公开(公告)号：US20240358503A1

公开(公告)日：2024-10-31

申请号：US18767437

申请日：2024-07-09

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Nikolai Gurovich ,  Michael Bukin ,  Alexey Tsypenyuk ,  Elena Sherman ,  Dikla Kersh ,  Boaz Manash ,  Liron Tayeb ,  Ziv Yohanan ,  Alexander Barash ,  Yair A. Neumann ,  Tomer Saar

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2220/0033 ,  A61F2220/0075 ,  A61F2220/0091 ,  A61F2230/0069

Abstract: A prosthetic heart valve includes an annular frame including a plurality of strut members, the frame being radially collapsible to a collapsed configuration and radially expandable to an expanded configuration. A leaflet structure is situated at least partially within the frame, the leaflet structure including a plurality of leaflets, each leaflet having opposing commissure tab portions on opposite sides of the leaflet, each commissure tab portion being paired with an adjacent commissure tab portion of an adjacent leaflet to form a commissure, the commissure tab portions of each leaflet being folded such that each commissure tab portion forms a plurality of layers. A reinforcement member of a plurality of reinforcement members is positioned between the layers of each commissure tab portion. Each commissure tab portion of each leaflet is positioned entirely within the frame.

公开(公告)号：US20240099844A1

公开(公告)日：2024-03-28

申请号：US18478083

申请日：2023-09-29

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Arvin T. Chang ,  Yair A. Neumann ,  Gil Senesh ,  Hernan Altman ,  Scott Louis Pool ,  Hannah Gibson ,  Amanda Kristine Anderson White ,  Peter Phong Tran ,  Ly Th Phan

IPC: A61F2/24

CPC classification number: A61F2/2439 ,  A61F2/2418 ,  A61F2/2436

Abstract: A delivery apparatus for a medical device can include a handle, a shaft, a plurality of sleeves, and a suture. The shaft includes a proximal end portion coupled to the handle and is configured to be disposed outside of a patient's body during an implantation procedure and a distal end portion configured to be disposed inside a patient's body during the implantation procedure. Each of the sleeves includes a connection portion coupled to the distal end portion of the shaft and a receiving portion configured to receive an apex of a stent or a prosthetic heart valve. The suture extends through the shaft and the sleeves and is configured for releasably securing the stent or the prosthetic heart valve to the receiving portions of the sleeves.

公开(公告)号：US11801138B2

公开(公告)日：2023-10-31

申请号：US16808145

申请日：2020-03-03

Applicant: Edwards Lifesciences Corporation

Inventor： Arvin T. Chang ,  Yair A. Neumann ,  Gil Senesh ,  Hernan Altman ,  Scott Louis Pool ,  Hannah Gibson ,  Amanda Kristine Anderson White ,  Peter Phong Tran ,  Ly Th Phan

IPC: A61F2/24

CPC classification number: A61F2/2439 ,  A61F2/2418 ,  A61F2/2436

Abstract: A method for delivering a prosthetic valve to a native annulus of a heart can include inserting a delivery apparatus into a patient's body, advancing the delivery apparatus to an implantation location within the native annulus, retracting a delivery sheath of the delivery apparatus relative to the prosthetic valve to expose the prosthetic valve from a distal end of the delivery sheath, and after the prosthetic valve is exposed from the delivery sheath, expanding the prosthetic valve from a radially compressed state to a radially expanded state by reducing axial tension on a first end and a second end of the prosthetic valve.

公开(公告)号：US20230009249A1

公开(公告)日：2023-01-12

申请号：US17732185

申请日：2022-04-28

Applicant: Edwards Lifesciences Corporation

Inventor： Oren Cohen ,  Tomer Saar ,  Tamir S. Levi ,  Yair A. Neumann ,  David Maimon

IPC: A61F2/24

Abstract: A transcatheter delivery system including an expandable transition element is disclosed. As one example, an assembly may comprise a prosthetic valve and a delivery device. The delivery device may comprise an outer shaft with a distal end portion forming a sheath adapted to enclose the prosthetic valve therein in a radially compressed configuration; an inner shaft arranged within the outer shaft and including a nosecone arranged at a distal end of the inner shaft, the nosecone arranged outside of the outer shaft, at the distal end portion of the outer shaft; and an expandable transition element adapted to expand from a non-expanded state within the outer shaft to an expanded state outside the outer shaft, wherein, in the expanded state, the transition element forms a continuous transition from the nosecone to the prosthetic valve when the sheath is moved away from the nosecone to uncover the prosthetic valve.

公开(公告)号：US11344408B2

公开(公告)日：2022-05-31

申请号：US16813637

申请日：2020-03-09

Applicant: Edwards Lifesciences Corporation

Inventor： David Maimon ,  Boaz Manash ,  Eyal Leiba ,  Ziv Yohanan ,  Yair A. Neumann ,  Anatoly Dvorsky ,  Jonathan Bar-Or ,  Oren Cohen ,  Ofir Witzman ,  Liron Tayeb ,  Elazar Levi Schwarcz ,  Noam Miller ,  Tomer Saar

IPC: A61F2/24

Abstract: An assembly can comprise a radially expandable and compressible annular frame, at least one linear actuator assembly coupled to the frame and at least one locking mechanism coupled to the frame. The linear actuator can be configured to apply a distally directed force and/or a proximally directed force to the frame to radially expand or compress the frame. The locking mechanism can comprise a first sleeve member connected to the frame at a first location, a second sleeve member having internal threads and being connected to the frame at a second location, and a first screw configured to engage the internal threads of the second sleeve member to retain the frame in a radially expanded state.

公开(公告)号：US11135056B2

公开(公告)日：2021-10-05

申请号：US15978459

申请日：2018-05-14

Applicant: Edwards Lifesciences Corporation

Inventor： Nikolay Gurovich ,  Michael Bukin ,  Alexey M. Tsypenyuk ,  Elena Sherman ,  Dikla Kersh ,  Boaz Manash ,  Liron Tayeb ,  Ziv Yohanan ,  Alexander Barash ,  Yair A. Neumann ,  Tomer Saar

IPC: A61F2/24

Abstract: A prosthetic heart valve includes an annular frame including a plurality of strut members that is radially collapsible and expandable. A leaflet structure is situated within the frame, and includes a plurality of leaflets having opposing commissure tab portions on opposite sides of the leaflet. Each commissure tab portion is paired with an adjacent commissure tab portion of an adjacent leaflet to form one or more commissures. A commissure support element is positioned at each of the commissures, and comprise a first member and a second member that are separable from each other and configured to receive leaflets therebetween. The first and second members are detached from the frame and spaced radially inwardly from the frame such that the members contact the leaflets radially inward from the frame and limit movement of the leaflets so that they articulate at a location that is spaced radially inwardly from the frame.

公开(公告)号：US11026785B2

公开(公告)日：2021-06-08

申请号：US16208263

申请日：2018-12-03

Applicant: Edwards Lifesciences Corporation

Inventor： Alexander Barash ,  Yair A. Neumann ,  Tomer Saar ,  Ziv Yohanan ,  Noam Nir ,  Michael Bukin ,  Boaz Manash

IPC: A61F2/24 ,  A61F2/95

Abstract: In one embodiment, a prosthetic valve can comprise a radially expandable and compressible frame, which can include a plurality of struts which are pivotally joined together without requiring individual rivets. In some embodiments, the struts are interwoven, and can be joined using integral hinges formed in the struts, such as by performing alternate cuts on the struts, bending the struts to form stopper tabs adjacent to joints and/or drilling holes in the struts to facilitate interconnecting struts at joints, or otherwise forming integral hinges and corresponding holes at junction points between the struts. In another embodiment, the frame comprises a plurality of inner struts and outer struts which are connected by a plurality of chains of interconnected rivets, avoiding the need to provide individual rivets at each junction between struts. In still another embodiment, separate hinges or flanged rivets are provided to interconnect the struts.

公开(公告)号：US20180325665A1

公开(公告)日：2018-11-15

申请号：US15978459

申请日：2018-05-14

Applicant: Edwards Lifesciences Corporation

Inventor： Nikolay Gurovich ,  Michael Bukin ,  Alexey M. Tsypenyuk ,  Elena Sherman ,  Dikla Kersh ,  Boaz Manash ,  Liron Tayeb ,  Ziv Yohanan ,  Alexander Barash ,  Yair A. Neumann ,  Tomer Saar

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2220/0033 ,  A61F2220/0075 ,  A61F2220/0091 ,  A61F2230/0069

Abstract: A prosthetic heart valve includes an annular frame including a plurality of strut members that is radially collapsible and expandable. A leaflet structure is situated within the frame, and includes a plurality of leaflets having opposing commissure tab portions on opposite sides of the leaflet. Each commissure tab portion is paired with an adjacent commissure tab portion of an adjacent leaflet to form one or more commissures. A commissure support element is positioned at each of the commissures, and comprise a first member and a second member that are separable from each other and configured to receive leaflets therebetween. The first and second members are detached from the frame and spaced radially inwardly from the frame such that the members contact the leaflets radially inward from the frame and limit movement of the leaflets so that they articulate at a location that is spaced radially inwardly from the frame.

公开(公告)号：US20180153689A1

公开(公告)日：2018-06-07

申请号：US15831197

申请日：2017-12-04

Applicant: Edwards Lifesciences Corporation

Inventor： David Maimon ,  Boaz Manash ,  Eyal Leiba ,  Ziv Yohanan ,  Yair A. Neumann ,  Anatoly Dvorsky ,  Jonathan Bar-Or ,  Oren Cohen ,  Ofir Witzman ,  Liron Tayeb ,  Elazar Levi Schwarcz ,  Noam Miller ,  Tomer Saar

IPC: A61F2/24

Abstract: An assembly can comprise a radially expandable and compressible annular frame, at least one linear actuator assembly coupled to the frame and at least one locking mechanism coupled to the frame. The linear actuator can be configured to apply a distally directed force and/or a proximally directed force to the frame to radially expand or compress the frame. The locking mechanism can comprise a first sleeve member connected to the frame at a first location, a second sleeve member having internal threads and being connected to the frame at a second location, and a first screw configured to engage the internal threads of the second sleeve member to retain the frame in a radially expanded state.

公开(公告)号：US12127960B2

公开(公告)日：2024-10-29

申请号：US17673601

申请日：2022-02-16

Applicant: Edwards Lifesciences Corporation

Inventor： Eran Goldberg ,  Noa Axelrod Manela ,  Yair A. Neumann ,  Boaz Manash ,  David Maimon ,  Eyal Leiba ,  Ralph Schneider ,  Liron Tayeb

IPC: A61F2/966 ,  A61F2/24 ,  A61F2/95 ,  A61M25/00 ,  B29D23/00 ,  A61F2/958 ,  A61F2/962 ,  A61M29/00 ,  B29K105/08

CPC classification number: A61F2/966 ,  A61F2/2436 ,  A61F2/9526 ,  A61M25/0012 ,  A61M25/0023 ,  B29D23/00 ,  A61F2/9517 ,  A61F2/9522 ,  A61F2002/9583 ,  A61F2002/9623 ,  A61F2002/9665 ,  A61F2250/001 ,  A61M2025/0024 ,  A61M25/0045 ,  A61M25/005 ,  A61M25/0074 ,  A61M29/00 ,  A61M2205/0216 ,  B29K2105/0827

Abstract: An expandable sheath is disclosed herein, which has a first polymeric layer and a braided layer positioned radially outward of the first polymeric layer. The braided layer includes a plurality of filaments braided together. The expandable sheaths further include a resilient elastic layer positioned radially outward of the braided layer. The elastic layer is configured to apply radial force to the braided layer and the first polymeric layer. The expandable sheath further includes a second polymeric layer positioned radially outward of the elastic layer and bonded to the first polymeric layer such that the braided layer and the elastic layer are encapsulated between the first and second polymeric layers. Methods of making and using the devices disclosed herein are also disclosed, as are crimping devices that may be used in methods of making the devices disclosed herein.