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    LOW-PROFILE HEART VALVE AND DELIVERY SYSTEM
    21.
    发明申请
    LOW-PROFILE HEART VALVE AND DELIVERY SYSTEM 审中-公开

    公开(公告)号：US20180177592A1

    公开(公告)日：2018-06-28

    申请号：US15901782

    申请日：2018-02-21

    Applicant: Edwards Lifesciences Corporation

    Inventor： Netanel Benichou ,  Stanton J. Rowe ,  Sean Chow

    IPC: A61F2/24

    Abstract: Disclosed replacement heart valves can be designed to be delivered to a native valve site while crimped on a delivery catheter. The crimped profile of the replacement valve can be minimized by, for example, separating a frame or stent structure from a leaflet structure, along the axial direction. Disclosed replacement valves can be transitioned from a delivery configuration, in which the crimped profile can be minimized, to an operating configuration. The replacement valve can be fully assembled in both the delivery and operating configurations. In some embodiments, the leaflets can be positioned outside of the stent in the delivery configuration, and positioned inside of the stent lumen in the operating configuration. Disclosed replacement valves can include a flexible sleeve coupling the leaflets to the stent and facilitating the transition to the operating configuration. Methods of implanting said replacement valves are also disclosed.

    CARDIAC VALVE REPAIR DEVICES CONFIGURED FOR PERCUTANEOUS DELIVERY
    23.
    发明申请
    CARDIAC VALVE REPAIR DEVICES CONFIGURED FOR PERCUTANEOUS DELIVERY 审中-公开
    CARDIAC阀维修设备配置用于PERCUTANEOUS DELIVERY

    公开(公告)号：US20160346084A1

    公开(公告)日：2016-12-01

    申请号：US15167760

    申请日：2016-05-27

    Applicant: Edwards Lifesciences Corporation

    Inventor： David M. Taylor ,  Tri D. Tran ,  Sean Chow ,  David L. Hauser ,  Pui Tong Ho ,  Alexander H. Cooper

    IPC: A61F2/24

    CPC classification number: A61F2/2445 ,  A61F2/2418 ,  A61F2/243 ,  A61F2/2433 ,  A61F2/2448 ,  A61F2/2466 ,  A61F2210/0014 ,  A61F2250/0014

    Abstract: Disclosed herein are devices for improving coaption of the mitral valve leaflets to reduce or eliminate mitral valve regurgitation. The devices may be used to perform mitral valve annuloplasty, or to serve as a docking station for a transcatheter prosthetic heart valve. The various embodiments of devices are configured for percutaneous and, in some cases, transvascular delivery. Delivery systems useful for routing the devices to the mitral valve are also disclosed, including catheters, balloons and/or mechanical expansion systems. The devices themselves include at least one tissue penetrating member. Methods of delivery include partially embedding the devices in the mitral valve annulus via at least one tissue penetrating member. Tissue penetrating members may be embedded into the tissue in a simultaneous or a nearly simultaneous fashion. Upon embedding, the devices employ various expansion and/or contraction features to adjust the mitral valve diameter. Adjustments may continue until the leaflets fully coapt and the problem of mitral regurgitation is reduced or eliminated.

    Abstract translation: 本文公开了用于改善二尖瓣小叶的缩小以减少或消除二尖瓣反流的装置。 该装置可用于进行二尖瓣瓣膜成形术，或用作经导管假体心脏瓣膜的对接站。 装置的各种实施例被配置用于经皮的，在一些情况下被配置为经血管递送。 还公开了用于将装置路由到二尖瓣的输送系统，包括导管，球囊和/或机械膨胀系统。 装置本身包括至少一个组织穿透构件。 递送方法包括通过至少一个组织穿透构件将装置部分地嵌入二尖瓣环中。 组织穿透构件可以以同时或几乎同时的方式嵌入组织中。 在嵌入时，装置采用各种膨胀和/或收缩特征来调节二尖瓣直径。 调整可能会继续，直到传单完全适应，并减少或消除二尖瓣反流问题。

    Crimping devices and methods
    25.
    发明授权
    Crimping devices and methods 有权

    公开(公告)号：US11963871B2

    公开(公告)日：2024-04-23

    申请号：US18080043

    申请日：2022-12-13

    Applicant: Edwards Lifesciences Corporation

    Inventor： Nicholas Brandon Aders ,  Kristen Hicks ,  Gil Senesh ,  Michael R. Bialas ,  Tung T. Le ,  Sean Chow ,  Thanh Huy Le

    IPC: B23P11/00 ,  A61F2/24 ,  A61F2/95

    CPC classification number: A61F2/2433 ,  B23P11/005 ,  A61F2/9524 ,  A61F2240/001 ,  A61F2250/0039

    Abstract: Devices and methods for crimping a prosthetic heart valve onto a delivery device are described. In some embodiments, valves are crimped over an inflatable balloon and between proximal and distal shoulders mounted on a shaft inside the balloon. Crimping methods can include multiple compression steps with the valve located in different axial positions relative to the crimping jaws at each different step. In some methods, the valve may extend partially outside of the crimping jaws during certain crimping steps, such that the crimping force is only applied to the part of the valve that is inside the jaws. Exemplary crimping devices can include two or more adjacent sets of jaws that close down to different inner diameters, such that different parts of a valve get compressed to different outer diameters at the same time during a single crimping step.

    Prosthetic heart valve having an inner frame and an outer frame
    27.
    发明授权
    Prosthetic heart valve having an inner frame and an outer frame 有权

    公开(公告)号：US11065115B2

    公开(公告)日：2021-07-20

    申请号：US16992332

    申请日：2020-08-13

    Applicant: Edwards Lifesciences Corporation

    Inventor： Netanel Benichou ,  Stanton J. Rowe ,  Sean Chow

    IPC: A61F2/24

    Abstract: Prosthetic heart valves are described. Prosthetic heart valves can include radially expandable and compressible inner and outer metal frames. The inner frame can be disposed within a lumen of the outer frame and can be coupled to the outer frame. An outflow end of the inner frame can be coupled to and/or located at an outflow end of the outer frame. An end portion of the inner frame can be spaced radially inwardly from an inner surface of the outer frame, such that a radial gap exists between the inner surface of the outer frame and an outer surface of the inner frame. Prosthetic heart valves can further include a plurality of leaflets disposed within and supported by the inner frame, such as by commissure posts of the inner frame.

    Delivery systems for prosthetic heart valve
    29.
    发明授权
    Delivery systems for prosthetic heart valve 有权

    公开(公告)号：US10856977B2

    公开(公告)日：2020-12-08

    申请号：US15789526

    申请日：2017-10-20

    Applicant: Edwards Lifesciences Corporation

    Inventor： Tri D. Tran ,  Ronaldo C. Cayabyab ,  David J. Evans ,  Sean Chow ,  Christopher Chia ,  Tamir S. Levi

    IPC: A61F2/24 ,  A61F2/958 ,  A61M25/10 ,  A61F2/95 ,  A61F2/48

    Abstract: A delivery apparatus for a prosthetic heart valve includes a shaft, an inner balloon, and an outer balloon. The shaft has a lumen extending from a proximal end portion to a distal end portion and a plurality of openings formed in the distal end portion. The shaft is configured such that a fluid can flow through the lumen and the openings. The inner balloon has end portions and a center portion disposed between the end portions. The inner balloon is mounted on the distal end portion of the shaft and is in fluid communication with the openings of the shaft. When the inner balloon is inflated with the fluid, the end portions expand farther radially outwardly than the center portion. The outer balloon is mounted to the shaft and disposed over the inner balloon. The outer balloon is configured to fully expand after the inner balloon at least partially expands.

    Steerable catheter with pull wire
    30.
    发明授权
    Steerable catheter with pull wire 有权

    公开(公告)号：US10792467B2

    公开(公告)日：2020-10-06

    申请号：US16128294

    申请日：2018-09-11

    Applicant: Edwards Lifesciences Corporation

    Inventor： Tri D. Tran ,  Sean Chow ,  Ronaldo C. Cayabyab

    IPC: A61M25/01 ,  A61F2/24 ,  A61M25/00

    Abstract: In one representative embodiment, a steerable catheter device comprises a shaft comprising a proximal portion, a distal portion, and a pull-wire lumen that extends at least partially through the proximal and distal portions. A pull wire extends through the pull-wire lumen and has a proximal end portion and a distal end portion, wherein the distal end portion of pull wire is fixed to the distal end portion of the shaft. An adjustment mechanism is operatively connected to the proximal end portion of the pull wire and configured to increase and decrease tension in the pull wire to adjust the curvature of the distal portion of the shaft. An axially non-compressible pull-wire sleeve extends co-axially through the pull-wire lumen and over the pull wire.

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