layer and the second encapsulating layer can be fused or bonded along specified regions and form one or more pockets that enable free movement of sections of the reinforcing layer disposed therein.

公开(公告)号：US20240350262A1

公开(公告)日：2024-10-24

申请号：US18761769

申请日：2024-07-02

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Noam Miller ,  Anatoly Dvorsky ,  Eran Grosu ,  Michael Bukin ,  Nikolai Gurovich

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/243

Abstract: A prosthetic valve includes a frame having a first frame portion and a first window formed in the first frame portion. A threaded rod is coupled to the first frame portion and extends through the first window. Rotation of the threaded rod relative to the first frame portion radially expands or radially compresses the frame. A stopper is disposed within the first window and coupled to the threaded rod. The stopper is fixed in axial position relative to the threaded rod and axially movable within the first window by rotation of the threaded rod. The stopper can engage a first edge of the window to produce radial compression of the frame.

公开(公告)号：US20240350261A1

公开(公告)日：2024-10-24

申请号：US18761651

申请日：2024-07-02

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Alon Ben-Yosef ,  Eran Grosu ,  Michael Bukin ,  Nikolai Gurovich ,  Anatoly Dvorsky ,  Noam Miller ,  Ilan Leshecz ,  Joseph Mordechai Leichner

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2220/0033 ,  A61F2230/0006 ,  A61F2250/001

Abstract: This disclosure is directed to prosthetic heart valves having frames with features configured to increase the flexibility of certain frame components and/or to allow the frame to maintain an at least substantially cylindrical shape during deployment. In one example, a frame for an implantable device can include a first end, a second end, a plurality of angled struts, and a plurality of vertical struts. One or more vertical struts of the plurality of vertical struts includes a fixed end portion connected to a vertical strut junction, a free end portion, and a plurality of apertures disposed between the fixed end portion and the free end portion and configured to increase the flexibility of the one or more vertical struts. In some examples, one or more vertical struts of the plurality of vertical struts comprises an axially compressible aperture configured to enable the axial compression of the strut.

公开(公告)号：US20240325145A1

公开(公告)日：2024-10-03

申请号：US18739032

申请日：2024-06-10

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Anatoly Dvorsky ,  Eran Grosu ,  Michael Bukin ,  Nikolai Gurovich

IPC: A61F2/24

CPC classification number: A61F2/2433 ,  A61F2/2418 ,  A61F2250/001 ,  A61F2250/0098

Abstract: Certain examples of the disclosure concern a prosthetic device. The prosthetic device can include a radially compressible and expandable frame and a screw actuator coupled to the frame and configured to be rotated to radially expand the frame from a radially compressed state to a radially expanded state. The frame can include two or more pairs of first markers and second markers. The pairs of first and second markers can be circumferentially spaced apart from each other. The first and second markers of each pair can be axially aligned and axially movable relative to one another as the frame radially expands. Positions of the first and second markers can be configured so that a difference in axial distances between respective pairs of the first markers and second markers can indicate a degree of evenness of the frame's radial expansion.

公开(公告)号：US12048623B2

公开(公告)日：2024-07-30

申请号：US17492408

申请日：2021-10-01

Applicant: Edwards Lifesciences Corporation

Inventor： Nikolay Gurovich ,  Michael Bukin ,  Alexey Tsypenyuk ,  Elena Sherman ,  Dikla Kersh ,  Boaz Manash ,  Liron Tayeb ,  Ziv Yohanan ,  Alexander Barash ,  Yair A. Neumann ,  Tomer Saar

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2220/0033 ,  A61F2220/0075 ,  A61F2220/0091 ,  A61F2230/0069

Abstract: A prosthetic valve has an annular frame including a plurality of strut members that is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration. A leaflet structure is situated at least partially within the frame. The leaflet structure includes a plurality of leaflets, each leaflet having opposing commissure tab portions on opposite sides of the leaflet. Each commissure tab portion is paired with an adjacent commissure tab portion of an adjacent leaflet to form a commissure. The commissure tab portions of each leaflet are folded to form a plurality of layers positioned on the inside of the frame. A reinforcement member is positioned between the layers of each commissure tab portion.

公开(公告)号：US20240173129A1

公开(公告)日：2024-05-30

申请号：US18519557

申请日：2023-11-27

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Noam Nir ,  Michael Bukin

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/243 ,  A61F2002/9511 ,  A61F2250/0071

Abstract: A skirt for an implantable prosthetic device can include an annular fabric matrix radially expandable from a radially compressed configuration to a first diameter upon application of a radially outwardly directed force via the implantable prosthetic device, and a plurality of frangible restriction filaments embedded in the fabric matrix. Each restriction filament can have a selected maximum diameter different from that of at least one of the other restriction filaments, and each restriction filament can break when a radially outwardly directed force applied to the restriction filament exceeds a predetermined threshold.

公开(公告)号：US11925550B2

公开(公告)日：2024-03-12

申请号：US17694578

申请日：2022-03-14

Applicant: Edwards Lifesciences Corporation

Inventor： Tomer Saar ,  Michael Bukin ,  Elena Sherman ,  Alexander Barash ,  Yana Mayatskaya

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2412 ,  A61F2210/0014 ,  A61F2220/0075

Abstract: An implantable prosthetic valve that is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration includes an annular frame including a plurality of angled strut members, a plurality of leaflets disposed within the frame and secured to the frame, and a skirt member secured to the frame. The skirt member is disposed about an edge portion of a leaflet of the plurality of leaflets, and the skirt member includes a plurality of extension portions wrapped around at least one strut member. A cord member is threaded through at least a portion of the plurality of extension portions in a direction along an axis of the at least one strut member to secure the skirt member to the at least one strut member.

公开(公告)号：US20230372093A1

公开(公告)日：2023-11-23

申请号：US18358845

申请日：2023-07-25

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Michael Bukin ,  Nikolai Gurovich ,  Noam Nir ,  Tomer Saar ,  Tamir S. Levi

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2250/0069

Abstract: The present invention relates to implantable prosthetic devices, and more particularly, to 3D-shaped skirts having various coatings and/or configurations thereof.

公开(公告)号：US20230240843A1

公开(公告)日：2023-08-03

申请号：US18131325

申请日：2023-04-05

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Haim Yushtein ,  Noam Nir ,  Michael Bukin ,  David Maimon

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2403

Abstract: An implantable prosthetic device can include a radially expandable and compressible frame including an inflow end portion and an outflow end portion. The frame can include an expansion and locking mechanism comprising a member having a first set of lateral extensions disposed adjacent an outflow end and a second set of lateral extensions axially spaced from the first set, each lateral extension comprising a bore extending into the lateral extension. The frame can further comprise a commissure attachment member having a first set of arms each extending into a respective inner bore of the first set of lateral extensions and a second set of arms each extending into a respective inner bore of the second set of lateral extensions such that the commissure attachment member is restrained from movement relative to the expansion and locking mechanism in the radial and axial directions.

公开(公告)号：US11690710B2

公开(公告)日：2023-07-04

申请号：US17660394

申请日：2022-04-22

Applicant: Edwards Lifesciences Corporation

Inventor： Ziv Yohanan ,  Tamir S. Levi ,  Netanel Benichou ,  Michael Bukin ,  Nikolai Gurovich ,  Elena Sherman

IPC: A61F2/24

CPC classification number: A61F2/2409 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2220/0075 ,  A61F2230/0013 ,  A61F2230/0054 ,  A61F2250/0036 ,  A61F2250/0039

Abstract: A method of implanting a prosthetic heart valve within a patient can comprise inserting a distal end portion of a delivery apparatus and a prosthetic heart valve into the patient and advancing the prosthetic heart valve to a deployment location within the heart of the patient and inflating one or more of a plurality of differently-sized balloons in a balloon-assembly on the distal end portion of the delivery apparatus. The prosthetic heart valve can be mounted on the balloon assembly in a crimped state and the inflating of the one or more of the plurality of differently-sized balloons can expand the prosthetic heart valve from the crimped state to a radially expanded state having a non-cylindrical shape.